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1SVV
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INITIAL STUCTURAL ANALYSIS OF LEISHMANIA MAJOR THREONINE ALDOLASE
Descriptor:THREONINE ALDOLASE, UNKNOWN LIGAND
Authors:Hol, W.G.J., Robien, M.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-03-30
Release date:2004-08-17
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Initial Structural Analysis of Leishmania major Threonine Aldolase
To be Published
1RHD
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STRUCTURE OF BOVINE LIVER RHODANESE. I. STRUCTURE DETERMINATION AT 2.5 ANGSTROMS RESOLUTION AND A COMPARISON OF THE CONFORMATION AND SEQUENCE OF ITS TWO DOMAINS
Descriptor:RHODANESE
Authors:Hol, W.G.J., Ploegman, J.H., Kalk, K.H., Drent, G.
Deposit date:1977-11-23
Release date:1978-01-16
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of bovine liver rhodanese. I. Structure determination at 2.5 A resolution and a comparison of the conformation and sequence of its two domains.
J.Mol.Biol., 123, 1978
1PBB
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CRYSTAL STRUCTURES OF WILD-TYPE P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE, 2,4-DIHYDROXYBENZOATE AND 2-HYDROXY-4-AMINOBENZOATE AND OF THE TRY222ALA MUTANT, COMPLEXED WITH 2-HYDROXY-4-AMINOBENZOATE. EVIDENCE FOR A PROTON CHANNEL AND A NEW BINDING MODE OF THE FLAVIN RING
Descriptor:P-HYDROXYBENZOATE HYDROXYLASE, FLAVIN-ADENINE DINUCLEOTIDE, 2,4-DIHYDROXYBENZOIC ACID
Authors:Schreuder, H.A., Mattevi, A., Hol, W.G.J.
Deposit date:1994-07-06
Release date:1994-09-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring
Biochemistry, 33, 1994
1PBD
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CRYSTAL STRUCTURES OF WILD-TYPE P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE, 2,4-DIHYDROXYBENZOATE AND 2-HYDROXY-4-AMINOBENZOATE AND OF THE TRY222ALA MUTANT, COMPLEXED WITH 2-HYDROXY-4-AMINOBENZOATE. EVIDENCE FOR A PROTON CHANNEL AND A NEW BINDING MODE OF THE FLAVIN RING
Descriptor:P-HYDROXYBENZOATE HYDROXYLASE, FLAVIN-ADENINE DINUCLEOTIDE, 4-AMINOBENZOIC ACID
Authors:Schreuder, H.A., Mattevi, A., Hol, W.G.J.
Deposit date:1994-07-06
Release date:1994-09-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring
Biochemistry, 33, 1994
1PBE
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CRYSTAL STRUCTURE OF THE P-HYDROXYBENZOATE HYDROXYLASE-SUBSTRATE COMPLEX REFINED AT 1.9 ANGSTROMS RESOLUTION. ANALYSIS OF THE ENZYME-SUBSTRATE AND ENZYME-PRODUCT COMPLEXES
Descriptor:P-HYDROXYBENZOATE HYDROXYLASE, FLAVIN-ADENINE DINUCLEOTIDE, P-HYDROXYBENZOIC ACID
Authors:Schreuder, H.A., Hol, W.G.J., Drenth, J.
Deposit date:1994-07-06
Release date:1994-09-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the p-hydroxybenzoate hydroxylase-substrate complex refined at 1.9 A resolution. Analysis of the enzyme-substrate and enzyme-product complexes.
J.Mol.Biol., 208, 1989
1HC1
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CRYSTAL STRUCTURE OF HEXAMERIC HAEMOCYANIN FROM PANULIRUS INTERRUPTUS REFINED AT 3.2 ANGSTROMS RESOLUTION
Descriptor:ARTHROPODAN HEMOCYANIN, COPPER (II) ION
Authors:Volbeda, A., Hol, W.G.J.
Deposit date:1991-05-15
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution.
J.Mol.Biol., 209, 1989
1HCY
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CRYSTAL STRUCTURE OF HEXAMERIC HAEMOCYANIN FROM PANULIRUS INTERRUPTUS REFINED AT 3.2 ANGSTROMS RESOLUTION
Descriptor:ARTHROPODAN HEMOCYANIN, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Volbeda, A., Hol, W.G.J.
