Author results

3BTN
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CRYSTAL STRUCTURE OF ANTIZYME INHIBITOR, AN ORNITHINE DECARBOXYLASE HOMOLOGOUS PROTEIN
Descriptor:Antizyme inhibitor 1
Authors:Dym, O., Unger, T., Albeck, S., Kahana, C., Israel Structural Proteomics Center (ISPC)
Deposit date:2007-12-30
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function.
Protein Sci., 17, 2008
2V8Z
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CRYSTAL STRUCTURE OF YAGE, A PROPHAGE PROTEIN BELONGING TO THE DIHYDRODIPICOLINIC ACID SYNTHASE FAMILY FROM E. COLI K12
Descriptor:YAGE
Authors:Manicka, S., Peleg, Y., Unger, T., Albeck, S., Dym, O., Greenblatt, H.M., Bourenkov, G., Lamzin, V., Krishnaswamy, S., Sussman, J.L.
Deposit date:2007-08-16
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Yage, a Putative Dhdps Like Protein from Escherichia Coli K12.
Proteins: Struct., Funct., Bioinf., 71, 2008
2V9D
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CRYSTAL STRUCTURE OF YAGE, A PROPHAGE PROTEIN BELONGING TO THE DIHYDRODIPICOLINIC ACID SYNTHASE FAMILY FROM E. COLI K12
Descriptor:YAGE
Authors:Manicka, S., Peleg, Y., Unger, T., Albeck, S., Dym, O., Greenblatt, H.M., Bourenkov, G., Lamzin, V., Krishnaswamy, S., Sussman, J.L.
Deposit date:2007-08-23
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of Yage, a Putative Dhdps Like Protein from Escherichia Coli K12.
Proteins: Struct., Funct., Bioinf., 71, 2008
3Q9N
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IN SILICO AND IN VITRO CO-EVOLUTION OF A HIGH AFFINITY COMPLEMENTARY PROTEIN-PROTEIN INTERFACE
Descriptor:CoA binding protein, consensus ankyrin repeat, CARBAMOYL SARCOSINE, ...
Authors:Karanicolas, J., Corn, J.E., Chen, I., Joachimiak, L.A., Dym, O., Chung, S., Albeck, S., Unger, T., Hu, W., Liu, G., Delbecq, S., Montelione, G.T., Spiegel, C., Liu, D., Baker, D., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-01-09
Release date:2011-04-27
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:A de novo protein binding pair by computational design and directed evolution.
Mol.Cell, 42, 2011
3Q9U
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IN SILICO AND IN VITRO CO-EVOLUTION OF A HIGH AFFINITY COMPLEMENTARY PROTEIN-PROTEIN INTERFACE
Descriptor:CoA binding protein, consensus ankyrin repeat, COENZYME A
Authors:Karanicolas, J., Corn, J.E., Chen, I., Joachimiak, L.A., Dym, O., Chung, S., Albeck, S., Unger, T., Hu, W., Liu, G., Delbecq, S., Montelione, G.T., Spiegel, C., Liu, D., Baker, D., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-01-10
Release date:2011-04-20
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A de novo protein binding pair by computational design and directed evolution.
Mol.Cell, 42, 2011
3RON
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CRYSTAL STRUCTURE AND HEMOLYTIC ACTIVITY OF THE CYT1AA TOXIN FROM BACILLUS THURINGIENSIS SUBSP. ISRAELENSIS
Descriptor:Type-1Aa cytolytic delta-endotoxin
Authors:Cohen, S., Albeck, S., Ben-Dov, E., Cahan, R., Firer, M., Zaritsky, A., Dym, O., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-04-26
Release date:2011-10-12
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Cyt1Aa Toxin: Crystal Structure Reveals Implications for Its Membrane-Perforating Function.
J.Mol.Biol., 413, 2011
6FEF
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PHOSPHOTRIESTERASE PTE_A53_2
Descriptor:Phosphotriesterase, FORMIC ACID, ZINC ION, ...
Authors:Dym, O., Aggarwal, N., Albeck, S., Unger, T., Hamer Rogotner, S., Silman, I., Leader, H., Ashani, Y., Goldsmith, M., Greisen, P., Tawfik, D., Sussman, L.J.
Deposit date:2018-01-02
Release date:2019-01-30
Method:X-RAY DIFFRACTION (1.774 Å)
Cite:Crystal Structures of Bacterial Phosphotriesterase Variants with High Catalytic Activity Towards Organophosphate Nerve Agents Developed by Use of Structure-Based Design and Molecular Evolution
To Be Published
6FEV
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PHOSPHOTRIESTERASE PTE_A53_4
Descriptor:Parathion hydrolase, FORMIC ACID, ZINC ION, ...
