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1MML
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MECHANISTIC IMPLICATIONS FROM THE STRUCTURE OF A CATALYTIC FRAGMENT OF MMLV REVERSE TRANSCRIPTASE
Descriptor:MMLV REVERSE TRANSCRIPTASE
Authors:Georgiadis, M.M., Jessen, S.M., Ogata, C.M., Telesnitsky, A., Goff, S.P., Hendrickson, W.A.
Deposit date:1995-07-18
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase.
Structure, 3, 1995
2O3C
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CRYSTAL STRUCTURE OF ZEBRAFISH APE
Descriptor:APEX nuclease 1, LEAD (II) ION
Authors:Georgiadis, M.M., Gaur, R.K., Delaplane, S., Svenson, J.
Deposit date:2006-12-01
Release date:2007-12-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease
Mutat.Res., 643, 2008
2O3H
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CRYSTAL STRUCTURE OF THE HUMAN C65A APE
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, SAMARIUM (III) ION, ACETATE ION
Authors:Georgiadis, M.M., Gaur, R.K., Delaplane, S., Svenson, J.
Deposit date:2006-12-01
Release date:2007-12-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease
Mutat.Res., 643, 2008
4XNO
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CRYSTAL STRUCTURE OF 5'-CTTATPPPZZZATAAG
Descriptor:DNA (5'-D(*CP*TP*(BRU)P*AP*TP*(1WA)P*(1WA)P*(1WA)P*(1W5)P*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3')
Authors:Georgiadis, M.M., Singh, I.
Deposit date:2015-01-15
Release date:2015-05-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.985 Å)
Cite:Structural basis for a six nucleotide genetic alphabet.
J. Am. Chem. Soc., 137, 2015
4XO0
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CRYSTAL STRUCTURE OF 5'-CTTATPPTAZZATAAG IN A HOST-GUEST COMPLEX
Descriptor:reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*T)-3'), DNA (5'-D(P*AP*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3')
Authors:Georgiadis, M.M., Singh, I.
Deposit date:2015-01-16
Release date:2015-05-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for a six nucleotide genetic alphabet.
J. Am. Chem. Soc., 137, 2015
4XPC
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CRYSTAL STRUCTURE OF 5'- CTTATAAATTTATAAG IN A HOST-GUEST COMPLEX
Descriptor:reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*TP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*AP*TP*AP*AP*G)-3'), ...
Authors:Georgiadis, M.M., Singh, I.
Deposit date:2015-01-16
Release date:2015-05-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural basis for a six nucleotide genetic alphabet.
J. Am. Chem. Soc., 137, 2015
4XPE
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CRYSTAL STRUCTURE OF 5'-CTTATGGGCCCATAAG IN A HOST-GUEST COMPLEX
Descriptor:reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*AP*AP*G)-3'), ...
Authors:Georgiadis, M.M., Singh, I.
Deposit date:2015-01-16
Release date:2015-05-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis for a six nucleotide genetic alphabet.
J. Am. Chem. Soc., 137, 2015
1NIP
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CRYSTALLOGRAPHIC STRUCTURE OF THE NITROGENASE IRON PROTEIN FROM AZOTOBACTER VINELANDII
Descriptor:NITROGENASE IRON PROTEIN, MAGNESIUM ION, IRON/SULFUR CLUSTER, ...
Authors:Komiya, H., Georgiadis, M.M., Chakrabarti, P., Woo, D., Kornuc, J.J., Rees, D.C.
Deposit date:1992-09-29
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystallographic structure of the nitrogenase iron protein from Azotobacter vinelandii.
Science, 257, 1992
6MIG
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CRYSTAL STRUCTURE OF HOST-GUEST COMPLEX WITH PB HACHIMOJI DNA
Descriptor:Gag-Pol polyprotein, DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*(DS))-3'), DNA (5'-D(P*(DB)P*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3')
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
6MIH
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CRYSTAL STRUCTURE OF HOST-GUEST COMPLEX WITH PC HACHIMOJI DNA
Descriptor:N-terminal fragment of MMLV reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*(1WA)P*CP*(DB)P*T)-3'), DNA (5'-D(P*AP*(DS)P*GP*(1W5)P*TP*AP*AP*G)-3')
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
6MIK
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CRYSTAL STRUCTURE OF HOST-GUEST COMPLEX WITH PP HACHIMOJI DNA
Descriptor:N-terminal fragment of MMLV reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*TP*(1WA)P*(1WA)P*(DS))-3'), DNA (5'-D(P*(DB)P*(1W5)P*(1W5)P*AP*TP*AP*AP*G)-3')
Authors:Georgiadis, M.M.
