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2FU5
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BU of 2fu5 by Molmil
structure of Rab8 in complex with MSS4
Descriptor: BETA-MERCAPTOETHANOL, Guanine nucleotide exchange factor MSS4, Ras-related protein Rab-8A, ...
Authors:Itzen, A, Pylypenko, O, Goody, R.S, Rak, A.
Deposit date:2006-01-26
Release date:2006-04-04
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nucleotide exchange via local protein unfolding-structure of Rab8 in complex with MSS4
Embo J., 25, 2006
5L3A
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BU of 5l3a by Molmil
Fragment-based discovery of 6-arylindazole JAK inhibitors
Descriptor: Tyrosine-protein kinase JAK2, ~{N}-(1~{H}-indazol-4-yl)methanesulfonamide
Authors:Soerensen, M.D, Dack, K.N, Greve, D.R, Ritzen, A.
Deposit date:2016-04-06
Release date:2016-04-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Fragment-Based Discovery of 6-Arylindazole JAK Inhibitors.
Acs Med.Chem.Lett., 7, 2016
8CIL
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BU of 8cil by Molmil
Crystal structure of Coxiella burnetii Fic protein 2
Descriptor: Fic family protein
Authors:Hoepfner, D, Itzen, A, Pogenberg, V.
Deposit date:2023-02-10
Release date:2023-11-15
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3.
Commun Biol, 6, 2023
4LI0
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BU of 4li0 by Molmil
Crystal structure of GDP-bound Rab8:GRAB
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide exchange factor for Rab-3A, Ras-related protein Rab-8A
Authors:Guo, Z, Hou, X.M, Goody, R.S, Itzen, A.
Deposit date:2013-07-01
Release date:2013-10-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
J.Biol.Chem., 288, 2013
4LHV
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BU of 4lhv by Molmil
Crystal structure of Rab8 in its inactive GDP-bound form
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-8A
Authors:Guo, Z, Hou, X.M, Goody, R.S, Itzen, A.
Deposit date:2013-07-01
Release date:2013-10-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
J.Biol.Chem., 288, 2013
4LHY
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BU of 4lhy by Molmil
Crystal structure of GDP-bound Rab8:Rabin8
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Rab-3A-interacting protein, Ras-related protein Rab-8A, ...
Authors:Guo, Z, Hou, X.M, Goody, R.S, Itzen, A.
Deposit date:2013-07-01
Release date:2013-10-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
J.Biol.Chem., 288, 2013
4LHZ
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BU of 4lhz by Molmil
Crystal structure of GTP-bound Rab8:Rabin8
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Rab-3A-interacting protein, Ras-related protein Rab-8A
Authors:Guo, Z, Hou, X.M, Goody, R.S, Itzen, A.
Deposit date:2013-07-01
Release date:2013-10-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
J.Biol.Chem., 288, 2013
5LPN
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BU of 5lpn by Molmil
Structure of human Rab10 in complex with the bMERB domain of Mical-1
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Protein-methionine sulfoxide oxidase MICAL1, ...
Authors:Rai, A, Oprisko, A, Campos, J, Fu, Y, Friese, T, Itzen, A, Goody, R.S, Mueller, M.P, Gazdag, E.M.
Deposit date:2016-08-14
Release date:2016-08-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.
Elife, 5, 2016
3JZA
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BU of 3jza by Molmil
Crystal structure of human Rab1b in complex with the GEF domain of DrrA/SidM from Legionella pneumophila
Descriptor: PHOSPHATE ION, Ras-related protein Rab-1B, Uncharacterized protein DrrA
Authors:Schoebel, S, Oesterlin, L.K, Blankenfeldt, W, Goody, R.S, Itzen, A.
Deposit date:2009-09-23
Release date:2010-01-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity.
Mol.Cell, 36, 2009
3JZ9
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BU of 3jz9 by Molmil
Crystal structure of the GEF domain of DrrA/SidM from Legionella pneumophila
Descriptor: Uncharacterized protein DrrA
Authors:Schoebel, S, Oesterlin, L.K, Blankenfeldt, W, Goody, R.S, Itzen, A.
Deposit date:2009-09-23
Release date:2010-01-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity.
Mol.Cell, 36, 2009
8AGG
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BU of 8agg by Molmil
Structure of the Legionella phosphocholine hydrolase Lem3
Descriptor: MAGNESIUM ION, Phosphocholine hydrolase Lem3
Authors:Kaspers, M.S, Itzen, A, Pogenberg, V.
Deposit date:2022-07-20
Release date:2023-04-12
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b.
Nat Commun, 14, 2023
8ALK
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BU of 8alk by Molmil
Structure of the Legionella phosphocholine hydrolase Lem3 in complex with its substrate Rab1
Descriptor: 2-[[[5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxyethyl-[3-(2-chloranylethanoylamino)propyl]-dimethyl-azanium, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Kaspers, M.S, Pett, C, Hedberg, C, Itzen, A, Pogenberg, V.
Deposit date:2022-08-01
Release date:2023-04-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b.
Nat Commun, 14, 2023
6YX5
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BU of 6yx5 by Molmil
Structure of DrrA from Legionella pneumophilia in complex with human Rab8a
Descriptor: MAGNESIUM ION, Multifunctional virulence effector protein DrrA, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Schneider, S, Du, J, von Wrisberg, M.K, Lang, K, Itzen, A.
Deposit date:2020-04-30
Release date:2020-12-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1.
Nat Commun, 12, 2021
6ZMD
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BU of 6zmd by Molmil
Crystal structure of HYPE covalently tethered to BiP bound to AMP-PNP
Descriptor: Endoplasmic reticulum chaperone BiP, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Fauser, J, Gulen, B, Pett, C, Hedberg, C, Itzen, A, Pogenberg, V.
