Author results

6G4Q
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STRUCTURE OF HUMAN ADP-FORMING SUCCINYL-COA LIGASE COMPLEX SUCLG1-SUCLA2
Descriptor:Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial, Succinate--CoA ligase [ADP-forming] subunit beta, ...
Authors:Bailey, H.J., Shrestha, L., Rembeza, E., Sorrell, F.J., Newman, J., Strain-Damerell, C., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2018-03-28
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2
To Be Published
6HRH
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STRUCTURE OF HUMAN ERYTHROID-SPECIFIC 5'-AMINOLEVULINATE SYNTHASE, ALAS2
Descriptor:5-aminolevulinate synthase, erythroid-specific, mitochondrial, ...
Authors:Bailey, H.J., Shrestha, L., Rembeza, E., Newman, J., Kupinska, K., Diaz-saez, L., Kennedy, E., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2018-09-27
Release date:2018-11-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of human erythroid-specific 5'-aminolevulinate synthase, ALAS2
To Be Published
6QH4
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CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA EPIMERASE (MCEE) P.ARG143CYS VARIANT
Descriptor:Methylmalonyl-CoA epimerase, mitochondrial, COBALT (II) ION
Authors:Bailey, H.J., Chaikuid, A., Krysztofinska, E., Froese, D.S., Sorrell, F.J., Diaz-Saez, L., Kennedy, E., Edwards, A.M., Bountra, C., Yue, W.W.
Deposit date:2019-01-15
Release date:2019-02-27
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.922 Å)
Cite:Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant
To Be Published
6EQJ
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) TYR195PIPHE MUTANT, APO FORM
Descriptor:Glycogenin-1, 1,2-ETHANEDIOL
Authors:Bailey, H.J., Kopec, J., Bilyard, M.K., Bezerra, G.A., Seo Lee, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Davis, B.G., Yue, W.W.
Deposit date:2017-10-13
Release date:2017-12-20
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis.
Nature, 563, 2018
6EQL
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) TYR195PIPHE MUTANT COMPLEXED WITH MANGANESE AND UDP
Descriptor:Glycogenin-1, URIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Bailey, H.J., Kopec, J., Bilyard, M.K., Bezerra, G.A., Seo Lee, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Davis, B.G., Yue, W.W.
Deposit date:2017-10-13
Release date:2017-12-20
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis.
Nature, 563, 2018
6HVD
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HUMAN SLK BOUND TO A MALEIMIDE INHIBITOR
Descriptor:STE20-like serine/threonine-protein kinase, 1,2-ETHANEDIOL, 3-(1,3-benzothiazol-2-ylamino)-4-(2-methoxyphenyl)pyrrole-2,5-dione, ...
Authors:Sorrell, F.J., Berger, B.T., Salah, E., Serafim, R.A.M., Savitsky, P.A., Krojer, T., Bailey, H.J., Pinkas, D., Burgess-Brown, N.A., von Delft, F., Knapp, S., Arrowsmith, C., Bountra, C., Edwards, A.M., Elkins, J.M.
Deposit date:2018-10-10
Release date:2018-10-17
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Human SLK bound to a maleimide inhibitor
To Be Published
6HXF
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HUMAN STK10 BOUND TO A MALEIMIDE INHIBITOR
Descriptor:Serine/threonine-protein kinase 10, 3-(2-methoxyphenyl)-4-[[4-(phenylcarbonyl)phenyl]amino]pyrrole-2,5-dione, 1,2-ETHANEDIOL, ...
Authors:Sorrell, F.J., Salah, E., Serafim, R.A.M., Savitsky, P.A., Krojer, T., Bailey, H.J., Pinkas, D., Burgess-Brown, N.A., von Delft, F., Knapp, S., Arrowsmith, C., Bountra, C., Edwards, A.M., Elkins, J.M.
