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1TTH
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ASPARTATE TRANSCARBAMOYLASE CATALYTIC CHAIN MUTANT GLU50ALA COMPLEXED WITH N-(PHOSPHONACETYL-L-ASPARTATE) (PALA)
Descriptor:Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ...
Authors:Stieglitz, K., Stec, B., Baker, D.P., Kantrowitz, E.R.
Deposit date:2004-06-22
Release date:2004-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Monitoring the Transition from the T to the R State in E.coli Aspartate Transcarbamoylase by X-ray Crystallography: Crystal Structures of the E50A Mutant Enzyme in Four Distinct Allosteric States.
J.Mol.Biol., 341, 2004
1TU0
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ASPARTATE TRANSCARBAMOYLASE CATALYTIC CHAIN MUTANT E50A COMPLEX WITH PHOSPHONOACETAMIDE
Descriptor:Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, PHOSPHONOACETAMIDE, ...
Authors:Stieglitz, K., Stec, B., Baker, D.P., Kantrowitz, E.R.
Deposit date:2004-06-23
Release date:2004-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Monitoring the Transition from the T to the R State in E.coli Aspartate Transcarbamoylase by X-ray Crystallography: Crystal Structures of the E50A Mutant Enzyme in Four Distinct Allosteric States.
J.Mol.Biol., 341, 2004
1TUG
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ASPARTATE TRANSCARBAMOYLASE CATALYTIC CHAIN MUTANT E50A COMPLEX WITH PHOSPHONOACETAMIDE, MALONATE, AND CYTIDINE-5-PRIME-TRIPHOSPHATE (CTP)
Descriptor:Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, MALONATE ION, ...
Authors:Stieglitz, K., Stec, B., Baker, D.P., Kantrowitz, E.R.
Deposit date:2004-06-24
Release date:2004-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Monitoring the Transition from the T to the R State in E.coli Aspartate Transcarbamoylase by X-ray Crystallography: Crystal Structures of the E50A Mutant Enzyme in Four Distinct Allosteric States.
J.Mol.Biol., 341, 2004
2W2K
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CRYSTAL STRUCTURE OF THE APO FORMS OF RHODOTORULA GRAMINIS D- MANDELATE DEHYDROGENASE AT 1.8A.
Descriptor:D-MANDELATE DEHYDROGENASE
Authors:Vachieri, S.G., Cole, A.R., Bagneris, C., Baker, D.P., Fewson, C.A., Basak, A.K.
Deposit date:2008-11-02
Release date:2009-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of the Apo and Holo Forms of Rhodotorula Graminis D(-)-Mandelate Dehydrogenase
To be Published
2W2L
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CRYSTAL STRUCTURE OF THE HOLO FORMS OF RHODOTORULA GRAMINIS D- MANDELATE DEHYDROGENASE AT 2.5A.
Descriptor:D-MANDELATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
Authors:Vachieri, S.G., Cole, A.R., Bagneris, C., Baker, D.P., Fewson, C.A., Basak, A.K.
Deposit date:2008-11-02
Release date:2009-11-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Apo and Holo Forms of Rhodotorula Graminis D(-)-Mandelate Dehydrogenase
To be Published
3GEN
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THE 1.6 A CRYSTAL STRUCTURE OF HUMAN BRUTON'S TYROSINE KINASE BOUND TO A PYRROLOPYRIMIDINE-CONTAINING COMPOUND
Descriptor:Tyrosine-protein kinase BTK, 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane
Authors:Marcotte, D.J., Liu, Y.T., Arduini, R.M., Hession, C.A., Miatkowski, K., Wildes, C.P., Cullen, P.F., Hopkins, B., Mertsching, E., Jenkins, T.J., Romanowski, M.J., Baker, D.P., Silvian, L.F.
Deposit date:2009-02-25
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Protein Sci., 19, 2010
3K54
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STRUCTURES OF HUMAN BRUTON'S TYROSINE KINASE IN ACTIVE AND INACTIVE CONFORMATIONS SUGGESTS A MECHANISM OF ACTIVATION FOR TEC FAMILY KINASES.
Descriptor:Tyrosine-protein kinase BTK, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE
Authors:Marcotte, D.J., Liu, Y.-T., Arduini, R.M., Hession, C.A., Miatkowski, K., Wildes, C.P., Cullen, P.F., Hopkins, B.T., Mertsching, E., Jenkins, T.J., Romanowski, M.J., Baker, D.P., Silvian, L.F.
Deposit date:2009-10-06
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Protein Sci., 19, 2010
2O8Y
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APO IRAK4 KINASE DOMAIN
Descriptor:Interleukin-1 receptor-associated kinase 4
Authors:Boriack-Sjodin, P.A., Mol, C.
Deposit date:2006-12-12
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of the apo and inhibited IRAK4 kinase domain
To be Published
6AR4
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CRYSTAL STRUCTURE OF PICK1 IN COMPLEX WITH THE SMALL MOLECULE INHIBITOR 1O
Descriptor:PRKCA-binding protein, N-[4-(4-bromophenyl)-1-{[2-(trifluoromethyl)phenyl]methyl}piperidine-4-carbonyl]-3-cyclopropyl-L-alanine
Authors:Marcotte, D.
Deposit date:2017-08-21
Release date:2018-08-22
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction.
Sci Rep, 8, 2018
6BJN
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PICK1 PDZ DOMAIN IN COMPLEX WITH THE CLASS I PDZ BINDING MOTIF QSAV
Descriptor:PRKCA-binding protein
Authors:Marcotte, D.J.
Deposit date:2017-11-06
Release date:2018-01-10
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine-based inhibitor co-crystal structure.
Protein Sci., 27, 2018
6BJO
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PICK1 PDZ DOMAIN IN COMPLEX WITH THE SMALL MOLECULE INHIBITOR BIO124.
Descriptor:PRKCA-binding protein, (2S)-({4-(4-bromophenyl)-1-[1-(tert-butoxycarbonyl)-L-prolyl]piperidine-4-carbonyl}amino)(cyclopentyl)acetic acid
Authors:Marcotte, D.J.
Deposit date:2017-11-06
Release date:2018-01-10
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine-based inhibitor co-crystal structure.
Protein Sci., 27, 2018