Author results

4Q91
  • Download 4q91
  • View 4q91
Molmil generated image of 4q91
CRYSTAL STRUCTURE OF C16A/K12V/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, FORMIC ACID, PHOSPHATE ION
Authors:Xia, X., Blaber, M.
Deposit date:2014-04-28
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4XKI
  • Download 4xki
  • View 4xki
Molmil generated image of 4xki
HUMAN FIBROBLAST GROWTH FACTOR - 1 (FGF-1) MUTANT S116R
Descriptor:Fibroblast growth factor 1, SULFATE ION, PHOSPHATE ION, ...
Authors:Xia, X.
Deposit date:2015-01-12
Release date:2016-01-20
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biophysical characterizations of Fibroblast Growth Factor - 1 mutant with increased heparin binding affinity
To Be Published
4YOL
  • Download 4yol
  • View 4yol
Molmil generated image of 4yol
HUMAN FIBROBLAST GROWTH FACTOR-1 C16S/A66C/C117A/P134A
Descriptor:Fibroblast growth factor 1, CITRATE ANION, IMIDAZOLE
Authors:Xia, X., Blaber, M.
Deposit date:2015-03-11
Release date:2016-03-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
J.Pharm.Sci., 105, 2016
5HZR
  • Download 5hzr
  • View 5hzr
Molmil generated image of 5hzr
CRYSTAL STRUCTURE OF MTSNF2
Descriptor:SNF2-family ATP dependent chromatin remodeling factor like protein, 3-(1-methylpiperidinium-1-yl)propane-1-sulfonate, SODIUM ION, ...
Authors:Chen, Z.C., Xia, X.
Deposit date:2016-02-02
Release date:2016-07-20
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structure of chromatin remodeler Swi2/Snf2 in the resting state
Nat.Struct.Mol.Biol., 23, 2016
4Q9G
  • Download 4q9g
  • View 4q9g
Molmil generated image of 4q9g
CRYSTAL STRUCTURE OF K12V/C16S/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, FORMIC ACID, PHOSPHATE ION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.554 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4Q9P
  • Download 4q9p
  • View 4q9p
Molmil generated image of 4q9p
CRYSTAL STRUCTURE OF C16T/K12V/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QAL
  • Download 4qal
  • View 4qal
Molmil generated image of 4qal
CRYSTAL STRUCTURE OF C117A MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-05
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBC
  • Download 4qbc
  • View 4qbc
Molmil generated image of 4qbc
CRYSTAL STRUCTURE OF C117T MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR IN SODIUM FORMATE BUFFER
Descriptor:Fibroblast growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-07
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.519 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBV
  • Download 4qbv
  • View 4qbv
Molmil generated image of 4qbv
CRYSTAL STRUCTURE OF C117T MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR IN SODIUM CITRATE BUFFER
Descriptor:Fibroblast growth factor 1, CITRATE ANION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-08
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QC4
  • Download 4qc4
  • View 4qc4
Molmil generated image of 4qc4
CRYSTAL STRUCTURE OF C117S MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION, SODIUM ION, ...
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-09
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
5X0X
  • Download 5x0x
  • View 5x0x
Molmil generated image of 5x0x
COMPLEX OF SNF2-NUCLEOSOME COMPLEX WITH SNF2 BOUND TO POSITION +6 OF THE NUCLEOSOME
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Liu, X., Xia, X., Chen, Z., Li, X.
Deposit date:2017-01-23
Release date:2017-04-19
Last modified:2017-06-07
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure.
Nature, 544, 2017
5X0Y
  • Download 5x0y
  • View 5x0y
Molmil generated image of 5x0y
COMPLEX OF SNF2-NUCLEOSOME COMPLEX WITH SNF2 BOUND TO SHL2 OF THE NUCLEOSOME
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Liu, X., Xia, X., Chen, Z., Li, X.
Deposit date:2017-01-23
Release date:2017-04-19
Last modified:2017-06-07
Method:ELECTRON MICROSCOPY (4.69 Å)
Cite:Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure.
Nature, 544, 2017
5Z3L
  • Download 5z3l
  • View 5z3l
Molmil generated image of 5z3l
STRUCTURE OF SNF2-NUCLEOSOME COMPLEX IN APO STATE
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (4.31 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
5Z3O
  • Download 5z3o
  • View 5z3o
Molmil generated image of 5z3o
STRUCTURE OF SNF2-NUCLEOSOME COMPLEX IN ADP STATE
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
5Z3T
  • Download 5z3t
  • View 5z3t
Molmil generated image of 5z3t
STRUCTURE OF SNF2-NUCLEOSOME COMPLEX IN ADP BEFX STATE
Descriptor:Transcription regulatory protein SNF2, Histone H3.2, Histone H4, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (4.06 Å)
Cite:The structures of Snf2-nucleosome complex in the ADP and ADP-BeFx states
To Be Published
6IY2
  • Download 6iy2
  • View 6iy2
Molmil generated image of 6iy2
STRUCTURE OF SNF2-MMTV-A NUCLEOSOME COMPLEX AT SHL2 IN ADP STATE
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-12-12
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
6IY3
  • Download 6iy3
  • View 6iy3
Molmil generated image of 6iy3
STRUCTURE OF SNF2-MMTV-A NUCLEOSOME COMPLEX AT SHL-2 IN ADP STATE
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-12-12
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
2XUT
  • Download 2xut
  • View 2xut
Molmil generated image of 2xut
CRYSTAL STRUCTURE OF A PROTON DEPENDENT OLIGOPEPTIDE (POT) FAMILY TRANSPORTER.
