Author results

2PZE
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-17
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZF
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER WITH DELTA F508
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-18
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZG
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A MONOMER
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-18
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
1Q3H
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MOUSE CFTR NBD1 WITH AMP.PNP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
Deposit date:2003-07-29
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1R0W
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CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) NUCLEOTIDE-BINDING DOMAIN ONE (NBD1) APO
Descriptor:Cystic fibrosis transmembrane conductance regulator, ACETIC ACID
Authors:Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
Deposit date:2003-09-23
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1R0X
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CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) NUCLEOTIDE-BINDING DOMAIN ONE (NBD1) WITH ATP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
Deposit date:2003-09-23
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1R0Y
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CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) NUCLEOTIDE-BINDING DOMAIN ONE (NBD1) WITH ADP
Descriptor:Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-DIPHOSPHATE, ACETIC ACID
Authors:Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
Deposit date:2003-09-23
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1R0Z
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PHOSPHORYLATED CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) NUCLEOTIDE-BINDING DOMAIN ONE (NBD1) WITH ATP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
Deposit date:2003-09-23
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1R10
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CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) NUCLEOTIDE-BINDING DOMAIN ONE (NBD1) WITH ATP, I4122 SPACE GROUP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Lewis, H.A., Buchanan, S.G., Burley, S.K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W.B., Hendrickson, W.A.
Deposit date:2003-09-23
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
1XMI
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CRYSTAL STRUCTURE OF HUMAN F508A NBD1 DOMAIN WITH ATP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Lewis, H.A., Zhao, X., Wang, C., Sauder, J.M., Rooney, I., Noland, B.W., Lorimer, D., Kearins, M.C., Conners, K., Condon, B., Maloney, P.C., Guggino, W.B., Hunt, J.F., Emtage, S., Structural GenomiX
Deposit date:2004-10-02
Release date:2004-11-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Impact of the delta-F508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure
J.Biol.Chem., 280, 2005
1XMJ
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CRYSTAL STRUCTURE OF HUMAN DELTAF508 HUMAN NBD1 DOMAIN WITH ATP
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Lewis, H.A., Zhao, X., Wang, C., Sauder, J.M., Rooney, I., Noland, B.W., Lorimer, D., Kearins, M.C., Conners, K., Condon, B., Maloney, P.C., Guggino, W.B., Hunt, J.F., Emtage, S., Structural GenomiX
Deposit date:2004-10-02
Release date:2004-11-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Impact of the delta-F508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure
J.Biol.Chem., 280, 2005
2BBO
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HUMAN NBD1 WITH PHE508
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Lewis, H.A., Kearins, M.C., Conners, K., Zhao, X., Lu, F., Sauder, J.M., Emtage, S.
Deposit date:2005-10-17
Release date:2005-11-01
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.
J.Mol.Biol., 396, 2010
2BBS
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HUMAN DELTAF508 NBD1 WITH THREE SOLUBILIZING MUTATIONS
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Lewis, H.A., Kearins, M.C., Conners, K., Zhao, X., Lu, F., Sauder, J.M., Emtage, S.
Deposit date:2005-10-17
Release date:2005-11-01
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.
J.Mol.Biol., 396, 2010
2BBT
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HUMAN DELTAF508 NBD1 WITH TWO SOLUBLIZING MUTATIONS.
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Lewis, H.A., Kearins, M.C., Conners, K., Zhao, X., Lu, F., Sauder, J.M., Emtage, S.
Deposit date:2005-10-17
Release date:2005-11-01
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.
J.Mol.Biol., 396, 2010
3GD7
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CRYSTAL STRUCTURE OF HUMAN NBD2 COMPLEXED WITH N6-PHENYLETHYL-ATP (P-ATP)
Descriptor:Fusion complex of Cystic fibrosis transmembrane conductance regulator, residues 1193-1427 and Maltose/maltodextrin import ATP-binding protein malK, residues 219-371, ...
Authors:Atwell, S., Antonysamy, S., Conners, K., Emtage, S., Gheyi, T., Lewis, H.A., Lu, F., Sauder, J.M., Wasserman, S.R., Zhao, X.
Deposit date:2009-02-23
Release date:2010-03-02
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
To be Published
5KW2
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THE EXTRA-HELICAL BINDING SITE OF GPR40 AND THE STRUCTURAL BASIS FOR ALLOSTERIC AGONISM AND INCRETIN STIMULATION
Descriptor:Free fatty acid receptor 1,Lysozyme,Free fatty acid receptor 1, (3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid
Authors:Ho, J.D., Chau, B., Rodgers, L., Lu, F., Wilbur, K.L., Otto, K.A., Chen, Y., Song, M., Riley, J.P., Yang, H.-C., Reynolds, N.A., Kahl, S.D., Lewis, A.P., Groshong, C., Madsen, R.E., Conners, K., Linswala, J.P., Gheyi, T., Saflor, M.D., Lee, M.R., Benach, J., Baker, K.A., Montrose-Rafizadeh, C., Genin, M.J., Miller, A.R., Hamdouchi, C.
Deposit date:2016-07-15
Release date:2018-05-02
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural basis for GPR40 allosteric agonism and incretin stimulation.
Nat Commun, 9, 2018
5KZN
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METABOTROPIC GLUTAMATE RECEPTOR
Descriptor:Metabotropic glutamate receptor 2, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION
Authors:Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.
Deposit date:2016-07-25
Release date:2016-12-28
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J. Med. Chem., 59, 2016
5KZQ
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METABOTROPIC GLUTAMATE RECEPTOR IN COMPLEX WITH ANTAGONIST (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-AZANYL-3-[[3,4-BIS(FLUORANYL)PHENYL]SULFANYLMETHYL]-4-OXIDANYL-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID
Descriptor:Metabotropic glutamate receptor 2, (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, N-ACETYL-D-GLUCOSAMINE
Authors:Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.
Deposit date:2016-07-25
Release date:2016-12-28
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J. Med. Chem., 59, 2016