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4CRO
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BU of 4cro by Molmil
PROTEIN-DNA CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURE OF A LAMBDA CRO-OPERATOR COMPLEX
Descriptor: DNA (5'-D(*TP*AP*TP*CP*AP*CP*CP*GP*CP*GP*GP*GP*TP*GP*AP*TP*A)-3'), PROTEIN (LAMBDA CRO)
Authors:Brennan, R.G, Roderick, S.L, Takeda, Y, Matthews, B.W.
Deposit date:1992-01-15
Release date:1992-01-15
Last modified:2022-11-23
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex.
Proc.Natl.Acad.Sci.USA, 87, 1990
1DN8
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BU of 1dn8 by Molmil
STRUCTURE OF A Z-DNA WITH TWO DIFFERENT BACKBONE CHAIN CONFORMATIONS. STABILIZATION OF THE DECADEOXYOLIGONUCLEOTIDE D(CGTACGTACG) BY (CO(NH3)6)3+ BINDING TO THE GUANINE
Descriptor: COBALT HEXAMMINE(III), DNA (5'-D(*P*CP*GP*TP*AP*CP*GP*TP*AP*CP*G)-3')
Authors:Brennan, R.G, Westhof, E, Sundaralingam, M.
Deposit date:1987-05-12
Release date:1988-04-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of a Z-DNA with two different backbone chain conformations. Stabilization of the decadeoxyoligonucleotide d(CGTACGTACG) by [Co(NH3)6]3+ binding to the guanine.
J.Biomol.Struct.Dyn., 3, 1986
3ECO
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BU of 3eco by Molmil
Crystal structure of MepR, a transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA
Descriptor: MepR, SULFATE ION
Authors:Brennan, R.G, Kumaraswami, M.
Deposit date:2008-09-01
Release date:2009-02-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.
Nucleic Acids Res., 37, 2009
2PEX
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BU of 2pex by Molmil
Structure of reduced C22S OhrR from Xanthamonas Campestris
Descriptor: FORMIC ACID, Transcriptional regulator OhrR
Authors:Brennan, R.G, Newberry, K.J.
Deposit date:2007-04-03
Release date:2007-12-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Mechanism of Organic Hydroperoxide Induction of the Transcription Regulator OhrR.
Mol.Cell, 28, 2007
2PFB
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BU of 2pfb by Molmil
Structure of oxidized OhrR from Xanthamonas campestris
Descriptor: Transcriptional regulator OhrR
Authors:Brennan, R.G, Newberry, K.J.
Deposit date:2007-04-04
Release date:2007-12-11
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Mechanism of Organic Hydroperoxide Induction of the Transcription Regulator OhrR.
Mol.Cell, 28, 2007
1WET
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BU of 1wet by Molmil
STRUCTURE OF THE PURR-GUANINE-PURF OPERATOR COMPLEX
Descriptor: DNA (5'-D(*AP*AP*CP*GP*AP*AP*AP*AP*CP*GP*TP*TP*TP*TP*CP*GP*T )-3'), GUANINE, PROTEIN (PURINE REPRESSOR)
Authors:Schumacher, M.A, Glasfeld, A, Zalkin, H, Brennan, R.G.
Deposit date:1997-04-27
Release date:1997-11-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity.
J.Biol.Chem., 272, 1997
3D6Y
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BU of 3d6y by Molmil
Crystal structure of R275E mutant of BMRR bound to DNA and berberine
Descriptor: BERBERINE, BMR promoter DNA, GLYCEROL, ...
Authors:Newberry, K.J, Brennan, R.G.
Deposit date:2008-05-20
Release date:2008-08-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine Expulsion
J.Biol.Chem., 283, 2008
3D70
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BU of 3d70 by Molmil
Crystal structure of E253A mutant of BMRR bound to 22-bp oligonucleotide
Descriptor: BMR promoter DNA, GLYCEROL, IMIDAZOLE, ...
Authors:Newberry, K.J, Brennan, R.G.
Deposit date:2008-05-20
Release date:2008-08-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine Expulsion
J.Biol.Chem., 283, 2008
1KQ1
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BU of 1kq1 by Molmil
1.55 A Crystal structure of the pleiotropic translational regulator, Hfq
Descriptor: ACETIC ACID, Host Factor for Q beta
Authors:Schumacher, M.A, Pearson, R.F, Moller, T, Valentin-Hansen, P, Brennan, R.G.
Deposit date:2002-01-03
Release date:2002-07-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein.
EMBO J., 21, 2002
1KQ2
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BU of 1kq2 by Molmil
Crystal Structure of an Hfq-RNA Complex
Descriptor: 5'-R(*AP*UP*UP*UP*UP*UP*G)-3', Host factor for Q beta
Authors:Schumacher, M.A, Pearson, R.F, Moller, T, Valentin-Hansen, P, Brennan, R.G.
Deposit date:2002-01-03
Release date:2002-07-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein.
EMBO J., 21, 2002
1LIJ
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BU of 1lij by Molmil
STRUCTURE OF T. GONDII ADENOSINE KINASE BOUND TO PRODRUG 2 7-IODOTUBERCIDIN AND AMP-PCP
Descriptor: 2-RIBOFURANOSYL-3-IODO-2,3-DIHYDRO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Schumacher, M.A, Scott, D.M, Mathews, I.I, Ealick, S.E, Roos, D.S, Ullman, B, Brennan, R.G.
