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1QPU
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BU of 1qpu by Molmil
SOLUTION STRUCTURE OF OXIDIZED ESCHERICHIA COLI CYTOCHROME B562
Descriptor: CYTOCHROME B562, PROTOPORPHYRIN IX CONTAINING FE
Authors:Arnesano, F, Banci, L, Bertini, I, Faraone-Mennella, J, Rosato, A, Barker, P.D, Fersht, A.R.
Deposit date:1999-05-30
Release date:1999-06-02
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:The solution structure of oxidized Escherichia coli cytochrome b562.
Biochemistry, 38, 1999
2WXC
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BU of 2wxc by Molmil
The folding mechanism of BBL: Plasticity of transition-state structure observed within an ultrafast folding protein family.
Descriptor: DIHYDROLIPOYLTRANSSUCCINASE
Authors:Neuweiler, H, Sharpe, T.D, Rutherford, T.J, Johnson, C.M, Allen, M.D, Ferguson, N, Fersht, A.R.
Deposit date:2009-11-06
Release date:2009-11-17
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The Folding Mechanism of Bbl: Plasticity of Transition-State Structure Observed within an Ultrafast Folding Protein Family.
J.Mol.Biol., 390, 2009
2XWR
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BU of 2xwr by Molmil
Crystal structure of the DNA-binding domain of human p53 with extended N terminus
Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C, Natan, E, Fersht, A.R.
Deposit date:2010-11-04
Release date:2011-03-30
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Interaction of the P53 DNA-Binding Domain with its N-Terminal Extension Modulates the Stability of the P53 Tetramer.
J.Mol.Biol., 409, 2011
2KZG
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BU of 2kzg by Molmil
A Transient and Low Populated Protein Folding Intermediate at Atomic Resolution
Descriptor: Pre-mRNA-processing factor 40 homolog A
Authors:Korzhnev, D.M, Religa, T.L, Banachewicz, W, Fersht, A.R, Kay, L.E.
Deposit date:2010-06-17
Release date:2010-09-29
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:A transient and low-populated protein-folding intermediate at atomic resolution.
Science, 329, 2010
2YBG
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BU of 2ybg by Molmil
Structure of Lys120-acetylated p53 core domain
Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Arbely, E, Allen, M.D, Joerger, A.C, Fersht, A.R.
Deposit date:2011-03-08
Release date:2011-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Acetylation of Lysine 120 of P53 Endows DNA- Binding Specificity at Effective Physiological Salt Concentration.
Proc.Natl.Acad.Sci.USA, 108, 2011
5LAP
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BU of 5lap by Molmil
p53 cancer mutant Y220C with Cys182 alkylation
Descriptor: 5-chloranylpyrimidine-4-carboxylic acid, Cellular tumor antigen p53, ZINC ION
Authors:Joerger, A.C, Bauer, M.R, Fersht, A.R.
Deposit date:2016-06-14
Release date:2016-08-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.
Proc.Natl.Acad.Sci.USA, 113, 2016
1UOL
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BU of 1uol by Molmil
Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.
Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C, Allen, M.D, Fersht, A.R.
Deposit date:2003-09-19
Release date:2003-10-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of a Superstable Mutant of Human P53 Core Domain. Insights Into the Mechanism of Rescuing Oncogenic Mutations
J.Biol.Chem., 279, 2004
2BIO
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BU of 2bio by Molmil
human p53 core domain mutant M133L-V203A-N239Y-R249S-N268D
Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C, Fersht, A.R.
Deposit date:2005-01-25
Release date:2005-01-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005
2BIQ
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BU of 2biq by Molmil
human p53 core domain mutant T123A-M133L-H168R-V203A-N239Y-R249S- N268D
Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C, Fersht, A.R.
Deposit date:2005-01-25
Release date:2005-01-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005
2BIP
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BU of 2bip by Molmil
human p53 core domain mutant M133L-H168R-V203A-N239Y-R249S-N268D
Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C, Fersht, A.R.
Deposit date:2005-01-25
Release date:2005-01-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005
2BIN
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BU of 2bin by Molmil
human p53 core domain mutant M133L-H168R-V203A-N239Y-N268D
Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C, Fersht, A.R.
Deposit date:2005-01-25
Release date:2005-01-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005
2BIM
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BU of 2bim by Molmil
human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H
Descriptor: CELLULAR TUMOR ANTIGEN P53, SULFATE ION, ZINC ION
Authors:Joerger, A.C, Fersht, A.R.
Deposit date:2005-01-25
Release date:2005-01-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005
1JON
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BU of 1jon by Molmil
GROEL (HSP60 CLASS) FRAGMENT COMPRISING RESIDUES 191-345
Descriptor: GROEL, HSP60 CLASS
Authors:Buckle, A.M, Fersht, A.R.
Deposit date:1996-05-30
Release date:1997-03-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Chaperone activity and structure of monomeric polypeptide binding domains of GroEL.
