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1XJV
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BU of 1xjv by Molmil
Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)
Descriptor: Protection of telomeres 1, hT10 d(TTAGGGTTAG)
Authors:Lei, M, Podell, E.R, Cech, T.R.
Deposit date:2004-09-25
Release date:2004-12-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
Nat.Struct.Mol.Biol., 11, 2004
1YHV
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BU of 1yhv by Molmil
Crystal Structure of PAK1 kinase domain with two point mutations (K299R, T423E)
Descriptor: Serine/threonine-protein kinase PAK 1
Authors:Lei, M, Robinson, M.A, Harrison, S.C.
Deposit date:2005-01-10
Release date:2005-05-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Active Conformation of the PAK1 Kinase Domain
Structure, 13, 2005
1YHW
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BU of 1yhw by Molmil
Crystal Structure of PAK1 kinase domain with one point mutations (K299R)
Descriptor: Serine/threonine-protein kinase PAK 1
Authors:Lei, M, Robinson, M.A, Harrison, S.C.
Deposit date:2005-01-10
Release date:2005-05-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Active Conformation of the PAK1 Kinase Domain
Structure, 13, 2005
6OGK
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BU of 6ogk by Molmil
MeCP2 MBD in complex with DNA
Descriptor: CALCIUM ION, DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3'), ...
Authors:Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-04-02
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
Biochim Biophys Acta Gene Regul Mech, 1862, 2019
7LMT
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BU of 7lmt by Molmil
Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a
Descriptor: Histone-lysine N-methyltransferase NSD2, UNKNOWN ATOM OR ION, ~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide
Authors:Lei, M, Freitas, R.F, Dong, A, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2021-02-05
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a
To Be Published
1F3M
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BU of 1f3m by Molmil
CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1
Descriptor: IODIDE ION, SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA
Authors:Lei, M, Lu, W, Meng, W, Parrini, M.-C, Eck, M.J, Mayer, B.J, Harrison, S.C.
Deposit date:2000-06-05
Release date:2000-06-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Cell(Cambridge,Mass.), 102, 2000
6OGJ
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BU of 6ogj by Molmil
MeCP2 MBD in complex with DNA
Descriptor: DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*CP*AP*CP*TP*CP*CP*G)-3'), Methyl-CpG-binding protein 2, ...
Authors:Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2019-04-02
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
Biochim Biophys Acta Gene Regul Mech, 1862, 2019
1QZH
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BU of 1qzh by Molmil
Crystal structure of Pot1 (protection of telomere)- ssDNA complex
Descriptor: Protection of telomeres protein 1, telomeric single-stranded DNA
Authors:Lei, M, Podell, E.R, Baumann, P, Cech, T.R.
Deposit date:2003-09-16
Release date:2003-11-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Nature, 426, 2003
1QZG
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BU of 1qzg by Molmil
Crystal structure of Pot1 (protection of telomere)- ssDNA complex
Descriptor: Protection of telomeres protein 1, THYMIDINE-5'-PHOSPHATE, telomeric single-stranded DNA
Authors:Lei, M, Podell, E.R, Baumann, P, Cech, T.R.
Deposit date:2003-09-16
Release date:2003-11-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Nature, 426, 2003
2UV8
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BU of 2uv8 by Molmil
Crystal structure of yeast fatty acid synthase with stalled acyl carrier protein at 3.1 angstrom resolution
Descriptor: FATTY ACID SYNTHASE SUBUNIT ALPHA (FAS2), FATTY ACID SYNTHASE SUBUNIT BETA (FAS1), FLAVIN MONONUCLEOTIDE
Authors:Leibundgut, M, Jenni, S, Frick, C, Ban, N.
Deposit date:2007-03-09
Release date:2007-04-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase
Science, 316, 2007
1CTF
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BU of 1ctf by Molmil
STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RIBOSOMAL PROTEIN L7/L12 FROM ESCHERICHIA COLI AT 1.7 ANGSTROMS
Descriptor: RIBOSOMAL PROTEIN L7/L12, SULFATE ION
Authors:Leijonmarck, M, Liljas, A.
Deposit date:1986-09-02
Release date:1987-01-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the C-terminal domain of the ribosomal protein L7/L12 from Escherichia coli at 1.7 A.
J.Mol.Biol., 195, 1987
1NH2
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BU of 1nh2 by Molmil
Crystal structure of a yeast TFIIA/TBP/DNA complex
Descriptor: 5'-D(*GP*TP*TP*TP*TP*AP*TP*AP*TP*AP*CP*AP*TP*AP*CP*A)-3', 5'-D(*TP*GP*TP*AP*(5IU)P*GP*TP*AP*TP*AP*(5IU)P*AP*AP*AP*AP*C)-3', Transcription initiation factor IIA large chain, ...
