Author results

1YNN
  • Download 1ynn
  • View 1ynn
Molmil generated image of 1ynn
TAQ RNA POLYMERASE-RIFAMPICIN COMPLEX
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A., Pavlova, O., Zenkin, N., Leon, F., Irschik, H., Jansen, R., Severinov, K., Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
1I6V
  • Download 1i6v
  • View 1i6v
Molmil generated image of 1i6v
THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX
Descriptor:DNA-DIRECTED RNA POLYMERASE, RIFAMPICIN, MAGNESIUM ION, ...
Authors:Campbell, E.A., Korzheva, N., Mustaev, A., Murakami, K., Goldfarb, A., Darst, S.A.
Deposit date:2001-03-05
Release date:2001-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural mechanism for rifampicin inhibition of bacterial rna polymerase.
Cell(Cambridge,Mass.), 104, 2001
1KU2
  • Download 1ku2
  • View 1ku2
Molmil generated image of 1ku2
CRYSTAL STRUCTURE OF THERMUS AQUATICUS RNA POLYMERASE SIGMA SUBUNIT FRAGMENT CONTAINING REGIONS 1.2 TO 3.1
Descriptor:sigma factor sigA, SULFATE ION
Authors:Campbell, E.A., Muzzin, O., Chlenov, M., Sun, J.L., Olson, C.A., Weinman, O., Trester-Zedlitz, M.L., Darst, S.A.
Deposit date:2002-01-21
Release date:2002-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the bacterial RNA polymerase promoter specificity sigma subunit.
Mol.Cell, 9, 2002
1KU3
  • Download 1ku3
  • View 1ku3
Molmil generated image of 1ku3
CRYSTAL STRUCTURE OF THERMUS AQUATICUS RNA POLYMERASE SIGMA SUBUNIT FRAGMENT, REGION 4
Descriptor:sigma factor sigA
Authors:Campbell, E.A., Muzzin, O., Chlenov, M., Sun, J.L., Olson, C.A., Weinman, O., Trester-Zedlitz, M.L., Darst, S.A.
Deposit date:2002-01-21
Release date:2002-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the bacterial RNA polymerase promoter specificity sigma subunit.
Mol.Cell, 9, 2002
1KU7
  • Download 1ku7
  • View 1ku7
Molmil generated image of 1ku7
CRYSTAL STRUCTURE OF THERMUS AQUATICS RNA POLYMERASE SIGMAA SUBUNIT REGION 4 BOUND TO-35 ELEMENT DNA
Descriptor:5'-D(*CP*CP*TP*TP*GP*AP*CP*AP*AP*AP*G)-3', 5'-D(*CP*CP*TP*TP*TP*GP*TP*CP*AP*AP*G)-3', sigma factor sigA
Authors:Campbell, E.A., Muzzin, O., Chlenov, M., Sun, J.L., Olson, C.A., Weinman, O., Trester-Zedlitz, M.L., Darst, S.A.
Deposit date:2002-01-21
Release date:2002-03-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the bacterial RNA polymerase promoter specificity sigma subunit.
Mol.Cell, 9, 2002
1L0O
  • Download 1l0o
  • View 1l0o
Molmil generated image of 1l0o
CRYSTAL STRUCTURE OF THE BACILLUS STEAROTHERMOPHILUS ANTI-SIGMA FACTOR SPOIIAB WITH THE SPORULATION SIGMA FACTOR SIGMAF
Descriptor:Anti-sigma F factor, sigma factor, MAGNESIUM ION, ...
Authors:Campbell, E.A., Masuda, S., Sun, J.L., Muzzin, O., Olson, C.A., Wang, S., Darst, S.A.
Deposit date:2002-02-12
Release date:2002-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the Bacillus stearothermophilus anti-sigma factor SpoIIAB with the sporulation sigma factor sigmaF.
Cell(Cambridge,Mass.), 108, 2002
1OR7
  • Download 1or7
  • View 1or7
Molmil generated image of 1or7
CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMAE WITH THE CYTOPLASMIC DOMAIN OF ITS ANTI-SIGMA RSEA
Descriptor:RNA polymerase sigma-E factor, Sigma-E factor negative regulatory protein
Authors:Campbell, E.A., Tupy, J.L., Gruber, T.M., Wang, S., Sharp, M.M., Gross, C.A., Darst, S.A.
Deposit date:2003-03-12
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA.
Mol.Cell, 11, 2003
1YNJ
  • Download 1ynj
  • View 1ynj
Molmil generated image of 1ynj
TAQ RNA POLYMERASE-SORANGICIN COMPLEX
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A., Pavlova, O., Zenkin, N., Leon, F., Irschik, H., Jansen, R., Severinov, K., Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
2Q1Z
  • Download 2q1z
  • View 2q1z
Molmil generated image of 2q1z
CRYSTAL STRUCTURE OF RHODOBACTER SPHAEROIDES SIGE IN COMPLEX WITH THE ANTI-SIGMA CHRR
Descriptor:RpoE, ECF SigE, Anti-Sigma factor ChrR, ...
