Author results

1OGK
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THE CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DUTPASE IN COMPLEX WITH DUDP
Descriptor:DEOXYURIDINE TRIPHOSPHATASE, DEOXYURIDINE-5'-DIPHOSPHATE
Authors:Harkiolaki, M., Dodson, E.J., Bernier-Villamor, V., Turkenburg, J.P., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2003-05-07
Release date:2004-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Crystal Structure of Trypanosoma Cruzi Dutpase Reveals a Novel Dutp/Dudp Binding Fold
Structure, 12, 2004
1OGL
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THE CRYSTAL STRUCTURE OF NATIVE TRYPANOSOMA CRUZI DUTPASE
Descriptor:DEOXYURIDINE TRIPHOSPHATASE
Authors:Harkiolaki, M., Dodson, E.J., Bernier-Villamor, V., Turkenburg, J.P., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2003-05-07
Release date:2004-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Crystal Structure of Trypanosoma Cruzi Dutpase Reveals a Novel Dutp/Dudp Binding Fold
Structure, 12, 2004
1W2Y
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THE CRYSTAL STRUCTURE OF A COMPLEX OF CAMPYLOBACTER JEJUNI DUTPASE WITH SUBSTRATE ANALOGUE DUPNHP
Descriptor:DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-DIPHOSPHATE, MAGNESIUM ION
Authors:Moroz, O.V., Harkiolaki, M., Galperin, M.Y., Vagin, A.A., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2004-07-09
Release date:2004-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Crystal Structure of a Complex of Campylobacter Jejuni Dutpase with Substrate Analogue Sheds Light on the Mechanism and Suggests the "Basic Module" for Dimeric D(C/U)Tpases
J.Mol.Biol., 342, 2004
2CIC
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THE CRYSTAL STRUCTURE OF A COMPLEX OF CAMPYLOBACTER JEJUNI DUTPASE WITH SUBSTRATE ANALOGUE DUPNHPP
Descriptor:DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, MAGNESIUM ION
Authors:Moroz, O.V., Harkiolaki, M., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2006-03-17
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of the Leishmania Major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, Dump, and Deoxyuridine.
J.Biol.Chem., 286, 2011
2CJE
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THE CRYSTAL STRUCTURE OF A COMPLEX OF LEISHMANIA MAJOR DUTPASE WITH SUBSTRATE ANALOGUE DUPNHP
Descriptor:DUTPASE, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-DIPHOSPHATE, MAGNESIUM ION
Authors:Moroz, O.V., Fogg, M.J., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2006-03-31
Release date:2007-04-17
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:The Crystal Structure of the Leishmania Major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, Dump, and Deoxyuridine.
J.Biol.Chem., 286, 2011
2J63
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CRYSTAL STRUCTURE OF AP ENDONUCLEASE LMAP FROM LEISHMANIA MAJOR
Descriptor:AP-ENDONUCLEASE
Authors:Vidal, A.E., Harkiolaki, M., Gallego, C., Castillo-Acosta, V.M., Ruiz-Perez, L.M., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2006-09-25
Release date:2007-08-28
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal Structure and DNA Repair Activities of the Ap Endonuclease from Leishmania Major.
J.Mol.Biol., 373, 2007
2WWF
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH TMP AND ADP
Descriptor:THYMIDILATE KINASE, PUTATIVE, THYMIDINE-5'-PHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P.G., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
2WWG
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH DGMP AND ADP
Descriptor:THYMIDILATE KINASE, PUTATIVE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
2WWH
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH AP5DT
Descriptor:THYMIDILATE KINASE, PUTATIVE, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P.G., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
2WWI
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH AZTMP AND ADP
Descriptor:THYMIDILATE KINASE, PUTATIVE, 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ...
Authors:Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P.G., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.
Deposit date:2009-10-23
Release date:2010-04-21
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
2Y8C
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PLASMODIUM FALCIPARUM DUTPASE IN COMPLEX WITH A TRITYL LIGAND
Descriptor:DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, (2S)-2-[(2,4-dioxopyrimidin-1-yl)methyl]-N-(2-hydroxyethyl)-4-trityloxy-butanamide, SULFATE ION
Authors:Baragana, B., McCarthy, O., Sanchez, P., Bosch, C., Kaiser, M., Brun, R., Whittingham, J.L., Roberts, S., Zhou, X.-X., Wilson, K.S., Johansson, N.G., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2011-02-04
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Beta-Branched Acyclic Nucleoside Analogues as Inhibitors of Plasmodium Falciparum Dutpase
Bioorg.Med.Chem., 19, 2011
2YAY
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THE CRYSTAL STRUCTURE OF LEISHMANIA MAJOR DUTPASE IN COMPLEX WITH SUBSTRATE ANALOGUE DUPNPP
Descriptor:DUTPASE, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION
Authors:Hemsworth, G.R., Moroz, O.V., Fogg, M.J., Scott, B., Bosch-Navarrete, C., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2011-02-25
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:The Crystal Structure of the Leishmania Major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, Dump, and Deoxyuridine.
