Author results

1EVJ
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CRYSTAL STRUCTURE OF GLUCOSE-FRUCTOSE OXIDOREDUCTASE (GFOR) DELTA1-22 S64D
分子名称:GLUCOSE-FRUCTOSE OXIDOREDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Lott, J.S., Halbig, D., Baker, H.M., Hardman, M.J., Sprenger, G.A., Baker, E.N.
登録日2000-04-20
公開日2000-12-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation.
J.Mol.Biol., 304, 2000
1WVQ
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STRUCTURE OF CONSERVED HYPOTHETICAL PROTEIN PAE2307 FROM PYROBACULUM AEROPHILUM
分子名称:hypothetical protein PAE2307, PHOSPHATE ION
著者Lott, J.S., Delbaere, L.T., Banfield, M.J., Sigrell-Simon, J.A., Baker, E.N.
登録日2004-12-24
公開日2006-01-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases.
J.Biol.Chem., 281, 2006
2GL0
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STRUCTURE OF PAE2307 IN COMPLEX WITH ADENOSINE
分子名称:conserved hypothetical protein, ADENOSINE, PHOSPHATE ION
著者Lott, J.S., Paget, B., Johnston, J.M., Baker, E.N.
登録日2006-04-04
公開日2006-06-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The Structure of an Ancient Conserved Domain Establishes a Structural Basis for Stable Histidine Phosphorylation and Identifies a New Family of Adenosine-specific Kinases.
J.Biol.Chem., 281, 2006
4NF7
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CRYSTAL STRUCTURE OF THE GH5 FAMILY CATALYTIC DOMAIN OF ENDO-1,4-BETA-GLUCANASE CEL5C FROM BUTYRIVIBRIO PROTEOCLASTICUS.
分子名称:Endo-1,4-beta-glucanase Cel5C
著者Lott, J.S., Colbert, D.A.
登録日2013-10-30
公開日2014-11-05
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.111 Å)
主引用文献Structural and functional characterisation of endo-1,4-beta-glucanase Cel5C from bovine rumen microbe Butyrivibrio proteoclasticus
To be Published
1H5Y
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HISF PROTEIN FROM PYROBACULUM AEROPHILUM
分子名称:HISF, PHOSPHATE ION, GLYCEROL
著者Banfield, M.J., Lott, J.S., McCarthy, A.A., Baker, E.N.
登録日2001-05-31
公開日2001-06-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of Hisf, a Histidine Biosynthetic Protein from Pyrobaculum Aerophilum
Acta Crystallogr.,Sect.D, 57, 2001
1XKF
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CRYSTAL STRUCTURE OF HYPOXIC RESPONSE PROTEIN I (HRPI) WITH TWO COORDINATED ZINC IONS
分子名称:hypothetical protein RV2626C, ZINC ION
著者Sharpe, M.L., Baker, E.N., Lott, J.S.
登録日2004-09-28
公開日2005-10-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis
J.Mol.Biol., 383, 2008
1XVW
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CRYSTAL STRUCTURE OF AHPE FROM MYCOBACTERIUM TUBERCULOSIS, A 1-CYS PEROXIREDOXIN
分子名称:Hypothetical protein Rv2238c/MT2298
著者Li, S., Peterson, N.A., Kim, M.Y., Kim, C.Y., Hung, L.W., Yu, M., Lekin, T., Segelke, B.W., Lott, J.S., Baker, E.N., TB Structural Genomics Consortium (TBSGC)
登録日2004-10-28
公開日2005-02-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys Peroxiredoxin
J.Mol.Biol., 346, 2005
1XXU
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CRYSTAL STRUCTURE OF AHPE FROM MYCROBACTERIUM TUBERCULOSIS, A 1-CYS PEROXIREDOXIN
分子名称:Hypothetical protein Rv2238c/MT2298
著者Li, S., Peterson, N.A., Kim, M.Y., Kim, C.Y., Hung, L.W., Yu, M., Lekin, T., Segelke, B.W., Lott, J.S., Baker, E.N., TB Structural Genomics Consortium (TBSGC)
登録日2004-11-08
公開日2005-02-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys Peroxiredoxin
J.Mol.Biol., 346, 2005
1Y5H
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CRYSTAL STRUCTURE OF TRUNCATED SE-MET HYPOXIC RESPONSE PROTEIN I (HRPI)
分子名称:hypothetical protein RV2626C
著者Sharpe, M.L., Baker, E.N., Lott, J.S.
登録日2004-12-02
公開日2005-11-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis
J.Mol.Biol., 383, 2008
1ZVW
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THE CRYSTAL STRUCTURE OF TRPD (RV2192C) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PRPP AND MAGNESIUM
分子名称:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, ...
著者Lee, C.E., Lott, J.S., Baker, E.N., Arcus, V.L., Javid-Majd, F., Goodfellow, C., Hung, L.-W., TB Structural Genomics Consortium (TBSGC)
登録日2005-06-02
公開日2006-01-17
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Crystal Structure of TrpD, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate.
J.Mol.Biol., 355, 2006
2B7O
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THE STRUCTURE OF 3-DEOXY-D-ARABINO-HEPTULOSONATE 7-PHOSPHATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS
分子名称:3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG, MANGANESE (II) ION, SULFATE ION, ...
