Author results

1UMR
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CRYSTAL STRUCTURE OF THE PLATELET ACTIVATOR CONVULXIN, A DISULFIDE LINKED A4B4 CYCLIC TETRAMER FROM THE VENOM OF CROTALUS DURISSUS TERRIFICUS
Descriptor:CONVULXIN ALPHA, CONVULXIN BETA
Authors:Murakami, M.T., Zela, S.P., Gava, L.M., Michelan-Duarte, S., Cintra, A.C.O., Arni, R.K.
Deposit date:2003-08-28
Release date:2003-11-21
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Platelet Activator Convulxin, a Disulfide Linked A4B4 Cyclic Tetramer from the Venom of Crotalus Durissus Terrificus
Biochem.Biophys.Res.Commun., 310, 2003
1XX1
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STRUCTURAL BASIS FOR ION-COORDINATION AND THE CATALYTIC MECHANISM OF SPHINGOMYELINASES D
Descriptor:Sphingomyelinase I, SULFATE ION, MAGNESIUM ION, ...
Authors:Murakami, M.T., Tambourgi, D.V., Arni, R.K.
Deposit date:2004-11-03
Release date:2005-01-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases d
J.Biol.Chem., 280, 2005
1ZL7
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CRYSTAL STRUCTURE OF CATALYTICALLY-ACTIVE PHOSPHOLIPASE A2 WITH BOUND CALCIUM
Descriptor:hypotensive phospholipase A2, CALCIUM ION, GLYCEROL
Authors:Murakami, M.T., Cintra, A.C., Gabdoulkhakov, A., Genov, N., Betzel, C., Arni, R.K.
Deposit date:2005-05-05
Release date:2006-04-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca(2+) free and bound states.
Biochimie, 88, 2006
1ZLB
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CRYSTAL STRUCTURE OF CATALYTICALLY-ACTIVE PHOSPHOLIPASE A2 IN THE ABSENCE OF CALCIUM
Descriptor:hypotensive phospholipase A2
Authors:Murakami, M.T., Cintra, A.C., Gabdoulkhakov, A., Genov, N., Betzel, C., Arni, R.K.
Deposit date:2005-05-05
Release date:2006-04-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca(2+) free and bound states.
Biochimie, 88, 2006
1XXN
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CRYSTAL STRUCTURE OF A MESOPHILIC XYLANASE A FROM BACILLUS SUBTILIS 1A1
Descriptor:Endo-1,4-beta-xylanase A, S,R MESO-TARTARIC ACID
Authors:Murakami, M.T., Ruller, R., Ward, R.J., Arni, R.K.
Deposit date:2004-11-07
Release date:2005-10-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Correlation of temperature induced conformation change with optimum catalytic activity in the recombinant G/11 xylanase A from Bacillus subtilis strain 168 (1A1).
Febs Lett., 579, 2005
1Y4L
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CRYSTAL STRUCTURE OF BOTHROPS ASPER MYOTOXIN II COMPLEXED WITH THE ANTI-TRYPANOSOMAL DRUG SURAMIN
Descriptor:Phospholipase A2 homolog 2, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ISOPROPYL ALCOHOL, ...
Authors:Murakami, M.T., Arruda, E.Z., Melo, P.A., Martinez, A.B., Calil-Elias, S., Tomaz, M.A., Lomonte, B., Gutierrez, J.M., Arni, R.K.
Deposit date:2004-12-01
Release date:2005-06-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of Myotoxic Activity of Bothrops asper Myotoxin II by the Anti-trypanosomal Drug Suramin.
J.Mol.Biol., 350, 2005
2AIP
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CRYSTAL STRUCTURE OF NATIVE PROTEIN C ACTIVATOR FROM THE VENOM OF COPPERHEAD SNAKE AGKISTRODON CONTORTRIX CONTORTRIX
Descriptor:Protein C activator, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Murakami, M.T., Arni, R.K.
Deposit date:2005-07-30
Release date:2005-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Thrombomodulin-independent Activation of Protein C and Specificity of Hemostatically Active Snake Venom Serine Proteinases: CRYSTAL STRUCTURES OF NATIVE AND INHIBITED AGKISTRODON CONTORTRIX CONTORTRIX PROTEIN C ACTIVATOR.
J.Biol.Chem., 280, 2005
2AIQ
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CRYSTAL STRUCTURE OF BENZAMIDINE-INHIBITED PROTEIN C ACTIVATOR FROM THE VENOM OF COPPERHEAD SNAKE AGKISTRODON CONTORTRIX CONTORTRIX
Descriptor:Protein C activator, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Murakami, M.T., Arni, R.K.
Deposit date:2005-07-30
Release date:2005-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Thrombomodulin-independent Activation of Protein C and Specificity of Hemostatically Active Snake Venom Serine Proteinases: CRYSTAL STRUCTURES OF NATIVE AND INHIBITED AGKISTRODON CONTORTRIX CONTORTRIX PROTEIN C ACTIVATOR.
