4GYV | | CRYSTAL STRUCTURE OF THE DH DOMAIN OF FARP2 | | Descriptor: | FERM, RhoGEF and pleckstrin domain-containing protein 2 | | Authors: | He, X., Zhang, X. | | Deposit date: | 2012-09-05 | | Release date: | 2013-03-13 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
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4GZU | | CRYSTAL STRUCTURE OF THE DH-PH-PH DOMAIN OF FARP2 | | Descriptor: | FERM, RhoGEF and pleckstrin domain-containing protein 2 | | Authors: | He, X., Zhang, X. | | Deposit date: | 2012-09-06 | | Release date: | 2013-03-13 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
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4H6Y | | CRYSTAL STRUCTURE OF THE DH-PH-PH DOMAIN OF FARP1 | | Descriptor: | FERM, RhoGEF and pleckstrin domain-containing protein 1 | | Authors: | He, X., Zhang, X. | | Deposit date: | 2012-09-19 | | Release date: | 2013-03-13 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (4.09 Å) | | Cite: | Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
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3CM8 | | A RNA POLYMERASE SUBUNIT STRUCTURE FROM VIRUS | | Descriptor: | Polymerase acidic protein, peptide from RNA-directed RNA polymerase catalytic subunit | | Authors: | He, X., Zhou, J., Zeng, Z., Ma, J., Zhang, R., Rao, Z., Liu, Y. | | Deposit date: | 2008-03-21 | | Release date: | 2008-07-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.899 Å) | | Cite: | Crystal structure of the polymerase PAC-PB1N complex from an avian influenza H5N1 virus
Nature, 454, 2008
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1K8D | | CRYSTAL STRUCTURE OF THE NON-CLASSICAL MHC CLASS IB QA-2 COMPLEXED WITH A SELF PEPTIDE | | Descriptor: | QA-2 antigen, BETA-2-MICROGLOBULIN, 60S RIBOSOMAL PROTEIN | | Authors: | He, X., Tabaczewski, P., Ho, J., Stroynowski, I., Garcia, K.C. | | Deposit date: | 2001-10-23 | | Release date: | 2001-12-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation.
Structure, 9, 2001
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1Q32 | | CRYSTAL STRUCTURE ANALYSIS OF THE YEAST TYROSYL-DNA PHOSPHODIESTERASE | | Descriptor: | tyrosyl-DNA phosphodiesterase | | Authors: | He, X., Babaoglu, K., Price, A., Nitiss, K.C., Nitiss, J.L., White, S.W. | | Deposit date: | 2003-07-28 | | Release date: | 2004-09-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison
J.Mol.Biol., 372, 2007
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2NSD | |
3MKT | | STRUCTURE OF A CATION-BOUND MULTIDRUG AND TOXIN COMPOUND EXTRUSION (MATE) TRANSPORTER | | Descriptor: | Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump | | Authors: | He, X., Szewczyk, P., Karyakin, A., Evin, M., Hong, W.-X., Zhang, Q., Chang, G. | | Deposit date: | 2010-04-15 | | Release date: | 2010-09-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.65 Å) | | Cite: | Structure of a cation-bound multidrug and toxic compound extrusion transporter.
Nature, 467, 2010
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3MKU | | STRUCTURE OF A CATION-BOUND MULTIDRUG AND TOXIN COMPOUND EXTRUSION (MATE) TRANSPORTER | | Descriptor: | Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump, RUBIDIUM ION | | Authors: | He, X., Szewczyk, P., Karyakin, A., Evin, M., Hong, W.-X., Zhang, Q., Chang, G. | | Deposit date: | 2010-04-15 | | Release date: | 2010-09-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Structure of a cation-bound multidrug and toxic compound extrusion transporter.
Nature, 467, 2010
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3UPU | | CRYSTAL STRUCTURE OF THE T4 PHAGE SF1B HELICASE DDA | | Descriptor: | ATP-dependent DNA helicase dda, 5'-D(*TP*TP*TP*TP*TP*TP*TP*T)-3' | | Authors: | He, X., Yun, M.K., Pemble IV, C.W., Kreuzer, K.N., Raney, K.D., White, S.W. | | Deposit date: | 2011-11-18 | | Release date: | 2012-06-20 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (3.299 Å) | | Cite: | The T4 Phage SF1B Helicase Dda Is Structurally Optimized to Perform DNA Strand Separation.