Deposit date:2018-09-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hachimoji DNA and RNA: A genetic system with eight building blocks.
Science, 363, 2019
6MK3
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CRYSTALLOGRAPHIC SOLVENT MAPPING ANALYSIS OF DMSO BOUND TO APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, DIMETHYL SULFOXIDE, 1,2-ETHANEDIOL
Authors:Georgiadis, M.M., He, H., Chen, Q.
Deposit date:2018-09-24
Release date:2019-01-30
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.478 Å)
Cite:Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.
J. Med. Chem., 62, 2019
6MKK
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CRYSTALLOGRAPHIC SOLVENT MAPPING ANALYSIS OF DMSO/MG BOUND TO APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Georgiadis, M.M., He, H., Chen, Q.
Deposit date:2018-09-25
Release date:2019-01-30
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.442 Å)
Cite:Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.
J. Med. Chem., 62, 2019
6MKM
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CRYSTALLOGRAPHIC SOLVENT MAPPING ANALYSIS OF DMSO/TRIS BOUND TO APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYL SULFOXIDE, ...
Authors:Georgiadis, M.M., He, H., Chen, Q.
Deposit date:2018-09-25
Release date:2019-01-30
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.673 Å)
Cite:Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.
J. Med. Chem., 62, 2019
6MKO
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CRYSTALLOGRAPHIC SOLVENT MAPPING ANALYSIS OF GLYCEROL BOUND TO APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, GLYCEROL
Authors:Georgiadis, M.M., He, H., Chen, Q.
Deposit date:2018-09-25
Release date:2019-01-30
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.
J. Med. Chem., 62, 2019
1N4L
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A DNA ANALOGUE OF THE POLYPURINE TRACT OF HIV-1
Descriptor:5'-D(*CP*TP*TP*TP*TP*TP*AP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3', 5'-D(*CP*TP*TP*TP*TP*CP*TP*TP*TP*TP*AP*AP*AP*AP*AP*G)-3', Reverse Transcriptase
Authors:Cote, M.L., Pflomm, M., Georgiadis, M.M.
Deposit date:2002-10-31
Release date:2003-06-24
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Staying Straight with A-tracts: A DNA Analog of the HIV-1 Polypurine Tract
J.Mol.Biol., 330, 2003
1D1U
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USE OF AN N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE TO FACILITATE CRYSTALLIZATION AND ANALYSIS OF A PSEUDO-16-MER DNA MOLECULE CONTAINING G-A MISPAIRS
Descriptor:DNA (5'-D(*CP*TP*CP*GP*TP*G)-3'), DNA (5'-D(*AP*CP*GP*GP*CP*AP*CP*GP*AP*G)-3'), PROTEIN (REVERSE TRANSCRIPTASE)
Authors:Cote, M.L., Yohannan, S., Georgiadis, M.M.
Deposit date:1999-09-21
Release date:2000-04-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Use of an N-terminal fragment from moloney murine leukemia virus reverse transcriptase to facilitate crystallization and analysis of a pseudo-16-mer DNA molecule containing G-A mispairs.
Acta Crystallogr.,Sect.D, 56, 2000
1KOH
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THE CRYSTAL STRUCTURE AND MUTATIONAL ANALYSIS OF A NOVEL RNA-BINDING DOMAIN FOUND IN THE HUMAN TAP NUCLEAR MRNA EXPORT FACTOR
Descriptor:TIP ASSOCIATING PROTEIN
Authors:Ho, D.N., Coburn, G.A., Kang, Y., Cullen, B.R., Georgiadis, M.M.
Deposit date:2001-12-20
Release date:2002-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor.
Proc.Natl.Acad.Sci.USA, 99, 2002
1KOO
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THE CRYSTAL STRUCTURE AND MUTATIONAL ANALYSIS OF A NOVEL RNA-BINDING DOMAIN FOUND IN THE HUMAN TAP NUCLEAR MRNA EXPORT FACTOR
Descriptor:TIP ASSOCIATING PROTEIN
Authors:Ho, D.N., Coburn, G.A., Kang, Y., Cullen, B.R., Georgiadis, M.M.
