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5ZR1
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SACCHAROMYCES CEREVISIAE ORIGIN RECOGNITION COMPLEX BOUND TO A 72-BP ORIGIN DNA CONTAINING ACS AND B1 ELEMENT
Descriptor:Origin recognition complex subunit 1, Origin recognition complex subunit 2, Origin recognition complex subunit 3, ...
Authors:Li, N., Lam, W.H., Zhai, Y., Cheng, J., Cheng, E., Zhao, Y., Gao, N., Tye, B.K.
Deposit date:2018-04-21
Release date:2018-07-11
Last modified:2018-07-25
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the origin recognition complex bound to DNA replication origin.
Nature, 559, 2018
3JCD
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STRUCTURE OF ESCHERICHIA COLI EF4 IN POSTTRANSLOCATIONAL RIBOSOMES (POST EF4)
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, D., Yan, K., Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Low, J., Gao, N., Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
3JCE
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STRUCTURE OF ESCHERICHIA COLI EF4 IN PRETRANSLOCATIONAL RIBOSOMES (PRE EF4)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, D., Yan, K., Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Low, J., Gao, N., Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2017-02-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
5H7I
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CRYO-EM STRUCTURE OF THE CDT1-MCM2-7 COMPLEX IN AMPPNP STATE
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Zhai, Y., Cheng, E., Wu, H., Li, N., Yung, P.Y., Gao, N., Tye, B.K.
Deposit date:2016-11-18
Release date:2017-02-08
Last modified:2017-03-15
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer
Nat. Struct. Mol. Biol., 24, 2017
5XF8
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CRYO-EM STRUCTURE OF THE CDT1-MCM2-7 COMPLEX IN AMPPNP STATE
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Zhai, Y., Cheng, E., Wu, H., Li, N., Yung, P.Y., Gao, N., Tye, B.K.
Deposit date:2017-04-09
Release date:2017-05-03
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer
Nat. Struct. Mol. Biol., 24, 2017
4JN9
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CRYSTAL STRUCTURE OF THE DEPH
Descriptor:DepH, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ...
Authors:Li, J., Wang, C., Zhang, Z.M., Zhou, J.H., Cheng, E.
Deposit date:2013-03-14
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis.
Sci Rep, 4, 2014
4JNA
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CRYSTAL STRUCTURE OF THE DEPH COMPLEX WITH DIMETHYL-FK228
Descriptor:DepH, Dimethyl FK228, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Li, J., Wang, C., Zhang, Z.M., Zhou, J.H., Cheng, E.
Deposit date:2013-03-14
Release date:2014-03-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis.
Sci Rep, 4, 2014
3SBD
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CRYSTAL STRUCTURE OF RAC1 P29S MUTANT
Descriptor:Ras-related C3 botulinum toxin substrate 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION
Authors:Ha, B.H., Boggon, T.J.
Deposit date:2011-06-03
Release date:2012-07-18
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
3SBE
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CRYSTAL STRUCTURE OF RAC1 P29S MUTANT
Descriptor:Ras-related C3 botulinum toxin substrate 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION
Authors:Ha, B.H., Boggon, T.J.
Deposit date:2011-06-03
Release date:2012-07-18
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
3TH5
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CRYSTAL STRUCTURE OF WILD-TYPE RAC1
Descriptor:Ras-related C3 botulinum toxin substrate 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION
Authors:Ha, B.H., Boggon, T.J.
Deposit date:2011-08-18
Release date:2012-07-18
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
4O13
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THE CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH GNE-618
Descriptor:Nicotinamide phosphoribosyltransferase, N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, PHOSPHATE ION, ...
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O14
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STRUCTURAL BASIS FOR RESISTANCE TO DIVERSE CLASSES OF NAMPT INHIBITORS
Descriptor:Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, 1,2-ETHANEDIOL
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.871 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O15
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THE CRYSTAL STRUCTURE OF A MUTANT NAMPT (S165F) IN COMPLEX WITH GNE-618
Descriptor:Nicotinamide phosphoribosyltransferase, N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, PHOSPHATE ION, ...
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O16
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STRUCTURAL BASIS FOR RESISTANCE TO DIVERSE CLASSES OF NAMPT INHIBITORS
Descriptor:Nicotinamide phosphoribosyltransferase, 6-({4-[(3,5-difluorophenyl)sulfonyl]benzyl}carbamoyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)imidazo[1,2-a]pyridin-1-ium, PHOSPHATE ION, ...
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.783 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O17
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STRUCTURAL BASIS FOR RESISTANCE TO DIVERSE CLASSES OF NAMPT INHIBITORS
Descriptor:Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, 1,2-ETHANEDIOL
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O18
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STRUCTURAL BASIS FOR RESISTANCE TO DIVERSE CLASSES OF NAMPT INHIBITORS
Descriptor:Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, 1,2-ETHANEDIOL
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O19
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THE CRYSTAL STRUCTURE OF A MUTANT NAMPT (G217V)
Descriptor:Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, 1,2-ETHANEDIOL
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O1A
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THE CRYSTAL STRUCTURE OF THE MUTANT NAMPT G217R
Descriptor:Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, 1,2-ETHANEDIOL
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O1B
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THE CRYSTAL STRUCTURE OF A MUTANT NAMPT (G217R) IN COMPLEX WITH AN INHIBITOR APO866
Descriptor:Nicotinamide phosphoribosyltransferase, (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, PHOSPHATE ION, ...
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O1C
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THE CRYSTAL STRUCTURES OF A MUTANT NAMPT H191R
Descriptor:Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, 1,2-ETHANEDIOL
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O1D
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STRUCTURAL BASIS FOR RESISTANCE TO DIVERSE CLASSES OF NAMPT INHIBITORS
Descriptor:Nicotinamide phosphoribosyltransferase, (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, PHOSPHATE ION, ...
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-15
Release date:2014-10-22
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (1.705 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4O28
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STRUCTURAL BASIS FOR RESISTANCE TO DIVERSE CLASSES OF NAMPT INHIBITORS
Descriptor:Nicotinamide phosphoribosyltransferase, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide, PHOSPHATE ION, ...
Authors:Oh, A., Coons, M., Brillantes, B., Wang, W.
Deposit date:2013-12-17
Release date:2014-10-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Plos One, 9, 2014
4WQ6
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THE CRYSTAL STRUCTURE OF HUMAN NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) IN COMPLEX WITH N-(4-{(S)-[1-(2-METHYLPROPYL)PIPERIDIN-4-YL]SULFINYL}BENZYL)FURO[2,3-C]PYRIDINE-2-CARBOXAMIDE INHIBITOR (COMPOUND 21)
Descriptor:Nicotinamide phosphoribosyltransferase, N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide, PHOSPHATE ION, ...
Authors:Li, D., Wang, W.
Deposit date:2014-10-21
Release date:2015-02-11
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg.Med.Chem.Lett., 25, 2015