J.Biol.Chem., 280, 2005
2F9R
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CRYSTAL STRUCTURE OF THE INACTIVE STATE OF THE SMASE I, A SPHINGOMYELINASE D FROM LOXOSCELES LAETA VENOM
Descriptor:Sphingomyelinase D 1, MAGNESIUM ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Murakami, M.T., Gabdoulkhakov, A., Fernandes-Pedrosa, M.F., Betzel, C., Tambourgi, D.V., Arni, R.K.
Deposit date:2005-12-06
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D.
J.Biol.Chem., 280, 2005
2H8I
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CRYSTAL STRUCTURE OF THE BOTHROPSTOXIN-I COMPLEXED WITH POLYETHYLENE GLYCOL
Descriptor:Phospholipase A2 homolog 1, DI(HYDROXYETHYL)ETHER
Authors:Murakami, M.T., Arni, R.K.
Deposit date:2006-06-07
Release date:2007-06-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Interfacial surface charge and free accessibility to the PLA2-active site-like region are essential requirements for the activity of Lys49 PLA2 homologues
Toxicon, 49, 2007
2H8U
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BUCAIN, A CARDIOTOXIN FROM THE MALAYAN KRAIT BUNGARUS CANDIDUS
Descriptor:Bucain
Authors:Murakami, M.T., Kini, R.M., Arni, R.K.
Deposit date:2006-06-08
Release date:2007-06-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Bucain
To be Published
2H9E
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CRYSTAL STRUCTURE OF FXA/SELECTIDE/NAPC2 TERNARY COMPLEX
Descriptor:Coagulation factor X heavy chain, Coagulation factor X light chain, Anti-coagulant protein C2, ...
Authors:Murakami, M.T., Geiger, G., Tulinsky, A., Arni, R.K.
Deposit date:2006-06-09
Release date:2007-02-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Intermolecular Interactions and Characterization of the Novel Factor Xa Exosite Involved in Macromolecular Recognition and Inhibition: Crystal Structure of Human Gla-domainless Factor Xa Complexed with the Anticoagulant Protein NAPc2 from the Hematophagous Nematode Ancylostoma caninum.
J.Mol.Biol., 366, 2007
2PH4
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CRYSTAL STRUCTURE OF A NOVEL ARG49 PHOSPHOLIPASE A2 HOMOLOGUE FROM ZHAOERMIA MANGSHANENSIS VENOM
Descriptor:Zhaoermiatoxin, SULFATE ION, DI(HYDROXYETHYL)ETHER
Authors:Murakami, M.T., Kuch, U., Mebs, D., Arni, R.K.
Deposit date:2007-04-10
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of a novel myotoxic Arg49 phospholipase A(2) homolog (zhaoermiatoxin) from Zhaoermia mangshanensis snake venom: Insights into Arg49 coordination and the role of Lys122 in the polarization of the C-terminus.
Toxicon, 51, 2008
4E2B
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HIGH RESOLUTION CRYSTAL STRUCTURE OF THE OLD YELLOW ENZYME FROM TRYPANOSOMA CRUZI
Descriptor:Old Yellow Enzyme, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Murakami, M.T., Rodrigues, N.C., Gava, L.M., Canduri, F., Oliva, G., Barbosa, L.R.S., Borgers, J.C.
Deposit date:2012-03-08
Release date:2013-03-27
Method:X-RAY DIFFRACTION (1.269 Å)
Cite:High resolution crystal structure and in solution studies of the old yellow enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity
To be Published
4E2D
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STRUCTURE OF THE OLD YELLOW ENZYME FROM TRYPANOSOMA CRUZI
Descriptor:Old Yellow Protein, FLAVIN MONONUCLEOTIDE, DIMETHYL SULFOXIDE
Authors:Murakami, M.T., Rodrigues, N.C., Gava, L.M., Canduri, F., Oliva, G., Barbosa, L.R.S., Borgers, J.C.
Deposit date:2012-03-08
Release date:2013-03-27
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:High resolution crystal structure and in solution studies of the Old Yellow Enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity
To be Published
1UMV
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CRYSTAL STRUCTURE OF AN ACIDIC, NON-MYOTOXIC PHOSPHOLIPASE A2 FROM THE VENOM OF BOTHROPS JARARACUSSU
Descriptor:HYPOTENSIVE PHOSPHOLIPASE A2, CALCIUM ION
Authors:Murakami, M.T., Watanabe, L., Cintra, A.C.O., Arni, R.K.
Deposit date:2003-08-28
Release date:2003-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal Structure of an Acidic Platelet Aggregation Inhibitor and Hypotensive Phospholipase A(2) in the Monomeric and Dimeric States: Insights Into its Oligomeric State
Biochem.Biophys.Res.Commun., 323, 2004
2AOZ
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CRYSTAL STRUCTURE OF THE MYOTOXIN-II FROM ATROPOIDES NUMMIFER VENOM
Descriptor:Phospholipase A2 homolog, SULFATE ION
Authors:Melo, C.C., Murakami, M.T., Angulo, Y., Lomonte, B., Arni, R.K.
Deposit date:2005-08-15
Release date:2006-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom.