Authors:Campbell, E.A., Darst, S.A.
Deposit date:2007-05-25
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.
Mol.Cell, 27, 2007
2Z2S
  • Download 2z2s
  • View 2z2s
Molmil generated image of 2z2s
CRYSTAL STRUCTURE OF RHODOBACTER SPHAEROIDES SIGE IN COMPLEX WITH THE ANTI-SIGMA CHRR
Descriptor:RpoE, ECF SigE, Anti-Sigma factor ChrR, ...
Authors:Darst, S.A., Campbell, E.A.
Deposit date:2007-05-26
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria.
Mol.Cell, 27, 2007
5UI5
  • Download 5ui5
  • View 5ui5
Molmil generated image of 5ui5
CRYSTAL STRUCTURE OF AQUIFEX AEOLICUS SIGMAN BOUND TO PROMOTER DNA
Descriptor:DNA (31-MER), DNA (30-MER), RNA polymerase sigma factor RpoN
Authors:Darst, S.A., Campbell, E.A., Rajashankar, K.
Deposit date:2017-01-12
Release date:2017-02-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of Aquifex aeolicus sigma (N) bound to promoter DNA and the structure of sigma (N)-holoenzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UI8
  • Download 5ui8
  • View 5ui8
Molmil generated image of 5ui8
STRUCTURE OF SIGMAN-HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A.
Deposit date:2017-01-13
Release date:2017-02-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.76 Å)
Cite:Crystal structure of Aquifex aeolicus sigma (N) bound to promoter DNA and the structure of sigma (N)-holoenzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4X8K
  • Download 4x8k
  • View 4x8k
Molmil generated image of 4x8k
MYCOBACTERIUM TUBERCULOSIS RBPA-SID IN COMPLEX WITH SIGMAA DOMAIN 2
Descriptor:RNA polymerase sigma factor SigA, RNA polymerase-binding protein RbpA, SULFATE ION, ...
Authors:Hubin, E.A., Flack, J.E., Tabib-Salazar, A., Paget, M.S., Darst, S.A., Campbell, E.A.
Deposit date:2014-12-10
Release date:2015-06-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA.
Proc.Natl.Acad.Sci.USA, 112, 2015
5TW1
  • Download 5tw1
  • View 5tw1
Molmil generated image of 5tw1
CRYSTAL STRUCTURE OF A MYCOBACTERIUM SMEGMATIS TRANSCRIPTION INITIATION COMPLEX WITH RBPA
Descriptor:RNA polymerase-binding protein RbpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Hubin, E.A., Darst, S.A., Campbell, E.A.
Deposit date:2016-11-10
Release date:2017-01-18
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA.
Elife, 6, 2017
5VI8
  • Download 5vi8
  • View 5vi8
Molmil generated image of 5vi8
STRUCTURE OF A MYCOBACTERIUM SMEGMATIS TRANSCRIPTION INITIATION COMPLEX WITH AN UPSTREAM-FORK PROMOTER FRAGMENT
Descriptor:RNA polymerase-binding protein RbpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Hubin, E.A., Campbell, E.A., Darst, S.A.
Deposit date:2017-04-14
Release date:2017-04-26
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Nat Commun, 8, 2017
6C04
  • Download 6c04
  • View 6c04
Molmil generated image of 6c04
MTB RNAP HOLO/RBPA/DOUBLE FORK DNA -CLOSED CLAMP
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C05
  • Download 6c05
  • View 6c05
Molmil generated image of 6c05
MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA IN RELAXED STATE
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C06
  • Download 6c06
  • View 6c06
Molmil generated image of 6c06
MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA/FIDAXOMICIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
5VI5
  • Download 5vi5
  • View 5vi5
Molmil generated image of 5vi5
STRUCTURE OF MYCOBACTERIUM SMEGMATIS TRANSCRIPTION INITIATION COMPLEX WITH A FULL TRANSCRIPTION BUBBLE
Descriptor:DNA (49-MER), DNA (44-MER), RNA (5'-R(*UP*CP*GP*A)-3'), ...
Authors:Darst, S.A., Campbell, E.A., Lilic, M.
Deposit date:2017-04-14
Release date:2017-07-26
Method:X-RAY DIFFRACTION (3.196 Å)
Cite:Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Nat Commun, 8, 2017
1HQM
  • Download 1hqm
  • View 1hqm
Molmil generated image of 1hqm
CRYSTAL STRUCTURE OF THERMUS AQUATICUS CORE RNA POLYMERASE-INCLUDES COMPLETE STRUCTURE WITH SIDE-CHAINS (EXCEPT FOR DISORDERED REGIONS)-FURTHER REFINED FROM ORIGINAL DEPOSITION-CONTAINS ADDITIONAL SEQUENCE INFORMATION
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Minakhin, L., Bhagat, S., Brunning, A., Campbell, E.A., Darst, S.A., Ebright, R.H., Severinov, K.
