Author results

1F3M
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CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1
分子名称:SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA, IODIDE ION
著者Lei, M., Lu, W., Meng, W., Parrini, M.-C., Eck, M.J., Mayer, B.J., Harrison, S.C.
登録日2000-06-05
公開日2000-06-29
最終更新日2017-02-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Cell(Cambridge,Mass.), 102, 2000
1QZG
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CRYSTAL STRUCTURE OF POT1 (PROTECTION OF TELOMERE)- SSDNA COMPLEX
分子名称:telomeric single-stranded DNA, Protection of telomeres protein 1, THYMIDINE-5'-PHOSPHATE
著者Lei, M., Podell, E.R., Baumann, P., Cech, T.R.
登録日2003-09-16
公開日2003-11-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Nature, 426, 2003
1QZH
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CRYSTAL STRUCTURE OF POT1 (PROTECTION OF TELOMERE)- SSDNA COMPLEX
分子名称:telomeric single-stranded DNA, Protection of telomeres protein 1
著者Lei, M., Podell, E.R., Baumann, P., Cech, T.R.
登録日2003-09-16
公開日2003-11-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Nature, 426, 2003
1XJV
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CRYSTAL STRUCTURE OF HUMAN POT1 BOUND TO TELOMERIC SINGLE-STRANDED DNA (TTAGGGTTAG)
分子名称:hT10 d(TTAGGGTTAG), Protection of telomeres 1
著者Lei, M., Podell, E.R., Cech, T.R.
登録日2004-09-25
公開日2004-12-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
Nat.Struct.Mol.Biol., 11, 2004
1YHV
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CRYSTAL STRUCTURE OF PAK1 KINASE DOMAIN WITH TWO POINT MUTATIONS (K299R, T423E)
分子名称:Serine/threonine-protein kinase PAK 1
著者Lei, M., Robinson, M.A., Harrison, S.C.
登録日2005-01-10
公開日2005-05-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Active Conformation of the PAK1 Kinase Domain
Structure, 13, 2005
1YHW
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CRYSTAL STRUCTURE OF PAK1 KINASE DOMAIN WITH ONE POINT MUTATIONS (K299R)
分子名称:Serine/threonine-protein kinase PAK 1
著者Lei, M., Robinson, M.A., Harrison, S.C.
登録日2005-01-10
公開日2005-05-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Active Conformation of the PAK1 Kinase Domain
Structure, 13, 2005
6OGJ
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MECP2 MBD IN COMPLEX WITH DNA
分子名称:Methyl-CpG-binding protein 2, DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*CP*AP*CP*TP*CP*CP*G)-3'), ...
著者Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2019-04-02
公開日2019-05-01
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
Biochim Biophys Acta Gene Regul Mech, 1862, 2019
6OGK
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MECP2 MBD IN COMPLEX WITH DNA
分子名称:Methyl-CpG-binding protein 2, DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), ...
著者Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
登録日2019-04-02
公開日2019-05-01
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
Biochim Biophys Acta Gene Regul Mech, 1862, 2019
6C1T
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MBD2 IN COMPLEX WITH A PARTIALLY METHYLATED DNA
分子名称:Methyl-CpG-binding domain protein 2, 12-mer DNA, SULFATE ION, ...
著者Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-01-05
公開日2018-02-14
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1U
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MBD2 IN COMPLEX WITH A DEOXY-OLIGONUCLEOTIDE
分子名称:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
著者Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-01-05
公開日2018-02-14
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1V
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MBD2 IN COMPLEX WITH DOUBLE-STRANDED DNA
分子名称:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
著者Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-01-05
公開日2018-02-14
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
3BQO
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CRYSTAL STRUCTURE OF TRF1 TRFH DOMAIN AND TIN2 PEPTIDE COMPLEX
分子名称:Telomeric repeat-binding factor 1, TERF1-interacting nuclear factor 2
著者Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M.
登録日2007-12-20
公開日2008-02-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
3BU8
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CRYSTAL STRUCTURE OF TRF2 TRFH DOMAIN AND TIN2 PEPTIDE COMPLEX
分子名称:Telomeric repeat-binding factor 2, TERF1-interacting nuclear factor 2
著者Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M.
登録日2008-01-02
公開日2008-02-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
3BUA
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CRYSTAL STRUCTURE OF TRF2 TRFH DOMAIN AND APOLLO PEPTIDE COMPLEX
分子名称:Telomeric repeat-binding factor 2, DNA cross-link repair 1B protein
著者Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M.