Descriptor:PROTON/PEPTIDE SYMPORTER FAMILY PROTEIN
Authors:Newstead, S., Drew, D., Cameron, A.D., Postis, V.L., Xia, X., Fowler, P.W., Ingram, J.C., Carpenter, E.P., Sansom, M.S.P., McPherson, M.J., Baldwin, S.A., Iwata, S.
Deposit date:2010-10-21
Release date:2010-12-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Crystal Structure of a Prokaryotic Homologue of the Mammalian Oligopeptide-Proton Symporters, Pept1 and Pept2.
Embo J., 30, 2011
4F34
  • Download 4f34
  • View 4f34
Molmil generated image of 4f34
SYMFOIL-4V SYNTHETIC PROTEIN WITH T30E/T72E/T116E MUTATIONS, AND DELTA HIS TAG
Descriptor:de novo protein Symfoil-4V
Authors:Blaber, M., Xia, X.
Deposit date:2012-05-08
Release date:2013-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Symfoil-4V synthetic protein with T30E/T72E/T116E mutations, and delta His tag
TO BE PUBLISHED
4QO3
  • Download 4qo3
  • View 4qo3
Molmil generated image of 4qo3
CRYSTAL STRUCTURE OF C16S/N18S/K12V/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION, IMIDAZOLE
Authors:Blaber, M., Xia, X.
Deposit date:2014-06-19
Release date:2015-05-06
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Thermodynamics of Cysteine Substitution Suggest Unique Structural Role for Cysteine in Proteins
To be Published
5C65
  • Download 5c65
  • View 5c65
Molmil generated image of 5c65
STRUCTURE OF THE HUMAN GLUCOSE TRANSPORTER GLUT3 / SLC2A3
Descriptor:Solute carrier family 2, facilitated glucose transporter member 3, Octyl Glucose Neopentyl Glycol, ...
Authors:Pike, A.C.W., Quigley, A., Chu, A., Tessitore, A., Xia, X., Mukhopadhyay, S., Wang, D., Kupinska, K., Strain-Damerell, C., Chalk, R., Burgess-Brown, N.A., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2015-06-22
Release date:2015-07-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the human glucose transporter GLUT3 / SLC2A3
To Be Published
5WLP
  • Download 5wlp
  • View 5wlp
Molmil generated image of 5wlp
SOLUTION STRUCTURE OF THE PSEUDO-RECEIVER DOMAIN OF ATG32
Descriptor:Autophagy-related protein 32
Authors:Xue, X., Pellegrini, M., Ragusa, M.J.
Deposit date:2017-07-27
Release date:2018-07-04
Last modified:2019-02-20
Method:SOLUTION NMR
Cite:A pseudo-receiver domain in Atg32 is required for mitophagy.
Autophagy, 14, 2018
2YPT
  • Download 2ypt
  • View 2ypt
Molmil generated image of 2ypt
CRYSTAL STRUCTURE OF THE HUMAN NUCLEAR MEMBRANE ZINC METALLOPROTEASE ZMPSTE24 MUTANT (E336A) IN COMPLEX WITH A SYNTHETIC CSIM TETRAPEPTIDE FROM THE C-TERMINUS OF PRELAMIN A
Descriptor:CAAX PRENYL PROTEASE 1 HOMOLOG, PRELAMIN-A/C, ZINC ION
Authors:Pike, A.C.W., Dong, Y.Y., Quigley, A., Dong, L., Savitsky, P., Cooper, C.D.O., Chaikuad, A., Goubin, S., Shrestha, L., Li, Q., Mukhopadhyay, S., Yang, J., Xia, X., Shintre, C.A., Barr, A.J., Berridge, G., Chalk, R., Bray, J.E., von Delft, F., Bullock, A., Bountra, C., Arrowsmith, C.H., Edwards, A., Burgess-Brown, N., Carpenter, E.P.
Deposit date:2012-11-01
Release date:2012-12-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:The Structural Basis of Zmpste24-Dependent Laminopathies.
Science, 339, 2013
4AW6
  • Download 4aw6
  • View 4aw6
Molmil generated image of 4aw6
CRYSTAL STRUCTURE OF THE HUMAN NUCLEAR MEMBRANE ZINC METALLOPROTEASE ZMPSTE24 (FACE1)
Descriptor:CAAX PRENYL PROTEASE 1 HOMOLOG, ZINC ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Authors:Pike, A.C.W., Dong, Y.Y., Quigley, A., Dong, L., Cooper, C.D.O., Chaikuad, A., Goubin, S., Shrestha, L., Li, Q., Mukhopadhyay, S., Yang, J., Xia, X., Shintre, C.A., Barr, A.J., Berridge, G., Chalk, R., Bray, J.E., von Delft, F., Bullock, A., Bountra, C., Arrowsmith, C.H., Edwards, A., Burgess-Brown, N., Carpenter, E.P.
Deposit date:2012-05-31
Release date:2012-07-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Structural Basis of Zmpste24-Dependent Laminopathies.
Science, 339, 2013
4AYT
  • Download 4ayt
  • View 4ayt
Molmil generated image of 4ayt
STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10 MITOCHONDRIAL, GLYCINE, MAGNESIUM ION, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
<12>