Author results

6NBU
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CRISPR COMPLEX SUBUNIT CSM2 FROM STAPHYLOCOCCUS EPIDERMIDIS RP62A
Descriptor:CRISPR-associated protein
Authors:Dorsey, B.W., Huang, L., Mondragon, A.
Deposit date:2018-12-10
Release date:2019-02-13
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural organization of a Type III-A CRISPR effector subcomplex determined by X-ray crystallography and cryo-EM.
Nucleic Acids Res., 2019
6NBT
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CRISPR COMPLEX SUBUNIT CSM3 FROM STAPHYLOCOCCUS EPIDERMIDIS RP62A
Descriptor:CRISPR-associated protein, CALCIUM ION, SAMARIUM (III) ION
Authors:Dorsey, B.W., Mondragon, A.
Deposit date:2018-12-10
Release date:2019-02-13
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural organization of a Type III-A CRISPR effector subcomplex determined by X-ray crystallography and cryo-EM.
Nucleic Acids Res., 2019
6MPN
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RACEMIC M2-TM I42E CRYSTALLIZED FROM RACEMIC DETERGENT
Descriptor:Matrix protein 2, B-OCTYLGLUCOSIDE
Authors:Kreitler, D.F., Yao, Z., Mortenson, D.E., Forest, K.T., Gellman, S.H.
Deposit date:2018-10-07
Release date:2019-01-30
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation.
J. Am. Chem. Soc., 141, 2019
6MPM
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RACEMIC M2-TM I42A CRYSTALLIZED FROM RACEMIC DETERGENT
Descriptor:Matrix protein 2, B-OCTYLGLUCOSIDE
Authors:Kreitler, D.F., Yao, Z., Mortenson, D.E., Forest, K.T., Gellman, S.H.
Deposit date:2018-10-07
Release date:2019-01-30
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation.
J. Am. Chem. Soc., 141, 2019
6MPL
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RACEMIC M2-TM I39A CRYSTALLIZED FROM RACEMIC DETERGENT
Descriptor:Matrix protein 2, B-OCTYLGLUCOSIDE, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Kreitler, D.F., Yao, Z., Mortenson, D.E., Forest, K.T., Gellman, S.H.
Deposit date:2018-10-07
Release date:2019-01-30
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation.
J. Am. Chem. Soc., 141, 2019
6HCT
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CRYSTAL STRUCTURE OF ARCHEOGLOBUS FULGIDUS L7AE BOUND TO ITS COGNATE UTR K-TURN
Descriptor:RNA (5'-R(*GP*CP*CP*GP*AP*UP*GP*AP*AP*UP*GP*CP*AP*UP*GP*AP*AP*GP*C)-3'), 50S ribosomal protein L7Ae, RNA (5'-R(*GP*CP*CP*GP*AP*UP*GP*AP*AP*UP*G)-3'), ...
Authors:Huang, L., Lilley, D.M.J.
Deposit date:2018-08-16
Release date:2018-10-31
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (3.091 Å)
Cite:The role of RNA structure in translational regulation by L7Ae protein in archaea.
RNA, 25, 2019
6HC5
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THE STRUCTURE OF THE G. VIOLACEUS GUANIDINE II RIBOSWITCH P2 STEM-LOOP WITH AUDOUINE
Descriptor:RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3'), SULFATE ION, SODIUM ION, ...
Authors:Huang, L., Lilley, D.M.J.
Deposit date:2018-08-14
Release date:2019-02-20
Method:X-RAY DIFFRACTION (1.413 Å)
Cite:Structure-guided design of a high affinity ligand for a riboswitch.
RNA, 2019
6HBX
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THE STRUCTURE OF THE G. VIOLACEUS GUANIDINE II RIBOSWITCH P2 STEM-LOOP WITH ETHYLGUANIDINE
Descriptor:RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3'), N-ETHYLGUANIDINE, SULFATE ION, ...
Authors:Huang, L., Lilley, D.M.J.
Deposit date:2018-08-13
Release date:2019-02-20
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structure-guided design of a high affinity ligand for a riboswitch.
RNA, 2019
6HBT
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THE STRUCTURE OF THE G. VIOLACEUS GUANIDINE II RIBOSWITCH P2 STEM-LOOP WITH ARCAINE
Descriptor:RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3'), SULFATE ION, 1-(4-carbamimidamidobutyl)guanidine
Authors:Huang, L., Lilley, D.M.J.