Authors:Dym, O., Aggarwal, N., Albeck, S., Unger, T., Hamer Rogotner, S., Silman, I., Leader, H., Ashani, Y., Goldsmith, M., Greisen, P., Tawfik, D., Sussman, L.J.
Deposit date:2018-01-03
Release date:2019-01-30
Method:X-RAY DIFFRACTION (1.929 Å)
Cite:Phosphotriesterase PTE_A53_4
To Be Published
6FFW
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PHOSPHOTRIESTERASE PTE_A53_5
Descriptor:Parathion hydrolase, FORMIC ACID, ZINC ION, ...
Authors:Dym, O., Aggarwal, N., Albeck, S., Unger, T., Hamer Rogotner, S., Silman, I., Leader, H., Ashani, Y., Goldsmith, M., Greisen, P., Tawfik, D., Sussman, L.J.
Deposit date:2018-01-09
Release date:2019-03-13
Method:X-RAY DIFFRACTION (1.495 Å)
Cite:Phosphotriesterase PTE_A53_5
To Be Published
6FHE
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HIGHLY ACTIVE ENZYMES BY AUTOMATED MODULAR BACKBONE ASSEMBLY AND SEQUENCE DESIGN
Descriptor:Synthetic construct
Authors:Lapidot, G., Khersonsky, O., Lipsh, R., Dym, O., Albeck, S., Rogotner, S., Fleishman, J.S.
Deposit date:2018-01-14
Release date:2018-07-25
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Highly active enzymes by automated combinatorial backbone assembly and sequence design.
Nat Commun, 9, 2018
6FHF
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HIGHLY ACTIVE ENZYMES BY AUTOMATED MODULAR BACKBONE ASSEMBLY AND SEQUENCE DESIGN
Descriptor:Design, SODIUM ION
Authors:Lapidot, G., Khersonsky, O., Lipsh, R., Dym, O., Albeck, S., Rogotner, S., Fleishman, J.S.
Deposit date:2018-01-14
Release date:2018-07-25
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Highly active enzymes by automated combinatorial backbone assembly and sequence design.
Nat Commun, 9, 2018
6FOR
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PHOSPHOTRIESTERASE PTE_A53_6
Descriptor:Parathion hydrolase, FORMIC ACID, ZINC ION, ...
Authors:Dym, O., Aggarwal, N., Albeck, S., Unger, T., Hamer Rogotner, S., Silman, I., Leader, H., Ashani, Y., Goldsmith, M., Greisen, P., Tawfik, D., Sussman, L.J.
Deposit date:2018-02-08
Release date:2019-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures of Bacterial Phosphotriesterase Variants with High Catalytic Activity Towards Organophosphate Nerve Agents Developed by Use of Structure-Based Design and Molecular Evolution
To Be Published
6FQE
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PHOSPHOTRIESTERASE PTE_A53_4
Descriptor:Parathion hydrolase, FORMIC ACID, ZINC ION, ...
Authors:Dym, O., Aggarwal, N., Albeck, S., Unger, T., Hamer Rogotner, S., Silman, I., Leader, H., Ashani, Y., Goldsmith, M., Greisen, P., Tawfik, D., Sussman, L.J.
Deposit date:2018-02-14
Release date:2019-03-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Phosphotriesterase PTE_A53_4
To Be Published
6FRZ
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PHOSPHOTRIESTERASE PTE_A53_7
Descriptor:Parathion hydrolase, FORMIC ACID, ZINC ION, ...
Authors:Dym, O., Aggarwal, N., Albeck, S., Unger, T., Hamer Rogotner, S., Silman, I., Leader, H., Ashani, Y., Goldsmith, M., Greisen, P., Tawfik, D., Sussman, L.J.
Deposit date:2018-02-18
Release date:2019-03-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Phosphotriesterase PTE_A53_7
To Be Published
6FU0
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PHOSPHOTRIESTERASE PTE_A53_4
Descriptor:Parathion hydrolase, FORMIC ACID, ZINC ION
Authors:Dym, O., Aggarwal, N., Albeck, S., Unger, T., Hamer Rogotner, S., Silman, I., Leader, H., Ashani, Y., Goldsmith, M., Greisen, P., Tawfik, D., Sussman, L.J.
Deposit date:2018-02-26
Release date:2019-03-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Phosphotriesterase PTE_C23_1
To Be Published
6FU6
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PHOSPHOTRIESTERASE PTE_C23_2
Descriptor:Parathion hydrolase, FORMIC ACID, ZINC ION, ...
Authors:Dym, O., Aggarwal, N., Albeck, S., Unger, T., Hamer Rogotner, S., Silman, I., Leader, H., Ashani, Y., Goldsmith, M., Greisen, P., Tawfik, D., Sussman, L.J.
