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5I9U
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE
分子名称:Ephrin type-A receptor 2, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.889 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9Y
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH DASATINIB
分子名称:Ephrin type-A receptor 2, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.228 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA4
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH FORETINIB (XL880)
分子名称:Ephrin type-A receptor 2, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.797 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9V
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH AGS
分子名称:Ephrin type-A receptor 2, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.458 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9W
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH ANP
分子名称:Ephrin type-A receptor 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.359 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9X
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH BOSUTINIB (SKI-606)
分子名称:Ephrin type-A receptor 2, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.427 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9Z
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH DANUSERTIB (PHA739358)
分子名称:Ephrin type-A receptor 2, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA0
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH ALISERTIB (MLN8237)
分子名称:Ephrin type-A receptor 2, alisertib, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.948 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA1
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH MLN8054
分子名称:Ephrin type-A receptor 2, 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (2.036 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA2
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 66
分子名称:Ephrin type-A receptor 2, 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.619 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA3
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH PD173955
分子名称:Ephrin type-A receptor 2, 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.788 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA5
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH GOLVATINIB (E7050)
分子名称:Ephrin type-A receptor 2, golvatinib, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.776 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5NJZ
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 1G
分子名称:Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-(piperidin-4-ylcarbamoyl)phenyl]amino]-1,3-thiazole-5-carboxamide
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.768 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK0
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 1J
分子名称:Ephrin type-A receptor 2, 2-[[3-[(3-azanyl-2,2-dimethyl-propyl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.597 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK1
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 1K
分子名称:Ephrin type-A receptor 2, 2-[[3-[(4-azanyl-6-methyl-1,3,5-triazin-2-yl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.548 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK2
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 2B
分子名称:Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{R},4~{R})-3-fluoranylpiperidin-4-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.649 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK3
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 1L
分子名称:Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{S})-pyrrolidin-3-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.586 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK4
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 2C
分子名称:Ephrin type-A receptor 2, 2-[[3-[[(4~{R})-3,3-bis(fluoranyl)piperidin-4-yl]carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK5
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 1M
分子名称:Ephrin type-A receptor 2, 2-[[3-[(3-aminophenyl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.329 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK6
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 2D
分子名称:Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[(4-oxidanylcyclohexyl)carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.267 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK7
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 2A
分子名称:Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{R},4~{R})-3-fluoranylpiperidin-4-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.889 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK8
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 2F
分子名称:Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[(2,2,6,6-tetramethyl-1-oxidanyl-piperidin-4-yl)carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.761 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK9
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 2E
分子名称:Ephrin type-A receptor 2, (2~{Z})-~{N}-(2-chloranyl-6-methyl-phenyl)-2-[3-[(4-methyl-4-oxidanyl-cyclohexyl)carbamoyl]phenyl]imino-1,3-thiazolidine-5-carboxamide
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.588 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NKA
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 2G
分子名称:Ephrin type-A receptor 2, 4-[[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylamino]cyclohexane-1-carboxylic acid, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.377 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NKB
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 4A
分子名称:Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[(3,5-dimorpholin-4-ylphenyl)amino]-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
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