Author results

1R3U
  • Download 1r3u
  • View 1r3u
Molmil generated image of 1r3u
CRYSTAL STRUCTURE OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE FROM THERMOANAEROBACTER TENGCONGENSIS
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, ACETATE ION
Authors:Chen, Q., Liang, Y.H., Gu, X.C., Luo, M., Su, X.D.
Deposit date:2003-10-03
Release date:2004-10-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis
To be published
1YFZ
  • Download 1yfz
  • View 1yfz
Molmil generated image of 1yfz
NOVEL IMP BINDING IN FEEDBACK INHIBITION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE FROM THERMOANAEROBACTER TENGCONGENSIS
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, ACETATE ION, MAGNESIUM ION, ...
Authors:Chen, Q., Liang, Y., Su, X., Gu, X., Zheng, X., Luo, M.
Deposit date:2005-01-04
Release date:2005-05-10
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Alternative IMP Binding in Feedback Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis.
J.Mol.Biol., 348, 2005
2AIN
  • Download 2ain
  • View 2ain
Molmil generated image of 2ain
SOLUTION STRUCTURE OF THE AF-6 PDZ DOMAIN COMPLEXED WITH THE C-TERMINAL PEPTIDE FROM THE BCR PROTEIN
Descriptor:Afadin, 6-mer peptide from Breakpoint cluster region protein
Authors:Chen, Q., Wu, J., Shi, Y.
Deposit date:2005-07-30
Release date:2006-07-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complex.
Protein Sci., 16, 2007
2GEB
  • Download 2geb
  • View 2geb
Molmil generated image of 2geb
CRYSTAL STRUCTURE OF THE THERMOANAEROBACTER TENGCONGENSIS HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE L160I MUTANT: INSIGHTS INTO THE INHIBITOR DESIGN
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, CALCIUM ION
Authors:Chen, Q., Luo, M.
Deposit date:2006-03-19
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design.
Febs J., 274, 2007
3LAF
  • Download 3laf
  • View 3laf
Molmil generated image of 3laf
STRUCTURE OF DCC, A NETRIN-1 RECEPTOR
Descriptor:Deleted in Colorectal Cancer, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Chen, Q., Liu, J.-H., Wang, J.-H.
Deposit date:2010-01-06
Release date:2011-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors.
J.Cell.Sci., 126, 2013
3LCY
  • Download 3lcy
  • View 3lcy
Molmil generated image of 3lcy
TITIN IG TANDEM DOMAINS A164-A165
Descriptor:Titin
Authors:Chen, Q., Groves, M.R., Wilmanns, M.
Deposit date:2010-01-12
Release date:2011-05-25
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural investigation of the Titin A-band tandem Ig domains A164-A165
To be Published
4Z90
  • Download 4z90
  • View 4z90
Molmil generated image of 4z90
ELIC BOUND WITH THE ANESTHETIC ISOFLURANE IN THE RESTING STATE
Descriptor:Gamma-aminobutyric-acid receptor subunit beta-1, (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Chen, Q., Kinde, M., Arjunan, P., Cohen, A., Xu, Y., Tang, P.
Deposit date:2015-04-09
Release date:2015-09-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep, 5, 2015
4Z91
  • Download 4z91
  • View 4z91
Molmil generated image of 4z91
ELIC COCRYSTALLIZED WITH ISOFLUORANE IN A DESENSITIZED STATE
Descriptor:Gamma-aminobutyric-acid receptor subunit beta-1, (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Chen, Q., Kinde, M.N., Arjunan, P., Cohen, A., Xu, Y., Tang, P.
Deposit date:2015-04-09
Release date:2015-09-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.3915 Å)
Cite:Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep, 5, 2015
5SXU
  • Download 5sxu
  • View 5sxu
Molmil generated image of 5sxu
X-RAY STRUCTURE OF 2-BROMOETHANOL BOUND TO A PENTAMERIC LIGAND GATED ION CHANNEL (ELIC) IN A DESENSITIZED STATE
Descriptor:Gamma-aminobutyric-acid receptor subunit beta-1, 2-BROMOETHANOL, 3-AMINOPROPANE, ...
Authors:Chen, Q., Kinde, M., Cohen, A., Xu, Y., Tang, P.
Deposit date:2016-08-10
Release date:2017-06-21
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.