Acta Crystallogr.,Sect.F, 62, 2006
1U73
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CRYSTAL STRUCTURE OF A DIMERIC ACIDIC PLATELET AGGREGATION INHIBITOR AND HYPOTENSIVE PHOSPHOLIPASE A2 FROM BOTHROPS JARARACUSSU
Descriptor:hypotensive phospholipase A2
Authors:Magro, A.J., Murakami, M.T., Soares, A.M., Arni, R.K., Fontes, M.R.
Deposit date:2004-08-02
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of an acidic platelet aggregation inhibitor and hypotensive phospholipase A(2) in the monomeric and dimeric states: insights into its oligomeric state
Biochem.Biophys.Res.Commun., 323, 2004
2KQ5
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SOLUTION NMR STRUCTURE OF A SECTION OF THE REPEAT DOMAIN OF THE TYPE III EFFECTOR PROTEIN PTHA
Descriptor:Avirulence protein
Authors:Neves, J.L., Sforca, M.L., Murakami, M.T., Benedetti, C.E., Zeri, A.C.
Deposit date:2009-10-28
Release date:2010-09-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR-based structural model of the PthA repeat region reveals a TPR fold that would account for protein-protein and protein-DNA interactions
To be Published
2L8A
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STRUCTURE OF A NOVEL CBM3 LACKING THE CALCIUM-BINDING SITE
Descriptor:Endoglucanase
Authors:Paiva, J.H., Meza, A.N., Sforca, M.L., Navarro, R.Z., Neves, J.L., Santos, C.R., Murakami, M.T., Zeri, A.C.
Deposit date:2011-01-07
Release date:2011-12-21
Last modified:2011-12-28
Method:SOLUTION NMR
Cite:Dissecting structure-function-stability relationships of a thermostable GH5-CBM3 cellulase from Bacillus subtilis 168.
Biochem.J., 441, 2012
2P3F
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CRYSTAL STRUCTURE OF THE FACTOR XA/NAP5 COMPLEX
Descriptor:Coagulation factor X, Anti-coagulant protein 5, SODIUM ION
Authors:Rios-Steiner, J.L., Murakami, M.T., Tulinsky, A., Arni, R.K.
Deposit date:2007-03-08
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Active and exo-site inhibition of human factor Xa: structure of des-Gla factor Xa inhibited by NAP5, a potent nematode anticoagulant protein from Ancylostoma caninum
J.Mol.Biol., 371, 2007
3BCQ
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CRYSTAL STRUCTURE OF OXY-HEMOGLOBIN FROM BRYCON CEPHALUS
Descriptor:Alpha-chain hemoglobin, Beta-chain hemoglobin, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Poy, C.D., Leopoldino, A.M., Rahal, P., de Azevedo, W.F., Rodriguez, G.O.B., Murakami, M.T.
Deposit date:2007-11-13
Release date:2008-10-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of oxy-hemoglobin from Brycon cephalus
To be Published
3GBO
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CRYSTAL STRUCTURE OF BMOOMPALPHA-I, A NON-HEMORRHAGIC METALLOPROTEINASE ISOLATED FROM BOTHROPS MOOJENI SNAKE VENOM
Descriptor:Zinc metalloproteinase BmooMPalfa-I, CALCIUM ION, ZINC ION
Authors:Akao, P.K., Tonoli, C.C.C., Murakami, M.T.
Deposit date:2009-02-20
Release date:2009-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural studies of BmooMPalpha-I, a non-hemorrhagic metalloproteinase from Bothrops moojeni venom.
Toxicon, 55, 2010
3KVE
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STRUCTURE OF NATIVE L-AMINO ACID OXIDASE FROM VIPERA AMMODYTES AMMODYTES: STABILIZATION OF THE QUATERNARY STRUCTURE BY DIVALENT IONS AND STRUCTURAL CHANGES IN THE DYNAMIC ACTIVE SITE
Descriptor:L-amino acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gergiova, D., Murakami, M.T., Perbandt, M., Arni, R.K., Betzel, C.
Deposit date:2009-11-30
Release date:2010-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structure of native L-amino acid oxidase from Vipera ammodytes ammodytes: stabilization of the quaternary structure by divalent ions and structural changes in the dynamic active site
To be Published
3N8T
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NATIVE STRUCTURE OF TK1436, A GH57 BRANCHING ENZYME FROM HYPERTHERMOPHILIC ARCHAEON THERMOCOCCUS KODAKARAENSIS
Descriptor:alpha-amylase, GH57 family, DI(HYDROXYETHYL)ETHER, ...
Authors:Santos, C.R., Tonoli, C.C.C., Trindade, D.M., Betzel, C., Takata, H., Kuriki, T., Kanai, T., Imanaka, T., Arni, R.K., Murakami, M.T.
Deposit date:2010-05-28
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for branching-enzyme activity of glycoside hydrolase family 57: Structure and stability studies of a novel branching enzyme from the hyperthermophilic archaeon Thermococcus Kodakaraensis KOD1.
Proteins, 79, 2011