4WQ6
The crystal structure of human Nicotinamide phosphoribosyltransferase (NAMPT) in complex with N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide inhibitor (compound 21)
Summary for 4WQ6
Entry DOI | 10.2210/pdb4wq6/pdb |
Descriptor | Nicotinamide phosphoribosyltransferase, N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P43490 |
Total number of polymer chains | 2 |
Total formula weight | 115950.66 |
Authors | |
Primary citation | Zak, M.,Liederer, B.M.,Sampath, D.,Yuen, P.W.,Bair, K.W.,Baumeister, T.,Buckmelter, A.J.,Clodfelter, K.H.,Cheng, E.,Crocker, L.,Fu, B.,Han, B.,Li, G.,Ho, Y.C.,Lin, J.,Liu, X.,Ly, J.,O'Brien, T.,Reynolds, D.J.,Skelton, N.,Smith, C.C.,Tay, S.,Wang, W.,Wang, Z.,Xiao, Y.,Zhang, L.,Zhao, G.,Zheng, X.,Dragovich, P.S. Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. Bioorg.Med.Chem.Lett., 25:529-541, 2015 Cited by PubMed: 25556090DOI: 10.1016/j.bmcl.2014.12.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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