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1DQS
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CRYSTAL STRUCTURE OF DEHYDROQUINATE SYNTHASE (DHQS) COMPLEXED WITH CARBAPHOSPHONATE, NAD+ AND ZN2+
Descriptor:PROTEIN (3-DEHYDROQUINATE SYNTHASE), ZINC ION, CHLORIDE ION, ...
Authors:Carpenter, E.P., Hawkins, A.R., Frost, J.W., Brown, K.A.
Deposit date:1998-04-09
Release date:1999-07-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.
Nature, 394, 1998
1XGK
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CRYSTAL STRUCTURE OF N12G AND A18G MUTANT NMRA
Descriptor:NITROGEN METABOLITE REPRESSION REGULATOR NMRA, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Lamb, H.K., Ren, J., Park, A., Johnson, C., Leslie, K., Cocklin, S., Thompson, P., Mee, C., Cooper, A., Stammers, D.K., Hawkins, A.R.
Deposit date:2004-09-17
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis
Protein Sci., 13, 2004
1TI7
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CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR, IN COMPLEX WITH NADP AT 1.7A RESOLUTION
Descriptor:nitrogen metabolite repression regulator NmrA, POTASSIUM ION, CHLORIDE ION, ...
Authors:Lamb, H.K., Leslie, K., Dodds, A.L., Nutley, M., Cooper, A., Johnson, C., Thompson, P., Stammers, D.K., Hawkins, A.R.
Deposit date:2004-06-02
Release date:2004-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides.
J.Biol.Chem., 278, 2003
1K6I
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CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR (TRIGONAL FORM)
Descriptor:NmrA, CHLORIDE ION
Authors:Stammers, D.K., Ren, J., Leslie, K., Nichols, C.E., Lamb, H.K., Cocklin, S., Dodds, A., Hawkins, A.R.
Deposit date:2001-10-16
Release date:2001-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
EMBO J., 20, 2001
1K6J
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CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR (MONOCLINIC FORM)
Descriptor:NmrA, CHLORIDE ION
Authors:Stammers, D.K., Ren, J., Leslie, K., Nichols, C.E., Lamb, H.K., Cocklin, S., Dodds, A., Hawkins, A.R.
Deposit date:2001-10-16
Release date:2002-02-20
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
EMBO J., 20, 2001
1K6X
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CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR IN COMPLEX WITH NAD AT 1.5 A RESOLUTION (TRIGONAL FORM)
Descriptor:NmrA, CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Stammers, D.K., Ren, J., Leslie, K., Nichols, C.E., Lamb, H.K., Cocklin, S., Dodds, A., Hawkins, A.R.
Deposit date:2001-10-17
Release date:2002-02-20
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
EMBO J., 20, 2002
1NR5
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CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD AND CARBAPHOSPHONATE
Descriptor:3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ...
Authors:Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K.
Deposit date:2003-01-23
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
1NRX
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CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD
Descriptor:3-dehydroquinate synthase, ZINC ION, CHLORIDE ION, ...
Authors:Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K.
Deposit date:2003-01-26
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
1NUA
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CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+
Descriptor:3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION
Authors:Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K.
Deposit date:2003-01-31
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
1NVA
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CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND ADP
Descriptor:3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ...
Authors:Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K.
Deposit date:2003-02-03
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
1NVB
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CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND CARBAPHOSPHONATE
Descriptor:3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ...
Authors:Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K.
Deposit date:2003-02-03
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
1NVD
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CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND CARBAPHOSPHONATE
Descriptor:3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ...
Authors:Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K.
Deposit date:2003-02-03
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
1NVE
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CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD
Descriptor:3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ...
Authors:Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K.
Deposit date:2003-02-03
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
1NVF
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CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, ADP AND CARBAPHOSPHONATE
Descriptor:3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ...
Authors:Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K.
Deposit date:2003-02-03
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
1QFE
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THE STRUCTURE OF TYPE I 3-DEHYDROQUINATE DEHYDRATASE FROM SALMONELLA TYPHI
Descriptor:PROTEIN (3-DEHYDROQUINATE DEHYDRATASE), 3-AMINO-4,5-DIHYDROXY-CYCLOHEX-1-ENECARBOXYLATE
Authors:Shrive, A.K., Polikarpov, I., Sawyer, L., Coggins, J.R., Hawkins, A.R.
Deposit date:1999-04-05
Release date:2000-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction.
Nat.Struct.Biol., 6, 1999
2WKS
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STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE WITH A NEW CARBASUGAR-THIOPHENE INHIBITOR.
Descriptor:3-DEHYDROQUINATE DEHYDRATASE, (1R,4S,5R)-1,4,5-trihydroxy-3-[(5-methyl-1-benzothiophen-2-yl)methoxy]cyclohex-2-ene-1-carboxylic acid
Authors:Otero, J.M., Guardado-Calvo, P., Llamas-Saiz, A.L., Prazeres, V.F.V., Tizon, L., Castedo, L., Lamb, H., Hawkins, A.R., Gonzalez-Bello, C., van Raaij, M.J.
