1F3M | | CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1 | | Descriptor: | SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA, IODIDE ION | | Authors: | Lei, M., Lu, W., Meng, W., Parrini, M.-C., Eck, M.J., Mayer, B.J., Harrison, S.C. | | Deposit date: | 2000-06-05 | | Release date: | 2000-06-29 | | Last modified: | 2017-02-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Cell(Cambridge,Mass.), 102, 2000
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1QZG | | CRYSTAL STRUCTURE OF POT1 (PROTECTION OF TELOMERE)- SSDNA COMPLEX | | Descriptor: | telomeric single-stranded DNA, Protection of telomeres protein 1, THYMIDINE-5'-PHOSPHATE | | Authors: | Lei, M., Podell, E.R., Baumann, P., Cech, T.R. | | Deposit date: | 2003-09-16 | | Release date: | 2003-11-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Nature, 426, 2003
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1QZH | | CRYSTAL STRUCTURE OF POT1 (PROTECTION OF TELOMERE)- SSDNA COMPLEX | | Descriptor: | telomeric single-stranded DNA, Protection of telomeres protein 1 | | Authors: | Lei, M., Podell, E.R., Baumann, P., Cech, T.R. | | Deposit date: | 2003-09-16 | | Release date: | 2003-11-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Nature, 426, 2003
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1XJV | |
1YHV | |
1YHW | |
6OGJ | | MECP2 MBD IN COMPLEX WITH DNA | | Descriptor: | Methyl-CpG-binding protein 2, DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*CP*AP*CP*TP*CP*CP*G)-3'), ... | | Authors: | Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2019-04-02 | | Release date: | 2019-05-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | MeCP2 MBD in complex with DNA
To Be Published
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6OGK | | MECP2 MBD IN COMPLEX WITH DNA | | Descriptor: | Methyl-CpG-binding protein 2, DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), ... | | Authors: | Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC) | | Deposit date: | 2019-04-02 | | Release date: | 2019-05-01 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | MeCP2 MBD in complex with DNA
To Be Published
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6C1T | | MBD2 IN COMPLEX WITH A PARTIALLY METHYLATED DNA | | Descriptor: | Methyl-CpG-binding domain protein 2, 12-mer DNA, SULFATE ION, ... | | Authors: | Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2018-01-05 | | Release date: | 2018-02-14 | | Last modified: | 2018-05-23 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
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6C1U | | MBD2 IN COMPLEX WITH A DEOXY-OLIGONUCLEOTIDE | | Descriptor: | Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION | | Authors: | Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2018-01-05 | | Release date: | 2018-02-14 | | Last modified: | 2018-05-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
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6C1V | | MBD2 IN COMPLEX WITH DOUBLE-STRANDED DNA | | Descriptor: | Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION | | Authors: | Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2018-01-05 | | Release date: | 2018-02-14 | | Last modified: | 2018-05-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
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3BQO | | CRYSTAL STRUCTURE OF TRF1 TRFH DOMAIN AND TIN2 PEPTIDE COMPLEX | | Descriptor: | Telomeric repeat-binding factor 1, TERF1-interacting nuclear factor 2 | | Authors: | Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M. | | Deposit date: | 2007-12-20 | | Release date: | 2008-02-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
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3BU8 | | CRYSTAL STRUCTURE OF TRF2 TRFH DOMAIN AND TIN2 PEPTIDE COMPLEX | | Descriptor: | Telomeric repeat-binding factor 2, TERF1-interacting nuclear factor 2 | | Authors: | Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M. | | Deposit date: | 2008-01-02 | | Release date: | 2008-02-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
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3BUA | | CRYSTAL STRUCTURE OF TRF2 TRFH DOMAIN AND APOLLO PEPTIDE COMPLEX | | Descriptor: | Telomeric repeat-binding factor 2, DNA cross-link repair 1B protein | | Authors: | Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M. | | Deposit date: | 2008-01-02 | | Release date: | 2008-02-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
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3CRT | | STRUCTURAL CHARACTERIZATION OF AN ENGINEERED ALLOSTERIC PROTEIN | | Descriptor: | Glutathione S-transferase class-mu 26 kDa isozyme, GLUTATHIONE | | Authors: | Sagermann, M., Chapleau, R., DeLorimier, E., Lei, M. | | Deposit date: | 2008-04-07 | | Release date: | 2009-02-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
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3CRU | | STRUCTURAL CHARACTERIZATION OF AN ENGINEERED ALLOSTERIC PROTEIN | | Descriptor: | Glutathione S-transferase class-mu 26 kDa isozyme, GLUTATHIONE | | Authors: | Sagermann, M., Chapleau, R., DeLorimier, E., Lei, M. | | Deposit date: | 2008-04-07 | | Release date: | 2009-02-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
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5H65 | | CRYSTAL STRUCTURE OF HUMAN POT1 AND TPP1 | | Descriptor: | Protection of telomeres protein 1, Adrenocortical dysplasia protein homolog, ZINC ION | | Authors: | Chen, C., Wu, J., Lei, M. | | Deposit date: | 2016-11-10 | | Release date: | 2017-05-31 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.