Deposit date:2002-04-17
Release date:2002-05-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
J.Mol.Biol., 298, 2000
1LIK
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BU of 1lik by Molmil
STRUCTURE OF T. GONDII ADENOSINE KINASE BOUND TO ADENOSINE
Descriptor: ADENOSINE, CHLORIDE ION, SULFATE ION, ...
Authors:Schumacher, M.A, Scott, D.M, Mathews, I.I, Ealick, S.E, Roos, D.S, Ullman, B, Brennan, R.G.
Deposit date:2002-04-17
Release date:2002-05-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
J.Mol.Biol., 298, 2000
4LLL
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BU of 4lll by Molmil
Crystal structure of S. aureus MepR-DNA complex
Descriptor: MepR, Palindromized mepR operator sequence
Authors:Birukou, I, Brennan, R.G.
Deposit date:2013-07-09
Release date:2014-05-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.036 Å)
Cite:Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR.
Nucleic Acids Res., 42, 2014
4L9J
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BU of 4l9j by Molmil
Crystal structure of S. aureus MepR in DNA-binding conformation
Descriptor: MepR
Authors:Birukou, I, Brennan, R.G.
Deposit date:2013-06-18
Release date:2013-09-11
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus.
MBio, 4, 2013
4L9T
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BU of 4l9t by Molmil
Crystal structure of MepR F27L mutant from multidrug resistant S. aureus clinical isolate
Descriptor: MepR, SULFATE ION
Authors:Birukou, I, Brennan, R.G.
Deposit date:2013-06-18
Release date:2013-09-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.794 Å)
Cite:The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus.
MBio, 4, 2013
4LLN
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BU of 4lln by Molmil
Crystal structure of S. aureus MepR-DNA complex
Descriptor: MepR, Palindromized mepR operator sequence
Authors:Birukou, I, Brennan, R.G.
Deposit date:2013-07-09
Release date:2014-05-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.842 Å)
Cite:Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR.
Nucleic Acids Res., 42, 2014
8FHW
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BU of 8fhw by Molmil
Cryo-EM structure of Cryptococcus neoformans trehalose-6-phosphate synthase homotetramer in complex with uridine diphosphate and glucose-6-phosphate
Descriptor: 6-O-phosphono-alpha-D-glucopyranose, Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE
Authors:Washington, E.J, Brennan, R.G.
Deposit date:2022-12-15
Release date:2023-12-20
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans : a target for novel antifungals.
Biorxiv, 2024
8FO1
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BU of 8fo1 by Molmil
Cryo-EM structure of Cryptococcus neoformans trehalose-6-phosphate synthase homotetramer in apo form
Descriptor: Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Authors:Washington, E.J, Brennan, R.G.
Deposit date:2022-12-29
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of Cryptococcus neoformans trehalose-6-phosphate synthase homotetramer in apo form
To Be Published
8FW0
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BU of 8fw0 by Molmil
MtrR from Neisseria gonorrhoeae bound to beta-Estradiol
Descriptor: ESTRADIOL, GLYCEROL, HTH-type transcriptional regulator MtrR, ...
Authors:Hooks, G.H, Brennan, R.G.
Deposit date:2023-01-20
Release date:2024-01-24
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR.
Nat Commun, 15, 2024
8FW8
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BU of 8fw8 by Molmil
MtrR from Neisseria gonorrhoeae bound to Progesterone
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, HTH-type transcriptional regulator MtrR, PHOSPHATE ION, ...
Authors:Hooks, G.H, Brennan, R.G.
Deposit date:2023-01-20
Release date:2024-01-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR.
Nat Commun, 15, 2024
2PUE
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BU of 2pue by Molmil
CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES
Descriptor: ADENINE, DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), PROTEIN (PURINE REPRESSOR )
Authors:Lu, F, Schumacher, M.A, Arvidson, D.N, Haldimann, A, Wanner, B.L, Zalkin, H, Brennan, R.G.
Deposit date:1997-10-04
Release date:1998-05-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190.
Biochemistry, 37, 1998
1BDH
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BU of 1bdh by Molmil
PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX
Descriptor: DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR)
Authors:Glasfeld, A, Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G.
Deposit date:1996-07-25
Release date:1997-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex
J.Am.Chem.Soc., 118, 1996
1BDI
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BU of 1bdi by Molmil
PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX
Descriptor: DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR)
Authors:Glasfeld, A, Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G.
Deposit date:1996-07-25
Release date:1997-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex
J.Am.Chem.Soc., 118, 1996
8FW3
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BU of 8fw3 by Molmil
MtrR from Neisseria gonorrhoeae bound to Testosterone
Descriptor: HTH-type transcriptional regulator MtrR, PHOSPHATE ION, TESTOSTERONE
Authors:Hooks, G.H, Brennan, R.G.
Deposit date:2023-01-20
Release date:2024-01-24
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR.
Nat Commun, 15, 2024
2PUG
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BU of 2pug by Molmil
CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES
Descriptor: DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR)
Authors:Lu, F, Schumacher, M.A, Arvidson, D.N, Haldimann, A, Wanner, B.L, Zalkin, H, Brennan, R.G.
Deposit date:1997-10-04
Release date:1998-05-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190.
Biochemistry, 37, 1998

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