3RPB
 
 | | THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN | | Descriptor: | RABPHILIN 3-A | | Authors: | Ubach, J, Garcia, J, Nittler, M.P, Sudhof, T.C, Rizo, J. | | Deposit date: | 1999-04-19 | | Release date: | 1999-12-23 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of the Janus-faced C2B domain of rabphilin.
Nat.Cell Biol., 1, 1999
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6HZU
 | | HUMAN JAK1 IN COMPLEX WITH LASW1393 | | Descriptor: | 2-[4-[8-oxidanylidene-2-[(~{E})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{H}-purin-9-yl]cyclohexyl]ethanenitrile, Tyrosine-protein kinase JAK1 | | Authors: | Lozoya, E, Segarra, V, Bach, J, Jestel, A, Lammens, A, Blaesse, M. | | Deposit date: | 2018-10-24 | | Release date: | 2019-10-23 | | Last modified: | 2019-11-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
J.Med.Chem., 62, 2019
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6HZV
 | | HUMAN JAK3 IN COMPLEX WITH LASW959 PROTEIN IN COMPLEX WITH LIGAND | | Descriptor: | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile, Tyrosine-protein kinase JAK3 | | Authors: | Lozoya, E, Segarra, V, Bach, J, Jestel, A, Lammens, A, Blaesse, M. | | Deposit date: | 2018-10-24 | | Release date: | 2019-10-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
J.Med.Chem., 62, 2019
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8QU5
 | | mt-LSU assembly intermediate in GTPBP8 knock-out cells, state 2 | | Descriptor: | 16S ribosomal RNA, 39S ribosomal protein L10, mitochondrial, ... | | Authors: | Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M. | | Deposit date: | 2023-10-13 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.42 Å) | | Cite: | GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Nat Commun, 15, 2024
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8QRM
 | | mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 3 | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M. | | Deposit date: | 2023-10-09 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Nat Commun, 15, 2024
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8QRK
 | | mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 1 | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M. | | Deposit date: | 2023-10-09 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (6.69 Å) | | Cite: | GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Nat Commun, 15, 2024
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8QRN
 | | mt-SSU in GTPBP8 knock-out cells, state 4 | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M. | | Deposit date: | 2023-10-09 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Nat Commun, 15, 2024
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8QRL
 | | mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 2 | | Descriptor: | 12S mitochondrial rRNA, 12S rRNA N4-methylcytidine (m4C) methyltransferase, 28S ribosomal protein S10, ... | | Authors: | Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M. | | Deposit date: | 2023-10-09 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Nat Commun, 15, 2024
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8QU1
 | | mt-LSU assembly intermediate in GTPBP8 knock-out cells, state 1 | | Descriptor: | 16S ribosomal RNA, 39S ribosomal protein L10, mitochondrial, ... | | Authors: | Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M. | | Deposit date: | 2023-10-13 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Nat Commun, 15, 2024
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2K9I
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7NYQ
 | | Crystal structure of the Mei-P26 NHL domain | | Descriptor: | Meiotic P26, isoform C | | Authors: | Salerno-Kochan, A, Gaik, M, Medenbach, J, Glatt, S. | | Deposit date: | 2021-03-23 | | Release date: | 2022-05-04 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26.
Life Sci Alliance, 5, 2022
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7P2E
 | | Human mitochondrial ribosome small subunit in complex with IF3, GMPPMP and streptomycin | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Itoh, Y, Khawaja, A, Singh, V, Rorbach, J, Amunts, A. | | Deposit date: | 2021-07-05 | | Release date: | 2022-07-27 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Structure of the mitoribosomal small subunit with streptomycin reveals Fe-S clusters and physiological molecules.
Elife, 11, 2022
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1BR0
 | | THREE DIMENSIONAL STRUCTURE OF THE N-TERMINAL DOMAIN OF SYNTAXIN 1A | | Descriptor: | PROTEIN (SYNTAXIN 1-A) | | Authors: | Fernandez, I, Ubach, J, Dubulova, I, Zhang, X, Sudhof, T.C, Rizo, J. | | Deposit date: | 1998-08-25 | | Release date: | 1998-09-02 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A.
Cell(Cambridge,Mass.), 94, 1998
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5AEN
 | | Structure of human Leukotriene A4 hydrolase in complex with inhibitor dimethyl(2- (4-phenoxyphenoxy)ethyl)amine | | Descriptor: | IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, N,N-dimethyl-2-(4-phenoxyphenoxy)ethanamine, ... | | Authors: | Moser, D, Wittmann, S.K, Kramer, J, Blocher, R, Achenbach, J, Pogoryelov, D, Proschak, E. | | Deposit date: | 2015-01-06 | | Release date: | 2015-02-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.864 Å) | | Cite: | Peng: A Neural Gas-Based Approach for Pharmacophore Elucidation. Method Design, Validation and Virtual Screening for Novel Ligands of Lta4H.
