2AOZ

Crystal structure of the myotoxin-II from Atropoides nummifer venom

Summary for 2AOZ

• Entry DOI: 10.2210/pdb2aoz/pdb
• Descriptor: Phospholipase A2 homolog, SULFATE ION (3 entities in total)
• Functional Keywords: x-ray diffration, myotoxicity, phospholipase a2, atropoides nummifer, toxin
• Biological source: Atropoides nummifer
• Cellular location: Secreted: P82950
• Total number of polymer chains: 1
• Total formula weight: 13828.92

Authors

Melo, C.C.,Murakami, M.T.,Angulo, Y.,Lomonte, B.,Arni, R.K. (deposition date: 2005-08-15, release date: 2006-07-25, Last modification date: 2024-10-16)

Primary citation

Murakami, M.T.,Melo, C.C.,Angulo, Y.,Lomonte, B.,Arni, R.K.
Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom.
Acta Crystallogr.,Sect.F, 62:423-426, 2006

PubMed Abstract: Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 angstroms resolution and the anion-binding site has been characterized.

PubMed: 16682766
DOI: 10.1107/S1744309106010700

Experimental method

X-RAY DIFFRACTION (2.08 Å)