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5I9X

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with bosutinib (SKI-606)

Summary for 5I9X
Entry DOI10.2210/pdb5i9x/pdb
DescriptorEphrin type-A receptor 2, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordstransferase, tyrosine-protein kinase, receptor, atp-binding
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains1
Total formula weight35241.56
Authors
Kudlinzki, D.,Linhard, V.L.,Gande, S.L.,Sreeramulu, S.,Saxena, K.,Heinzlmeir, S.,Medard, G.,Kuester, B.,Schwalbe, H. (deposition date: 2016-02-21, release date: 2016-11-09, Last modification date: 2024-01-10)
Primary citationHeinzlmeir, S.,Kudlinzki, D.,Sreeramulu, S.,Klaeger, S.,Gande, S.L.,Linhard, V.,Wilhelm, M.,Qiao, H.,Helm, D.,Ruprecht, B.,Saxena, K.,Medard, G.,Schwalbe, H.,Kuster, B.
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11:3400-3411, 2016
Cited by
PubMed: 27768280
DOI: 10.1021/acschembio.6b00709
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.427 Å)
Structure validation

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