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6HZV

HUMAN JAK3 IN COMPLEX WITH LASW959 PROTEIN IN COMPLEX WITH LIGAND

Summary for 6HZV
Entry DOI10.2210/pdb6hzv/pdb
DescriptorTyrosine-protein kinase JAK3, 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile (3 entities in total)
Functional Keywordsprotein kinase, janus kinase, jak3, protein binding, proteros biostructures gmbh
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight132382.84
Authors
Lozoya, E.,Segarra, V.,Bach, J.,Jestel, A.,Lammens, A.,Blaesse, M. (deposition date: 2018-10-24, release date: 2019-10-23, Last modification date: 2024-01-24)
Primary citationBach, J.,Eastwood, P.,Gonzalez, J.,Gomez, E.,Alonso, J.A.,Fonquerna, S.,Lozoya, E.,Orellana, A.,Maldonado, M.,Calaf, E.,Alberti, J.,Perez, J.,Andres, A.,Prats, N.,Carreno, C.,Calama, E.,De Alba, J.,Calbet, M.,Miralpeix, M.,Ramis, I.
Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
J.Med.Chem., 62:9045-9060, 2019
Cited by
PubMed: 31609613
DOI: 10.1021/acs.jmedchem.9b00533
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.46 Å)
Structure validation

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