Author results

1IKN
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IKAPPABALPHA/NF-KAPPAB COMPLEX
Descriptor:PROTEIN (NF-KAPPA-B P65 SUBUNIT), PROTEIN (NF-KAPPA-B P50D SUBUNIT), PROTEIN (I-KAPPA-B-ALPHA)
Authors:Huxford, T., Huang, D.-B., Malek, S., Ghosh, G.
Deposit date:1998-11-13
Release date:1999-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.
Cell(Cambridge,Mass.), 95, 1998
1MY5
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NF-KAPPAB P65 SUBUNIT DIMERIZATION DOMAIN HOMODIMER
Descriptor:NF-kappaB p65 (RelA) subunit
Authors:Huxford, T., Mishler, D., Phelps, C.B., Huang, D.-B., Sengchanthalangsy, L.L., Reeves, R., Hughes, C.A., Komives, E.A., Ghosh, G.
Deposit date:2002-10-03
Release date:2002-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/I kappaB alpha complex formation
J.Mol.Biol., 324, 2002
1MY7
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NF-KAPPAB P65 SUBUNIT DIMERIZATION DOMAIN HOMODIMER N202R MUTATION
Descriptor:NF-kappaB p65 (RelA) subunit
Authors:Huxford, T., Mishler, D., Phelps, C.B., Huang, D.-B., Sengchanthalangsy, L.L., Reeves, R., Hughes, C.A., Komives, E.A., Ghosh, G.
Deposit date:2002-10-03
Release date:2002-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaB alpha complex formation
J.Mol.Biol., 324, 2002
5KVL
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HUMANIZED 10G4 ANTI-LEUKOTRIENE C4 ANTIBODY FAB FRAGMENT IN COMPLEX WITH LEUKOTRIENE C4
Descriptor:Humanized 10G4 anti-Leukotriene C4 Immunoglobulin G (IgG) heavy chain Fab fragment, Humanized 10G4 anti-Leukotriene C4 Immunoglobulin G (IgG) light chain, ZINC ION, ...
Authors:Huxford, T., King, A., Fleming, J.K., Wojciak, J.M.
Deposit date:2016-07-14
Release date:2017-05-24
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Humanized 10G4 anti-leukotriene C4 antibody Fab fragment in complex with leukotriene C4
To Be Published
6NL6
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CRYSTAL STRUCTURE OF MUTANT B1 IMMUNOGLOBULIN-BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G (T16F, T18A, V21E, T25L, K28Y, V29I, K31R, Q32H, Y33L, N35K, D36H, N37Q)
Descriptor:Immunoglobulin G-binding protein G, ZINC ION, CHLORIDE ION
Authors:Huxford, T., Maniaci, B.
Deposit date:2019-01-08
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mutant of Protein G Beta 1 Domain (T16F, T18A, V21E, T25L, K28Y, V29I, K31R, Q32A, Y33L, N35K, D36A, N37Q)
To Be Published
6NL7
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CRYSTAL STRUCTURE OF B1 IMMUNOGLOBULIN-BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G (T16F, T18A, V21H, T25H, K28Y, V29I, K31R, Q32A, Y33L, N35K, D36A, N37Q)
Descriptor:Immunoglobulin G-binding protein G, ZINC ION, ACETATE ION, ...
Authors:Huxford, T., Maniaci, B.
Deposit date:2019-01-08
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mutant of Protein G Beta 1 domain (T16F, T18A, V21H, T25H, K28Y, V29I, K31R, Q32A, Y33L, N35K, D36A, N37Q)
To Be Published
6NLA
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED METAL-CONTROLLED DIMER OF B1 IMMUNOGLOBULIN-BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G (L12H, E15V, T16L, T18I, V29H, Y33H, N37L)-ZINC
Descriptor:Immunoglobulin G-binding protein G, ZINC ION, CHLORIDE ION, ...
Authors:Huxford, T., Maniaci, B.
Deposit date:2019-01-08
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Crystal structure of de novo designed metal-controlled dimer of B1 immunoglobulin-binding domain of Streptococcal Protein G (L12H, E15V, T16L, T18I, V29H, Y33H, N37L)-zinc
To Be Published
6NLB
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED METAL-CONTROLLED DIMER OF MUTANT B1 IMMUNOGLOBULIN-BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G (L12H, E15V, T16L, T18I, V29H, Y33H, N37L)-APO
Descriptor:Immunoglobulin G-binding protein G, MAGNESIUM ION
Authors:Huxford, T., Maniaci, B.
Deposit date:2019-01-08
Release date:2019-01-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of de novo designed metal-controlled dimer of mutant B1 immunoglobulin-binding domain of Streptococcal Protein G (L12H, E15V, T16L, T18I, V29H, Y33H, N37L)-apo
To Be Published
3I9G
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CRYSTAL STRUCTURE OF THE LT1009 (SONEPCIZUMAB) ANTIBODY FAB FRAGMENT IN COMPLEX WITH SPHINGOSINE-1-PHOSPHATE
Descriptor:Sonepcizumab antibody Fab fragment, heavy chain, light chain, ...
Authors:Huxford, T.
Deposit date:2009-07-10
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen.
Proc.Natl.Acad.Sci.USA, 106, 2009
6NL8
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED METAL-CONTROLLED DIMER OF MUTANT B1 IMMUNOGLOBULIN-BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G (L12H, T16L, V29H, Y33H, N37L)-ZINC
Descriptor:Immunoglobulin G-binding protein G, ZINC ION, CHLORIDE ION
Authors:Maniaci, B., Huxford, T.
