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1B27
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STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
Descriptor:PROTEIN (BARNASE), PROTEIN (BARSTAR)
Authors:Vaughan, C.K., Buckle, A.M., Fersht, A.R.
Deposit date:1998-12-04
Release date:1998-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural response to mutation at a protein-protein interface.
J.Mol.Biol., 286, 1999
1B2S
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STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
Descriptor:PROTEIN (BARNASE), PROTEIN (BARSTAR), SULFATE ION
Authors:Vaughan, C.K., Buckle, A.M., Fersht, A.R.
Deposit date:1998-11-30
Release date:1998-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural response to mutation at a protein-protein interface.
J.Mol.Biol., 286, 1999
1B2U
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STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
Descriptor:PROTEIN (BARNASE), PROTEIN (BARSTAR)
Authors:Vaughan, C.K., Buckle, A.M., Fersht, A.R.
Deposit date:1998-12-01
Release date:1998-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural response to mutation at a protein-protein interface.
J.Mol.Biol., 286, 1999
1B3S
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STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
Descriptor:PROTEIN (BARNASE), PROTEIN (BARSTAR)
Authors:Vaughan, C.K., Buckle, A.M., Fersht, A.R.
Deposit date:1998-12-01
Release date:1998-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural response to mutation at a protein-protein interface.
J.Mol.Biol., 286, 1999
1BRS
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PROTEIN-PROTEIN RECOGNITION: CRYSTAL STRUCTURAL ANALYSIS OF A BARNASE-BARSTAR COMPLEX AT 2.0-A RESOLUTION
Descriptor:BARNASE, BARSTAR
Authors:Buckle, A.M., Schreiber, G., Fersht, A.R.
Deposit date:1994-03-11
Release date:1994-06-22
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Protein-protein recognition: crystal structural analysis of a barnase-barstar complex at 2.0-A resolution.
Biochemistry, 33, 1994
1CIQ
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COMPLEX OF TWO FRAGMENTS OF CI2, RESIDUES 1-40 AND 41-64
Descriptor:CHYMOTRYPSIN INHIBITOR 2
Authors:Buckle, A.M., Fersht, A.R.
Deposit date:1995-10-02
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2. Direct evidence for a nucleation-condensation mechanism
Structure Fold.Des., 1, 1996
1CIR
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COMPLEX OF TWO FRAGMENTS OF CI2 [(1-40)(DOT)(41-64)]
Descriptor:CHYMOTRYPSIN INHIBITOR 2
Authors:Davis, B.J., Fersht, A.R.
Deposit date:1995-10-02
Release date:1996-01-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2. Direct evidence for a nucleation-condensation mechanism
Structure Fold.Des., 1, 1996
2J1W
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HUMAN P53 CORE DOMAIN MUTANT M133L-V143A-V203A-N239Y-N268D
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J1X
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y220C-N239Y-N268D
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J1Y
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-G245S-N268D
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION, CALCIUM ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J1Z
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-F270L
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J20
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-R273C
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION, SULFATE ION
Authors:Joerger, A.C., Ang, H.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J21
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-R282W
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
1BAN
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THE CONTRIBUTION OF BURIED HYDROGEN BONDS TO PROTEIN STABILITY: THE CRYSTAL STRUCTURES OF TWO BARNASE MUTANTS
Descriptor:BARNASE
Authors:Chen, Y.W., Fersht, A.R., Henrick, K.
Deposit date:1993-05-19
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Contribution of buried hydrogen bonds to protein stability. The crystal structures of two barnase mutants.
J.Mol.Biol., 234, 1993
1BAO
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THE CONTRIBUTION OF BURIED HYDROGEN BONDS TO PROTEIN STABILITY: THE CRYSTAL STRUCTURES OF TWO BARNASE MUTANTS
Descriptor:BARNASE, ZINC ION
Authors:Chen, Y.W., Fersht, A.R., Henrick, K.
Deposit date:1993-05-19
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Contribution of buried hydrogen bonds to protein stability. The crystal structures of two barnase mutants.
J.Mol.Biol., 234, 1993
1BRG
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CRYSTALLOGRAPHIC ANALYSIS OF PHE->LEU SUBSTITUTION IN THE HYDROPHOBIC CORE OF BARNASE
Descriptor:BARNASE, ZINC ION
Authors:Chen, Y.W., Fersht, A.R., Henrick, K.
Deposit date:1994-03-30
Release date:1994-06-22
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystallographic analysis of Phe-->Leu substitution in the hydrophobic core of barnase.
Acta Crystallogr.,Sect.D, 51, 1995
1BSA
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CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE
Descriptor:BARNASE
Authors:Buckle, A.M., Henrick, K., Fersht, A.R.
Deposit date:1993-07-19
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1BSB
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CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE
Descriptor:BARNASE
Authors:Buckle, A.M., Henrick, K., Fersht, A.R.
Deposit date:1993-07-19
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1BSC
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CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE
Descriptor:BARNASE
Authors:Buckle, A.M., Henrick, K., Fersht, A.R.
Deposit date:1993-07-19
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1BSD
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CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE
Descriptor:BARNASE
Authors:Buckle, A.M., Henrick, K., Fersht, A.R.
Deposit date:1993-07-19
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1BSE
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CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE
Descriptor:BARNASE
Authors:Buckle, A.M., Henrick, K., Fersht, A.R.
Deposit date:1993-07-19
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
1FY9
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CRYSTAL STRUCTURE OF THE HEXA-SUBSTITUTED MUTANT OF THE MOLECULAR CHAPERONIN GROEL APICAL DOMAIN
Descriptor:60 KD CHAPERONIN, GLYCEROL
Authors:Wang, Q., Buckle, A.M., Fersht, A.R.
Deposit date:2000-09-28
Release date:2000-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Stabilization of GroEL minichaperones by core and surface mutations.
J.Mol.Biol., 298, 2000
1FYA
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CRYSTAL STRUCTURE OF THE HEXA-SUBSTITUTED MUTANT OF THE MOLECULAR CHAPERONIN GROEL APICAL DOMAIN
Descriptor:60 KD CHAPERONIN, GLYCEROL
Authors:Wang, Q., Buckle, A.M., Fersht, A.R.
Deposit date:2000-09-28
Release date:2000-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Stabilization of GroEL minichaperones by core and surface mutations.
J.Mol.Biol., 298, 2000
1UOL
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CRYSTAL STRUCTURE OF THE HUMAN P53 CORE DOMAIN MUTANT M133L/V203A/N239Y/N268D AT 1.9 A RESOLUTION.
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Allen, M.D., Fersht, A.R.
Deposit date:2003-09-19
Release date:2003-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of a Superstable Mutant of Human P53 Core Domain. Insights Into the Mechanism of Rescuing Oncogenic Mutations
J.Biol.Chem., 279, 2004
2BIM
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-R273H
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION, SULFATE ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2005-01-25
Release date:2005-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005