Author results

2PZE
  • Download 2pze
  • View 2pze
Molmil generated image of 2pze
MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
登録日2007-05-17
公開日2007-10-09
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZF
  • Download 2pzf
  • View 2pzf
Molmil generated image of 2pzf
MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER WITH DELTA F508
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
登録日2007-05-18
公開日2007-10-09
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZG
  • Download 2pzg
  • View 2pzg
Molmil generated image of 2pzg
MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A MONOMER
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
登録日2007-05-18
公開日2007-10-09
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
1Q3H
  • Download 1q3h
  • View 1q3h
Molmil generated image of 1q3h
MOUSE CFTR NBD1 WITH AMP.PNP
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
登録日2003-07-29
公開日2003-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1R0W
  • Download 1r0w
  • View 1r0w
Molmil generated image of 1r0w
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) NUCLEOTIDE-BINDING DOMAIN ONE (NBD1) APO
分子名称:Cystic fibrosis transmembrane conductance regulator, ACETIC ACID
著者Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
登録日2003-09-23
公開日2003-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1R0X
  • Download 1r0x
  • View 1r0x
Molmil generated image of 1r0x
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) NUCLEOTIDE-BINDING DOMAIN ONE (NBD1) WITH ATP
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
登録日2003-09-23
公開日2003-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1R0Y
  • Download 1r0y
  • View 1r0y
Molmil generated image of 1r0y
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) NUCLEOTIDE-BINDING DOMAIN ONE (NBD1) WITH ADP
分子名称:Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-DIPHOSPHATE, ACETIC ACID
著者Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
登録日2003-09-23
公開日2003-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1R0Z
  • Download 1r0z
  • View 1r0z
Molmil generated image of 1r0z
PHOSPHORYLATED CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) NUCLEOTIDE-BINDING DOMAIN ONE (NBD1) WITH ATP
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
登録日2003-09-23
公開日2003-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1R10
  • Download 1r10
  • View 1r10
Molmil generated image of 1r10
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) NUCLEOTIDE-BINDING DOMAIN ONE (NBD1) WITH ATP, I4122 SPACE GROUP
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
登録日2003-09-23
公開日2003-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1XMI
  • Download 1xmi
  • View 1xmi
Molmil generated image of 1xmi
CRYSTAL STRUCTURE OF HUMAN F508A NBD1 DOMAIN WITH ATP
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Lewis, H.A., Zhao, X., Wang, C., Sauder, J.M., Rooney, I., Noland, B.W., Lorimer, D., Kearins, M.C., Conners, K., Condon, B., Maloney, P.C., Guggino, W.B., Hunt, J.F., Emtage, S., Structural GenomiX
登録日2004-10-02
公開日2004-11-09
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Impact of the delta-F508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure
J.Biol.Chem., 280, 2005
1XMJ
  • Download 1xmj
  • View 1xmj
Molmil generated image of 1xmj
CRYSTAL STRUCTURE OF HUMAN DELTAF508 HUMAN NBD1 DOMAIN WITH ATP
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Lewis, H.A., Zhao, X., Wang, C., Sauder, J.M., Rooney, I., Noland, B.W., Lorimer, D., Kearins, M.C., Conners, K., Condon, B., Maloney, P.C., Guggino, W.B., Hunt, J.F., Emtage, S., Structural GenomiX
登録日2004-10-02
公開日2004-11-09
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Impact of the delta-F508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure
J.Biol.Chem., 280, 2005
2BBO
  • Download 2bbo
  • View 2bbo
Molmil generated image of 2bbo
HUMAN NBD1 WITH PHE508
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Lewis, H.A., Kearins, M.C., Conners, K., Zhao, X., Lu, F., Sauder, J.M., Emtage, S.
登録日2005-10-17
公開日2005-11-01
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.
J.Mol.Biol., 396, 2010
2BBS
  • Download 2bbs
  • View 2bbs
Molmil generated image of 2bbs
HUMAN DELTAF508 NBD1 WITH THREE SOLUBILIZING MUTATIONS
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Lewis, H.A., Kearins, M.C., Conners, K., Zhao, X., Lu, F., Sauder, J.M., Emtage, S.
登録日2005-10-17
公開日2005-11-01
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.
J.Mol.Biol., 396, 2010
2BBT
  • Download 2bbt
  • View 2bbt
Molmil generated image of 2bbt
HUMAN DELTAF508 NBD1 WITH TWO SOLUBLIZING MUTATIONS.
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Lewis, H.A., Kearins, M.C., Conners, K., Zhao, X., Lu, F., Sauder, J.M., Emtage, S.
登録日2005-10-17
公開日2005-11-01
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.
J.Mol.Biol., 396, 2010
3GD7
  • Download 3gd7
  • View 3gd7
Molmil generated image of 3gd7
CRYSTAL STRUCTURE OF HUMAN NBD2 COMPLEXED WITH N6-PHENYLETHYL-ATP (P-ATP)
分子名称:Fusion complex of Cystic fibrosis transmembrane conductance regulator, residues 1193-1427 and Maltose/maltodextrin import ATP-binding protein malK, residues 219-371, ...
著者Atwell, S., Antonysamy, S., Conners, K., Emtage, S., Gheyi, T., Lewis, H.A., Lu, F., Sauder, J.M., Wasserman, S.R., Zhao, X.
登録日2009-02-23
公開日2010-03-02
最終更新日2018-11-21
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
To be Published
5KW2
  • Download 5kw2
  • View 5kw2
Molmil generated image of 5kw2
THE EXTRA-HELICAL BINDING SITE OF GPR40 AND THE STRUCTURAL BASIS FOR ALLOSTERIC AGONISM AND INCRETIN STIMULATION
分子名称:Free fatty acid receptor 1,Lysozyme,Free fatty acid receptor 1, (3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid
著者Ho, J.D., Chau, B., Rodgers, L., Lu, F., Wilbur, K.L., Otto, K.A., Chen, Y., Song, M., Riley, J.P., Yang, H.-C., Reynolds, N.A., Kahl, S.D., Lewis, A.P., Groshong, C., Madsen, R.E., Conners, K., Linswala, J.P., Gheyi, T., Saflor, M.D., Lee, M.R., Benach, J., Baker, K.A., Montrose-Rafizadeh, C., Genin, M.J., Miller, A.R., Hamdouchi, C.
登録日2016-07-15
公開日2018-05-02
最終更新日2018-05-09
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Structural basis for GPR40 allosteric agonism and incretin stimulation.
Nat Commun, 9, 2018
5KZN
  • Download 5kzn
  • View 5kzn
Molmil generated image of 5kzn
METABOTROPIC GLUTAMATE RECEPTOR
分子名称:Metabotropic glutamate receptor 2, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION
著者Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.
登録日2016-07-25
公開日2016-12-28
最終更新日2017-01-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J. Med. Chem., 59, 2016
5KZQ
  • Download 5kzq
  • View 5kzq
Molmil generated image of 5kzq
METABOTROPIC GLUTAMATE RECEPTOR IN COMPLEX WITH ANTAGONIST (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-AZANYL-3-[[3,4-BIS(FLUORANYL)PHENYL]SULFANYLMETHYL]-4-OXIDANYL-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID
分子名称:Metabotropic glutamate receptor 2, (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, N-ACETYL-D-GLUCOSAMINE
著者Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.
登録日2016-07-25
公開日2016-12-28
最終更新日2017-01-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J. Med. Chem., 59, 2016