4U0K
Crystal structure of Mycobacterium tuberculosis enoyl reductase complexed with N-(5-chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide
Replaces: 2H7NSummary for 4U0K
Entry DOI | 10.2210/pdb4u0k/pdb |
Related | 4TRJ 4TZK 4TZT 4U0J |
Descriptor | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, pyrrolidine carboxamide |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 29553.05 |
Authors | He, X.,Alian, A.,Stroud, R.M.,Ortiz de Montellano, P.R. (deposition date: 2014-07-11, release date: 2014-07-30, Last modification date: 2023-09-27) |
Primary citation | He, X.,Alian, A.,Stroud, R.M.,Ortiz de Montellano, P.R. Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis J. Med. Chem., :6308-6323, 2006 Cited by PubMed: 17034137DOI: 10.1021/JM060715Y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)