Author results

3CMP
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CRYSTAL STRUCTURE OF SIDEROCALIN (NGAL, LIPOCALIN 2) K125A MUTANT COMPLEXED WITH FERRIC ENTEROBACTIN
Descriptor:Neutrophil gelatinase-associated lipocalin, FE (III) ION, SODIUM ION, ...
Authors:Clifton, M.C., Strong, R.K.
Deposit date:2008-03-24
Release date:2009-05-12
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands
To be Published
3HWD
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CRYSTAL STRUCTURE OF SIDEROCALIN (NGAL, LIPOCALIN 2) K125A-K134A MUTANT COMPLEXED WITH FERRIC ENTEROBACTIN
Descriptor:Neutrophil gelatinase-associated lipocalin, SODIUM ION
Authors:Clifton, M.C.
Deposit date:2009-06-17
Release date:2010-06-02
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands
To be Published
3HWE
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CRYSTAL STRUCTURE OF SIDEROCALIN (NGAL, LIPOCALIN 2) COMPLEXED WITH FE-BISHACAM
Descriptor:Neutrophil gelatinase-associated lipocalin, FE (III) ION, methyl N~6~-acetyl-N~2~-[(2,3-dihydroxyphenyl)carbonyl]-N~6~-hydroxy-D-lysyl-N~6~-acetyl-N~6~-hydroxy-L-lysinate, ...
Authors:Clifton, M.C.
Deposit date:2009-06-17
Release date:2010-06-02
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands
To be Published
3HWF
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CRYSTAL STRUCTURE OF SIDEROCALIN (NGAL, LIPOCALIN 2) COMPLEXED WITH FE-TRENCAM2-HOPO
Descriptor:Neutrophil gelatinase-associated lipocalin, FE (III) ION, SULFATE ION, ...
Authors:Clifton, M.C.
Deposit date:2009-06-17
Release date:2010-06-02
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands
To be Published
3HWG
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CRYSTAL STRUCTURE OF SIDEROCALIN (NGAL, LIPOCALIN 2) COMPLEXED WITH FE-TRENCAM-HOPO2
Descriptor:Neutrophil gelatinase-associated lipocalin, FE (III) ION, N,N'-{[(2-{[(2,3-dihydroxyphenyl)carbonyl]amino}ethyl)imino]diethane-2,1-diyl}bis(1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxamide), ...
Authors:Clifton, M.C.
Deposit date:2009-06-17
Release date:2010-06-02
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands
To be Published
3I0A
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CRYSTAL STRUCTURE OF SIDEROCALIN (NGAL, LIPOCALIN 2) K134A MUTANT COMPLEXED WITH FERRIC ENTEROBACTIN
Descriptor:Neutrophil gelatinase-associated lipocalin, SULFATE ION, FE (III) ION, ...
Authors:Clifton, M.C.
Deposit date:2009-06-24
Release date:2010-06-09
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands
To be Published
3K3L
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CRYSTAL STRUCTURE OF SIDEROCALIN (NGAL, LIPOCALIN 2) COMPLEXED WITH APO ENTEROBACTIN
Descriptor:Neutrophil gelatinase-associated lipocalin, 2-(2,3-DIHYDROXY-BENZOYLAMINO)-3-HYDROXY-PROPIONIC ACID, 2,3-DIHYDROXY-BENZOIC ACID, ...
Authors:Clifton, M.C.
Deposit date:2009-10-02
Release date:2010-08-18
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands
To be Published
3TCQ
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CRYSTAL STRUCTURE OF MATRIX PROTEIN VP40 FROM EBOLA VIRUS SUDAN
Descriptor:Matrix protein VP40
Authors:Clifton, M.C., Edwards, T.E., Anderson, V., Atkins, K., Raymond, A., Saphire, E.O., Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-08-09
Release date:2012-10-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus.
J Infect Dis, 212 Suppl 2, 2015
3TNY
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STRUCTURE OF YFIY FROM BACILLUS CEREUS BOUND TO THE SIDEROPHORE IRON (III) SCHIZOKINEN
Descriptor:YfiY (ABC transport system substrate-binding protein), [2-(hydroxy-kappaO)-4-[(3-{(hydroxy-kappaO)[1-(hydroxy-kappaO)ethenyl]amino}propyl)amino]-2-{2-[(3-{(hydroxy-kappaO)[1-(hydroxy-kappaO)ethenyl]amino}propyl)amino]-2-oxoethyl}-4-oxobutanoato(6-)-kappaO]iron
Authors:Clifton, M.C.
