Author results

1NTP
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USE OF THE NEUTRON DIFFRACTION H/D EXCHANGE TECHNIQUE TO DETERMINE THE CONFORMATIONAL DYNAMICS OF TRYPSIN
Descriptor:BETA-TRYPSIN, PHOSPHORYLISOPROPANE
Authors:Kossiakoff, A.A.
Deposit date:1987-09-16
Release date:1988-01-16
Last modified:2017-11-29
Method:NEUTRON DIFFRACTION (1.8 Å)
Cite:Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin
Basic Life Sci., 27, 1984
1TGN
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STRUCTURE OF BOVINE TRYPSINOGEN AT 1.9 ANGSTROMS RESOLUTION
Descriptor:TRYPSINOGEN
Authors:Kossiakoff, A.A., Stroud, R.M.
Deposit date:1979-09-19
Release date:1979-10-19
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of bovine trypsinogen at 1.9 A resolution.
Biochemistry, 16, 1977
3PGF
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CRYSTAL STRUCTURE OF MALTOSE BOUND MBP WITH A CONFORMATIONALLY SPECIFIC SYNTHETIC ANTIGEN BINDER (SAB)
Descriptor:Maltose-binding periplasmic protein, SAB Heavy Chain, SAB Light Chain, ...
Authors:Kossiakoff, A.A., Duguid, E.M., Sandstrom, A.
Deposit date:2010-11-01
Release date:2011-03-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.
Nat.Struct.Mol.Biol., 18, 2011
1AAL
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STRUCTURAL EFFECTS INDUCED BY MUTAGENESIS AFFECTED BY CRYSTAL PACKING FACTORS: THE STRUCTURE OF A 30-51 DISULFIDE MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR
Descriptor:BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C., Randal, M., Kossiakoff, A.A.
Deposit date:1992-04-09
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor.
Proteins, 14, 1992
1CA0
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BOVINE CHYMOTRYPSIN COMPLEXED TO APPI
Descriptor:BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
Authors:Scheidig, A.J., Kossiakoff, A.A.
Deposit date:1997-01-23
Release date:1997-07-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
1CBW
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BOVINE CHYMOTRYPSIN COMPLEXED TO BPTI
Descriptor:BOVINE CHYMOTRYPSIN, BPTI, SULFATE ION
Authors:Hynes, T.R., Scheidig, A.J., Kossiakoff, A.A.
Deposit date:1996-12-22
Release date:1997-07-23
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
1F6F
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR
Descriptor:PLACENTAL LACTOGEN, PROLACTIN RECEPTOR
Authors:Elkins, P.A., Christinger, H.W., Sandowski, Y., Sakal, E., Gertler, A., De Vos, A.M., Kossiakoff, A.A.
Deposit date:2000-06-21
Release date:2000-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Nat.Struct.Biol., 7, 2000
1FYH
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1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR
Descriptor:Interferon gamma, Interferon gamma receptor 1, CHLORIDE ION
Authors:Randal, M., Kossiakoff, A.A.
Deposit date:2000-09-29
Release date:2000-10-11
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex.
Structure, 9, 2001
1TAW
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BOVINE TRYPSIN COMPLEXED TO APPI
Descriptor:TRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR, CALCIUM ION
Authors:Hynes, T.R., Kossiakoff, A.A.
Deposit date:1996-12-19
Release date:1997-06-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
3HHR
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HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX
Descriptor:HUMAN GROWTH HORMONE, HUMAN GROWTH HORMONE RECEPTOR (hGHbp)
Authors:De Vos, A.M., Ultsch, M., Kossiakoff, A.A.
Deposit date:1993-12-30
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Science, 255, 1992
5EII
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STRUCTURAL DETERMINATION OF AN PROTEIN COMPLEX OF A FAB WITH INCREASED SOLUBILITY
Descriptor:Fab Heavy Chain, Fab Light Chain, Histone chaperone ASF1
Authors:Bailey, L.J., Kossiakoff, A.A., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS)
Deposit date:2015-10-29
Release date:2016-11-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structural determination of an protein complex of a Fab with increased solubility
To Be Published
5UEA
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STRUCTURE OF ANTIGEN-FAB COMPLEX WITH HISTONE CHAPERONE ASF1
Descriptor:Fab Heavy Chain, Histone chaperone ASF1, Fab Light Chain
Authors:Bailey, L.J., Kossiakoff, A.A.
Deposit date:2016-12-29
Release date:2018-01-10
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Antibody Switch Residue Engineering for Improved Crystallization Chaperones
To Be Published
5UEK
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STRUCTURE OF ANTIGEN-FAB 12E COMPLEX WITH HISTONE CHAPERONE ASF1
Descriptor:Histone chaperone ASF1, Fab 12E Heavy Chain, Fab 12E Light Chain
Authors:Bailey, L.J., Kossiakoff, A.A.
