1DQS | | CRYSTAL STRUCTURE OF DEHYDROQUINATE SYNTHASE (DHQS) COMPLEXED WITH CARBAPHOSPHONATE, NAD+ AND ZN2+ | | Descriptor: | PROTEIN (3-DEHYDROQUINATE SYNTHASE), ZINC ION, CHLORIDE ION, ... | | Authors: | Carpenter, E.P., Hawkins, A.R., Frost, J.W., Brown, K.A. | | Deposit date: | 1998-04-09 | | Release date: | 1999-07-26 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.
Nature, 394, 1998
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1XGK | | CRYSTAL STRUCTURE OF N12G AND A18G MUTANT NMRA | | Descriptor: | NITROGEN METABOLITE REPRESSION REGULATOR NMRA, PHOSPHATE ION, POTASSIUM ION, ... | | Authors: | Lamb, H.K., Ren, J., Park, A., Johnson, C., Leslie, K., Cocklin, S., Thompson, P., Mee, C., Cooper, A., Stammers, D.K., Hawkins, A.R. | | Deposit date: | 2004-09-17 | | Release date: | 2004-12-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis
Protein Sci., 13, 2004
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1TI7 | | CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR, IN COMPLEX WITH NADP AT 1.7A RESOLUTION | | Descriptor: | nitrogen metabolite repression regulator NmrA, POTASSIUM ION, CHLORIDE ION, ... | | Authors: | Lamb, H.K., Leslie, K., Dodds, A.L., Nutley, M., Cooper, A., Johnson, C., Thompson, P., Stammers, D.K., Hawkins, A.R. | | Deposit date: | 2004-06-02 | | Release date: | 2004-06-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides.
J.Biol.Chem., 278, 2003
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1K6I | | CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR (TRIGONAL FORM) | | Descriptor: | NmrA, CHLORIDE ION | | Authors: | Stammers, D.K., Ren, J., Leslie, K., Nichols, C.E., Lamb, H.K., Cocklin, S., Dodds, A., Hawkins, A.R. | | Deposit date: | 2001-10-16 | | Release date: | 2001-12-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
EMBO J., 20, 2001
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1K6J | | CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR (MONOCLINIC FORM) | | Descriptor: | NmrA, CHLORIDE ION | | Authors: | Stammers, D.K., Ren, J., Leslie, K., Nichols, C.E., Lamb, H.K., Cocklin, S., Dodds, A., Hawkins, A.R. | | Deposit date: | 2001-10-16 | | Release date: | 2002-02-20 | | Last modified: | 2017-02-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
EMBO J., 20, 2001
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1K6X | | CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR IN COMPLEX WITH NAD AT 1.5 A RESOLUTION (TRIGONAL FORM) | | Descriptor: | NmrA, CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Stammers, D.K., Ren, J., Leslie, K., Nichols, C.E., Lamb, H.K., Cocklin, S., Dodds, A., Hawkins, A.R. | | Deposit date: | 2001-10-17 | | Release date: | 2002-02-20 | | Last modified: | 2011-11-16 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
EMBO J., 20, 2002
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1NR5 | | CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD AND CARBAPHOSPHONATE | | Descriptor: | 3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ... | | Authors: | Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2003-01-23 | | Release date: | 2003-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
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1NRX | | CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD | | Descriptor: | 3-dehydroquinate synthase, ZINC ION, CHLORIDE ION, ... | | Authors: | Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2003-01-26 | | Release date: | 2003-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
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1NUA | | CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ | | Descriptor: | 3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION | | Authors: | Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2003-01-31 | | Release date: | 2003-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
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1NVA | | CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND ADP | | Descriptor: | 3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ... | | Authors: | Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2003-02-03 | | Release date: | 2003-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.62 Å) | | Cite: | Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
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1NVB | | CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND CARBAPHOSPHONATE | | Descriptor: | 3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ... | | Authors: | Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2003-02-03 | | Release date: | 2003-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
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1NVD | | CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND CARBAPHOSPHONATE | | Descriptor: | 3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ... | | Authors: | Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2003-02-03 | | Release date: | 2003-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
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1NVE | | CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD | | Descriptor: | 3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ... | | Authors: | Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2003-02-03 | | Release date: | 2003-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
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1NVF | | CRYSTAL STRUCTURE OF 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, ADP AND CARBAPHOSPHONATE | | Descriptor: | 3-DEHYDROQUINATE SYNTHASE, ZINC ION, CHLORIDE ION, ... | | Authors: | Nichols, C.E., Ren, J., Lamb, H.K., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2003-02-03 | | Release date: | 2003-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Ligand-induced Conformational Changes and a Mechanism for Domain Closure in Aspergillus nidulans Dehydroquinate Synthase
J.MOL.BIOL., 327, 2003
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1QFE | | THE STRUCTURE OF TYPE I 3-DEHYDROQUINATE DEHYDRATASE FROM SALMONELLA TYPHI | | Descriptor: | PROTEIN (3-DEHYDROQUINATE DEHYDRATASE), 3-AMINO-4,5-DIHYDROXY-CYCLOHEX-1-ENECARBOXYLATE | | Authors: | Shrive, A.K., Polikarpov, I., Sawyer, L., Coggins, J.R., Hawkins, A.R. | | Deposit date: | 1999-04-05 | | Release date: | 2000-04-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction.
