Author results

3E8J
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COPROPORPHYRINOGEN III OXIDASE FROM LEISHMANIA NAIFFI
Descriptor:COPROPORPHYRINOGEN III OXIDASE, ACETATE ION, GLYCEROL
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2008-08-19
Release date:2008-09-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural investigation of a protozoan coproporphyrinogen III oxidase
To be Published
3IAL
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GIARDIA LAMBLIA PROLYL-TRNA SYNTHETASE IN COMPLEX WITH PROLYL-ADENYLATE
Descriptor:Prolyl-tRNA synthetase, 5'-O-[(R)-hydroxy{[(2S)-pyrrolidin-2-ylcarbonyl]oxy}phosphoryl]adenosine, GLYCEROL
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-07-14
Release date:2009-08-11
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Acta Crystallogr.,Sect.D, 68, 2012
4Y5Q
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ACTIVATED CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM CRYPTOSPORIDIUM PARVUM (CPCDPK1) IN COMPLEX WITH AMP
Descriptor:Calmodulin-domain protein kinase 1, putative, CALCIUM ION, ...
Authors:Merritt, E.A., Larson, E.T., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2015-02-11
Release date:2015-02-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with AMP
To Be Published
3KKK
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Y92C CATALYTIC RESIDUE MUTANT OF PHOSPHOGLYCERATE MUTASE FROM PLASMODIUM FALCIPARUM
Descriptor:Phosphoglycerate mutase
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-11-05
Release date:2009-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structure of a phosphoglycerate mutase from Plasmodium falciparum
To be Published
3MWU
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ACTIVATED CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM CRYPTOSPORIDIUM PARVUM (CPCDPK1) IN COMPLEX WITH BUMPED KINASE INHIBITOR RM-1-95
Descriptor:Calmodulin-domain protein kinase 1, CALCIUM ION, 3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-05-06
Release date:2010-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.
ACS Med Chem Lett, 1, 2010
3S4O
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PROTEIN TYROSINE PHOSPHATASE (PUTATIVE) FROM LEISHMANIA MAJOR
Descriptor:Protein tyrosine phosphatase-like protein, THIOSULFATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Merritt, E.A., Arakaki, T., Medical Structural Genomics of Pathogenic Protozoa (MSGPP), Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2011-05-19
Release date:2011-06-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Protein Tyrosine Phosphatase from Leishmania major
To be Published
3EJO
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COPROPORPHYRINOGEN III OXIDASE FROM LEISHMANIA DONOVANI
Descriptor:Coproporphyrinogen III oxidase, ACETATE ION
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2008-09-18
Release date:2008-10-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural investigation of a protozoan coproporphyrinogen iii oxidase
to be published
3HFD
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NUCLEOSOME ASSEMBLY PROTEIN 1 FROM PLASMODIUM KNOWLESI
Descriptor:Nucleosome assembly protein 1
Authors:Arakaki, T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-05-11
Release date:2009-05-26
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Nucleosome Assembly Protein 1 from Plasmodium knowlesi
To be Published
3P0H
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LEISHMANIA MAJOR TYROSYL-TRNA SYNTHETASE IN COMPLEX WITH FISETIN, CUBIC CRYSTAL FORM
Descriptor:Tyrosyl-tRNA synthetase, 3,7,3',4'-TETRAHYDROXYFLAVONE
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-09-28
Release date:2011-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer.
J.Mol.Biol., 409, 2011
3P0I
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LEISHMANIA MAJOR TYROSYL-TRNA SYNTHETASE IN COMPLEX WITH TYROSINOL, CUBIC CRYSTAL FORM
Descriptor:Tyrosyl-tRNA synthetase, 4-[(2S)-2-amino-3-hydroxypropyl]phenol
Authors:Merritt, E.A., Larson, E.T., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-09-28
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer.
J.Mol.Biol., 409, 2011
3P0J
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LEISHMANIA MAJOR TYROSYL-TRNA SYNTHETASE IN COMPLEX WITH TYROSINOL, TRICLINIC CRYSTAL FORM 1
Descriptor:Tyrosyl-tRNA synthetase, 4-[(2S)-2-amino-3-hydroxypropyl]phenol, SODIUM ION
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-09-28
Release date:2011-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer.
J.Mol.Biol., 409, 2011
3SO4
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METHIONINE-ADENOSYLTRANSFERASE FROM ENTAMOEBA HISTOLYTICA
Descriptor:Methionine-adenosyltransferase, ACETATE ION
Authors:Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2011-06-29
Release date:2011-07-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Methionine-adenosyltransferase from Entamoeba histolytica
To be Published
3F75
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ACTIVATED TOXOPLASMA GONDII CATHEPSIN L (TGCPL) IN COMPLEX WITH ITS PROPEPTIDE
Descriptor:Cathepsin L Protease, Cathepsin L Propeptide, CHLORIDE ION, ...
