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1FTK
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CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2I) IN COMPLEX WITH KAINATE AT 1.6 A RESOLUTION
Descriptor:GLUTAMATE RECEPTOR SUBUNIT 2, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE
Authors:Gouaux, E., Armstrong, N.
Deposit date:2000-09-12
Release date:2000-11-01
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
1FTM
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CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION
Descriptor:GLUTAMATE RECEPTOR SUBUNIT 2, ZINC ION, (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
Authors:Gouaux, E., Armstrong, N.
Deposit date:2000-09-12
Release date:2000-11-01
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
2NWL
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CRYSTAL STRUCTURE OF GLTPH IN COMPLEX WITH L-ASP
Descriptor:glutamate symport protein, PALMITIC ACID, ASPARTIC ACID
Authors:Gouaux, E., Boudker, O., Ryan, R., Yernool, D., Shimamoto, K.
Deposit date:2006-11-15
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
2NWW
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CRYSTAL STRUCTURE OF GLTPH IN COMPLEX WITH TBOA
Descriptor:425aa long hypothetical proton glutamate symport protein, (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID
Authors:Gouaux, E., Boudker, O., Ryan, R., Yernool, D., Shimamoto, K.
Deposit date:2006-11-16
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
2NWX
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CRYSTAL STRUCTURE OF GLTPH IN COMPLEX WITH L-ASPARTATE AND SODIUM IONS
Descriptor:425aa long hypothetical proton glutamate symport protein, SODIUM ION, ASPARTIC ACID, ...
Authors:Gouaux, E., Boudker, O., Ryan, R., Yernool, D., Shimamoto, K.
Deposit date:2006-11-16
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
4M48
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X-RAY STRUCTURE OF DOPAMINE TRANSPORTER ELUCIDATES ANTIDEPRESSANT MECHANISM
Descriptor:Transporter, 9D5 antibody, light chain, ...
Authors:Gouaux, E., Penmatsa, A., Wang, K.
Deposit date:2013-08-06
Release date:2013-09-18
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.955 Å)
Cite:X-ray structure of dopamine transporter elucidates antidepressant mechanism.
Nature, 503, 2013
4TLL
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CRYSTAL STRUCTURE OF GLUN1/GLUN2B NMDA RECEPTOR, STRUCTURE 1
Descriptor:receptor subunit GluN1, receptor subunit GluN2B, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gouaux, E., Lee, C.-H., Lu, W.
Deposit date:2014-05-30
Release date:2014-07-02
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:NMDA receptor structures reveal subunit arrangement and pore architecture.
Nature, 511, 2014
4TLM
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CRYSTAL STRUCTURE OF GLUN1/GLUN2B NMDA RECEPTOR, STRUCTURE 2
Descriptor:receptor subunit GluN1, receptor subunit GluN2B, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gouaux, E., Lee, C.-H., Lu, W.
Deposit date:2014-05-30
Release date:2014-07-02
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (3.77 Å)
Cite:NMDA receptor structures reveal subunit arrangement and pore architecture.
Nature, 511, 2014
4XP1
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X-RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO NEUROTRANSMITTER DOPAMINE
Descriptor:Dopamine transporter, isoform B, Antibody fragment light chain, ...
Authors:Gouaux, E., Penmatsa, A., Wang, K.
Deposit date:2015-01-16
Release date:2015-05-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
4XP5
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X-RAY STRUCTURE OF DROSOPHILA DOPAMINE TRANSPORTER BOUND TO COCAINE ANALOGUE-RTI55
Descriptor:Dopamine transporter, isoform B, Antibody fragment heavy chain-protein, ...
Authors:Gouaux, E., Penmatsa, A., Wang, K.
Deposit date:2015-01-16
Release date:2015-05-06
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
6C10
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CRYSTAL STRUCTURE OF MOUSE PCDH15 EC11-EL
Descriptor:Protocadherin-15, ALPHA-D-MANNOSE
Authors:Gouaux, E., Elferich, J., Ge, J.
Deposit date:2018-01-03
Release date:2018-08-15
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018
6C13
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CRYOEM STRUCTURE OF MOUSE PCDH15-4EC-LHFPL5 COMPLEX
Descriptor:Protocadherin-15, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Gouaux, E., Ge, J., Elferich, J.
Deposit date:2018-01-03
Release date:2018-08-15
Method:ELECTRON MICROSCOPY (11.33 Å)
Cite:Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018
6C14
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CRYOEM STRUCTURE OF MOUSE PCDH15-1EC-LHFPL5 COMPLEX
Descriptor:Protocadherin-15, LHFPL tetraspan subfamily member 5 protein
Authors:Gouaux, E., Elferich, J., Ge, J.
Deposit date:2018-01-03
Release date:2018-08-15
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018
1MQD
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X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-DES-ME-AMPA AT 1.46 A RESOLUTION. CRYSTALLIZATION IN THE PRESENCE OF LITHIUM SULFATE.
Descriptor:Glutamate receptor subunit 2, SULFATE ION, (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID, ...
Authors:Kasper, C., Lunn, M.-L., Liljefors, T., Gouaux, E., Egebjerg, J., Kastrup, J.S.
Deposit date:2002-09-16
Release date:2003-07-01
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:GluR2 ligand-binding core complexes: Importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists.
