Author results

1CM0
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CRYSTAL STRUCTURE OF THE PCAF/COENZYME-A COMPLEX
Descriptor:P300/CBP ASSOCIATING FACTOR, COENZYME A
Authors:Clements, A., Rojas, J.R., Trievel, R.C., Wang, L., Berger, S.L., Marmorstein, R.
Deposit date:1999-05-12
Release date:1999-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A.
EMBO J., 18, 1999
1FY7
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CRYSTAL STRUCTURE OF YEAST ESA1 HISTONE ACETYLTRANSFERASE DOMAIN COMPLEXED WITH COENZYME A
Descriptor:ESA1 HISTONE ACETYLTRANSFERASE, SODIUM ION, COENZYME A
Authors:Yan, Y., Barlev, N.A., Haley, R.H., Berger, S.L., Marmorstein, R.
Deposit date:2000-09-28
Release date:2000-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases.
Mol.Cell, 6, 2000
1PU9
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CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 WITH BOUND COENZYME A AND A 19-RESIDUE HISTONE H3 PEPTIDE
Descriptor:HAT A1, Histone H3, COENZYME A
Authors:Clements, A., Poux, A.N., Lo, W.S., Pillus, L., Berger, S.L., Marmorstein, R.
Deposit date:2003-06-24
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for histone and phospho-histone binding by the GCN5 histone acetyltransferase
Mol.Cell, 12, 2003
1PUA
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CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 WITH BOUND COENZYME A AND A PHOSPHORYLATED, 19-RESIDUE HISTONE H3 PEPTIDE
Descriptor:HAT A1, Histone H3, COENZYME A
Authors:Clements, A., Poux, A.N., Lo, W.S., Pillus, L., Berger, S.L., Marmorstein, R.
Deposit date:2003-06-24
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for histone and phospho-histone binding by the GCN5 histone acetyltransferase
Mol.Cell, 12, 2003
1QSN
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CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 WITH BOUND COENZYME A AND HISTONE H3 PEPTIDE
Descriptor:TGCN5 HISTONE ACETYL TRANSFERASE, HISTONE H3, COENZYME A
Authors:Rojas, J.R., Trievel, R.C., Zhou, J., Mo, Y., Li, X., Berger, S.L., David Allis, C., Marmorstein, R.
Deposit date:1999-06-22
Release date:1999-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide.
Nature, 401, 1999
1QSR
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CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 WITH BOUND ACETYL-COENZYME A
Descriptor:TGCN5 HISTONE ACETYL TRANSFERASE, ACETYL COENZYME *A
Authors:Rojas, J.R., Trievel, R.C., Zhou, J., Mo, Y., Li, X., Berger, S.L., David Allis, C., Marmorstein, R.
Deposit date:1999-06-23
Release date:1999-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide.
Nature, 401, 1999
1QST
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CRYSTAL STRUCTURE OF TETRAHYMENA GCN5
Descriptor:TGCN5 HISTONE ACETYL TRANSFERASE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Rojas, J.R., Trievel, R.C., Zhou, J., Mo, Y., Li, X., Berger, S.L., David Allis, C., Marmorstein, R.
Deposit date:1999-06-23
Release date:1999-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide.
Nature, 401, 1999
1YGH
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HAT DOMAIN OF GCN5 FROM SACCHAROMYCES CEREVISIAE
Descriptor:PROTEIN (TRANSCRIPTIONAL ACTIVATOR GCN5), GLYCEROL
Authors:Trievel, R.C., Rojas, J.R., Sterner, D.E., Venkataramani, R., Wang, L., Zhou, J., Allis, C.D., Berger, S.L., Marmorstein, R.
Deposit date:1999-05-27
Release date:1999-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator.
Proc.Natl.Acad.Sci.USA, 96, 1999
1Q2C
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CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 WITH BOUND COENZYME A AND A 19-RESIDUE HISTONE H4 PEPTIDE
Descriptor:histone acetyltransferase GCN5, Histone H4 peptide, COENZYME A
Authors:Poux, A.N., Marmorstein, R.
Deposit date:2003-07-24
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase
Mol.Cell, 12, 2003
2FH9
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STRUCTURE AND DIMERIZATION OF THE KINASE DOMAIN FROM YEAST SNF1
Descriptor:Snf1 kinase
Authors:Nayak, V.
