6HZV
HUMAN JAK3 IN COMPLEX WITH LASW959 PROTEIN IN COMPLEX WITH LIGAND
Summary for 6HZV
Entry DOI | 10.2210/pdb6hzv/pdb |
Descriptor | Tyrosine-protein kinase JAK3, 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile (3 entities in total) |
Functional Keywords | protein kinase, janus kinase, jak3, protein binding, proteros biostructures gmbh |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 132382.84 |
Authors | Lozoya, E.,Segarra, V.,Bach, J.,Jestel, A.,Lammens, A.,Blaesse, M. (deposition date: 2018-10-24, release date: 2019-10-23, Last modification date: 2024-01-24) |
Primary citation | Bach, J.,Eastwood, P.,Gonzalez, J.,Gomez, E.,Alonso, J.A.,Fonquerna, S.,Lozoya, E.,Orellana, A.,Maldonado, M.,Calaf, E.,Alberti, J.,Perez, J.,Andres, A.,Prats, N.,Carreno, C.,Calama, E.,De Alba, J.,Calbet, M.,Miralpeix, M.,Ramis, I. Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases. J.Med.Chem., 62:9045-9060, 2019 Cited by PubMed: 31609613DOI: 10.1021/acs.jmedchem.9b00533 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.46 Å) |
Structure validation
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