FEBS Lett., 531, 2002
1MS7
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X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-DES-ME-AMPA AT 1.97 A RESOLUTION, CRYSTALLIZATION IN THE PRESENCE OF ZINC ACETATE
Descriptor:Glutamate receptor subunit 2, ZINC ION, (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID
Authors:Kasper, C., Lunn, M.-L., Liljefors, T., Gouaux, E., Egebjerg, J., Kastrup, J.S.
Deposit date:2002-09-19
Release date:2003-07-08
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists
FEBS Lett., 531, 2002
1N0T
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X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH THE ANTAGONIST (S)-ATPO AT 2.1 A RESOLUTION.
Descriptor:Glutamate receptor 2, (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID, SULFATE ION, ...
Authors:Hogner, A., Greenwood, J.R., Liljefors, T., Lunn, M.-L., Egebjerg, J., Larsen, I.K., Gouaux, E., Kastrup, J.S.
Deposit date:2002-10-15
Release date:2003-03-04
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.
J.Med.Chem., 46, 2003
1NNK
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X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-ATPA AT 1.85 A RESOLUTION. CRYSTALLIZATION WITH ZINC IONS.
Descriptor:Glutamate receptor 2, ZINC ION, CHLORIDE ION, ...
Authors:Lunn, M.-L., Hogner, A., Stensbol, T.B., Gouaux, E., Egebjerg, J., Kastrup, J.S.
Deposit date:2003-01-14
Release date:2003-03-04
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist (S)-ATPA: Implications for Receptor Subunit Selectivity.
J.Med.Chem., 46, 2003
1NNP
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X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-ATPA AT 1.9 A RESOLUTION. CRYSTALLIZATION WITHOUT ZINC IONS.
Descriptor:Glutamate receptor 2, SULFATE ION, 3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE
Authors:Lunn, M.L., Hogner, A., Stensbol, T.B., Gouaux, E., Egebjerg, J., Kastrup, J.S.
Deposit date:2003-01-14
Release date:2003-03-11
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist (S)-ATPA: Implications for Receptor Subunit Selectivity.
J.Med.Chem., 46, 2003
1M5B
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X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-ME-TET-AMPA AT 1.85 A RESOLUTION.
Descriptor:Glutamate receptor 2, ZINC ION, (S)-2-AMINO-3-[3-HYDROXY-5-(2-METHYL-2H-TETRAZOL-5-YL)ISOXAZOL-4-YL]PROPIONIC ACID
Authors:Hogner, A., Kastrup, J.S., Jin, R., Liljefors, T., Mayer, M.L., Egebjerg, J., Larsen, I.K., Gouaux, E.
Deposit date:2002-07-09
Release date:2002-09-18
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
J.Mol.Biol., 322, 2002
1M5C
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X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH BR-HIBO AT 1.65 A RESOLUTION
Descriptor:Glutamate receptor 2, (S)-2-AMINO-3-(4-BROMO-3-HYDROXY-ISOXAZOL-5-YL)PROPIONIC ACID
Authors:Hogner, A., Kastrup, J.S., Jin, R., Liljefors, T., Mayer, M.L., Egebjerg, J., Larsen, I.K., Gouaux, E.
Deposit date:2002-07-09
Release date:2002-09-18
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
J.Mol.Biol., 322, 2002
1M5D
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X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH BR-HIBO AT 1.73 A RESOLUTION
Descriptor:Glutamate receptor 2, SULFATE ION, (S)-2-AMINO-3-(4-BROMO-3-HYDROXY-ISOXAZOL-5-YL)PROPIONIC ACID
Authors:Hogner, A., Kastrup, J.S., Jin, R., Liljefors, T., Mayer, M.L., Egebjerg, J., Larsen, I.K., Gouaux, E.
Deposit date:2002-07-09
Release date:2002-09-18
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
J.Mol.Biol., 322, 2002
1M5E
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X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH ACPA AT 1.46 A RESOLUTION
Descriptor:Glutamate receptor 2, ZINC ION, (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID, ...
Authors:Hogner, A., Kastrup, J.S., Jin, R., Liljefors, T., Mayer, M.L., Egebjerg, J., Larsen, I.K., Gouaux, E.
Deposit date:2002-07-09
Release date:2002-09-18
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
J.Mol.Biol., 322, 2002
1M5F
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X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH ACPA AT 1.95 A RESOLUTION
Descriptor:Glutamate receptor 2, ZINC ION, (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID, ...
Authors:Hogner, A., Kastrup, J.S., Jin, R., Liljefors, T., Mayer, M.L., Egebjerg, J., Larsen, I.K., Gouaux, E.
Deposit date:2002-07-09
Release date:2002-09-18
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
J.Mol.Biol., 322, 2002
2AL4
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CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH QUISQUALATE AND CX614.
Descriptor:Glutamate receptor 2, ZINC ION, (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, ...
Authors:Jin, R., Clark, S., Weeks, A.M., Dudman, J.T., Gouaux, E., Partin, K.M.
Deposit date:2005-08-04
Release date:2005-10-25
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanism of positive allosteric modulators acting on AMPA receptors.
J.Neurosci., 25, 2005
2AL5
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CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH FLUORO-WILLARDIINE AND ANIRACETAM
Descriptor:Glutamate receptor 2, 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE
Authors:Jin, R., Clark, S., Weeks, A.M., Dudman, J.T., Gouaux, E., Partin, K.M.
Deposit date:2005-08-04
Release date:2005-10-25
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mechanism of positive allosteric modulators acting on AMPA receptors.
J.Neurosci., 25, 2005