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2A0K
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CRYSTAL STRUCTURE OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE FROM TRYPANOSOMA BRUCEI AT 1.8 A RESOLUTION
Descriptor:Nucleoside 2-deoxyribosyltransferase, SULFATE ION, GLYCEROL
Authors:Bosch, J., Robien, M.A., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-06-16
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
J.Med.Chem., 49, 2006
2F2T
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CRYSTAL STRUCTURE OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE FROM TRYPANOSOMA BRUCEI AT 1.7 A RESOLUTION WITH 5-AMINOISOQUINOLINE BOUND
Descriptor:Nucleoside 2-deoxyribosyltransferase, SULFATE ION, ISOQUINOLIN-5-AMINE, ...
Authors:Bosch, J., Robien, M.A., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-11-17
Release date:2005-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
J.Med.Chem., 49, 2006
2F62
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CRYSTAL STRUCTURE OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE FROM TRYPANOSOMA BRUCEI AT 1.5 A RESOLUTION WITH (2-ETHYLPHENYL)METHANOL BOUND
Descriptor:Nucleoside 2-deoxyribosyltransferase, SULFATE ION, (2-ETHYLPHENYL)METHANOL, ...
Authors:Bosch, J., Robien, M.A., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-11-28
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
J.Med.Chem., 49, 2006
2F64
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CRYSTAL STRUCTURE OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE FROM TRYPANOSOMA BRUCEI AT 1.6 A RESOLUTION WITH 1-METHYLQUINOLIN-2(1H)-ONE BOUND
Descriptor:Nucleoside 2-deoxyribosyltransferase, SULFATE ION, 1-METHYLQUINOLIN-2(1H)-ONE, ...
Authors:Bosch, J., Robien, M.A., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-11-28
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
J.Med.Chem., 49, 2006
2F67
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CRYSTAL STRUCTURE OF NUCLEOSIDE 2-DEOXYRIBOSYLTRANSFERASE FROM TRYPANOSOMA BRUCEI AT 1.6 A RESOLUTION WITH BENZO[CD]INDOL-2(1H)-ONE BOUND
Descriptor:Nucleoside 2-deoxyribosyltransferase, SULFATE ION, BENZO[CD]INDOL-2(1H)-ONE, ...
Authors:Bosch, J., Robien, M.A., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-11-28
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
J.Med.Chem., 49, 2006
1X6O
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STRUCTURAL ANALYSIS OF LEISHMANIA BRAZILIENSIS EUKARYOTIC INITIATION FACTOR 5A
Descriptor:eukaryotic initiation factor 5a, DI(HYDROXYETHYL)ETHER
Authors:Bosch, J., Robien, M.A., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-08-11
Release date:2004-08-24
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Analysis of Leishmania braziliensis eukaryotic initiation factor 5a
To be Published
1XTD
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STRUCTURAL ANALYSIS OF LEISHMANIA MEXICANA EUKARYOTIC INITIATION FACTOR 5A
Descriptor:eukaryotic initiation factor 5a
Authors:Bosch, J., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-10-21
Release date:2004-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Analysis of Leishmania mexicana eukaryotic initiation factor 5a
To be Published
1Y13
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STRUCTURAL ANALYSIS OF PLASMODIUM FALCIPARUM 6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE (PTPS)
Descriptor:6-pyruvoyl tetrahydropterin synthase, ZINC ION, BIOPTERIN
Authors:Bosch, J., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-11-17
Release date:2005-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of Plasmodium falciparum 6-pyruvoyl tetrahydropterin synthase (PTPS)
To be Published
2A0S
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CRYSTAL STRUCTURE OF 6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE (PTPS) FROM PLASMODIUM VIVAX AT 2.2 A RESOLUTION
Descriptor:6-pyruvoyl tetrahydropterin synthase, ZINC ION, BIOPTERIN
Authors:Bosch, J., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-06-16
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of 6-pyruvoyl tetrahydropterin synthase (PTPS) from Plasmodium vivax at 2.2 A resolution
To be Published
2A0U
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CRYSTAL STRUCTURE OF THE EUKARYOTIC INITIATION FACTOR 2B FROM LEISHMANIA MAJOR AT 2.1 A RESOLUTION
Descriptor:initiation factor 2B, SULFATE ION
Authors:Bosch, J., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-06-17
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the eukaryotic initiation factor 2B from Leishmania major at 2.1 A resolution
To be Published
2AUC
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STRUCTURE OF THE PLASMODIUM MTIP-MYOA COMPLEX, A KEY COMPONENT OF THE PARASITE INVASION MOTOR
Descriptor:Myosin A Tail Interacting Protein, Myosin A
Authors:Bosch, J., Turley, S., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-08-27
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2EPH
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CRYSTAL STRUCTURE OF FRUCTOSE-BISPHOSPHATE ALDOLASE FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH TRAP-TAIL DETERMINED AT 2.7 ANGSTROM RESOLUTION
Descriptor:Fructose-bisphosphate aldolase, PbTRAP
Authors:Bosch, J., Buscaglia, C.A., Krumm, B., Cardozo, T., Nussenzweig, V., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-03-30
Release date:2007-04-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2GOP
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THE BETA-PROPELLER DOMAIN OF THE TRILOBED PROTEASE FROM PYROCOCCUS FURIOSUS REVEALS AN OPEN VELCRO TOPOLOGY
Descriptor:Trilobed Protease
Authors:Bosch, J., Tamura, T., Tamura, N., Baumeister, W., Essen, L.-O.
Deposit date:2006-04-13
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The beta-propeller domain of the trilobed protease from Pyrococcus furiosus reveals an open Velcro topology.
