7O4D

QR2 inhibitor from a novel sulfanamide series to tackle age related oxidative stress and cognitive decline

Summary for 7O4D

Entry DOI	10.2210/pdb7o4d/pdb
Descriptor	Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
Functional Keywords	inhibitors, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	58530.49
Authors	Gould, N.L.,Scherer, G.R.,Carvalh, S.,Shurrush, K.,Edry, E.,Elkobi, A.,David, O.,Dym, O.,Albeck, S.,Peleg, Y.,Germain, N.,Babaev, I.,Sharir, H.,Lefker, B.,Subramanyam, C.,Barr, H.,Rosenblum, K. (deposition date: 2021-04-06, release date: 2022-08-17, Last modification date: 2024-02-28)
Primary citation	Gould, N.L.,Scherer, G.R.,Carvalho, S.,Shurrush, K.,Kayyal, H.,Edry, E.,Elkobi, A.,David, O.,Foqara, M.,Thakar, D.,Pavesi, T.,Sharma, V.,Walker, M.,Maitland, M.,Dym, O.,Albeck, S.,Peleg, Y.,Germain, N.,Babaev, I.,Sharir, H.,Lalzar, M.,Shklyar, B.,Hazut, N.,Khamaisy, M.,Levesque, M.,Lajoie, G.,Avoli, M.,Amitai, G.,Lefker, B.,Subramanyam, C.,Shilton, B.,Barr, H.,Rosenblum, K. Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice. J.Clin.Invest., 133:-, 2023 Cited by PubMed: 37561584 DOI: 10.1172/JCI162120 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.249 Å)

Structure validation