Nat Commun, 8, 2017
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5XXE | | CRYSTAL STRUCTURE OF POZ1 AND TPZ1 | | Descriptor: | Protection of telomeres protein poz1, Protection of telomeres protein tpz1, SULFATE ION, ... | | Authors: | Xue, J., Chen, H., Wu, J., Lei, M. | | Deposit date: | 2017-07-03 | | Release date: | 2017-12-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.
Cell Res., 27, 2017
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5XXF | | CRYSTAL STRUCTURE OF POZ1, TPZ1 AND RAP1 | | Descriptor: | Protection of telomeres protein poz1, Protection of telomeres protein tpz1, Rap1, ... | | Authors: | Xue, J., Chen, H., Wu, J., Lei, M. | | Deposit date: | 2017-07-03 | | Release date: | 2017-12-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.
Cell Res., 27, 2017
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6AGB | | CRYO-EM STRUCTURE OF YEAST RIBONUCLEASE P | | Descriptor: | Ribonuclease P RNA, Ribonucleases P/MRP protein subunit POP1, Ribonucleases P/MRP protein subunit POP3, ... | | Authors: | Lan, P., Tan, M., Wu, J., Lei, M. | | Deposit date: | 2018-08-10 | | Release date: | 2018-10-17 | | Last modified: | 2019-02-20 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
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6AH3 | | CRYO-EM STRUCTURE OF YEAST RIBONUCLEASE P WITH PRE-TRNA SUBSTRATE | | Descriptor: | Ribonuclease P RNA, Ribonucleases P/MRP protein subunit POP1, Ribonucleases P/MRP protein subunit POP3, ... | | Authors: | Lan, P., Tan, M., Wu, J., Lei, M. | | Deposit date: | 2018-08-16 | | Release date: | 2018-10-17 | | Last modified: | 2018-12-26 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
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6AHR | | CRYO-EM STRUCTURE OF HUMAN RIBONUCLEASE P | | Descriptor: | H1 RNA, Ribonucleases P/MRP protein subunit POP1, Ribonuclease P protein subunit p38, ... | | Authors: | Wu, J., Niu, S., Tan, M., Lan, P., Lei, M. | | Deposit date: | 2018-08-20 | | Release date: | 2018-12-05 | | Method: | ELECTRON MICROSCOPY (3.92 Å) | | Cite: | Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
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6AHU | | CRYO-EM STRUCTURE OF HUMAN RIBONUCLEASE P WITH MATURE TRNA | | Descriptor: | H1 RNA, Ribonucleases P/MRP protein subunit POP1, Ribonuclease P protein subunit p38, ... | | Authors: | Wu, J., Niu, S., Tan, M., Lan, P., Lei, M. | | Deposit date: | 2018-08-20 | | Release date: | 2018-12-05 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
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6AHV | | CRYSTAL STRUCTURE OF HUMAN RPP40 | | Descriptor: | Ribonuclease P protein subunit p40 | | Authors: | Wu, J., Niu, S., Tan, M., Lan, P., Lei, M. | | Deposit date: | 2018-08-20 | | Release date: | 2018-12-05 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
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6K0A | | CRYO-EM STRUCTURE OF AN ARCHAEAL RIBONUCLEASE P | | Descriptor: | Ribonuclease P protein component 2, Ribonuclease P protein component 3, Ribonuclease P protein component 1, ... | | Authors: | Wan, F., Lan, P., Wu, J., Lei, M. | | Deposit date: | 2019-05-05 | | Release date: | 2019-06-19 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.
Nat Commun, 2019
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