Author results

1R3U
  • Download 1r3u
  • View 1r3u
Molmil generated image of 1r3u
CRYSTAL STRUCTURE OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE FROM THERMOANAEROBACTER TENGCONGENSIS
分子名称:Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, ACETATE ION
著者Chen, Q., Liang, Y.H., Gu, X.C., Luo, M., Su, X.D.
登録日2003-10-03
公開日2004-10-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis
To be published
1YFZ
  • Download 1yfz
  • View 1yfz
Molmil generated image of 1yfz
NOVEL IMP BINDING IN FEEDBACK INHIBITION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE FROM THERMOANAEROBACTER TENGCONGENSIS
分子名称:Hypoxanthine-guanine phosphoribosyltransferase, ACETATE ION, MAGNESIUM ION, ...
著者Chen, Q., Liang, Y., Su, X., Gu, X., Zheng, X., Luo, M.
登録日2005-01-04
公開日2005-05-10
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Alternative IMP Binding in Feedback Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis.
J.Mol.Biol., 348, 2005
2AIN
  • Download 2ain
  • View 2ain
Molmil generated image of 2ain
SOLUTION STRUCTURE OF THE AF-6 PDZ DOMAIN COMPLEXED WITH THE C-TERMINAL PEPTIDE FROM THE BCR PROTEIN
分子名称:Afadin, 6-mer peptide from Breakpoint cluster region protein
著者Chen, Q., Wu, J., Shi, Y.
登録日2005-07-30
公開日2006-07-18
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complex.
Protein Sci., 16, 2007
2GEB
  • Download 2geb
  • View 2geb
Molmil generated image of 2geb
CRYSTAL STRUCTURE OF THE THERMOANAEROBACTER TENGCONGENSIS HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE L160I MUTANT: INSIGHTS INTO THE INHIBITOR DESIGN
分子名称:Hypoxanthine-guanine phosphoribosyltransferase, CALCIUM ION
著者Chen, Q., Luo, M.
登録日2006-03-19
公開日2007-04-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design.
Febs J., 274, 2007
3LAF
  • Download 3laf
  • View 3laf
Molmil generated image of 3laf
STRUCTURE OF DCC, A NETRIN-1 RECEPTOR
分子名称:Deleted in Colorectal Cancer, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Chen, Q., Liu, J.-H., Wang, J.-H.
登録日2010-01-06
公開日2011-03-02
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors.
J.Cell.Sci., 126, 2013
3LCY
  • Download 3lcy
  • View 3lcy
Molmil generated image of 3lcy
TITIN IG TANDEM DOMAINS A164-A165
分子名称:Titin
著者Chen, Q., Groves, M.R., Wilmanns, M.
登録日2010-01-12
公開日2011-05-25
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural investigation of the Titin A-band tandem Ig domains A164-A165
To be Published
4Z90
  • Download 4z90
  • View 4z90
Molmil generated image of 4z90
ELIC BOUND WITH THE ANESTHETIC ISOFLURANE IN THE RESTING STATE
分子名称:Gamma-aminobutyric-acid receptor subunit beta-1, (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
著者Chen, Q., Kinde, M., Arjunan, P., Cohen, A., Xu, Y., Tang, P.
登録日2015-04-09
公開日2015-09-16
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep, 5, 2015
4Z91
  • Download 4z91
  • View 4z91
Molmil generated image of 4z91
ELIC COCRYSTALLIZED WITH ISOFLUORANE IN A DESENSITIZED STATE
分子名称:Gamma-aminobutyric-acid receptor subunit beta-1, (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Chen, Q., Kinde, M.N., Arjunan, P., Cohen, A., Xu, Y., Tang, P.
登録日2015-04-09
公開日2015-09-16
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (3.3915 Å)
主引用文献Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep, 5, 2015
5SXU
  • Download 5sxu
  • View 5sxu
Molmil generated image of 5sxu
X-RAY STRUCTURE OF 2-BROMOETHANOL BOUND TO A PENTAMERIC LIGAND GATED ION CHANNEL (ELIC) IN A DESENSITIZED STATE
分子名称:Gamma-aminobutyric-acid receptor subunit beta-1, 2-BROMOETHANOL, 3-AMINOPROPANE, ...
著者Chen, Q., Kinde, M., Cohen, A., Xu, Y., Tang, P.
登録日2016-08-10
公開日2017-06-21
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.