登録日2008-01-02
公開日2008-02-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
3CRT
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STRUCTURAL CHARACTERIZATION OF AN ENGINEERED ALLOSTERIC PROTEIN
分子名称:Glutathione S-transferase class-mu 26 kDa isozyme, GLUTATHIONE
著者Sagermann, M., Chapleau, R., DeLorimier, E., Lei, M.
登録日2008-04-07
公開日2009-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
3CRU
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STRUCTURAL CHARACTERIZATION OF AN ENGINEERED ALLOSTERIC PROTEIN
分子名称:Glutathione S-transferase class-mu 26 kDa isozyme, GLUTATHIONE
著者Sagermann, M., Chapleau, R., DeLorimier, E., Lei, M.
登録日2008-04-07
公開日2009-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
6AGB
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CRYO-EM STRUCTURE OF YEAST RIBONUCLEASE P
分子名称:Ribonuclease P RNA, Ribonucleases P/MRP protein subunit POP1, Ribonucleases P/MRP protein subunit POP3, ...
著者Lan, P., Tan, M., Wu, J., Lei, M.
登録日2018-08-10
公開日2018-10-17
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (3.48 Å)
主引用文献Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
6AH3
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CRYO-EM STRUCTURE OF YEAST RIBONUCLEASE P WITH PRE-TRNA SUBSTRATE
分子名称:Ribonuclease P RNA, Ribonucleases P/MRP protein subunit POP1, Ribonucleases P/MRP protein subunit POP3, ...
著者Lan, P., Tan, M., Wu, J., Lei, M.
登録日2018-08-16
公開日2018-10-17
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (3.48 Å)
主引用文献Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
6AHR
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CRYO-EM STRUCTURE OF HUMAN RIBONUCLEASE P
分子名称:H1 RNA, Ribonucleases P/MRP protein subunit POP1, Ribonuclease P protein subunit p38, ...
著者Wu, J., Niu, S., Tan, M., Lan, P., Lei, M.
登録日2018-08-20
公開日2018-12-05
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (3.92 Å)
主引用文献Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
6AHU
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CRYO-EM STRUCTURE OF HUMAN RIBONUCLEASE P WITH MATURE TRNA
分子名称:H1 RNA, Ribonucleases P/MRP protein subunit POP1, Ribonuclease P protein subunit p38, ...
著者Wu, J., Niu, S., Tan, M., Lan, P., Lei, M.
登録日2018-08-20
公開日2018-12-05
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (3.66 Å)
主引用文献Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
6AHV
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CRYSTAL STRUCTURE OF HUMAN RPP40
分子名称:Ribonuclease P protein subunit p40
著者Wu, J., Niu, S., Tan, M., Lan, P., Lei, M.
登録日2018-08-20
公開日2018-12-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
2HKO
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CRYSTAL STRUCTURE OF LSD1
分子名称:Lysine-specific histone demethylase 1, FLAVIN-ADENINE DINUCLEOTIDE
著者Chen, Y., Yang, Y.T., Wang, F., Yanane, K., Zhang, Y., Lei, M.
登録日2006-07-05
公開日2006-08-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Proc.Natl.Acad.Sci.Usa, 103, 2006
2I46
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CRYSTAL STRUCTURE OF HUMAN TPP1
分子名称:Adrenocortical dysplasia protein homolog
著者Wang, F., Podell, E.R., Zaug, A.J., Yang, Y.T., Baciu, P., Else, T., Hammer, G.D., Cech, T.R., Lei, M.
登録日2006-08-21
公開日2006-11-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature, 445, 2007
2L3N
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SOLUTION STRUCTURE OF RAP1-TAZ1 FUSION PROTEIN
分子名称:DNA-binding protein rap1,Telomere length regulator taz1
著者Zhou, Z.R., Wang, F., Chen, Y., Lei, M., Hu, H.
登録日2010-09-19
公開日2011-01-12
最終更新日2020-01-01
実験手法SOLUTION NMR
主引用文献A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
2SRC
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CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP
分子名称:TYROSINE-PROTEIN KINASE SRC, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Xu, W., Doshi, A., Lei, M., Eck, M.J., Harrison, S.C.
登録日1998-12-29
公開日1999-07-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
Mol.Cell, 3, 1999