著者Webby, C.J., Baker, H.M., Lott, J.S., Baker, E.N., Parker, E.J., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
登録日2005-10-05
公開日2005-10-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes
J.Mol.Biol., 354, 2005
2BPQ
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (APO STRUCTURE)
分子名称:ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE, BENZAMIDINE, GLYCEROL
著者Lee, C.E., Goodfellow, C., Javid-Majd, F., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
登録日2005-04-22
公開日2006-01-04
最終更新日2015-04-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Crystal Structure of Trpd, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium Tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate
J.Mol.Biol., 355, 2006
2G5F
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THE STRUCTURE OF MBTI FROM MYCOBACTERIUM TUBERCULOSIS, THE FIRST ENZYME IN THE SYNTHESIS OF MYCOBACTIN, REVEALS IT TO BE A SALICYLATE SYNTHASE
分子名称:COG0147: Anthranilate/para-aminobenzoate synthases component I, PYRUVIC ACID, IMIDAZOLE, ...
著者Harrison, A.J., Lott, J.S., Yu, M., Ramsay, R., Baker, E.N., TB Structural Genomics Consortium (TBSGC)
登録日2006-02-22
公開日2006-09-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Structure of MbtI from Mycobacterium tuberculosis, the First Enzyme in the Biosynthesis of the Siderophore Mycobactin, Reveals It To Be a Salicylate Synthase
J.Bacteriol., 188, 2006
2JB7
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PAE2307 WITH AMP
分子名称:HYPOTHETICAL PROTEIN PAE2307, ADENOSINE MONOPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Rajasekaran, K., Lott, J.S., Johnston, J.M.
登録日2006-12-04
公開日2008-08-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Pae2307 a Phosphotransferase
To be Published
3ITE
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THE THIRD ADENYLATION DOMAIN OF THE FUNGAL SIDN NON-RIBOSOMAL PEPTIDE SYNTHETASE
分子名称:SidN siderophore synthetase, SULFATE ION, CHLORIDE ION
著者Lee, T.V., Lott, J.S., Johnson, R.D., Johnson, L.J., Arcus, V.L.
登録日2009-08-28
公開日2009-11-17
最終更新日2014-02-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis
J.Biol.Chem., 285, 2010
3LOG
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CRYSTAL STRUCTURE OF MBTI FROM MYCOBACTERIUM TUBERCULOSIS
分子名称:Isochorismate synthase/isochorismate-pyruvate lyase mbtI, SUCCINIC ACID, GLYCEROL, ...
著者Bulloch, E.M.M., Lott, J.S., Baker, E.N., Johnston, J.M.
登録日2010-02-03
公開日2011-02-09
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI).
Chemmedchem, 5, 2010
3MNL
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THE CRYSTAL STRUCTURE OF KSTR (RV3574) FROM MYCOBACTERIUM TUBERCULOSIS H37RV
分子名称:TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY), TRIETHYLENE GLYCOL
著者Gao, C., Bunker, R.D., ten Bokum, A., Kendall, S.L., Stoker, N.G., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
登録日2010-04-21
公開日2011-04-27
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
J. Biol. Chem., 291, 2016
3OA5
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THE STRUCTURE OF CHI1, A CHITINASE FROM YERSINIA ENTOMOPHAGA
分子名称:Chi1, NONAETHYLENE GLYCOL, GLYCEROL
著者Busby, J.N., Lott, J.S., Hurst, M.R.H.
登録日2010-08-04
公開日2011-08-10
最終更新日2013-06-19
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Structural analysis of Chi1 Chitinase from Yen-Tc: the multisubunit insecticidal ABC toxin complex of Yersinia entomophaga
J.Mol.Biol., 415, 2012
3QQS
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS172)
分子名称:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
著者Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
登録日2011-02-16
公開日2012-08-22
最終更新日2014-01-01
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QR9
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (APO STRUCTURE)
分子名称:Anthranilate phosphoribosyltransferase, GLYCEROL
著者Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
登録日2011-02-17
公開日2011-06-15
最終更新日2013-11-27
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QS8
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS174)
分子名称:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
著者Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
登録日2011-02-20
公開日2012-08-22
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QSA
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR TAMU-A7)
分子名称:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
著者Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
登録日2011-02-20
公開日2012-08-22
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Inhibition of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase by blocking of an active site entrance tunnel.
To be Published
3R6C
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS179)
分子名称:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
著者Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
登録日2011-03-21
公開日2012-09-26
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3R88
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS145)
分子名称:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
著者Castell, A., Short, F.L., Lott, J.S.
登録日2011-03-23
公開日2012-09-26
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3RV6
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STRUCTURE OF A M. TUBERCULOSIS SALICYLATE SYNTHASE, MBTI, IN COMPLEX WITH AN INHIBITOR WITH PHENYL R-GROUP
分子名称:Isochorismate synthase/isochorismate-pyruvate lyase mbtI, 3-{[(E)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, MAGNESIUM ION, ...
著者Chi, G., Bulloch, E.M.M., Manos-Turvey, A., Payne, R.J., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
登録日2011-05-06
公開日2012-05-09
最終更新日2013-06-19
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012