Structure, 25, 2017
5SXV
  • Download 5sxv
  • View 5sxv
Molmil generated image of 5sxv
X-RAY STRUCTURE OF 2-BROMOETHANOL BOUND TO A PENTAMERIC LIGAND GATED ION CHANNEL (ELIC) IN A RESTING STATE
分子名称:Cys-loop ligand-gated ion channel, 2-BROMOETHANOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
著者Chen, Q., Kinde, M., Cohen, A., Xu, Y., Tang, P.
登録日2016-08-10
公開日2017-06-21
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.
Structure, 25, 2017
5TV1
  • Download 5tv1
  • View 5tv1
Molmil generated image of 5tv1
ACTIVE ARRESTIN-3 WITH INOSITOL HEXAKISPHOSPHATE
分子名称:Beta-arrestin-2, INOSITOL HEXAKISPHOSPHATE, GLYCEROL
著者Chen, Q., Gilbert, N.C., Perry, N.A., Vishniveteskiy, S., Gurevich, V.V., Iverson, T.M.
登録日2016-11-07
公開日2017-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis of arrestin-3 activation and signaling.
Nat Commun, 8, 2017
5WPQ
  • Download 5wpq
  • View 5wpq
Molmil generated image of 5wpq
CRYO-EM STRUCTURE OF MAMMALIAN ENDOLYSOSOMAL TRPML1 CHANNEL IN NANODISCS IN CLOSED I CONFORMATION AT 3.64 ANGSTROM RESOLUTION
分子名称:Mucolipin-1, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
著者Chen, Q., She, J., Guo, J., Bai, X., Jiang, Y.
登録日2017-08-07
公開日2017-10-18
最終更新日2019-11-20
実験手法ELECTRON MICROSCOPY (3.64 Å)
主引用文献Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
5WPT
  • Download 5wpt
  • View 5wpt
Molmil generated image of 5wpt
CRYO-EM STRUCTURE OF MAMMALIAN ENDOLYSOSOMAL TRPML1 CHANNEL IN NANODISCS IN CLOSED II CONFORMATION AT 3.75 ANGSTROM RESOLUTION
分子名称:Mucolipin-1, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
著者Chen, Q., She, J., Guo, J., Bai, X., Jiang, Y.
登録日2017-08-07
公開日2017-10-18
最終更新日2019-11-20
実験手法ELECTRON MICROSCOPY (3.75 Å)
主引用文献Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
5WPV
  • Download 5wpv
  • View 5wpv
Molmil generated image of 5wpv
CRYO-EM STRUCTURE OF MAMMALIAN ENDOLYSOSOMAL TRPML1 CHANNEL IN NANODISCS AT 3.59 ANGSTROM RESOLUTION
分子名称:Mucolipin-1, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
著者Chen, Q., She, J., Guo, J., Bai, X., Jiang, Y.
登録日2017-08-07
公開日2017-10-18
最終更新日2019-11-20
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
6C9O
  • Download 6c9o
  • View 6c9o
Molmil generated image of 6c9o
SELENOMETHIONINE MUTANT (V29SEM) OF PROTEIN GB1 EXAMINED BY X-RAY DIFFRACTION
分子名称:Immunoglobulin G-binding protein G, (4S)-2-METHYL-2,4-PENTANEDIOL
著者Chen, Q.
登録日2018-01-28
公開日2019-07-10
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献77Se-Selenomethionine as a probe of its environment in proteins
To Be Published
6CDU
  • Download 6cdu
  • View 6cdu
Molmil generated image of 6cdu
CRYSTAL STRUCTURE OF A CHIMERIC HUMAN ALPHA1GABAA RECEPTOR IN COMPLEX WITH ALPHAXALONE
分子名称:chimeric alpha1GABAA receptor, (3a,5a)-3-Hydroxypregnane-11,20-dione
著者Chen, Q., Arjunan, P., Cohen, A.E., Xu, Y., Tang, P.
登録日2018-02-09
公開日2018-08-22
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Structural basis of neurosteroid anesthetic action on GABAAreceptors.
Nat Commun, 9, 2018
6CHE
  • Download 6che
  • View 6che
Molmil generated image of 6che
SELENOMETHIONINE MUTANT (A34SEM) OF PROTEIN GB1 EXAMINED BY X-RAY DIFFRACTION
分子名称:Immunoglobulin G-binding protein G, (4S)-2-METHYL-2,4-PENTANEDIOL, IMIDAZOLE
著者Chen, Q.