Structure, 25, 2017
5SXV
  • Download 5sxv
  • View 5sxv
Molmil generated image of 5sxv
X-RAY STRUCTURE OF 2-BROMOETHANOL BOUND TO A PENTAMERIC LIGAND GATED ION CHANNEL (ELIC) IN A RESTING STATE
Descriptor:Cys-loop ligand-gated ion channel, 2-BROMOETHANOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Chen, Q., Kinde, M., Cohen, A., Xu, Y., Tang, P.
Deposit date:2016-08-10
Release date:2017-06-21
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.
Structure, 25, 2017
5TV1
  • Download 5tv1
  • View 5tv1
Molmil generated image of 5tv1
ACTIVE ARRESTIN-3 WITH INOSITOL HEXAKISPHOSPHATE
Descriptor:Beta-arrestin-2, INOSITOL HEXAKISPHOSPHATE, GLYCEROL
Authors:Chen, Q., Gilbert, N.C., Perry, N.A., Vishniveteskiy, S., Gurevich, V.V., Iverson, T.M.
Deposit date:2016-11-07
Release date:2017-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of arrestin-3 activation and signaling.
Nat Commun, 8, 2017
5WPQ
  • Download 5wpq
  • View 5wpq
Molmil generated image of 5wpq
CRYO-EM STRUCTURE OF MAMMALIAN ENDOLYSOSOMAL TRPML1 CHANNEL IN NANODISCS IN CLOSED I CONFORMATION AT 3.64 ANGSTROM RESOLUTION
Descriptor:Mucolipin-1, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
Authors:Chen, Q., She, J., Guo, J., Bai, X., Jiang, Y.
Deposit date:2017-08-07
Release date:2017-10-18
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
5WPT
  • Download 5wpt
  • View 5wpt
Molmil generated image of 5wpt
CRYO-EM STRUCTURE OF MAMMALIAN ENDOLYSOSOMAL TRPML1 CHANNEL IN NANODISCS IN CLOSED II CONFORMATION AT 3.75 ANGSTROM RESOLUTION
Descriptor:Mucolipin-1, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
Authors:Chen, Q., She, J., Guo, J., Bai, X., Jiang, Y.
Deposit date:2017-08-07
Release date:2017-10-18
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
5WPV
  • Download 5wpv
  • View 5wpv
Molmil generated image of 5wpv
CRYO-EM STRUCTURE OF MAMMALIAN ENDOLYSOSOMAL TRPML1 CHANNEL IN NANODISCS AT 3.59 ANGSTROM RESOLUTION
Descriptor:Mucolipin-1, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
Authors:Chen, Q., She, J., Guo, J., Bai, X., Jiang, Y.
Deposit date:2017-08-07
Release date:2017-10-18
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
6C9O
  • Download 6c9o
  • View 6c9o
Molmil generated image of 6c9o
SELENOMETHIONINE MUTANT (V29SEM) OF PROTEIN GB1 EXAMINED BY X-RAY DIFFRACTION
Descriptor:Immunoglobulin G-binding protein G, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Chen, Q.
Deposit date:2018-01-28
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:77Se-Selenomethionine as a probe of its environment in proteins
To Be Published
6CDU
  • Download 6cdu
  • View 6cdu
Molmil generated image of 6cdu
CRYSTAL STRUCTURE OF A CHIMERIC HUMAN ALPHA1GABAA RECEPTOR IN COMPLEX WITH ALPHAXALONE
Descriptor:chimeric alpha1GABAA receptor, (3a,5a)-3-Hydroxypregnane-11,20-dione
Authors:Chen, Q., Arjunan, P., Cohen, A.E., Xu, Y., Tang, P.
Deposit date:2018-02-09
Release date:2018-08-22
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Structural basis of neurosteroid anesthetic action on GABAAreceptors.
Nat Commun, 9, 2018
6CHE
  • Download 6che
  • View 6che
Molmil generated image of 6che
SELENOMETHIONINE MUTANT (A34SEM) OF PROTEIN GB1 EXAMINED BY X-RAY DIFFRACTION
Descriptor:Immunoglobulin G-binding protein G, (4S)-2-METHYL-2,4-PENTANEDIOL, IMIDAZOLE
Authors:Chen, Q.