Deposit date:2020-07-02
Release date:2021-04-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD.
Nat Commun, 12, 2021
3TNF
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BU of 3tnf by Molmil
LidA from Legionella in complex with active Rab8a
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, LidA, MAGNESIUM ION, ...
Authors:Schoebel, S, Cichy, A.L, Goody, R.S, Itzen, A.
Deposit date:2011-09-01
Release date:2011-11-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Protein LidA from Legionella is a Rab GTPase supereffector.
Proc.Natl.Acad.Sci.USA, 108, 2011
5O74
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BU of 5o74 by Molmil
Crystal structure of human Rab1b covalently bound to the GEF domain of DrrA/SidM from Legionella pneumophila in the presence of GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Multifunctional virulence effector protein DrrA, Ras-related protein Rab-1B
Authors:Cigler, M, Mueller, T, Horn-Ghetko, D, von Wrisberg, M.K, Fottner, M, Goody, R.S, Itzen, A, Mueller, M.P, Lang, K.
Deposit date:2017-06-08
Release date:2017-10-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo.
Angew. Chem. Int. Ed. Engl., 56, 2017
5OED
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BU of 5oed by Molmil
Human Rab32:GDP in complex with Salmonella GtgE C45A mutant
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GtgE, MAGNESIUM ION, ...
Authors:Wachtel, R, Braeuning, B, Mader, S.L, Ecker, F, Kaila, V.R.I, Groll, M, Itzen, A.
Deposit date:2017-07-07
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The protease GtgE from Salmonella exclusively targets inactive Rab GTPases.
Nat Commun, 9, 2018
5OEC
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BU of 5oec by Molmil
Human Rab32 (18-201):GDP in complex with Salmonella GtgE (21-214) C45A mutant
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GtgE, MAGNESIUM ION, ...
Authors:Wachtel, R, Braeuning, B, Mader, S.L, Ecker, F, Kaila, V.R.I, Groll, M, Itzen, A.
Deposit date:2017-07-07
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The protease GtgE from Salmonella exclusively targets inactive Rab GTPases.
Nat Commun, 9, 2018
8ANP
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BU of 8anp by Molmil
Legionella effector Lem3 mutant D190A in complex with Mg2+
Descriptor: MAGNESIUM ION, Phosphocholine hydrolase Lem3, SULFATE ION, ...
Authors:Kaspers, M.S, Pogenberg, V, Ernst, S, Ecker, F, Pett, C, Ochtrop, P, Hedberg, C, Groll, M, Itzen, A.
Deposit date:2022-08-05
Release date:2023-04-12
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b.
Nat Commun, 14, 2023
4OOJ
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BU of 4ooj by Molmil
Crystal structure of the N-terminal domain of the Legionella pneumophila protein SidC at 2.4A resolution
Descriptor: DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, SidC, ...
Authors:Gazdag, E.M, Shoebel, S, Shkumatov, A.V, Goody, R.S, Itzen, A.
Deposit date:2014-02-03
Release date:2014-02-26
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structure of the N-terminal domain of the Legionella protein SidC
J.Struct.Biol., 186, 2014
4PHG
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BU of 4phg by Molmil
Crystal structure of Ypt7 covalently modified with GTP
Descriptor: GTP-binding protein YPT7, MAGNESIUM ION, N-[3-(propanoylamino)propyl]guanosine 5'-(tetrahydrogen triphosphate), ...
Authors:Koch, D, Wiegandt, D, Vieweg, S, Hofmann, F, Wu, Y, Itzen, A, Mueller, M.P, Goody, R.S.
Deposit date:2014-05-06
Release date:2014-05-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Locking GTPases covalently in their functional states.
Nat Commun, 6, 2015
4PHH
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BU of 4phh by Molmil
Crystal structure of Ypt7 covalently modified with GNP
Descriptor: 5'-O-[(R)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-N-[3-(propanoylamino)propyl]guanosine, CHLORIDE ION, GTP-binding protein YPT7, ...
Authors:Wiegandt, D, Vieweg, S, Hofmann, F, Koch, D, Wu, Y, Itzen, A, Mueller, M.P, Goody, R.S.
Deposit date:2014-05-06
Release date:2014-05-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Locking GTPases covalently in their functional states.
Nat Commun, 6, 2015
4PHF
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BU of 4phf by Molmil
Crystal structure of Ypt7 covalently modified with GDP
Descriptor: GTP-binding protein YPT7, MAGNESIUM ION, N-[3-(propanoylamino)propyl]guanosine 5'-(trihydrogen diphosphate), ...
Authors:Vieweg, S, Wiegandt, D, Hofmann, F, Koch, D, Wu, Y, Itzen, A, Mueller, M.P, Goody, R.S.
Deposit date:2014-05-06
Release date:2014-05-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Locking GTPases covalently in their functional states.
Nat Commun, 6, 2015
3NKU
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BU of 3nku by Molmil
Crystal structure of the N-terminal domain of DrrA/SidM from Legionella pneumophila
Descriptor: DI(HYDROXYETHYL)ETHER, DrrA, TRIETHYLENE GLYCOL
Authors:Mueller, M.P, Peters, H, Blankenfeldt, W, Goody, R.S, Itzen, A.
Deposit date:2010-06-21
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b.
Science, 329, 2010
3N6O
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BU of 3n6o by Molmil
Crystal structure of the GEF and P4M domain of DrrA/SidM from Legionella pneumophila
Descriptor: SULFATE ION, guanine nucleotide exchange factor
Authors:Schoebel, S, Blankenfeldt, W, Goody, R.S, Itzen, A.
Deposit date:2010-05-26
Release date:2010-07-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA.
Embo Rep., 11, 2010

 

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