Authors:Bleichenbacher, M, Tan, S, Richmond, T.J.
Deposit date:2002-12-18
Release date:2003-10-21
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes.
J.Mol.Biol., 332, 2003
1NVP
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BU of 1nvp by Molmil
HUMAN TFIIA/TBP/DNA COMPLEX
Descriptor: 5'-D(*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*CP*CP*CP*CP*CP*C)-3', 5'-D(*GP*GP*GP*GP*GP*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*G)-3', TATA box binding protein, ...
Authors:Bleichenbacher, M, Tan, S, Richmond, T.J.
Deposit date:2003-02-04
Release date:2003-10-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes.
J.Mol.Biol., 332, 2003
4AC9
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BU of 4ac9 by Molmil
CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS IN COMPLEX WITH GDP
Descriptor: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, ...
Authors:Leibundgut, M, Frick, C, Thanbichler, M, Boeck, A, Ban, N.
Deposit date:2011-12-14
Release date:2012-08-22
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors.
Embo J., 24, 2005
4ACA
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BU of 4aca by Molmil
CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS, APO FORM
Descriptor: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GUANOSINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Leibundgut, M, Frick, C, Thanbichler, M, Boeck, A, Ban, N.
Deposit date:2011-12-14
Release date:2012-11-07
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors.
Embo J., 24, 2005
4ACB
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BU of 4acb by Molmil
CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS IN COMPLEX WITH THE GTP ANALOGUE GPPNHP
Descriptor: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, ...
Authors:Leibundgut, M, Frick, C, Thanbichler, M, Boeck, A, Ban, N.
Deposit date:2011-12-14
Release date:2012-11-07
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors.
Embo J., 24, 2005
7MDN
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BU of 7mdn by Molmil
Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a
Descriptor: Histone-lysine N-methyltransferase NSD2, UNKNOWN ATOM OR ION, ~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide
Authors:Lei, M, Freitas, R.F, Dong, A, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2021-04-05
Release date:2021-05-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
Nat.Chem.Biol., 18, 2022
8W8G
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BU of 8w8g by Molmil
Crystal structure of human TRF1 with PinX1
Descriptor: HEXANE-1,6-DIOL, PIN2/TERF1-interacting telomerase inhibitor 1, Telomeric repeat-binding factor 1
Authors:Lei, M, Wu, J.
Deposit date:2023-09-02
Release date:2024-09-04
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma.
Genes Dis, 12, 2025
6C1U
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BU of 6c1u by Molmil
MBD2 in complex with a deoxy-oligonucleotide
Descriptor: 12-mer DNA, Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION
Authors:Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1T
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BU of 6c1t by Molmil
MBD2 in complex with a partially methylated DNA
Descriptor: 12-mer DNA, GLYCEROL, Methyl-CpG-binding domain protein 2, ...
Authors:Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1V
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BU of 6c1v by Molmil
MBD2 in complex with double-stranded DNA
Descriptor: 12-mer DNA, Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION
Authors:Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
4P1Q
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BU of 4p1q by Molmil
GREEN FLUORESCENT PROTEIN E222H VARIANT
Descriptor: Green fluorescent protein, SODIUM ION
Authors:Klein, M, Carius, Y, Auerbach, D, Franz, S, Jung, G, Lancaster, C.R.D.
Deposit date:2014-02-27
Release date:2014-07-16
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Replacement of Highly Conserved E222 by the Photostable Non-photoconvertible Histidine in GFP.
Chembiochem, 15, 2014
7B12
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BU of 7b12 by Molmil
HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [2-(3-ethylphenyl)-1-[(2S)-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamido]ethyl]boronic acid
Descriptor: ((R)-2-(3-ethylphenyl)-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)ethyl)boronic acid, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ...
Authors:Musil, D, Klein, M, Crosignani, S.
Deposit date:2020-11-23
Release date:2021-12-01
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i).
J.Med.Chem., 64, 2021
5XXE
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BU of 5xxe by Molmil
Crystal structure of Poz1 and Tpz1
Descriptor: Protection of telomeres protein poz1, Protection of telomeres protein tpz1, SULFATE ION, ...
Authors:Xue, J, Chen, H, Wu, J, Lei, M.
Deposit date:2017-07-03
Release date:2017-12-20
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.
Cell Res., 27, 2017
5XXF
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BU of 5xxf by Molmil
Crystal structure of Poz1, Tpz1 and Rap1
Descriptor: Protection of telomeres protein poz1, Protection of telomeres protein tpz1, Rap1, ...
Authors:Xue, J, Chen, H, Wu, J, Lei, M.
Deposit date:2017-07-03
Release date:2017-12-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.
Cell Res., 27, 2017

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