6CML

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 2093)

Summary for 6CML

• Entry DOI: 10.2210/pdb6cml/pdb
• Descriptor: Methionyl-tRNA synthetase, METHIONINE, 1-[(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)methyl]-4-[(2-chloro-4-methoxyphenyl)methyl]-3-ethyl-1,3-dihydro-2H-imidazol-2-one, ... (5 entities in total)
• Functional Keywords: synthetase, ligase, methionine, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 2
• Total formula weight: 123335.04

Authors

Barros-Alvarez, X.,Hol, W.G.J. (deposition date: 2018-03-05, release date: 2019-03-13, Last modification date: 2024-03-13)

• Primary citation: Zhang, Z.,Barros-Alvarez, X.,Gillespie, J.R.,Ranade, R.M.,Huang, W.,Shibata, S.,Molasky, N.M.R.,Faghih, O.,Mushtaq, A.,Choy, R.K.M.,de Hostos, E.,Hol, W.G.J.,Verlinde, C.L.M.J.,Buckner, F.S.,Fan, E.; Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei; Rsc Med Chem, 11:885-895, 2020; DOI: 10.1039/D0MD00057D

Experimental method

X-RAY DIFFRACTION (2.7 Å)