Acta Crystallogr.,Sect.D, 63, 2007
2PC4
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CRYSTAL STRUCTURE OF FRUCTOSE-BISPHOSPHATE ALDOLASE FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH TRAP-TAIL DETERMINED AT 2.4 ANGSTROM RESOLUTION
Descriptor:Fructose-bisphosphate aldolase, PbTRAP
Authors:Bosch, J., Buscaglia, C.A., Krumm, B., Cardozo, T., Nussenzweig, V., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-03-29
Release date:2007-04-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QAC
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THE CLOSED MTIP-MYOSINA-TAIL COMPLEX FROM THE MALARIA PARASITE INVASION MACHINERY
Descriptor:Myosin A tail domain interacting protein MTIP, Myosin-A
Authors:Bosch, J., Turley, S., Roach, C.M., Daly, T.M., Bergman, L.W., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-06-14
Release date:2007-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Closed MTIP-Myosin A-Tail Complex from the Malaria Parasite Invasion Machinery.
J.Mol.Biol., 372, 2007
3BWB
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CRYSTAL STRUCTURE OF THE APO FORM OF SPERMIDINE SYNTHASE FROM TRYPANOSOMA CRUZI AT 2.5 A RESOLUTION
Descriptor:Spermidine synthase
Authors:Bosch, J., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-01-08
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of spermidine synthase from Trypanosoma cruzi.
To be Published
3BWC
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CRYSTAL STRUCTURE OF SPERMIDINE SYNTHASE FROM TRYPANOSOMA CRUZI IN COMPLEX WITH SAM AT 2.3 A RESOLUTION
Descriptor:Spermidine synthase, S-ADENOSYLMETHIONINE, BETA-MERCAPTOETHANOL
Authors:Bosch, J., Arakaki, T.L., Le Trong, I., Merritt, E.A., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-01-09
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of spermidine synthase from Trypanosoma cruzi.
To be Published
3TGH
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GAP50 THE ANCHOR IN THE INNER MEMBRANE COMPLEX OF PLASMODIUM
Descriptor:Glideosome-associated protein 50, SULFATE ION, COBALT (II) ION, ...
Authors:Bosch, J., Paige, M.H., Vaidya, A., Bergman, L., Hol, W.G.J.
Deposit date:2011-08-17
Release date:2012-03-07
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.
J.Struct.Biol., 178, 2012
4TR9
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TERNARY CO-CRYSTAL STRUCTURE OF FRUCTOSE-BISPHOSPHATE ALDOLASE FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH TRAP AND A SMALL MOLECULE INHIBITOR
Descriptor:Fructose-bisphosphate aldolase, ALA-ALA-SER-LEU-TYR-GLU-LYS-LYS-ALA-ALA, ALA-ALA-ALA-SER-LEU-TYR-GLU-LYS-LYS-ALA-ALA, ...
Authors:Bosch, G., Weltzer, R., O'Malley, K., Bosch, J.
Deposit date:2014-06-15
Release date:2015-08-26
Last modified:2015-09-02
Method:X-RAY DIFFRACTION (2.111 Å)
Cite:Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.
Malar.J., 14, 2015
1TQX
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CRYSTAL STRUCTURE OF PFAL009167 A PUTATIVE D-RIBULOSE 5-PHOSPHATE 3-EPIMERASE FROM P.FALCIPARUM
Descriptor:D-ribulose-5-phosphate 3-epimerase, putative, SULFATE ION, ...
Authors:Caruthers, J., Bosch, J., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-06-18
Release date:2004-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum.
Proteins, 62, 2006
3P1W
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CRYSTAL STRUCTURE OF RAB GDI FROM PLASMODIUM FALCIPARUM, PFL2060C
Descriptor:RabGDI protein
Authors:Wernimont, A.K., Neculai, A.M., Weadge, J., MacKenzie, F., Cossar, D., Tempel, W., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Langsley, G., Bosch, J., Hui, R., Pizzaro, J.C., Hutchinson, A., Structural Genomics Consortium (SGC)
Deposit date:2010-09-30
Release date:2010-12-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of RAB GDI from Plasmodium Falciparum, PFL2060c
To be published
1XIQ
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PLASMODIUM FALCIPARUM NUCLEOSIDE DIPHOSPHATE KINASE B
Descriptor:Nucleoside diphosphate kinase B
Authors:Robien, M.A., Bosch, J., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-09-21
Release date:2004-10-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of Nucleoside diphosphate kinase B from Plasmodium falciparum
To be Published
2B30
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INITIAL CRYSTALLOGRAPHIC STRUCTURAL ANALYSIS OF A PUTATIVE HAD/COF-LIKE HYDROLASE FROM PLASMODIUM VIVAX
Descriptor:Pvivax hypothetical protein, CALCIUM ION, CHLORIDE ION
Authors:Robien, M.A., Bosch, J., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-09-19
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Initial Crystallographic Structural Analysis of a putative HAD/COF-like hydrolase from Plasmodium vivax
To be Published
2B4R
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CRYSTAL STRUCTURE OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM PLASMODIUM FALCIPARUM AT 2.25 ANGSTROM RESOLUTION REVEALS INTRIGUING EXTRA ELECTRON DENSITY IN THE ACTIVE SITE
Descriptor:glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, ...
Authors:Robien, M.A., Bosch, J., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-09-26
Release date:2005-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site
Proteins, 62, 2006
2B4T
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CRYSTAL STRUCTURE OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM PLASMODIUM FALCIPARUM AT 2.25 ANGSTROM RESOLUTION REVEALS INTRIGUING EXTRA ELECTRON DENSITY IN THE ACTIVE SITE
Descriptor:glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
Authors:Robien, M.A., Bosch, J., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-09-26
Release date:2005-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site
Proteins, 62, 2006
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