J.Chem.Inf.Model., 55, 2015
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3LUO
 | | Crystal Structure and functional characterization of the thermophilic prolyl isomerase and chaperone SlyD | | Descriptor: | Peptidyl-prolyl cis-trans isomerase, Suc-Ala-Leu-Pro-Phe-pNA, ZINC ION | | Authors: | Loew, C, Neumann, P, Weininger, U, Stubbs, M.T, Balbach, J. | | Deposit date: | 2010-02-18 | | Release date: | 2010-03-31 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Crystal Structure Determination and Functional Characterization of the Metallochaperone SlyD from Thermus thermophilus
J.Mol.Biol., 398, 2010
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4J7Z
 | | Thermus thermophilus DNAJ J- and G/F-DOMAINS | | Descriptor: | Chaperone protein DnaJ 2, GLYCEROL | | Authors: | Barends, T.R.M, Brosi, R.W, Steinmetz, A, Scherer, A, Hartmann, E, Eschenbach, J, Lorenz, T, Seidel, R, Shoeman, R, Zimmermann, S, Bittl, R, Schlichting, I, Reinstein, J. | | Deposit date: | 2013-02-14 | | Release date: | 2013-07-31 | | Last modified: | 2024-02-28 | | Method: | EPR (1.64 Å), X-RAY DIFFRACTION | | Cite: | Combining crystallography and EPR: crystal and solution structures of the multidomain cochaperone DnaJ.
Acta Crystallogr.,Sect.D, 69, 2013
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4J80
 | | Thermus thermophilus DnaJ | | Descriptor: | Chaperone protein DnaJ 2 | | Authors: | Barends, T.R.M, Brosi, R.W, Steinmetz, A, Scherer, A, Hartmann, E, Eschenbach, J, Lorenz, T, Seidel, R, Shoeman, R, Zimmermann, S, Bittl, R, Schlichting, I, Reinstein, J. | | Deposit date: | 2013-02-14 | | Release date: | 2013-07-31 | | Last modified: | 2013-10-09 | | Method: | EPR (2.9 Å), X-RAY DIFFRACTION | | Cite: | Combining crystallography and EPR: crystal and solution structures of the multidomain cochaperone DnaJ.
Acta Crystallogr.,Sect.D, 69, 2013
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4R8I
 | | High Resolution Structure of a Mirror-Image RNA Oligonucleotide Aptamer in Complex with the Chemokine CCL2 | | Descriptor: | C-C motif chemokine 2, Mirror-Image RNA Oligonucleotide Aptamer NOXE36, POTASSIUM ION, ... | | Authors: | Oberthuer, D, Achenbach, J, Gabdulkhakov, A, Falke, S, Buchner, K, Maasch, C, Rehders, D, Klussmann, S, Betzel, C. | | Deposit date: | 2014-09-02 | | Release date: | 2015-04-29 | | Last modified: | 2015-05-06 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.
Nat Commun, 6, 2015
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7PNZ
 | | Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in complex with RBFA and METTL15 conformation c | | Descriptor: | 12S mitochondrial rRNA, 12S rRNA N4-methylcytidine (m4C) methyltransferase, 28S ribosomal protein S10, ... | | Authors: | Itoh, Y, Khawaja, A, Rorbach, J, Amunts, A. | | Deposit date: | 2021-09-08 | | Release date: | 2022-06-15 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Nature, 606, 2022
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7PO0
 | | Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in complex with RBFA and IF3 | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Itoh, Y, Khawaja, A, Rorbach, J, Amunts, A. | | Deposit date: | 2021-09-08 | | Release date: | 2022-06-15 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Nature, 606, 2022
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7PNT
 | | Assembly intermediate of mouse mitochondrial ribosome small subunit without mS37 in complex with RbfA and Tfb1m | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Itoh, Y, Khawaja, A, Laptev, I, Sergiev, P, Rorbach, J, Amunts, A. | | Deposit date: | 2021-09-08 | | Release date: | 2022-06-15 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Nature, 606, 2022
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7PNW
 | | Mouse mitochondrial ribosome small subunit lacking m5U modification | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Itoh, Y, Khawaja, A, Laptev, I, Sergiev, P, Rorbach, J, Amunts, A. | | Deposit date: | 2021-09-08 | | Release date: | 2022-06-15 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Nature, 606, 2022
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7PNU
 | | Assembly intermediate of mouse mitochondrial ribosome small subunit without mS37 in complex with RbfA inward conformation | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Itoh, Y, Khawaja, A, Laptev, I, Sergiev, P, Rorbach, J, Amunts, A. | | Deposit date: | 2021-09-08 | | Release date: | 2022-06-15 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Nature, 606, 2022
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7PO1
 | | Initiation complex of human mitochondrial ribosome small subunit with IF3 | | Descriptor: | 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... | | Authors: | Itoh, Y, Khawaja, A, Rorbach, J, Amunts, A. | | Deposit date: | 2021-09-08 | | Release date: | 2022-06-15 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Nature, 606, 2022
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7PNV
 | | Assembly intermediate of mouse mitochondrial ribosome small subunit without mS37 in complex with RbfA and Mettl15 | | Descriptor: | 12S mitochondrial rRNA, 12S rRNA N4-methylcytidine methyltransferase, 28S ribosomal protein S10, ... | | Authors: | Itoh, Y, Khawaja, A, Laptev, I, Sergiev, P, Rorbach, J, Amunts, A. | | Deposit date: | 2021-09-08 | | Release date: | 2022-06-15 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Nature, 606, 2022
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