Deposit date:2017-01-02
Release date:2018-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Antibody Switch Residue Engineering for Improved Crystallization Chaperones
To Be Published
1AAP
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X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
Descriptor:ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN
Authors:Hynes, T.R., Randal, M., Kennedy, L.A., Eigenbrot, C., Kossiakoff, A.A.
Deposit date:1990-09-14
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Biochemistry, 29, 1990
1BP3
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THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX
Descriptor:PROTEIN (GROWTH HORMONE), PROTEIN (PROLACTIN RECEPTOR), ZINC ION
Authors:Somers, W., Ultsch, M., De Vos, A.M., Kossiakoff, A.A.
Deposit date:1998-08-12
Release date:1998-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The X-ray structure of a growth hormone-prolactin receptor complex.
Nature, 372, 1994
1D9C
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BOVINE INTERFERON-GAMMA AT 2.0 ANGSTROMS
Descriptor:INTERFERON-GAMMA
Authors:Randal, M., Kossiakoff, A.A.
Deposit date:1999-10-27
Release date:1999-11-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species.
Acta Crystallogr.,Sect.D, 56, 2000
1D9G
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BOVINE INTERFERON-GAMMA AT 2.9 ANGSTROMS
Descriptor:INTERFERON-GAMMA
Authors:Randal, M., Kossiakoff, A.A.
Deposit date:1999-10-27
Release date:1999-11-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species.
Acta Crystallogr.,Sect.D, 56, 2000
1FVC
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X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor:IGG1-KAPPA 4D5 FV (LIGHT CHAIN), IGG1-KAPPA 4D5 FV (HEAVY CHAIN)
Authors:Eigenbrot, C., Randal, M., Kossiakoff, A.A., Presta, L.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1FVD
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X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor:IGG1-KAPPA 4D5 FAB (LIGHT CHAIN), IGG1-KAPPA 4D5 FAB (HEAVY CHAIN)
Authors:Eigenbrot, C., Presta, L., Randal, M., Kossiakoff, A.A.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1FVE
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X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor:IGG1-KAPPA 4D5 FAB (LIGHT CHAIN), IGG1-KAPPA 4D5 FAB (HEAVY CHAIN)
Authors:Eigenbrot, C., Randal, M., Presta, L., Kossiakoff, A.A.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1HUW
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THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION
Descriptor:HUMAN GROWTH HORMONE
Authors:Ultsch, M.H., Somers, W.S., Kossiakoff, A.A., De Vos, A.M.
Deposit date:1993-09-22
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of affinity-matured human growth hormone at 2 A resolution.
J.Mol.Biol., 236, 1994
1KF9
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PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR
Descriptor:PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE, EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238)
Authors:Schiffer, C.A., Ultsch, M., Walsh, S., Somers, W., De Vos, A.M., Kossiakoff, A.A.
Deposit date:2001-11-19
Release date:2002-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
J.Mol.Biol., 316, 2002
1TPK
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CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION
Descriptor:TISSUE PLASMINOGEN ACTIVATOR, CHLORIDE ION
Authors:De vos, A.M., Ultsch, M.H., Kelley, R.F., Padmanabhan, K., Tulinsky, A., Westbrook, M.L., Kossiakoff, A.A.
Deposit date:1991-09-24
Release date:1992-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Biochemistry, 31, 1992
1Y3T
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CRYSTAL STRUCTURE OF YXAG, A DIOXYGENASE FROM BACILLUS SUBTILIS
Descriptor:Hypothetical protein yxaG, FE (III) ION
Authors:Gopal, B., Madan, L.L., Betz, S.F., Kossiakoff, A.A.
Deposit date:2004-11-26
Release date:2005-01-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Crystal Structure of a Quercetin 2,3-Dioxygenase from Bacillus subtilis Suggests Modulation of Enzyme Activity by a Change in the Metal Ion at the Active Site(s)
Biochemistry, 44, 2005
1YIW
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X-RAY CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED UBIQUITIN
Descriptor:Ubiquitin, CADMIUM ION, CHLORIDE ION
Authors:Bang, D., Makhatadze, G.I., Tereshko, V., Kossiakoff, A.A., Kent, S.B.
Deposit date:2005-01-13
Release date:2005-06-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:X-ray Crystal Structure of a Chemically Synthesized [D-Gln35]Ubiquitin
Angew.Chem.Int.Ed.Engl., 44, 2005