8W8G

Crystal structure of human TRF1 with PinX1

Summary for 8W8G

• Entry DOI: 10.2210/pdb8w8g/pdb
• Related: 3BQO
• Descriptor: Telomeric repeat-binding factor 1, PIN2/TERF1-interacting telomerase inhibitor 1, HEXANE-1,6-DIOL, ... (4 entities in total)
• Functional Keywords: telomere, telomerase activity, tumorigenesis, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 107383.62

Authors

Lei, M.,Wu, J. (deposition date: 2023-09-02, release date: 2024-09-04, Last modification date: 2025-03-19)

• Primary citation: Weng, Y.,Yan, X.,Chen, B.,Bian, Z.,Ge, Y.,Lu, H.,He, S.,Wu, J.,Chen, Y.,Lei, M.,Zhang, Y.; PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma.; Genes Dis, 12:101319-101319, 2025; PubMed: 39634130; DOI: 10.1016/j.gendis.2024.101319

Experimental method

X-RAY DIFFRACTION (2.7 Å)