Structure, 20, 2012
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4TRJ | | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE, REFINED WITH NEW LIGAND RESTRAINTS | | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE | | Authors: | He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R. | | Deposit date: | 2014-06-17 | | Release date: | 2014-08-13 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
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4TZK | | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH 1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE | | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE | | Authors: | He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R. | | Deposit date: | 2014-07-10 | | Release date: | 2014-08-20 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
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4TZT | | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL- 5-OXOPYRROLIDINE-3-CARBOXAMIDE | | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE | | Authors: | He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R. | | Deposit date: | 2014-07-10 | | Release date: | 2014-08-20 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
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4U0J | | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH 1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE, REFINED WITH NEW LIGAND RESTRAINTS | | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE | | Authors: | He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R. | | Deposit date: | 2014-07-11 | | Release date: | 2014-07-30 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
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4U0K | | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE COMPLEXED WITH N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE | | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE | | Authors: | He, X., Alian, A., Stroud, R.M., Ortiz de Montellano, P.R. | | Deposit date: | 2014-07-11 | | Release date: | 2014-07-30 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem., 2006
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6D2K | |
4FA8 | | MULTI-PRONGED MODULATION OF CYTOKINE SIGNALING | | Descriptor: | Secreted protein BARF1, Macrophage colony-stimulating factor 1, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | He, X., Shim, A.H. | | Deposit date: | 2012-05-21 | | Release date: | 2012-08-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
Proc.Natl.Acad.Sci.USA, 109, 2012
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2IFG | |
3HX3 | | CRYSTAL STRUCTURE OF CRALBP MUTANT R234W | | Descriptor: | Retinaldehyde-binding protein 1, RETINAL | | Authors: | Stocker, A., He, X., Lobsiger, J. | | Deposit date: | 2009-06-19 | | Release date: | 2009-10-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3HY5 | | CRYSTAL STRUCTURE OF CRALBP | | Descriptor: | Retinaldehyde-binding protein 1, RETINAL, L(+)-TARTARIC ACID | | Authors: | Stocker, A., He, X., Lobsiger, J. | | Deposit date: | 2009-06-22 | | Release date: | 2009-10-20 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (3.04 Å) | | Cite: | Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W.
Proc.Natl.Acad.Sci.USA, 106, 2009
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5ZMM | | STRUCTURE OF THE TYPE IV PHOSPHOROTHIOATION-DEPENDENT RESTRICTION ENDONUCLEASE SCOMCRA | | Descriptor: | Uncharacterized protein McrA, ZINC ION, SULFATE ION | | Authors: | Liu, G., Fu, W., Zhang, Z., He, Y., Yu, H., Zhao, Y., Deng, Z., Wu, G., He, X. | | Deposit date: | 2018-04-04 | | Release date: | 2018-09-26 | | Last modified: | 2018-11-28 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Structural basis for the recognition of sulfur in phosphorothioated DNA.
Nat Commun, 9, 2018
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5ZMN | | SULFUR BINDING DOMAIN AND SRA DOMAIN OF SCOMCRA COMPLEXED WITH PHOSPHOROTHIOATED DNA | | Descriptor: | Uncharacterized protein McrA, DNA (5'-D(*CP*CP*CP*GP*(GS)P*CP*CP*GP*GP*G)-3'), SULFATE ION | | Authors: | Liu, G., Fu, W., Zhang, Z., He, Y., Yu, H., Zhao, Y., Deng, Z., Wu, G., He, X. | | Deposit date: | 2018-04-04 | | Release date: | 2018-09-26 | | Last modified: | 2018-11-28 | | Method: | X-RAY DIFFRACTION (3.29 Å) | | Cite: | Structural basis for the recognition of sulfur in phosphorothioated DNA.
Nat Commun, 9, 2018
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5ZMO | | SULFUR BINDING DOMAIN OF SCOMCRA COMPLEXED WITH PHOSPHOROTHIOATED DNA | | Descriptor: | Uncharacterized protein McrA, DNA (5'-D(P*CP*CP*GP*(GS)P*CP*CP*GP*G)-3'), PHOSPHATE ION | | Authors: | Liu, G., Fu, W., Zhang, Z., He, Y., Yu, H., Zhao, Y., Deng, Z., Wu, G., He, X. | | Deposit date: | 2018-04-04 | | Release date: | 2018-09-26 | | Last modified: | 2018-11-28 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Structural basis for the recognition of sulfur in phosphorothioated DNA.
Nat Commun, 9, 2018
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1S17 | | IDENTIFICATION OF NOVEL POTENT BICYCLIC PEPTIDE DEFORMYLASE INHIBITORS | | Descriptor: | Peptide deformylase, NICKEL (II) ION, 2-(3,4-DIHYDRO-3-OXO-2H-BENZO[B][1,4]THIAZIN-2-YL)-N-HYDROXYACETAMIDE, ... | | Authors: | Molteni, V., He, X., Nabakka, J., Yang, K., Kreusch, A., Gordon, P., Bursulaya, B., Ryder, N.S., Goldberg, R., He, Y. | | Deposit date: | 2004-01-05 | | Release date: | 2004-03-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Identification of novel potent bicyclic peptide deformylase inhibitors
Bioorg.Med.Chem.Lett., 14, 2004
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5YYC | | CRYSTAL STRUCTURE OF ALANINE RACEMASE FROM BACILLUS PSEUDOFIRMUS (OF4) | | Descriptor: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Dong, H., Hu, T.T., He, G.Z., Lu, D.R., Qi, J.X., Dou, Y.S., Long, W., He, X., Su, D., Ju, J.S. | | Deposit date: | 2017-12-08 | | Release date: | 2019-01-02 | | Method: | X-RAY DIFFRACTION (1.801 Å) | | Cite: | Structural features and kinetic characterization of alanine racemase from Bacillus pseudofirmus OF4.
Biochem. Biophys. Res. Commun., 497, 2018
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