Deposit date:1991-05-15
Release date:1994-01-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution.
J.Mol.Biol., 209, 1989
2PHH
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THE COENZYME ANALOGUE ADENOSINE 5-DIPHOSPHORIBOSE DISPLACES FAD IN THE ACTIVE SITE OF P-HYDROXYBENZOATE HYDROXYLASE. AN X-RAY CRYSTALLOGRAPHIC INVESTIGATION
Descriptor:P-HYDROXYBENZOATE HYDROXYLASE, ADENOSINE-5-DIPHOSPHORIBOSE, P-HYDROXYBENZOIC ACID
Authors:Van Derlaan, J.M., Drenth, J., Hol, W.G.J.
Deposit date:1989-06-19
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The coenzyme analogue adenosine 5-diphosphoribose displaces FAD in the active site of p-hydroxybenzoate hydroxylase. An x-ray crystallographic investigation.
Biochemistry, 28, 1989
4TIM
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CRYSTALLOGRAPHIC AND MOLECULAR MODELING STUDIES ON TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE: A CRITICAL ASSESSMENT OF THE PREDICTED AND OBSERVED STRUCTURES OF THE COMPLEX WITH 2-PHOSPHOGLYCERATE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, 2-PHOSPHOGLYCERIC ACID
Authors:Nobel, M.E.M., Wierenga, R.K., Hol, W.G.J.
Deposit date:1991-04-11
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate.
J.Med.Chem., 34, 1991
5TIM
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REFINED 1.83 ANGSTROMS STRUCTURE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE, CRYSTALLIZED IN THE PRESENCE OF 2.4 M-AMMONIUM SULPHATE. A COMPARISON WITH THE STRUCTURE OF THE TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE-GLYCEROL-3-PHOSPHATE COMPLEX
Descriptor:TRIOSEPHOSPHATE ISOMERASE, SULFATE ION, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Wierenga, R.K., Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex.
J.Mol.Biol., 220, 1991
6TIM
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THE ADAPTABILITY OF THE ACTIVE SITE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AS OBSERVED IN THE CRYSTAL STRUCTURES OF THREE DIFFERENT COMPLEXES
Descriptor:TRIOSEPHOSPHATE ISOMERASE, SN-GLYCEROL-3-PHOSPHATE
Authors:Noble, M.E.M., Wierenga, R.K., Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
Proteins, 10, 1991
1LTS
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REFINED STRUCTURE OF E. COLI HEAT LABILE ENTEROTOXIN, A CLOSE RELATIVE OF CHOLERA TOXIN
Descriptor:HEAT-LABILE ENTEROTOXIN, SUBUNIT B, SUBUNIT A
Authors:Sixma, T.K., Hol, W.G.J.
Deposit date:1992-07-15
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin.
J.Mol.Biol., 230, 1993
1NOP
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CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1) IN COMPLEX WITH VANADATE, DNA AND A HUMAN TOPOISOMERASE I-DERIVED PEPTIDE
Descriptor:5'-D(*AP*GP*AP*GP*TP*T)-3', tyrosyl-DNA phosphodiesterase 1, topoisomerase I-derived peptide, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.J.
Deposit date:2003-01-16
Release date:2003-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide
Chem.Biol., 10, 2003
1LTA
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2.2 ANGSTROMS CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN (LT) WITH BOUND GALACTOSE
Descriptor:HEAT-LABILE ENTEROTOXIN, SUBUNIT B, SUBUNIT A, ...
Authors:Merritt, E.A., Sixma, T.K., Kalk, K.H., Van Zanten, B.A.M., Hol, W.G.J.
Deposit date:1993-09-15
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT).
Mol.Microbiol., 13, 1994
1MAE
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THE ACTIVE SITE STRUCTURE OF METHYLAMINE DEHYDROGENASE: HYDRAZINES IDENTIFY C6 AS THE REACTIVE SITE OF THE TRYPTOPHAN DERIVED QUINONE COFACTOR
Descriptor:METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT), METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), NITROGEN MOLECULE
Authors:Huizinga, E.G., Vellieux, F.M.D., Hol, W.G.J.
Deposit date:1992-05-20
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor.