Deposit date:2001-12-21
Release date:2002-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor.
Proc.Natl.Acad.Sci.USA, 99, 2002
1D0E
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CRYSTAL STRUCTURES OF THE N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE COMPLEXED WITH NUCLEIC ACID: FUNCTIONAL IMPLICATIONS FOR TEMPLATE-PRIMER BINDING TO THE FINGERS DOMAIN
Descriptor:5'-D(*TP*TP*TP*CP*AP*TP*GP*CP*AP*TP*G)-3', REVERSE TRANSCRIPTASE
Authors:Najmudin, S., Cote, M.L., Sun, D., Yohannan, S., Montano, S.P., Gu, J., Georgiadis, M.M.
Deposit date:1999-09-09
Release date:2000-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain
J.Mol.Biol., 296, 2000
1QAI
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CRYSTAL STRUCTURES OF THE N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE COMPLEXED WITH NUCLEIC ACID: FUNCTIONAL IMPLICATIONS FOR TEMPLATE-PRIMER BINDING TO THE FINGERS DOMAIN
Descriptor:DNA (5'-D(*CP*AP*TP*GP*CP*AP*TP*G)-3'), REVERSE TRANSCRIPTASE, MERCURY (II) ION
Authors:Najmudin, S., Cote, M., Sun, D., Yohannan, S., Montano, S.P., Gu, J., Georgiadis, M.M.
Deposit date:1999-03-12
Release date:2000-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain.
J.Mol.Biol., 296, 2000
1QAJ
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CRYSTAL STRUCTURES OF THE N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE COMPLEXED WITH NUCLEIC ACID: FUNCTIONAL IMPLICATIONS FOR TEMPLATE-PRIMER BINDING TO THE FINGERS DOMAIN
Descriptor:DNA (5'-D(*CP*AP*TP*GP*CP*AP*TP*G)-3'), REVERSE TRANSCRIPTASE
Authors:Najmudin, S., Cote, M., Sun, D., Yohannan, S., Montano, S.P., Gu, J., Georgiadis, M.M.
Deposit date:1999-03-18
Release date:2000-04-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain.
J.Mol.Biol., 296, 2000
1I6J
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CRYSTAL STRUCTURE OF A PSEUDO-16-MER DNA WITH STACKED GUANINES AND TWO G-A MISPAIRS COMPLEXED WITH THE N-TERMINAL FRAGMENT OF MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE
Descriptor:5'-D(*GP*TP*CP*GP*TP*C)-3', 5'-D(*AP*CP*GP*GP*GP*AP*CP*GP*AP*C)-3', REVERSE TRANSCRIPTASE
Authors:Cote, M.L., Georgiadis, M.M.
Deposit date:2001-03-02
Release date:2001-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a pseudo-16-mer DNA with stacked guanines and two G-A mispairs complexed with the N-terminal fragment of Moloney murine leukemia virus reverse transcriptase.
Acta Crystallogr.,Sect.D, 57, 2001
1M6U
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CRYSTAL STRUCTURE OF A NOVEL DNA-BINDING DOMAIN FROM NDT80, A TRANSCRIPTIONAL ACTIVATOR REQUIRED FOR MEIOSIS IN YEAST
Descriptor:Ndt80 protein, SULFATE ION
Authors:Montano, S.P., Cote, M.L., Fingerman, I., Pierce, M., Vershon, A.K., Georgiadis, M.M.
Deposit date:2002-07-17
Release date:2002-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast
Proc.Natl.Acad.Sci.USA, 99, 2002
1M7U
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CRYSTAL STRUCTURE OF A NOVEL DNA-BINDING DOMAIN FROM NDT80, A TRANSCRIPTIONAL ACTIVATOR REQUIRED FOR MEIOSIS IN YEAST
Descriptor:Ndt80 protein
Authors:Montano, S.P., Cote, M.L., Fingerman, I., Pierce, M., Vershon, A.K., Georgiadis, M.M.
Deposit date:2002-07-22
Release date:2002-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast
Proc.Natl.Acad.Sci.USA, 99, 2002
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