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2008-11-07
Release date:2008-11-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.
J.Biol.Chem., 284, 2009
3HRI
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HISTIDYL-TRNA SYNTHETASE (APO) FROM TRYPANOSOMA BRUCEI
Descriptor:Histidyl-tRNA synthetase
Authors:Arakaki, T.L., Merritt, E.A., Larson, E.T., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-06-09
Release date:2009-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
J.Mol.Biol., 397, 2010
3HRK
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HISTIDYL-TRNA SYNTHETASE FROM TRYPANOSOMA CRUZI (HISTIDYL-ADENYLATE COMPLEX)
Descriptor:Histidyl-tRNA synthetase, HISTIDYL-ADENOSINE MONOPHOSPHATE, CHLORIDE ION
Authors:Arakaki, T.L., Merritt, E.A., Larson, E.T., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-06-09
Release date:2009-12-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
J.Mol.Biol., 397, 2010
3I7F
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ASPARTYL TRNA SYNTHETASE FROM ENTAMOEBA HISTOLYTICA
Descriptor:Aspartyl-tRNA synthetase
Authors:Arakaki, T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-07-08
Release date:2009-07-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.
Mol.Biochem.Parasitol., 169, 2010
3KFL
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LEISHMANIA MAJOR METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH METHIONYLADENYLATE AND PYROPHOSPHATE
Descriptor:Methionyl-tRNA synthetase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate, PYROPHOSPHATE 2-, ...
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2009-10-27
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate.
Biochimie, 93, 2011
3LC0
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HISTIDYL-TRNA SYNTHETASE FROM TRYPANOSOMA CRUZI (HISTIDINE COMPLEX)
Descriptor:Histidyl-tRNA synthetase, HISTIDINE
Authors:Merritt, E.A., Larson, E.T., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-01-08
Release date:2010-01-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs.
J.Mol.Biol., 397, 2010
3LSQ
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TRYPANOSOMA BRUCEI SERYL-TRNA SYNTHETASE
Descriptor:Seryl-tRNA synthetase, MALONATE ION, SODIUM ION
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-02-12
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray crystal structure of Seryl-tRNA synthetase from the eukaryotic parasite Trypanosoma brucei.
to be published
3LSS
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TRYPANOSOMA BRUCEI SERYL-TRNA SYNTHETASE IN COMPLEX WITH ATP
Descriptor:Seryl-tRNA synthetase, ADENOSINE-5'-TRIPHOSPHATE, MALONATE ION, ...
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-02-12
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:X-ray crystal structure of Seryl-tRNA synthetase from the eukaryotic parasite Trypanosoma brucei.
to be published
3LX3
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PLASMODIUM VIVAX 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE (PTPS) IN COMPLEX WITH XANTHOPTERIN
Descriptor:6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION, 2-amino-1,5-dihydropteridine-4,6-dione
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-02-24
Release date:2010-03-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites.
to be published
3LZE
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PLASMODIUM VIVAX 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE (PTPS), E37C CATALYTIC RESIDUE MUTANT
Descriptor:Putative 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION, PTERINE
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-03-01
Release date:2010-04-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites.
to be published
3M0N
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PLASMODIUM VIVAX 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE (PTPS), E37A CATALYTIC RESIDUE MUTANT
Descriptor:Putative 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION, PTERINE
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-03-03
Release date:2010-04-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites.
to be published
3M4P
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ENTAMOEBA HISTOLYTICA ASPARAGINYL-TRNA SYNTHETASE (ASNRS) IN COMPLEX WITH ASPARAGINYL-ADENYLATE
Descriptor:Asparaginyl-tRNA synthetase, putative, 4-AMINO-1,4-DIOXOBUTAN-2-AMINIUM ADENOSINE-5'-MONOPHOSPHATE, ...
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-03-11
Release date:2010-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:X-ray crystal structure of asparaginyl-tRNA synthetase from the eukaryotic human pathogen Entamoeba histolytica.
to be published
3M4Q
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ENTAMOEBA HISTOLYTICA ASPARAGINYL-TRNA SYNTHETASE (ASNRS)
Descriptor:Asparaginyl-tRNA synthetase, putative
Authors:Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-03-11
Release date:2010-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray crystal structure of asparaginyl-tRNA synthetase from the eukaryotic human pathogen Entamoeba histolytica.
to be published
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