登録日2018-02-22
公開日2019-07-10
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献77-Se-selenomethionine as a probe of its environment in proteins
To Be Published
6CNE
  • Download 6cne
  • View 6cne
Molmil generated image of 6cne
SELENOMETHIONINE MUTANT (L5SEM) OF PROTEIN GB1 EXAMINED BY X-RAY DIFFRACTION
分子名称:Immunoglobulin G-binding protein G, (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION
著者Chen, Q.
登録日2018-03-08
公開日2019-07-10
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献77Se-selenomethionine as a probe of its environment in proteins
To Be Published
6CPZ
  • Download 6cpz
  • View 6cpz
Molmil generated image of 6cpz
SELENOMETHIONINE MUTANT (I6SEM) OF PROTEIN GB1 EXAMINED BY X-RAY DIFFRACTION
分子名称:Immunoglobulin G-binding protein G, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
著者Chen, Q., Rozovsky, S.
登録日2018-03-14
公開日2019-07-10
実験手法X-RAY DIFFRACTION (1.12 Å)
主引用文献77-Se-Selenomethionine as a probe of its environment in proteins
To be published
6CTE
  • Download 6cte
  • View 6cte
Molmil generated image of 6cte
77SE-NMR PROBES THE PROTEIN ENVIRONMENT OF SELENOMETHIONINE
分子名称:Immunoglobulin G-binding protein G, (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, ...
著者Chen, Q., Rozovsky, S.
登録日2018-03-22
公開日2019-07-10
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献77-Se-selenomethionine as a probe of its environment in proteins
To Be Published
6D1S
  • Download 6d1s
  • View 6d1s
Molmil generated image of 6d1s
CRYSTAL STRUCTURE OF AN APO CHIMERIC HUMAN ALPHA1GABAA RECEPTOR
分子名称:chimeric alpha1GABAA receptor
著者Chen, Q., Arjunan, P., Cohen, A.E., Xu, Y., Tang, P.
登録日2018-04-12
公開日2018-08-22
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis of neurosteroid anesthetic action on GABAAreceptors.
Nat Commun, 9, 2018
6E5V
  • Download 6e5v
  • View 6e5v
Molmil generated image of 6e5v
HUMAN MGLU8 RECEPTOR AMINO TERMINAL DOMAIN IN COMPLEX WITH (S)-3,4-DICARBOXYPHENYLGLYCINE (DCPG)
分子名称:Metabotropic glutamate receptor 8, 4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic acid, CHLORIDE ION
著者Chen, Q., Ho, J.D., Ashok, S., Vargas, M.C., Wang, J., Atwell, S., Bures, M., Schkeryantz, J.M., Monn, J.A., Hao, J.
登録日2018-07-23
公開日2018-11-07
最終更新日2018-12-05
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8Receptor.
J. Med. Chem., 61, 2018
6KNZ
  • Download 6knz
  • View 6knz
Molmil generated image of 6knz
CRYSTAL STRUCTURE OF T2R-TTL-KXO1 COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Chen, Q., Yu, Y.
登録日2019-08-07
公開日2019-10-23
最終更新日2019-10-30
実験手法X-RAY DIFFRACTION (2.475 Å)
主引用文献Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of beta-tubulin explains KXO1's low clinical toxicity.
J.Biol.Chem., 2019
3Q5T
  • Download 3q5t
  • View 3q5t
Molmil generated image of 3q5t
V BETA/V BETA HOMODIMERIZATION-BASED PRE-TCR MODEL SUGGESTED BY TCR BETA CRYSTAL STRUCTURES
分子名称:TCR N30 beta
著者Chen, Q., Zhang, H., Wang, J.-H.
登録日2010-12-29
公開日2011-03-16
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.005 Å)
主引用文献A conserved hydrophobic patch on V beta domains revealed by TCR beta chain crystal structures: Implications for pre-TCR dimerization.
Front Immunol, 2, 2011
3Q5Y
  • Download 3q5y
  • View 3q5y
Molmil generated image of 3q5y
V BETA/V BETA HOMODIMERIZATION-BASED PRE-TCR MODEL SUGGESTED BY TCR BETA CRYSTAL STRUCTURES
分子名称:TCR N15 beta, GLYCEROL, DI(HYDROXYETHYL)ETHER, ...
著者Chen, Q., Zhang, H., Wang, J.-H.
登録日2010-12-30
公開日2011-03-09
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A conserved hydrophobic patch on Vbeta domains revealed by TCRbeta chain crystal structures: implications for pre-TCR dimerization
Front Immunol, 2, 2011