Deposit date:2019-01-08
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mutant of Protein G Beta 1 Domain (L12H, T16L, V29H, Y33H, N37L) with zinc
To Be Published
6NL9
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED METAL-CONTROLLED DIMER OF MUTANT B1 IMMUNOGLOBULIN-BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G (L12H, T16L, V29H, Y33H, N37L)-APO
Descriptor:Immunoglobulin G-binding protein G, MAGNESIUM ION, SODIUM ION
Authors:Maniaci, B., Huxford, T.
Deposit date:2019-01-08
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mutant of Protein G Beta 1 domain (L12H, T16L, V29H, Y33H, N37L)-apo
To Be Published
4ZF6
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CYTOCHROME P450 PENTAMUTANT FROM BM3 WITH BOUND PEG
Descriptor:Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, PENTAETHYLENE GLYCOL, ...
Authors:Rogers, W.E., Othman, T., Heidary, D.K., Huxford, T.
Deposit date:2015-04-21
Release date:2016-07-13
Method:X-RAY DIFFRACTION (2.773 Å)
Cite:Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
4ZF8
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CYTOCHROME P450 PENTAMUTANT FROM BM3 WITH BOUND METYRAPONE
Descriptor:Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, METYRAPONE, ...
Authors:Rogers, W.E., Othman, T., Heidary, D.K., Huxford, T.
Deposit date:2015-04-21
Release date:2016-07-13
Method:X-RAY DIFFRACTION (2.766 Å)
Cite:Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
4ZFA
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CYTOCHROME P450 WILD TYPE FROM BM3 WITH BOUND PEG
Descriptor:Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, PENTAETHYLENE GLYCOL, ...
Authors:Rogers, W.E., Othman, T., Heidary, D.K., Huxford, T.
Deposit date:2015-04-21
Release date:2016-07-13
Method:X-RAY DIFFRACTION (2.765 Å)
Cite:Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
4ZFB
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CYTOCHROME P450 PENTAMUTANT FROM BM3 BOUND TO PALMITIC ACID
Descriptor:Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, PALMITIC ACID, ...
Authors:Rogers, W.E., Othman, T., Heidary, D.K., Huxford, T.
Deposit date:2015-04-21
Release date:2016-07-13
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.
Biochemistry, 55, 2016
1BFS
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STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE
Descriptor:NUCLEAR FACTOR NF-KAPPA-B P50
Authors:Huang, D.B., Huxford, T., Chen, Y.Q., Ghosh, G.
Deposit date:1997-09-12
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.
Structure, 5, 1997
1BFT
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STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE
Descriptor:NUCLEAR FACTOR NF-KAPPA-B P65
Authors:Huang, D.B., Huxford, T., Chen, Y.Q., Ghosh, G.
Deposit date:1997-09-12
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.
Structure, 5, 1997
1K3Z
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X-RAY CRYSTAL STRUCTURE OF THE IKBB/NF-KB P65 HOMODIMER COMPLEX
Descriptor:Transcription factor p65, transcription factor inhibitor I-kappa-B-beta
Authors:Shiva, M., Huang, D.B., Chen, Y., Huxford, T., Ghosh, S., Ghosh, G.
Deposit date:2001-10-04
Release date:2002-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003
1OY3
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CRYSTAL STRUCTURE OF AN IKBBETA/NF-KB P65 HOMODIMER COMPLEX
Descriptor:Transcription factor p65, transcription factor inhibitor I-kappa-B-beta
Authors:Malek, S., Huang, D.B., Huxford, T., Ghosh, S., Ghosh, G.
Deposit date:2003-04-03
Release date:2003-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003
2BYN
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CRYSTAL STRUCTURE OF APO ACHBP FROM APLYSIA CALIFORNICA
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, TETRAETHYLENE GLYCOL, PENTAETHYLENE GLYCOL, ...
Authors:Hansen, S.B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., Bourne, Y.
Deposit date:2005-08-03
Release date:2005-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations.
Embo J., 24, 2005
2BYP
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CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH ALPHA- CONOTOXIN IMI
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, ALPHA-CONOTOXIN IMI, N-ACETYL-D-GLUCOSAMINE
Authors:Hansen, S.B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., Bourne, Y.
Deposit date:2005-08-03
Release date:2005-10-05
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations.
Embo J., 24, 2005
2BYQ
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CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH EPIBATIDINE
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, EPIBATIDINE
Authors:Hansen, S.B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., Bourne, Y.
Deposit date:2005-08-03
Release date:2005-10-05
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations.
Embo J., 24, 2005
2BYR
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CRYSTAL STRUCTURE OF ACHBP FROM APLYSIA CALIFORNICA IN COMPLEX WITH METHYLLYCACONITINE
Descriptor:ACETYLCHOLINE-BINDING PROTEIN, METHYLLYCACONITINE
Authors:Hansen, S.B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., Bourne, Y.
Deposit date:2005-08-03
Release date:2005-10-05
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations.
Embo J., 24, 2005
2BYS
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CRYSTAL STRUCTURE OF ACHBP FROM APLYSIA CALIFORNICA IN COMPLEX WITH LOBELINE
Descriptor:ACETYLCHOLINE-BINDING PROTEIN, LOBELINE
Authors:Hansen, S.B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., Bourne, Y.
Deposit date:2005-08-04
Release date:2005-10-05
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations.
Embo J., 24, 2005
3NOW
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UNC-45 FROM DROSOPHILA MELANOGASTER
Descriptor:UNC-45 protein, SD10334p
Authors:Lee, C.F., Hauenstein, A.V., Fleming, J.K., Gasper, W.C., Engelke, V., Banumathi, S., Bernstein, S.I., Huxford, T.
Deposit date:2010-06-25
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.992 Å)
Cite:X-ray Crystal Structure of the UCS Domain-Containing UNC-45 Myosin Chaperone from Drosophila melanogaster.
Structure, 19, 2011
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