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1A71
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TERNARY COMPLEX OF AN ACTIVE SITE DOUBLE MUTANT OF HORSE LIVER ALCOHOL DEHYDROGENASE, PHE93=>TRP, VAL203=>ALA WITH NAD AND TRIFLUOROETHANOL
Descriptor:LIVER ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Colby, T.D., Bahnson, B.J., Chin, J.K., Klinman, J.P., Goldstein, B.M.
Deposit date:1998-03-19
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Biochemistry, 37, 1998
1A72
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AN ACTIVE-SITE DOUBLE MUTANT (PHE93->TRP, VAL203->ALA) OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH THE ISOSTERIC NAD ANALOG CPAD
Descriptor:HORSE LIVER ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLPICOLINAMIDE ADENINE-DINUCLEOTIDE
Authors:Colby, T.D., Bahnson, B.J., Chin, J.K., Klinman, J.P., Goldstein, B.M.
Deposit date:1998-03-19
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Biochemistry, 37, 1998
1ADB
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CRYSTALLOGRAPHIC STUDIES OF ISOSTERIC NAD ANALOGUES BOUND TO ALCOHOL DEHYDROGENASE: SPECIFICITY AND SUBSTRATE BINDING IN TWO TERNARY COMPLEXES
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLNICOTINAMIDE ADENINE DINUCLEOTIDE, ...
Authors:Li, H., Hallows, W.A., Punzi, J.S., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
Deposit date:1993-12-13
Release date:1995-06-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.
Biochemistry, 33, 1994
1ADC
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CRYSTALLOGRAPHIC STUDIES OF ISOSTERIC NAD ANALOGUES BOUND TO ALCOHOL DEHYDROGENASE: SPECIFICITY AND SUBSTRATE BINDING IN TWO TERNARY COMPLEXES
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLPICOLINAMIDE ADENINE-DINUCLEOTIDE, ...
Authors:Li, H., Hallows, W.A., Punzi, J.S., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
Deposit date:1993-12-13
Release date:1995-06-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.
Biochemistry, 33, 1994
1ADF
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CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
Authors:Li, H., Hallows, W.A., Punzi, J.S., Marquez, V.E., Carrell, H.L., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
Deposit date:1993-10-18
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry, 33, 1994
1ADG
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CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, BETA-METHYLENE-SELENAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
Authors:Li, H., Hallows, W.A., Punzi, J.S., Marquez, V.E., Carrell, H.L., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
Deposit date:1993-10-18
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry, 33, 1994
1AXE
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CRYSTAL STRUCTURE OF THE ACTIVE-SITE MUTANT PHE93->TRP OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH NAD AND INHIBITOR TRIFLUOROETHANOL
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Colby, T.D., Chin, J.K., Goldstein, B.M.
Deposit date:1997-10-15
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A link between protein structure and enzyme catalyzed hydrogen tunneling.
Proc.Natl.Acad.Sci.USA, 94, 1997
1AXG
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CRYSTAL STRUCTURE OF THE VAL203->ALA MUTANT OF LIVER ALCOHOL DEHYDROGENASE COMPLEXED WITH COFACTOR NAD AND INHIBITOR TRIFLUOROETHANOL SOLVED TO 2.5 ANGSTROM RESOLUTION
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Colby, T.D., Chin, J.K., Bahnson, B.J., Goldstein, B.M., Klinman, J.P.
Deposit date:1997-10-15
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A link between protein structure and enzyme catalyzed hydrogen tunneling.
Proc.Natl.Acad.Sci.USA, 94, 1997
1B3O
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TERNARY COMPLEX OF HUMAN TYPE-II INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP AND SELENAZOLE ADENINE DINUCLEOTIDE
Descriptor:PROTEIN (INOSINE MONOPHOSPHATE DEHYDROGENASE 2), 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE, ...
Authors:Colby, T.D., Vanderveen, K., Strickler, M.D., Goldstein, B.M.
Deposit date:1998-12-14
Release date:1999-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design.
Proc.Natl.Acad.Sci.USA, 96, 1999
1JCN
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BINARY COMPLEX OF HUMAN TYPE-I INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP
Descriptor:INOSINE MONOPHOSPHATE DEHYDROGENASE I, 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE
Authors:Risal, D., Strickler, M.D., Goldstein, B.M.