Deposit date:2000-12-18
Release date:2001-02-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.
Proc.Natl.Acad.Sci.USA, 98, 2001
1L9Z
  • Download 1l9z
  • View 1l9z
Molmil generated image of 1l9z
THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME/FORK-JUNCTION PROMOTER DNA COMPLEX AT 6.5 A RESOLUTION
Descriptor:nontemplate DNA strand, template DNA strand, RNA POLYMERASE, ...
Authors:Murakami, K.S., Masuda, S., Campbell, E.A., Muzzin, O., Darst, S.A.
Deposit date:2002-03-27
Release date:2002-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (6.5 Å)
Cite:Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex.
Science, 296, 2002
1TH8
  • Download 1th8
  • View 1th8
Molmil generated image of 1th8
CRYSTAL STRUCTURES OF THE ADP AND ATP BOUND FORMS OF THE BACILLUS ANTI-SIGMA FACTOR SPOIIAB IN COMPLEX WITH THE ANTI-ANTI-SIGMA SPOIIAA: INHIBITORY COMPLEX WITH ADP, CRYSTAL FORM II
Descriptor:Anti-sigma F factor, Anti-sigma F factor antagonist, MAGNESIUM ION, ...
Authors:Masuda, S., Murakami, K.S., Wang, S., Olson, C.A., Donigian, J., Leon, F., Darst, S.A., Campbell, E.A.
Deposit date:2004-06-01
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of the ADP and ATP Bound Forms of the Bacillus Anti-sigma Factor SpoIIAB in Complex with the Anti-anti-sigma SpoIIAA.
J.Mol.Biol., 340, 2004
1THN
  • Download 1thn
  • View 1thn
Molmil generated image of 1thn
CRYSTAL STRUCTURES OF THE ADP AND ATP BOUND FORMS OF THE BACILLUS ANTI-SIGMA FACTOR SPOIIAB IN COMPLEX WITH THE ANTI-ANTI-SIGMA SPOIIAA: INHIBITORY COMPLEX WITH ADP, CRYSTAL FORM I
Descriptor:Anti-sigma F factor, Anti-sigma F factor antagonist, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Masuda, S., Murakami, K.S., Wang, S., Olson, C.A., Donigan, J., Leon, F., Darst, S.A., Campbell, E.A.
Deposit date:2004-06-01
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the ADP and ATP Bound Forms of the Bacillus Anti-sigma Factor SpoIIAB in Complex with the Anti-anti-sigma SpoIIAA.
J.Mol.Biol., 340, 2004
1TID
  • Download 1tid
  • View 1tid
Molmil generated image of 1tid
CRYSTAL STRUCTURES OF THE ADP AND ATP BOUND FORMS OF THE BACILLUS ANTI-SIGMA FACTOR SPOIIAB IN COMPLEX WITH THE ANTI-ANTI-SIGMA SPOIIAA: POISED FOR PHOSPHORYLATION COMPLEX WITH ATP, CRYSTAL FORM I
Descriptor:Anti-sigma F factor, Anti-sigma F factor antagonist, MAGNESIUM ION, ...
Authors:Masuda, S., Murakami, K.S., Wang, S., Olson, C.A., Donigan, J., Leon, F., Darst, S.A., Campbell, E.A.
Deposit date:2004-06-02
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the ADP and ATP Bound Forms of the Bacillus Anti-sigma Factor SpoIIAB in Complex with the Anti-anti-sigma SpoIIAA.
J.Mol.Biol., 340, 2004
1TIL
  • Download 1til
  • View 1til
Molmil generated image of 1til
CRYSTAL STRUCTURES OF THE ADP AND ATP BOUND FORMS OF THE BACILLUS ANTI-SIGMA FACTOR SPOIIAB IN COMPLEX WITH THE ANTI-ANTI-SIGMA SPOIIAA:POISED FOR PHOSPHORYLATION COMPLEX WITH ATP, CRYSTAL FORM II
Descriptor:Anti-sigma F factor, Anti-sigma F factor antagonist, MAGNESIUM ION, ...
Authors:Masuda, S., Murakami, K.S., Wang, S., Olson, C.A., Donigan, J., Leon, F., Darst, S.A., Campbell, E.A.
Deposit date:2004-06-02
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of the ADP and ATP Bound Forms of the Bacillus Anti-sigma Factor SpoIIAB in Complex with the Anti-anti-sigma SpoIIAA.
J.Mol.Biol., 340, 2004
<123>