Deposit date:2011-09-02
Release date:2012-09-05
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands
To be Published
4WMR
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STRUCTURE OF MCL1 BOUND TO BRD INHIBITOR LIGAND 1 AT 1.7A
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, 7-[2-(1H-imidazol-1-yl)-4-methylpyridin-3-yl]-3-[3-(naphthalen-1-yloxy)propyl]-1-[2-oxo-2-(piperazin-1-yl)ethyl]-1H-indole-2-carboxylic acid, ...
Authors:CLIFTON, M.C., EDWARDS, T.E.
Deposit date:2014-10-09
Release date:2015-05-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.
Plos One, 10, 2015
4WMS
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STRUCTURE OF APO MBP-MCL1 AT 1.9A
Descriptor:MBP-MCL1 chimera protein, MALTOSE, MAGNESIUM ION, ...
Authors:Clifton, M.C., Dranow, D.M.
Deposit date:2014-10-09
Release date:2015-05-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.
Plos One, 10, 2015
4WMT
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STRUCTURE OF MBP-MCL1 BOUND TO LIGAND 1 AT 2.35A
Descriptor:MBP-MCL1 chimera protein, MALTOSE, 7-[2-(1H-imidazol-1-yl)-4-methylpyridin-3-yl]-3-[3-(naphthalen-1-yloxy)propyl]-1-[2-oxo-2-(piperazin-1-yl)ethyl]-1H-indole-2-carboxylic acid, ...
Authors:Clifton, M.C., Dranow, D.M.
Deposit date:2014-10-09
Release date:2015-05-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.
Plos One, 10, 2015
4WMU
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STRUCTURE OF MBP-MCL1 BOUND TO LIGAND 2 AT 1.55A
Descriptor:MBP-MCL1 chimera protein,Induced myeloid leukemia cell differentiation protein Mcl-1, MALTOSE, 6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1H-indole-2-carboxylic acid, ...
Authors:Clifton, M.C., Faiman, J.W.
Deposit date:2014-10-09
Release date:2015-05-06
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.
Plos One, 10, 2015
4WMV
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STRUCTURE OF MBP-MCL1 BOUND TO LIGAND 4 AT 2.4A
Descriptor:MBL-MCL1 chimera protein, MALTOSE, CHLORIDE ION, ...
Authors:Clifton, M.C., Moulin, A.
Deposit date:2014-10-09
Release date:2015-05-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.
Plos One, 10, 2015
4WMW
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THE STRUCTURE OF MBP-MCL1 BOUND TO LIGAND 5 AT 1.9A
Descriptor:MBP-MCL1 chimera protein, MAGNESIUM ION, 1,2-ETHANEDIOL, ...
Authors:Clifton, M.C., Dranow, D.M.
Deposit date:2014-10-09
Release date:2015-05-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.
Plos One, 10, 2015
4WMX
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THE STRUCTURE OF MBP-MCL1 BOUND TO LIGAND 6 AT 2.0A
Descriptor:MBP-MCL1 chimera protein, MALTOSE, 4-ethenyl-2-[(phenylsulfonyl)amino]benzoic acid, ...
Authors:Clifton, M.C., Dranow, D.M.
Deposit date:2014-10-09
Release date:2015-05-06
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.
Plos One, 10, 2015
3BY0
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CRYSTAL STRUCTURE OF SIDEROCALIN (NGAL, LIPOCALIN 2) W79A-R81A COMPLEXED WITH FERRIC ENTEROBACTIN
Descriptor:Neutrophil gelatinase-associated lipocalin, FE (III) ION, SULFATE ION, ...
Authors:Clifton, M.C., Pizzaro, J.C., Strong, R.K.
Deposit date:2008-01-15
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.572 Å)
Cite:The siderocalin/enterobactin interaction: a link between mammalian immunity and bacterial iron transport.
J.Am.Chem.Soc., 130, 2008
3CBC
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CRYSTAL STRUCTURE OF SIDEROCALIN (NGAL, LIPOCALIN 2) Y106F COMPLEXED WITH FERRIC ENTEROBACTIN
Descriptor:Neutrophil gelatinase-associated lipocalin, SULFATE ION, SODIUM ION, ...