Biochemistry, 31, 1992
1MAF
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THE ACTIVE SITE STRUCTURE OF METHYLAMINE DEHYDROGENASE: HYDRAZINES IDENTIFY C6 AS THE REACTIVE SITE OF THE TRYPTOPHAN DERIVED QUINONE COFACTOR
Descriptor:METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT), METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), NITROGEN MOLECULE
Authors:Huizinga, E.G., Vellieux, F.M.D., Hol, W.G.J.
Deposit date:1992-05-20
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor.
Biochemistry, 31, 1992
2MAD
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THE ACTIVE SITE STRUCTURE OF METHYLAMINE DEHYDROGENASE: HYDRAZINES IDENTIFY C6 AS THE REACTIVE SITE OF THE TRYPTOPHAN DERIVED QUINONE COFACTOR
Descriptor:METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT), METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT)
Authors:Huizinga, E.G., Vellieux, F.M.D., Hol, W.G.J.
Deposit date:1992-05-20
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor.
Biochemistry, 31, 1992
1HTL
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MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS
Descriptor:HEAT-LABILE ENTEROTOXIN, SUBUNIT B, SUBUNIT A
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1995-02-15
Release date:1995-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli.
Nat.Struct.Biol., 2, 1995
1LTG
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THE ARG7LYS MUTANT OF HEAT-LABILE ENTEROTOXIN EXHIBITS GREAT FLEXIBILITY OF ACTIVE SITE LOOP 47-56 OF THE A SUBUNIT
Descriptor:HEAT-LABILE ENTEROTOXIN
Authors:Van Den Akker, F., Hol, W.G.J.
Deposit date:1995-06-13
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Arg7Lys mutant of heat-labile enterotoxin exhibits great flexibility of active site loop 47-56 of the A subunit.
Biochemistry, 34, 1995
1MU7
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CRYSTAL STRUCTURE OF A HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)-TUNGSTATE COMPLEX
Descriptor:Tyrosyl-DNA Phosphodiesterase, TUNGSTATE(VI)ION, GLYCEROL
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.J.
Deposit date:2002-09-23
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights Into Substrate Binding and Catalytic Mechanism of Human Tyrosyl-DNA Phosphodiesterase (Tdp1) from Vanadate- and Tungstate-Inhibited Structures
J.Mol.Biol., 324, 2003
1MU9
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CRYSTAL STRUCTURE OF A HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)-VANADATE COMPLEX
Descriptor:Tyrosyl-DNA Phosphodiesterase, VANADATE ION, GLYCEROL
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.J.
Deposit date:2002-09-23
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Insights Into Substrate Binding and Catalytic Mechanism of Human Tyrosyl-DNA Phosphodiesterase (Tdp1) from Vanadate- and Tungstate-Inhibited Structures
J.Mol.Biol., 324, 2002
1QB5
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ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor:PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1999-04-30
Release date:2003-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb
To be Published
1QCB
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ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor:PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1999-04-30
Release date:2003-06-10
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb
To be Published
1RL4
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PLASMODIUM FALCIPARUM PEPTIDE DEFORMYLASE COMPLEX WITH INHIBITOR
Descriptor:formylmethionine deformylase, COBALT (II) ION, (2R)-2-{[FORMYL(HYDROXY)AMINO]METHYL}HEXANOIC ACID, ...
Authors:Robien, M.A., Nguyen, K.T., Kumar, A., Hirsh, I., Turley, S., Pei, D., Hol, W.G.J.
Deposit date:2003-11-24
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:An improved crystal form of Plasmodium falciparum peptide deformylase.
Protein Sci., 13, 2004
2BP2
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THE STRUCTURE OF BOVINE PANCREATIC PROPHOSPHOLIPASE A2 AT 3.0 ANGSTROMS RESOLUTION
Descriptor:PHOSPHOLIPASE A2
Authors:Dijkstra, B.W., Vannes, G.J.H., Kalk, K.H., Brandenburg, N.P., Hol, W.G.J., Drenth, J.
Deposit date:1981-06-05
Release date:1981-07-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Structure of Bovine Pancreatic Prophospholipase A2 at 3.0 Angstroms Resolution
Acta Crystallogr.,Sect.B, 38, 1982