Deposit date:2018-02-22
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:77-Se-selenomethionine as a probe of its environment in proteins
To Be Published
6CNE
  • Download 6cne
  • View 6cne
Molmil generated image of 6cne
SELENOMETHIONINE MUTANT (L5SEM) OF PROTEIN GB1 EXAMINED BY X-RAY DIFFRACTION
Descriptor:Immunoglobulin G-binding protein G, (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION
Authors:Chen, Q.
Deposit date:2018-03-08
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:77Se-selenomethionine as a probe of its environment in proteins
To Be Published
6CPZ
  • Download 6cpz
  • View 6cpz
Molmil generated image of 6cpz
SELENOMETHIONINE MUTANT (I6SEM) OF PROTEIN GB1 EXAMINED BY X-RAY DIFFRACTION
Descriptor:Immunoglobulin G-binding protein G, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Chen, Q., Rozovsky, S.
Deposit date:2018-03-14
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:77-Se-Selenomethionine as a probe of its environment in proteins
To be published
6CTE
  • Download 6cte
  • View 6cte
Molmil generated image of 6cte
77SE-NMR PROBES THE PROTEIN ENVIRONMENT OF SELENOMETHIONINE
Descriptor:Immunoglobulin G-binding protein G, (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, ...
Authors:Chen, Q., Rozovsky, S.
Deposit date:2018-03-22
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:77-Se-selenomethionine as a probe of its environment in proteins
To Be Published
6D1S
  • Download 6d1s
  • View 6d1s
Molmil generated image of 6d1s
CRYSTAL STRUCTURE OF AN APO CHIMERIC HUMAN ALPHA1GABAA RECEPTOR
Descriptor:chimeric alpha1GABAA receptor
Authors:Chen, Q., Arjunan, P., Cohen, A.E., Xu, Y., Tang, P.
Deposit date:2018-04-12
Release date:2018-08-22
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of neurosteroid anesthetic action on GABAAreceptors.
Nat Commun, 9, 2018
6E5V
  • Download 6e5v
  • View 6e5v
Molmil generated image of 6e5v
HUMAN MGLU8 RECEPTOR AMINO TERMINAL DOMAIN IN COMPLEX WITH (S)-3,4-DICARBOXYPHENYLGLYCINE (DCPG)
Descriptor:Metabotropic glutamate receptor 8, 4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic acid, CHLORIDE ION
Authors:Chen, Q., Ho, J.D., Ashok, S., Vargas, M.C., Wang, J., Atwell, S., Bures, M., Schkeryantz, J.M., Monn, J.A., Hao, J.
Deposit date:2018-07-23
Release date:2018-11-07
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8Receptor.
J. Med. Chem., 61, 2018
3Q5T
  • Download 3q5t
  • View 3q5t
Molmil generated image of 3q5t
V BETA/V BETA HOMODIMERIZATION-BASED PRE-TCR MODEL SUGGESTED BY TCR BETA CRYSTAL STRUCTURES
Descriptor:TCR N30 beta
Authors:Chen, Q., Zhang, H., Wang, J.-H.
Deposit date:2010-12-29
Release date:2011-03-16
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:A conserved hydrophobic patch on V beta domains revealed by TCR beta chain crystal structures: Implications for pre-TCR dimerization.
Front Immunol, 2, 2011
3Q5Y
  • Download 3q5y
  • View 3q5y
Molmil generated image of 3q5y
V BETA/V BETA HOMODIMERIZATION-BASED PRE-TCR MODEL SUGGESTED BY TCR BETA CRYSTAL STRUCTURES
Descriptor:TCR N15 beta, GLYCEROL, DI(HYDROXYETHYL)ETHER, ...
Authors:Chen, Q., Zhang, H., Wang, J.-H.
Deposit date:2010-12-30
Release date:2011-03-09
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A conserved hydrophobic patch on Vbeta domains revealed by TCRbeta chain crystal structures: implications for pre-TCR dimerization
Front Immunol, 2, 2011
4D90
  • Download 4d90
  • View 4d90
Molmil generated image of 4d90
CRYSTAL STRUCTURE OF DEL-1 EGF DOMAINS
Descriptor:EGF-like repeat and discoidin I-like domain-containing protein 3, N-ACETYL-D-GALACTOSAMINE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Chen, Q., Schurpf, T., Springer, T., Wang, J.
Deposit date:2012-01-11
Release date:2012-05-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:The RGD finger of Del-1 is a unique structural feature critical for integrin binding.
Faseb J., 26, 2012