Authors:Clifton, M.C., Pizaro, J.C., Strong, R.K.
Deposit date:2008-02-21
Release date:2008-09-09
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:The siderocalin/enterobactin interaction: a link between mammalian immunity and bacterial iron transport.
J.Am.Chem.Soc., 130, 2008
3PEC
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SIDEROCALIN RECOGNITIN OF CARBOXYMYCOBACTINS: INTERFERENCE BY THE IMMUNE SYSTEM IN INTRACELLULAR IRON ACQUISITION BY MYCOBACTERIA TUBERCULOSIS
Descriptor:Neutrophil gelatinase-associated lipocalin, GLYCEROL, SULFATE ION, ...
Authors:Clifton, M.C.
Deposit date:2010-10-25
Release date:2011-10-05
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Siderocalin Recognitin of Carboxymycobactins: Interference by the immune system in intracellular iron acquisition by Mycobacteria tuberculosis
To be Published
3PED
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SIDEROCALIN RECOGNITIN OF CARBOXYMYCOBACTINS: INTERFERENCE BY THE IMMUNE SYSTEM IN INTRACELLULAR IRON ACQUISITION BY MYCOBACTERIA TUBERCULOSIS
Descriptor:Neutrophil gelatinase-associated lipocalin, FE (III) ION, (9Z)-11-{hydroxy[(5S)-6-{[(1S)-3-{[(3S)-1-hydroxy-2-oxoazepan-3-yl]amino}-1-methyl-3-oxopropyl]oxy}-5-({[(4S)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]carbonyl}amino)-6-oxohexyl]amino}-11-oxoundec-9-enoic acid, ...
Authors:Clifton, M.C.
Deposit date:2010-10-25
Release date:2011-10-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Siderocalin Recognitin of Carboxymycobactins: Interference by the immune system in intracellular iron acquisition by Mycobacteria tuberculosis
To be Published
4WGI
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A SINGLE DIASTEREOMER OF A MACROLACTAM CORE BINDS SPECIFICALLY TO MYELOID CELL LEUKEMIA 1 (MCL1)
Descriptor:Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, MALTOSE, (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid, ...
Authors:Clifton, M.C., Fairman, J.W., Fang, C., D'Souza, B., Fulroth, B., Leed, A., McCarren, P., Wang, L., Wang, Y., Kaushik, V., Palmer, M., Wei, G., Golub, T.R., Hubbard, B.K., Serrano-Wu, M.H.
Deposit date:2014-09-18
Release date:2014-11-19
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).
Acs Med.Chem.Lett., 5, 2014
4XUX
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STRUCTURE OF AMPC BOUND TO RPX-7009 AT 1.75 A
Descriptor:Beta-lactamase, {(3R,6S)-2-hydroxy-3-[(thiophen-2-ylacetyl)amino]-1,2-oxaborinan-6-yl}acetic acid, 1,2-ETHANEDIOL, ...
Authors:Clifton, M.C., Abendroth, J.
Deposit date:2015-01-26
Release date:2015-04-01
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of a Cyclic Boronic Acid beta-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
J.Med.Chem., 58, 2015
4XUZ
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STRUCTURE OF CTX-M-15 BOUND TO RPX-7009 AT 1.5 A
Descriptor:Beta-lactamase, CHLORIDE ION, CITRIC ACID, ...
Authors:Clifton, M.C., Gardberg, A.
Deposit date:2015-01-26
Release date:2015-04-01
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery of a Cyclic Boronic Acid beta-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
J.Med.Chem., 58, 2015
6O5D
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PYOCHELIN
Descriptor:Neutrophil gelatinase-associated lipocalin, SULFATE ION, GLYCEROL
Authors:Rupert, P.B., Strong, R.K., Clifton, M.C., Edwards, T.E., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-03-01
Release date:2019-09-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands
J.Struct.Biol., 2019
3HYI
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CRYSTAL STRUCTURE OF FULL-LENGTH DUF199/WHIA FROM THERMATOGA MARITIMA
Descriptor:Protein DUF199/WhiA, GLYCEROL, SODIUM ION
Authors:Kaiser, B.K., Clifton, M.C., Shen, B.W., Stoddard, B.L.
Deposit date:2009-06-22
Release date:2009-09-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease
Structure, 17, 2009