Deposit date:2001-06-11
Release date:2003-06-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Human Type I Inosine Monophosphate Dehydrogenase and Implications for Isoform Specificity
To be Published
1NF7
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TERNARY COMPLEX OF THE HUMAN TYPE II INOSINE MONOPHOSPHATE DEDHYDROGENASE WITH RIBAVIRIN MONOPHOSPHATE AND C2-MYCOPHENOLIC ADENINE DINUCLEOTIDE
Descriptor:Inosine-5'-monophosphate dehydrogenase 2, POTASSIUM ION, RIBAVIRIN MONOPHOSPHATE, ...
Authors:Risal, D., Strickler, M.D., Goldstein, B.M.
Deposit date:2002-12-13
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal Structure of Human Inosine Monophosphate Dehydrogenase type II complexed with the MPA/NAD analog C2-MAD
To be Published
1NFB
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TERNARY COMPLEX OF THE HUMAN TYPE II INOSINE MONOPHOSPHATE DEDHYDROGENASE WITH 6CL-IMP AND NAD
Descriptor:Inosine-5'-monophosphate dehydrogenase 2, 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE, ...
Authors:Risal, D., Strickler, M.D., Goldstein, B.M.
Deposit date:2002-12-13
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Conformation of NAD Bound to Human Inosine Monophosphate Dehydrogenase Type II
To be Published
1P2Y
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CRYSTAL STRUCTURE OF CYTOCHROME P450CAM IN COMPLEX WITH (S)-(-)-NICOTINE
Descriptor:Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE
Authors:Strickler, M., Goldstein, B.M., Maxfield, K., Shireman, L., Kim, G., Matteson, D., Jones, J.P.
Deposit date:2003-04-16
Release date:2003-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic Studies on the Complex Behavior of Nicotine Binding to P450cam (CYP101)(dagger).
Biochemistry, 42, 2003
1P7R
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CRYSTAL STRUCTURE OF REDUCED, CO-EXPOSED COMPLEX OF CYTOCHROME P450CAM WITH (S)-(-)-NICOTINE
Descriptor:Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE
Authors:Strickler, M., Goldstein, B.M., Maxfield, K., Shireman, L., Kim, G., Matteson, D., Jones, J.P.
Deposit date:2003-05-05
Release date:2003-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystallographic Studies on the Complex Behavior of Nicotine Binding to P450cam (CYP101)(dagger).
Biochemistry, 42, 2003
1RJW
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CRYSTAL STRUCTURE OF NAD(+)-DEPENDENT ALCOHOL DEHYDROGENASE FROM BACILLUS STEAROTHERMOPHILUS STRAIN LLD-R
Descriptor:Alcohol dehydrogenase, ZINC ION, TRIFLUOROETHANOL
Authors:Ceccarelli, C., Bahnson, B.J.
Deposit date:2003-11-20
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure and Amide H/D Exchange of Binary Complexes of Alcohol Dehydrogenase from Bacillus stearothermophilus: Insight into Thermostability and Cofactor Binding
Biochemistry, 43, 2004
6OWM
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HORSE LIVER F93W ALCOHOL DEHYDROGENASE COMPLEXED WITH NAD AND PENTAFLUOROBENZYL ALCOHOL
Descriptor:Alcohol dehydrogenase E chain, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ...
Authors:Plapp, B.V.
Deposit date:2019-05-10
Release date:2019-05-22
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Substitutions of amino acid residues in the substrate binding site of horse liver alcohol dehydrogenase have small effects on structure but significantly affect catalysis of hydrogen transfer.
To Be Published
6OWP
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HORSE LIVER F93W ALCOHOL DEHYDROGENASE COMPLEXED WITH NAD AND TRIFLUOROETHANOL
Descriptor:Alcohol dehydrogenase E chain, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ...
Authors:Plapp, B.V.
Deposit date:2019-05-10
Release date:2019-05-22
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Substitutions of amino acid residues in the substrate binding site of horse liver alcohol dehydrogenase have small effects on structure but significantly affect catalysis of hydrogen transfer.
To Be Published