Deposit date:2018-10-17
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Human STK10 bound to a maleimide inhibitor
To Be Published
6NZU
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STRUCTURE OF THE HUMAN FRATAXIN-BOUND IRON-SULFUR CLUSTER ASSEMBLY COMPLEX
Descriptor:Cysteine desulfurase, mitochondrial, LYR motif-containing protein 4, ...
Authors:Fox, N.G., Yu, X., Xidong, F., Alain, M., Joseph, N., Claire, S.D., Christine, B., Han, S., Yue, W.W.
Deposit date:2019-02-14
Release date:2019-05-22
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.
Nat Commun, 10, 2019
6Q6E
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STRUCTURAL AND FUNCTIONAL INSIGHTS INTO THE CONDENSIN ATPASE CYCLE
Descriptor:Condensin complex subunit 2,Structural maintenance of chromosomes protein,Structural maintenance of chromosomes protein
Authors:Simon, B., Hassler, M., Haering, C.H., Hennig, J.
Deposit date:2018-12-10
Release date:2019-07-03
Method:SOLUTION NMR
Cite:Structural Basis of an Asymmetric Condensin ATPase Cycle.
Mol.Cell, 74, 2019
6QJ0
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CRYSTAL STRUCTURE OF THE C. THERMOPHILUM CONDENSIN SMC2 ATPASE HEAD (CRYSTAL FORM II)
Descriptor:Structural maintenance of chromosomes protein,Structural maintenance of chromosomes protein
Authors:Hassler, M., Haering, C.H.
Deposit date:2019-01-22
Release date:2019-07-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis of an Asymmetric Condensin ATPase Cycle.
Mol.Cell, 74, 2019
6QJ1
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CRYSTAL STRUCTURE OF THE C. THERMOPHILUM CONDENSIN SMC2 ATPASE HEAD (CRYSTAL FROM I)
Descriptor:Structural maintenance of chromosomes protein,Structural maintenance of chromosomes protein
Authors:Hassler, M., Haering, C.H.
Deposit date:2019-01-22
Release date:2019-07-03
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structural Basis of an Asymmetric Condensin ATPase Cycle.
Mol.Cell, 74, 2019
6QJ2
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CRYSTAL STRUCTURE OF THE C. THERMOPHILUM CONDENSIN SMC4 ATPASE HEAD IN COMPLEX WITH THE C-TERMINAL DOMAIN OF BRN1
Descriptor:Smc4, Condensin complex subunit 2, SULFATE ION
Authors:Hassler, M., Haering, C.H.
Deposit date:2019-01-22
Release date:2019-07-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis of an Asymmetric Condensin ATPase Cycle.
Mol.Cell, 74, 2019
6QJ3
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CRYSTAL STRUCTURE OF THE C. THERMOPHILUM CONDENSIN YCS4-BRN1 SUBCOMPLEX
Descriptor:Condensin complex subunit 1,Condensin complex subunit 1,Ycs4, Condensin complex subunit 2, Brn1
Authors:Hassler, M., Haering, C.H., Kschonsak, M.
Deposit date:2019-01-22
Release date:2019-07-03
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural Basis of an Asymmetric Condensin ATPase Cycle.
Mol.Cell, 74, 2019
6QJ4
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CRYSTAL STRUCTURE OF THE C. THERMOPHILUM CONDENSIN YCS4-BRN1 SUBCOMPLEX BOUND TO THE SMC4 ATPASE HEAD IN COMPLEX WITH THE C-TERMINAL DOMAIN OF BRN1
Descriptor:Condensin complex subunit 1,Condensin complex subunit 1,Condensin complex subunit 1, Condensin complex subunit 2, Uncharacterized protein,Uncharacterized protein, ...
Authors:Hassler, M., Haering, C.H., Kschonsak, M.
Deposit date:2019-01-22
Release date:2019-07-03
Method:X-RAY DIFFRACTION (5.8 Å)
Cite:Structural Basis of an Asymmetric Condensin ATPase Cycle.
Mol.Cell, 74, 2019