Deposit date:2018-08-13
Release date:2019-02-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structure-guided design of a high affinity ligand for a riboswitch.
RNA, 2019
6FZ0
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CRYSTAL STRUCTURE OF THE METY SAM V RIBOSWITCH
Descriptor:metY SAM V (53-MER), SULFATE ION, SODIUM ION, ...
Authors:Huang, L., Lilley, D.M.J.
Deposit date:2018-03-13
Release date:2018-07-04
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (2.499 Å)
Cite:Structure and ligand binding of the SAM-V riboswitch.
Nucleic Acids Res., 46, 2018
6C6R
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HUMAN SQUALENE EPOXIDASE (SQLE, SQUALENE MONOOXYGENASE) STRUCTURE WITH FAD
Descriptor:Squalene monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
Authors:Padyana, A.K., Jin, L.
Deposit date:2018-01-19
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
Nat Commun, 10, 2019
6C6P
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HUMAN SQUALENE EPOXIDASE (SQLE, SQUALENE MONOOXYGENASE) STRUCTURE WITH FAD AND NB-598
Descriptor:Squalene monooxygenase, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, (2E)-N-({3-[([3,3'-bithiophen]-5-yl)methoxy]phenyl}methyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine, ...
Authors:Padyana, A.K., Jin, L.
Deposit date:2018-01-19
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
Nat Commun, 10, 2019
6C6N
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HUMAN SQUALENE EPOXIDASE (SQLE, SQUALENE MONOOXYGENASE) STRUCTURE WITH FAD AND CMPD-4"
Descriptor:Squalene monooxygenase, GLYCEROL, SULFATE ION, ...
Authors:Padyana, A.K., Jin, L.
Deposit date:2018-01-19
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
Nat Commun, 10, 2019
6B41
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MENIN BOUND TO M-525
Descriptor:Menin, methyl {(1S,2R)-2-[(S)-cyano[1-({1-[4-({1-[4-(dimethylamino)butanoyl]azetidin-3-yl}sulfonyl)phenyl]azetidin-3-yl}methyl)piperidin-4-yl](3-fluorophenyl)methyl]cyclopentyl}carbamate, praseodymium triacetate
Authors:Stuckey, J.A.
Deposit date:2017-09-25
Release date:2018-01-24
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.
Angew. Chem. Int. Ed. Engl., 57, 2018
6A2I
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ARCHITECTURAL ROLES OF CREN7 IN FOLDING CRENARCHAEAL CHROMATIN FILAMENT
Descriptor:Chromatin protein Cren7, DNA (5'-D(*CP*GP*TP*AP*GP*CP*TP*AP*AP*TP*TP*AP*GP*CP*TP*AP*CP*G)-3')
Authors:Zhang, Z.F., Zhao, M.H., Chen, Y.Y., Wang, L., Dong, Y.H., Gong, Y., Huang, L.
Deposit date:2018-06-11
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Architectural roles of Cren7 in folding crenarchaeal chromatin filament.
Mol. Microbiol., 2018
6A2H
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ARCHITECTURAL ROLES OF CREN7 IN FOLDING CRENARCHAEAL CHROMATIN FILAMENT
Descriptor:Chromatin protein Cren7, DNA (5'-D(P*GP*TP*AP*AP*TP*T)-3'), DNA (5'-D(P*AP*AP*TP*TP*AP*C)-3')
Authors:Zhang, Z.F., Zhao, M.H., Chen, Y.Y., Wang, L., Dong, Y.H., Gong, Y., Huang, L.
Deposit date:2018-06-11
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Architectural roles of Cren7 in folding crenarchaeal chromatin filament.
Mol. Microbiol., 2018
5YZ3
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CRYSTAL STRUCTURE OF T2R-TTL-28 COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Yu, Y., Chen, Q.
Deposit date:2017-12-12
Release date:2018-10-24
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.545 Å)
Cite:A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors.
Cancer Res., 78, 2018
5WWC
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THE CRYSTAL STRUCTURE OF CREN7 MUTANT L28M IN COMPLEX WITH DSDNA
Descriptor:Chromatin protein Cren7, DNA (5'-D(*GP*TP*AP*AP*TP*TP*AP*C)-3')
Authors:Zhang, Z.F., Zhao, M.H., Wang, L., Chen, Y.Y., Dong, Y.H., Gong, Y., Huang, L.