Proc.Natl.Acad.Sci.USA, 93, 1996
1HL2
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BU of 1hl2 by Molmil
Crystal structure of N-acetylneuraminate lyase from E. coli mutant L142R in complex with b-hydroxypyruvate
Descriptor: 3-HYDROXYPYRUVIC ACID, N-ACETYLNEURAMINATE LYASE SUBUNIT
Authors:Joerger, A.C, Fersht, A.R.
Deposit date:2003-03-12
Release date:2003-05-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mimicking Natural Evolution in Vitro: An N-Acetylneuraminate Lyase Mutant with an Increased Dihydrodipicolinate Synthase Activity
Proc.Natl.Acad.Sci.USA, 100, 2003
1KID
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BU of 1kid by Molmil
GROEL (HSP60 CLASS) FRAGMENT (APICAL DOMAIN) COMPRISING RESIDUES 191-376, MUTANT WITH ALA 262 REPLACED WITH LEU AND ILE 267 REPLACED WITH MET
Descriptor: GROEL (HSP60 CLASS)
Authors:Buckle, A.M, Fersht, A.R.
Deposit date:1996-12-13
Release date:1997-09-17
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A structural model for GroEL-polypeptide recognition.
Proc.Natl.Acad.Sci.USA, 94, 1997
1KCQ
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BU of 1kcq by Molmil
Human Gelsolin Domain 2 with a Cd2+ bound
Descriptor: CADMIUM ION, GELSOLIN
Authors:Kazmirski, S.L, Isaacson, R.L, An, C, Buckle, A, Johnson, C.M, Daggett, V, Fersht, A.R.
Deposit date:2001-11-09
Release date:2002-01-04
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type.
Nat.Struct.Biol., 9, 2002
5AOJ
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BU of 5aoj by Molmil
Structure of the p53 cancer mutant Y220C in complex with 2-hydroxy-3, 5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid
Descriptor: 2-hydroxy-3,5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ...
Authors:Joerger, A.C, Baud, M.G, Bauer, M.R, Fersht, A.R.
Deposit date:2015-09-10
Release date:2015-12-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53.
Structure, 23, 2015
1SS1
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BU of 1ss1 by Molmil
STAPHYLOCOCCAL PROTEIN A, B-DOMAIN, Y15W MUTANT, NMR, 25 STRUCTURES
Descriptor: Immunoglobulin G binding protein A
Authors:Sato, S, Religa, T.L, Daggett, V, Fersht, A.R.
Deposit date:2004-03-23
Release date:2004-04-06
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:From The Cover: Testing protein-folding simulations by experiment: B domain of protein A.
Proc.Natl.Acad.Sci.USA, 101, 2004
2C6A
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BU of 2c6a by Molmil
Solution structure of the C4 zinc-finger domain of HDM2
Descriptor: UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION
Authors:Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M.
Deposit date:2005-11-08
Release date:2006-01-04
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution Structure of the C4 Zinc Finger Domain of Hdm2.
Protein Sci., 15, 2006
2C6B
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BU of 2c6b by Molmil
Solution structure of the C4 zinc-finger domain of HDM2
Descriptor: UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION
Authors:Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M.
Deposit date:2005-11-08
Release date:2006-01-04
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution Structure of the C4 Zinc Finger Domain of Hdm2.
Protein Sci., 15, 2006
2FEJ
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BU of 2fej by Molmil
Solution structure of human p53 DNA binding domain.
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Perez-Canadillas, J.M, Tidow, H, Freund, S.M, Rutherford, T.J, Ang, H.C, Fersht, A.R.
Deposit date:2005-12-16
Release date:2006-01-31
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of p53 core domain: Structural basis for its instability
Proc.Natl.Acad.Sci.Usa, 103, 2006
1W4G
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BU of 1w4g by Molmil
Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state folding transitions
Descriptor: DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE
Authors:Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R.
Deposit date:2004-07-23
Release date:2005-07-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family.
J.Mol.Biol., 353, 2005
1W4F
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BU of 1w4f by Molmil
Peripheral-subunit from mesophilic, thermophilic and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions
Descriptor: DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE
Authors:Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Fersht, A.R.
Deposit date:2004-07-23
Release date:2005-07-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family.
J.Mol.Biol., 353, 2005
1W4H
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BU of 1w4h by Molmil
Peripheral-subunit from mesophilic, thermophilic and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions
Descriptor: DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE
Authors:Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Fersht, A.R.
Deposit date:2004-07-23
Release date:2005-07-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family.
J.Mol.Biol., 353, 2005
1W4J
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BU of 1w4j by Molmil
Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions
Descriptor: PYRUVATE DEHYDROGENASE E2
Authors:Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R.
Deposit date:2004-07-23
Release date:2005-07-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family.
J. Mol. Biol., 353, 2005

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