Deposit date:2005-12-23
Release date:2006-03-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and Dimerization of the Kinase Domain from Yeast Snf1, a Member of the Snf1/AMPK Protein Family
Structure, 14, 2006
3TO6
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CRYSTAL STRUCTURE OF YEAST ESA1 HAT DOMAIN COMPLEXED WITH H4K16COA BISUBSTRATE INHIBITOR
Descriptor:Histone acetyltransferase ESA1, Histone H4, CARBOXYMETHYL COENZYME *A
Authors:Yuan, H., Ding, E.C., Marmorstein, R.
Deposit date:2011-09-04
Release date:2011-11-09
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:MYST protein acetyltransferase activity requires active site lysine autoacetylation.
Embo J., 31, 2011
3TO7
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CRYSTAL STRUCTURE OF YEAST ESA1 HAT DOMAIN BOUND TO COENZYME A WITH ACTIVE SITE LYSINE ACETYLATED
Descriptor:Histone acetyltransferase ESA1, COENZYME A, CACODYLIC ACID, ...
Authors:Yuan, H., Ding, E.C., Marmorstein, R.
Deposit date:2011-09-04
Release date:2011-11-09
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:MYST protein acetyltransferase activity requires active site lysine autoacetylation.
Embo J., 31, 2011
3TO9
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CRYSTAL STRUCTURE OF YEAST ESA1 E338Q HAT DOMAIN BOUND TO COENZYME A WITH ACTIVE SITE LYSINE ACETYLATED
Descriptor:Histone acetyltransferase ESA1, COENZYME A, 1,2-ETHANEDIOL, ...
Authors:Yuan, H., Ding, E.C., Marmorstein, R.
Deposit date:2011-09-04
Release date:2011-11-09
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:MYST protein acetyltransferase activity requires active site lysine autoacetylation.
Embo J., 31, 2011
3TOA
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HUMAN MOF CRYSTAL STRUCTURE WITH ACTIVE SITE LYSINE PARTIALLY ACETYLATED
Descriptor:histone acetyltransferase MYST1, ZINC ION, CHLORIDE ION, ...
Authors:Yuan, H., Ding, E.C., Marmorstein, R.
Deposit date:2011-09-04
Release date:2011-11-09
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:MYST protein acetyltransferase activity requires active site lysine autoacetylation.
Embo J., 31, 2011
3TOB
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HUMAN MOF E350Q CRYSTAL STRUCTURE WITH ACTIVE SITE LYSINE PARTIALLY ACETYLATED
Descriptor:histone acetyltransferase MYST1, ZINC ION, CHLORIDE ION
Authors:Yuan, H., Ding, E.C., Marmorstein, R.
Deposit date:2011-09-04
Release date:2011-11-09
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:MYST protein acetyltransferase activity requires active site lysine autoacetylation.
Embo J., 31, 2011
4RLO
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HUMAN P70S6K1 WITH RUTHENIUM-BASED INHIBITOR EM5
Descriptor:Ribosomal protein S6 kinase beta-1, [(amino-kappaN)methanethiolato](3-fluoro-9-hydroxypyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dionato-kappa~2~N,N')(1,4,7-trithionane-kappa~3~S~1~,S~4~,S~7~)ruthenium, GLYCEROL, ...
Authors:Domsic, J.F., Barber-Rotenberg, J., Salami, J., Qin, J., Marmorstein, R.
Deposit date:2014-10-17
Release date:2015-01-21
Method:X-RAY DIFFRACTION (2.527 Å)
Cite:Development of Organometallic S6K1 Inhibitors.
J.Med.Chem., 58, 2015
4RLP
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HUMAN P70S6K1 WITH RUTHENIUM-BASED INHIBITOR FL772
Descriptor:p70S6K1, [(amino-kappaN)methanethiolato](3-fluoro-9-methoxypyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dionato-kappa~2~N,N')(N-methyl-1,4,7-trithiecan-9-amine-kappa~3~S~1~,S~4~,S~7~)ruthenium, CHLORIDE ION
Authors:Domsic, J.F., Barber-Rotenberg, J., Salami, J., Qin, J., Marmorstein, R.
Deposit date:2014-10-17
Release date:2015-01-21
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Development of Organometallic S6K1 Inhibitors.
J.Med.Chem., 58, 2015