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3D69
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BU of 3d69 by Molmil
Crystal Structure of the Fab Fragment of an Anti-Factor IX Antibody 10C12
Descriptor: anti-factor IX antibody, 10C12
Authors:Shi, X.L, Huang, M.D, Zeng, T.
Deposit date:2008-05-19
Release date:2009-03-31
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.77 Å)
Cite:Crystal structure of Fab Fragment of an anti-Factor IX antibody 10C12
CHIN.J.STRUCT.CHEM., 27, 2008
6J3B
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BU of 6j3b by Molmil
Crystal structure of human DHODH in complex with inhibitor 1289
Descriptor: (6R)-1-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one, ACETATE ION, CHLORIDE ION, ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-01-04
Release date:2019-08-21
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.
Febs Open Bio, 9, 2019
6J3C
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BU of 6j3c by Molmil
Crystal structure of human DHODH in complex with inhibitor 1291
Descriptor: (6R)-1-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-01-04
Release date:2019-08-21
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.
Febs Open Bio, 9, 2019
5BRR
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BU of 5brr by Molmil
Michaelis complex of tPA-S195A:PAI-1
Descriptor: GLYCEROL, Plasminogen activator inhibitor 1, TRIETHYLENE GLYCOL, ...
Authors:Gong, L.
Deposit date:2015-06-01
Release date:2015-09-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1
J.Biol.Chem., 290, 2015
8K4F
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BU of 8k4f by Molmil
DHODH in complex with compound A0
Descriptor: 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine, 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, ACETATE ION, ...
Authors:Jian, L, Sun, Q.
Deposit date:2023-07-18
Release date:2024-05-29
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease.
J.Med.Chem., 66, 2023
6JMD
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BU of 6jmd by Molmil
Crystal structure of human DHODH in complex with inhibitor 1223
Descriptor: 3-[3,5-bis(fluoranyl)-4-[3-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-03-08
Release date:2020-03-18
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.781 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6JME
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BU of 6jme by Molmil
Crystal structure of human DHODH in complex with inhibitor 0946
Descriptor: 3-[3,5-bis(fluoranyl)-4-(2-fluorophenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-03-08
Release date:2020-03-18
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6LP7
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BU of 6lp7 by Molmil
Crystal structure of human DHODH in complex with inhibitor 0944
Descriptor: 3-[3,5-bis(fluoranyl)-4-(3-methoxyphenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Chen, Q, Yu, Y.
Deposit date:2020-01-09
Release date:2020-09-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6LP6
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BU of 6lp6 by Molmil
Crystal structure of human DHODH in complex with inhibitor 1214
Descriptor: 3-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Chen, Q, Yu, Y.
Deposit date:2020-01-09
Release date:2020-09-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.795 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6LP8
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BU of 6lp8 by Molmil
Crystal structure of human DHODH in complex with inhibitor 1243
Descriptor: 3-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Chen, Q, Yu, Y.
Deposit date:2020-01-09
Release date:2020-09-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020

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