Nat.Struct.Biol., 6, 1999
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2WKS | | STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE WITH A NEW CARBASUGAR-THIOPHENE INHIBITOR. | | Descriptor: | 3-DEHYDROQUINATE DEHYDRATASE, (1R,4S,5R)-1,4,5-trihydroxy-3-[(5-methyl-1-benzothiophen-2-yl)methoxy]cyclohex-2-ene-1-carboxylic acid | | Authors: | Otero, J.M., Guardado-Calvo, P., Llamas-Saiz, A.L., Prazeres, V.F.V., Tizon, L., Castedo, L., Lamb, H., Hawkins, A.R., Gonzalez-Bello, C., van Raaij, M.J. | | Deposit date: | 2009-06-17 | | Release date: | 2009-11-24 | | Last modified: | 2018-02-14 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues.
J. Med. Chem., 53, 2010
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1SFJ | | 2.4A CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS TYPE I 3-DEHYDROQUINASE, WITH 3-DEHYDROQUINATE BOUND | | Descriptor: | 3-dehydroquinate dehydratase, 3-DEHYDROSHIKIMATE | | Authors: | Nichols, C.E., Lockyer, M., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2004-02-19 | | Release date: | 2004-10-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments
Proteins, 56, 2004
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1SFL | | 1.9A CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS TYPE I 3-DEHYDROQUINASE, APO FORM | | Descriptor: | 3-dehydroquinate dehydratase | | Authors: | Nichols, C.E., Lockyer, M., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2004-02-20 | | Release date: | 2004-10-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments.
Proteins, 56, 2004
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1SG6 | | CRYSTAL STRUCTURE OF ASPERGILLUS NIDULANS 3-DEHYDROQUINATE SYNTHASE (ANDHQS) IN COMPLEX WITH ZN2+ AND NAD+, AT 1.7D | | Descriptor: | Pentafunctional AROM polypeptide, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Nichols, C.E., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2004-02-23 | | Release date: | 2004-08-31 | | Last modified: | 2011-11-16 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of the 'open' form of Aspergillus nidulans 3-dehydroquinate synthase at 1.7 A resolution from crystals grown following enzyme turnover.
Acta Crystallogr.,Sect.D, 60, 2004
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1T4B | | 1.6 ANGSTROM STRUCTURE OF ESHERICHIA COLI ASPARTATE-SEMIALDEHYDE DEHYDROGENASE. | | Descriptor: | Aspartate-semialdehyde dehydrogenase, SODIUM ION | | Authors: | Nichols, C.E., Dhaliwal, B., Lockyer, M., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2004-04-29 | | Release date: | 2004-07-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | High-resolution Structures Reveal Details of Domain Closure and "Half-of-sites-reactivity" in Escherichia coli Aspartate beta-Semialdehyde Dehydrogenase.
J.Mol.Biol., 341, 2004
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1T4D | | CRYSTAL STRUCTURE OF ESCHERICHIA COLI ASPARTATE BETA-SEMIALDEHYDE DEHYDROGENASE (ECASADH), AT 1.95 ANGSTROM RESOLUTION | | Descriptor: | Aspartate-semialdehyde dehydrogenase | | Authors: | Nichols, C.E., Dhaliwal, B., Lockyer, M., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2004-04-29 | | Release date: | 2004-08-17 | | Last modified: | 2011-11-16 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | High-resolution Structures Reveal Details of Domain Closure and "Half-of-sites-reactivity" in Escherichia coli Aspartate beta-Semialdehyde Dehydrogenase.
J.Mol.Biol., 341, 2004
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1U8A | | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS SHIKIMATE KINASE IN COMPLEX WITH SHIKIMATE AND ADP AT 2.15 ANGSTROM RESOLUTION | | Descriptor: | Shikimate kinase, CHLORIDE ION, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Dhaliwal, B., Nichols, C.E., Ren, J., Lockyer, M., Charles, I., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2004-08-05 | | Release date: | 2004-10-19 | | Last modified: | 2018-04-04 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase.
Febs Lett., 574, 2004
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1XAG | | CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD+ AND CARBAPHOSPHONATE | | Descriptor: | 3-dehydroquinate synthase, ZINC ION, CHLORIDE ION, ... | | Authors: | Nichols, C.E., Ren, J., Leslie, K., Dhaliwal, B., Lockyer, M., Charles, I., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2004-08-25 | | Release date: | 2005-03-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Comparison of ligand induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.
J.Mol.Biol., 343, 2004
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1XAH | | CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+ AND NAD+ | | Descriptor: | 3-dehydroquinate synthase, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Nichols, C.E., Ren, J., Leslie, K., Dhaliwal, B., Lockyer, M., Charles, I., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2004-08-25 | | Release date: | 2005-03-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Comparison of ligand induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.
J.Mol.Biol., 343, 2004
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1XAI | | CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD+ AND CARBAPHOSPHONATE | | Descriptor: | 3-dehydroquinate synthase, ZINC ION, [1R-(1ALPHA,3BETA,4ALPHA,5BETA)]-5-(PHOSPHONOMETHYL)-1,3,4-TRIHYDROXYCYCLOHEXANE-1-CARBOXYLIC ACID | | Authors: | Nichols, C.E., Ren, J., Leslie, K., Dhaliwal, B., Lockyer, M., Charles, I., Hawkins, A.R., Stammers, D.K. | | Deposit date: | 2004-08-25 | | Release date: | 2005-03-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Comparison of ligand induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.
J.Mol.Biol., 343, 2004
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