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1A71
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TERNARY COMPLEX OF AN ACTIVE SITE DOUBLE MUTANT OF HORSE LIVER ALCOHOL DEHYDROGENASE, PHE93=>TRP, VAL203=>ALA WITH NAD AND TRIFLUOROETHANOL
Descriptor:LIVER ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Colby, T.D., Bahnson, B.J., Chin, J.K., Klinman, J.P., Goldstein, B.M.
Deposit date:1998-03-19
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Biochemistry, 37, 1998
1A72
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AN ACTIVE-SITE DOUBLE MUTANT (PHE93->TRP, VAL203->ALA) OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH THE ISOSTERIC NAD ANALOG CPAD
Descriptor:HORSE LIVER ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLPICOLINAMIDE ADENINE-DINUCLEOTIDE
Authors:Colby, T.D., Bahnson, B.J., Chin, J.K., Klinman, J.P., Goldstein, B.M.
Deposit date:1998-03-19
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Biochemistry, 37, 1998
1ADB
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CRYSTALLOGRAPHIC STUDIES OF ISOSTERIC NAD ANALOGUES BOUND TO ALCOHOL DEHYDROGENASE: SPECIFICITY AND SUBSTRATE BINDING IN TWO TERNARY COMPLEXES
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLNICOTINAMIDE ADENINE DINUCLEOTIDE, ...
Authors:Li, H., Hallows, W.A., Punzi, J.S., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
Deposit date:1993-12-13
Release date:1995-06-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.
Biochemistry, 33, 1994
1ADC
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CRYSTALLOGRAPHIC STUDIES OF ISOSTERIC NAD ANALOGUES BOUND TO ALCOHOL DEHYDROGENASE: SPECIFICITY AND SUBSTRATE BINDING IN TWO TERNARY COMPLEXES
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLPICOLINAMIDE ADENINE-DINUCLEOTIDE, ...
Authors:Li, H., Hallows, W.A., Punzi, J.S., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
Deposit date:1993-12-13
Release date:1995-06-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.
Biochemistry, 33, 1994
1ADF
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CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
Authors:Li, H., Hallows, W.A., Punzi, J.S., Marquez, V.E., Carrell, H.L., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
Deposit date:1993-10-18
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry, 33, 1994
1ADG
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CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, BETA-METHYLENE-SELENAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
Authors:Li, H., Hallows, W.A., Punzi, J.S., Marquez, V.E., Carrell, H.L., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
Deposit date:1993-10-18
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry, 33, 1994
1AXE
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CRYSTAL STRUCTURE OF THE ACTIVE-SITE MUTANT PHE93->TRP OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH NAD AND INHIBITOR TRIFLUOROETHANOL
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Colby, T.D., Chin, J.K., Goldstein, B.M.
Deposit date:1997-10-15
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A link between protein structure and enzyme catalyzed hydrogen tunneling.
Proc.Natl.Acad.Sci.USA, 94, 1997
1AXG
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CRYSTAL STRUCTURE OF THE VAL203->ALA MUTANT OF LIVER ALCOHOL DEHYDROGENASE COMPLEXED WITH COFACTOR NAD AND INHIBITOR TRIFLUOROETHANOL SOLVED TO 2.5 ANGSTROM RESOLUTION
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Colby, T.D., Chin, J.K., Bahnson, B.J., Goldstein, B.M., Klinman, J.P.
Deposit date:1997-10-15
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A link between protein structure and enzyme catalyzed hydrogen tunneling.
Proc.Natl.Acad.Sci.USA, 94, 1997
1B3O
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TERNARY COMPLEX OF HUMAN TYPE-II INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP AND SELENAZOLE ADENINE DINUCLEOTIDE
Descriptor:PROTEIN (INOSINE MONOPHOSPHATE DEHYDROGENASE 2), 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE, ...
Authors:Colby, T.D., Vanderveen, K., Strickler, M.D., Goldstein, B.M.
Deposit date:1998-12-14
Release date:1999-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design.
Proc.Natl.Acad.Sci.USA, 96, 1999
1JCN
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BINARY COMPLEX OF HUMAN TYPE-I INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP
Descriptor:INOSINE MONOPHOSPHATE DEHYDROGENASE I, 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE
Authors:Risal, D., Strickler, M.D., Goldstein, B.M.
Deposit date:2001-06-11
Release date:2003-06-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Human Type I Inosine Monophosphate Dehydrogenase and Implications for Isoform Specificity
To be Published
1NF7
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TERNARY COMPLEX OF THE HUMAN TYPE II INOSINE MONOPHOSPHATE DEDHYDROGENASE WITH RIBAVIRIN MONOPHOSPHATE AND C2-MYCOPHENOLIC ADENINE DINUCLEOTIDE
Descriptor:Inosine-5'-monophosphate dehydrogenase 2, POTASSIUM ION, RIBAVIRIN MONOPHOSPHATE, ...
Authors:Risal, D., Strickler, M.D., Goldstein, B.M.
Deposit date:2002-12-13
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal Structure of Human Inosine Monophosphate Dehydrogenase type II complexed with the MPA/NAD analog C2-MAD
To be Published
1NFB
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TERNARY COMPLEX OF THE HUMAN TYPE II INOSINE MONOPHOSPHATE DEDHYDROGENASE WITH 6CL-IMP AND NAD
Descriptor:Inosine-5'-monophosphate dehydrogenase 2, 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE, ...
Authors:Risal, D., Strickler, M.D., Goldstein, B.M.
Deposit date:2002-12-13
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Conformation of NAD Bound to Human Inosine Monophosphate Dehydrogenase Type II
To be Published
1P2Y
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CRYSTAL STRUCTURE OF CYTOCHROME P450CAM IN COMPLEX WITH (S)-(-)-NICOTINE
Descriptor:Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE
Authors:Strickler, M., Goldstein, B.M., Maxfield, K., Shireman, L., Kim, G., Matteson, D., Jones, J.P.
Deposit date:2003-04-16
Release date:2003-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic Studies on the Complex Behavior of Nicotine Binding to P450cam (CYP101)(dagger).
Biochemistry, 42, 2003
1P7R
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CRYSTAL STRUCTURE OF REDUCED, CO-EXPOSED COMPLEX OF CYTOCHROME P450CAM WITH (S)-(-)-NICOTINE
Descriptor:Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE
Authors:Strickler, M., Goldstein, B.M., Maxfield, K., Shireman, L., Kim, G., Matteson, D., Jones, J.P.
Deposit date:2003-05-05
Release date:2003-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystallographic Studies on the Complex Behavior of Nicotine Binding to P450cam (CYP101)(dagger).
Biochemistry, 42, 2003
1RJW
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CRYSTAL STRUCTURE OF NAD(+)-DEPENDENT ALCOHOL DEHYDROGENASE FROM BACILLUS STEAROTHERMOPHILUS STRAIN LLD-R
Descriptor:Alcohol dehydrogenase, ZINC ION, TRIFLUOROETHANOL
Authors:Ceccarelli, C., Bahnson, B.J.
Deposit date:2003-11-20
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure and Amide H/D Exchange of Binary Complexes of Alcohol Dehydrogenase from Bacillus stearothermophilus: Insight into Thermostability and Cofactor Binding
Biochemistry, 43, 2004