J.Biol.Chem., 286, 2011
2YAZ
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THE CRYSTAL STRUCTURE OF LEISHMANIA MAJOR DUTPASE IN COMPLEX DUMP
Descriptor:DUTPASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Hemsworth, G.R., Moroz, O.V., Fogg, M.J., Scott, B., Bosch-Navarrete, C., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2011-02-25
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Crystal Structure of the Leishmania Major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, Dump, and Deoxyuridine.
J.Biol.Chem., 286, 2011
2YB0
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THE CRYSTAL STRUCTURE OF LEISHMANIA MAJOR DUTPASE IN COMPLEX DEOXYURIDINE
Descriptor:DUTPASE, 2'-DEOXYURIDINE, SULFATE ION
Authors:Hemsworth, G.R., Moroz, O.V., Fogg, M.J., Scott, B., Bosch-Navarrete, C., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2011-02-25
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:The Crystal Structure of the Leishmania Major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, Dump, and Deoxyuridine.
J.Biol.Chem., 286, 2011
2YOF
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A (THIO)UREA- BETA-DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[[(2R,3S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]thiourea, ACETATE ION, ...
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
2YOG
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A (THIO)UREA- ALPHA-DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[[(2R,3S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]thiourea
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
2YOH
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PLASMODIUM FALCIPARUM THYMIDYLATE KINASE IN COMPLEX WITH A UREA-ALPHA- DEOXYTHYMIDINE INHIBITOR
Descriptor:THYMIDYLATE KINASE, 1-[[(2R,3S,5S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]-3-(4-nitrophenyl)urea
Authors:Huaqing, C., Carrero-Lerida, J., Silva, A.P.G., Whittingham, J.L., Brannigan, J.A., Ruiz-Perez, L.M., Read, K.D., Wilson, K.S., Gonzalez-Pacanowska, D., Gilbert, I.H.
Deposit date:2012-10-24
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
J.Med.Chem., 55, 2012
3T60
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, 2',5'-dideoxy-5'-(tritylamino)uridine, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-28
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
3T64
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, 5'-(BENZHYDRYLAMINO)-2',5'-DIDEOXYURIDINE, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-28
Release date:2012-08-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
3T6Y
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, peptide ALA-HIS-ALA, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-29
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
3T70
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, PEPTIDE GLY-HIS-GLY, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-29
Release date:2012-08-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
4DK2
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CRYSTAL STRUCTURE OF OPEN TRYPANOSOMA BRUCEI DUTPASE
Descriptor:Deoxyuridine triphosphatase
Authors:Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2012-02-03
Release date:2013-08-07
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:On the catalytic mechanism of dimeric dUTPases.
Biochem.J., 456, 2013
4DK4
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI DUTPASE WITH DUPNP, CA2+ AND NA+
Descriptor:Deoxyuridine triphosphatase, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-DIPHOSPHATE, CALCIUM ION, ...
Authors:Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2012-02-03
Release date:2013-08-07
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:On the catalytic mechanism of dimeric dUTPases.
Biochem.J., 456, 2013
4DKB
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI DUTPASE WITH DUPNP AND CA2+
Descriptor:Deoxyuridine triphosphatase, CALCIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-DIPHOSPHATE
Authors:Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2012-02-03
Release date:2013-08-07
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (1.831 Å)
Cite:On the catalytic mechanism of dimeric dUTPases.
Biochem.J., 456, 2013
4DL8
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI DUTPASE WITH DUMP, PLANAR [ALF3-OPO3] TRANSITION STATE ANALOGUE, MG2+, AND NA+
Descriptor:Deoxyuridine triphosphatase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ALUMINUM FLUORIDE, ...
Authors:Hemsworth, G.R., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2012-02-06
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:On the catalytic mechanism of dimeric dUTPases.
Biochem.J., 456, 2013
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