Deposit date:2016-12-31
Release date:2017-04-26
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Roles of Leu28 side chain intercalation in the interaction between Cren7 and DNA
Biochem. J., 474, 2017
5WVZ
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THE CRYSTAL STRUCTURE OF CREN7 MUTANT L28F IN COMPLEX WITH DSDNA
Descriptor:Chromatin protein Cren7, DNA (5'-D(*GP*CP*GP*AP*TP*CP*GP*C)-3')
Authors:Zhang, Z.F., Zhao, M.H., Wang, L., Chen, Y.Y., Dong, Y.H., Gong, Y., Huang, L.
Deposit date:2016-12-30
Release date:2017-04-26
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Roles of Leu28 side chain intercalation in the interaction between Cren7 and DNA
Biochem. J., 474, 2017
5WVY
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THE CRYSTAL STRUCTURE OF CREN7 MUTANT L28V IN COMPLEX WITH DSDNA
Descriptor:Chromatin protein Cren7, DNA (5'-D(*GP*TP*GP*AP*TP*CP*AP*C)-3')
Authors:Zhang, Z.F., Zhao, M.H., Wang, L., Chen, Y.Y., Dong, Y.H., Gong, Y., Huang, L.
Deposit date:2016-12-29
Release date:2017-04-26
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Roles of Leu28 side chain intercalation in the interaction between Cren7 and DNA
Biochem. J., 474, 2017
5WVW
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THE CRYSTAL STRUCTURE OF CREN7 MUTANT L28A IN COMPLEX WITH DSDNA
Descriptor:Chromatin protein Cren7, DNA (5'-D(*GP*TP*GP*AP*TP*CP*AP*C)-3')
Authors:Zhang, Z.F., Zhao, M.H., Wang, L., Chen, Y.Y., Dong, Y.H., Gong, Y., Huang, L.
Deposit date:2016-12-29
Release date:2017-04-26
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Roles of Leu28 side chain intercalation in the interaction between Cren7 and DNA
Biochem. J., 474, 2017
5WUK
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CRYSTAL STRUCTURE OF EED [G255D] IN COMPLEX WITH EZH2 PEPTIDE AND EED226 COMPOUND
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, GLYCEROL, ...
Authors:Chen, Z.
Deposit date:2016-12-19
Release date:2017-05-03
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Split luciferase-based biosensors for characterizing EED binders
Anal. Biochem., 522, 2017
5WE2
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STRUCTURAL BASIS FOR TELOMERE LENGTH REGULATION BY THE SHELTERIN BRIDGE
Descriptor:Protection of telomeres protein poz1, Protection of telomeres protein tpz1, DNA-binding protein rap1, ...
Authors:Kim, J.-K., Liu, J., Hu, X., Sankaran, B., Qiao, F.
Deposit date:2017-07-06
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Shelterin Bridge Assembly.
Mol. Cell, 68, 2017
5WE1
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STRUCTURAL BASIS FOR SHELTERIN BRIDGE ASSEMBLY
Descriptor:Protection of telomeres protein poz1,Protection of telomeres protein poz1, Protection of telomeres protein tpz1, ZINC ION
Authors:Kim, J.-K., Liu, J., Hu, X., Yu, C., Roskamp, K., Sankaran, B., Huang, L., Komives, E.-A., Qiao, F.
Deposit date:2017-07-06
Release date:2017-12-20
Method:X-RAY DIFFRACTION (3.202 Å)
Cite:Structural Basis for Shelterin Bridge Assembly.
Mol. Cell, 68, 2017
5WE0
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STRUCTURAL BASIS FOR SHELTERIN BRIDGE ASSEMBLY
Descriptor:Protection of telomeres protein poz1, Protection of telomeres protein tpz1, DNA-binding protein rap1, ...
Authors:Kim, J.-K., Liu, J., Hu, X., Yu, C., Roskamp, K., Sankaran, B., Huang, L., Komives, E.-A., Qiao, F.
Deposit date:2017-07-06
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Shelterin Bridge Assembly.
Mol. Cell, 68, 2017