Deposit date:2009-06-17
Release date:2009-11-24
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues.
J. Med. Chem., 53, 2010
1SFJ
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2.4A CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS TYPE I 3-DEHYDROQUINASE, WITH 3-DEHYDROQUINATE BOUND
Descriptor:3-dehydroquinate dehydratase, 3-DEHYDROSHIKIMATE
Authors:Nichols, C.E., Lockyer, M., Hawkins, A.R., Stammers, D.K.
Deposit date:2004-02-19
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments
Proteins, 56, 2004
1SFL
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1.9A CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS TYPE I 3-DEHYDROQUINASE, APO FORM
Descriptor:3-dehydroquinate dehydratase
Authors:Nichols, C.E., Lockyer, M., Hawkins, A.R., Stammers, D.K.
Deposit date:2004-02-20
Release date:2004-10-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments.
Proteins, 56, 2004
1SG6
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CRYSTAL STRUCTURE OF ASPERGILLUS NIDULANS 3-DEHYDROQUINATE SYNTHASE (ANDHQS) IN COMPLEX WITH ZN2+ AND NAD+, AT 1.7D
Descriptor:Pentafunctional AROM polypeptide, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Nichols, C.E., Hawkins, A.R., Stammers, D.K.
Deposit date:2004-02-23
Release date:2004-08-31
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the 'open' form of Aspergillus nidulans 3-dehydroquinate synthase at 1.7 A resolution from crystals grown following enzyme turnover.
Acta Crystallogr.,Sect.D, 60, 2004
1T4B
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1.6 ANGSTROM STRUCTURE OF ESHERICHIA COLI ASPARTATE-SEMIALDEHYDE DEHYDROGENASE.
Descriptor:Aspartate-semialdehyde dehydrogenase, SODIUM ION
Authors:Nichols, C.E., Dhaliwal, B., Lockyer, M., Hawkins, A.R., Stammers, D.K.
Deposit date:2004-04-29
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-resolution Structures Reveal Details of Domain Closure and "Half-of-sites-reactivity" in Escherichia coli Aspartate beta-Semialdehyde Dehydrogenase.
J.Mol.Biol., 341, 2004
1T4D
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ASPARTATE BETA-SEMIALDEHYDE DEHYDROGENASE (ECASADH), AT 1.95 ANGSTROM RESOLUTION
Descriptor:Aspartate-semialdehyde dehydrogenase
Authors:Nichols, C.E., Dhaliwal, B., Lockyer, M., Hawkins, A.R., Stammers, D.K.
Deposit date:2004-04-29
Release date:2004-08-17
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:High-resolution Structures Reveal Details of Domain Closure and "Half-of-sites-reactivity" in Escherichia coli Aspartate beta-Semialdehyde Dehydrogenase.
J.Mol.Biol., 341, 2004
1U8A
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS SHIKIMATE KINASE IN COMPLEX WITH SHIKIMATE AND ADP AT 2.15 ANGSTROM RESOLUTION
Descriptor:Shikimate kinase, CHLORIDE ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Dhaliwal, B., Nichols, C.E., Ren, J., Lockyer, M., Charles, I., Hawkins, A.R., Stammers, D.K.
Deposit date:2004-08-05
Release date:2004-10-19
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase.
Febs Lett., 574, 2004
1XAG
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CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD+ AND CARBAPHOSPHONATE
Descriptor:3-dehydroquinate synthase, ZINC ION, CHLORIDE ION, ...
Authors:Nichols, C.E., Ren, J., Leslie, K., Dhaliwal, B., Lockyer, M., Charles, I., Hawkins, A.R., Stammers, D.K.
Deposit date:2004-08-25
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Comparison of ligand induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.
J.Mol.Biol., 343, 2004
1XAH
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CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD+
Descriptor:3-dehydroquinate synthase, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Nichols, C.E., Ren, J., Leslie, K., Dhaliwal, B., Lockyer, M., Charles, I., Hawkins, A.R., Stammers, D.K.
Deposit date:2004-08-25
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparison of ligand induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.
J.Mol.Biol., 343, 2004
1XAI
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CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD+ AND CARBAPHOSPHONATE
Descriptor:3-dehydroquinate synthase, ZINC ION, [1R-(1ALPHA,3BETA,4ALPHA,5BETA)]-5-(PHOSPHONOMETHYL)-1,3,4-TRIHYDROXYCYCLOHEXANE-1-CARBOXYLIC ACID
Authors:Nichols, C.E., Ren, J., Leslie, K., Dhaliwal, B., Lockyer, M., Charles, I., Hawkins, A.R., Stammers, D.K.
Deposit date:2004-08-25
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Comparison of ligand induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.
J.Mol.Biol., 343, 2004