Deposit date:2018-02-26
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Phosphotriesterase PTE_A53_4
To Be Published
6FVK
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PHOSPHOTRIESTERASE PTE_C23_3
Descriptor:Parathion hydrolase, FORMIC ACID, ZINC ION, ...
Authors:Dym, O., Aggarwal, N., Albeck, S., Unger, T., Hamer Rogotner, S., Silman, I., Leader, H., Ashani, Y., Goldsmith, M., Greisen, P., Tawfik, D., Sussman, L.J.
Deposit date:2018-03-04
Release date:2019-03-20
Method:X-RAY DIFFRACTION (1.774 Å)
Cite:Phosphotriesterase PTE_C23_3
To Be Published
1XXM
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THE MODULAR ARCHITECTURE OF PROTEIN-PROTEIN BINDING SITE
Descriptor:Beta-lactamase TEM, Beta-lactamase inhibitory protein, CALCIUM ION
Authors:Reichmann, D., Rahat, O., Albeck, S., Meged, R., Dym, O., Schreiber, G., Israel Structural Proteomics Center (ISPC)
Deposit date:2004-11-07
Release date:2005-01-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The modular architecture of protein-protein binding interfaces
Proc.Natl.Acad.Sci.USA, 102, 2005
2RKX
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THE 3D STRUCTURE OF CHAIN D, CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROL_EVOLVEDCEROLPHOSPHATE SYNTHASE
Descriptor:Cyclase subunit of imidazoleglycerol_evolvedcerolphosphate synthase
Authors:Tawfik, D., Khersonsky, O., Albeck, S., Dym, O., Israel Structural Proteomics Center (ISPC)
Deposit date:2007-10-18
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Kemp elimination catalysts by computational enzyme design.
Nature, 453, 2008
2YAT
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CRYSTAL STRUCTURE OF ESTRADIOL DERIVED METAL CHELATE AND ESTROGEN RECEPTOR-LIGAND BINDING DOMAIN COMPLEX
Descriptor:ESTROGEN RECEPTOR, EUROPIUM ION, ESTRADIOL-PYRIDINIUM TETRAACETIC ACID, ...
Authors:Li, M.J., Greenblatt, H.M., Dym, O., Albeck, S., Degani, H., Sussman, J.L.
Deposit date:2011-02-24
Release date:2011-06-01
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators.
J.Med.Chem., 54, 2011
3BTP
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CRYSTAL STRUCTURE OF AGROBACTERIUM TUMEFACIENS VIRE2 IN COMPLEX WITH ITS CHAPERONE VIRE1: A NOVEL FOLD AND IMPLICATIONS FOR DNA BINDING
Descriptor:Single-strand DNA-binding protein, Protein virE1, AMMONIUM ION, ...
Authors:Dym, O., Albeck, S., Unger, T., Elbaum, M., Israel Structural Proteomics Center (ISPC)
Deposit date:2007-12-30
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3HQJ
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STRUCTURE-FUNCTION ANALYSIS OF MYCOBACTERIUM TUBERCULOSIS ACYL CARRIER PROTEIN SYNTHASE (ACPS).
Descriptor:Holo-[acyl-carrier-protein] synthase, MAGNESIUM ION, COENZYME A
Authors:Dym, O., Albeck, S., Peleg, Y., Schwarz, A., Shakked, Z., Burstein, Y., Zimhony, O., Israel Structural Proteomics Center (ISPC)
Deposit date:2009-06-07
Release date:2009-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-function analysis of the acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis.
J.Mol.Biol., 393, 2009
3Q2D
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OPTIMIZATION OF THE IN SILICO DESIGNED KEMP ELIMINASE KE70 BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION
Descriptor:Deoxyribose phosphate aldolase, 5-nitro-1H-benzotriazole
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Murphy, P., Dym, O., Albeck, S., Kiss, G., Houk, K.N., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-12-20
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
3UXA
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DESIGNED PROTEIN KE59 R1 7/10H
Descriptor:Kemp eliminase KE59 R1 7/10H, PHOSPHATE ION
Authors:Khersonsky, O., Kiss, G., Roethlisberger, D., Dym, O., Albeck, S., Houk, K.N., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-12-05
Release date:2012-06-06
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proc.Natl.Acad.Sci.USA, 109, 2012
3UXD
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DESIGNED PROTEIN KE59 R1 7/10H WITH DICHLOROBENZOTRIAZOLE (DBT)
Descriptor:Kemp eliminase KE59 R1 7/10H, 5,7-dichloro-1H-benzotriazole, PHOSPHATE ION
Authors:Khersonsky, O., Kiss, G., Roethlisberger, D., Dym, O., Albeck, S., Houk, K.N., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2011-12-05
Release date:2012-06-06
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.
Proc.Natl.Acad.Sci.USA, 109, 2012
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