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1UR6
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BU of 1ur6 by Molmil
NMR based structural model of the UbcH5B-CNOT4 complex
Descriptor: POTENTIAL TRANSCRIPTIONAL REPRESSOR NOT4HP, UBIQUITIN-CONJUGATING ENZYME E2-17 KDA 2, ZINC ION
Authors:Dominguez, C, Bonvin, A.M.J.J, Winkler, G.S, Van Schaik, F.M.A, Timmers, H.Th.M, Boelens, R.
Deposit date:2003-10-27
Release date:2004-05-07
Last modified:2024-05-15
Method:SOLUTION NMR, THEORETICAL MODEL
Cite:Structural Model of the Ubch5B/Cnot4 Complex Revealed by Combining NMR, Mutagenesis, and Docking Approaches.
Structure, 12, 2004
2HGL
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BU of 2hgl by Molmil
NMR structure of the first qRRM domain of human hnRNP F
Descriptor: Heterogeneous nuclear ribonucleoprotein F
Authors:Dominguez, C, Allain, F.H.-T.
Deposit date:2006-06-27
Release date:2006-07-11
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.
Nucleic Acids Res., 34, 2006
2HGN
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BU of 2hgn by Molmil
NMR structure of the third qRRM domain of human hnRNP F
Descriptor: Heterogeneous nuclear ribonucleoprotein F
Authors:Dominguez, C, Allain, F.H.-T.
Deposit date:2006-06-27
Release date:2006-07-11
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.
Nucleic Acids Res., 34, 2006
2HGM
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BU of 2hgm by Molmil
NMR structure of the second qRRM domain of human hnRNP F
Descriptor: Heterogeneous nuclear ribonucleoprotein F
Authors:Dominguez, C, Allain, F.H.-T.
Deposit date:2006-06-27
Release date:2006-07-11
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.
Nucleic Acids Res., 34, 2006
5EL3
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BU of 5el3 by Molmil
Structure of the KH domain of T-STAR
Descriptor: KH domain-containing, RNA-binding, signal transduction-associated protein 3, ...
Authors:Dominguez, C, Feracci, M.
Deposit date:2015-11-04
Release date:2016-01-13
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nat Commun, 7, 2016
5ELS
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BU of 5els by Molmil
Structure of the KH domain of T-STAR in complex with AAAUAA RNA
Descriptor: KH domain-containing, RNA-binding, signal transduction-associated protein 3, ...
Authors:Dominguez, C, Feracci, M.
Deposit date:2015-11-05
Release date:2016-01-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.873 Å)
Cite:Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nat Commun, 7, 2016
5ELR
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BU of 5elr by Molmil
Structure of the KH-QUA2 domain of T-STAR in complex with AAUAAU RNA
Descriptor: KH domain-containing, RNA-binding, signal transduction-associated protein 3, ...
Authors:Dominguez, C, Feracci, M.
Deposit date:2015-11-05
Release date:2016-01-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nat Commun, 7, 2016
5ELT
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BU of 5elt by Molmil
Structure of the QUA1-KH domain of T-STAR in complex with UAAU RNA
Descriptor: KH domain-containing, RNA-binding, signal transduction-associated protein 3, ...
Authors:Dominguez, C, Feracci, M.
Deposit date:2015-11-05
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nat Commun, 7, 2016
5EMO
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BU of 5emo by Molmil
Structure of the star domain of T-STAR in complex with AUUAAA RNA
Descriptor: KH domain-containing, RNA-binding, signal transduction-associated protein 3, ...
Authors:Dominguez, C, Feracci, M.
Deposit date:2015-11-06
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nat Commun, 7, 2016
2KG1
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BU of 2kg1 by Molmil
Structure of the third qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA
Descriptor: 5'-R(*AP*GP*GP*GP*AP*U)-3', Heterogeneous nuclear ribonucleoprotein F
Authors:Allain, F.H.T, Dominguez, C.
Deposit date:2009-03-02
Release date:2010-06-09
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs.
Nat.Struct.Mol.Biol., 17, 2010
2KFY
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BU of 2kfy by Molmil
NMR structure of the first qRRM of hnRNP F in complex with AGGGAU G-tract RNA
Descriptor: 5'-R(*AP*GP*GP*GP*AP*U)-3', Heterogeneous nuclear ribonucleoprotein F
Authors:Allain, F.H.T, Dominguez, C.
Deposit date:2009-03-02
Release date:2010-06-09
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs.
Nat.Struct.Mol.Biol., 17, 2010
2KG0
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BU of 2kg0 by Molmil
Structure of the second qRRM domain of hnRNP F in complex with a AGGGAU G-tract RNA
Descriptor: 5'-R(*AP*GP*GP*GP*AP*U)-3', Heterogeneous nuclear ribonucleoprotein F
Authors:Allain, F.H.T, Dominguez, C.
Deposit date:2009-03-02
Release date:2010-06-09
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs.
Nat.Struct.Mol.Biol., 17, 2010
8AU4
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BU of 8au4 by Molmil
Structural insights reveal a heterotetramer between oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
Descriptor: Ral guanine nucleotide dissociation stimulator-like 2
Authors:Tariq, M, Ikeya, T, Togashi, N, Fairall, L, Alejo, C.B, Kamei, S, Alonso, B.R, Campillo, M.A.M, Hudson, A, Ito, Y, Schwabe, J, Dominguez, C, Tanaka, K.
Deposit date:2022-08-25
Release date:2023-08-23
Last modified:2023-10-25
Method:SOLUTION NMR
Cite:Structural insights into the complex of oncogenic KRas4B G12V and Rgl2, a RalA/B activator.
Life Sci Alliance, 7, 2024
8B69
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BU of 8b69 by Molmil
Heterotetramer of K-Ras4B(G12V) and Rgl2(RBD)
Descriptor: Isoform 2B of GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Tariq, M, Fairall, L, Romartinez-Alonso, B, Dominguez, C, Schwabe, J.W.R, Tanaka, K.
Deposit date:2022-09-26
Release date:2023-08-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Structural insights into the complex of oncogenic KRas4B G12V and Rgl2, a RalA/B activator.
Life Sci Alliance, 7, 2024
2LSU
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BU of 2lsu by Molmil
The NMR high resolution structure of yeast Tah1 in a free form
Descriptor: TPR repeat-containing protein associated with Hsp90
Authors:Back, R, Dominguez, C, Rothe, B, Bobo, C, Beaufils, C, Morera, S, Meyer, P, Charpentier, B, Branlant, C, Allain, F, Manival, X.
Deposit date:2012-05-07
Release date:2013-05-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:High-Resolution Structural Analysis Shows How Tah1 Tethers Hsp90 to the R2TP Complex.
Structure, 21, 2013
2KXN
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BU of 2kxn by Molmil
NMR structure of human Tra2beta1 RRM in complex with AAGAAC RNA
Descriptor: 5'-R(*AP*AP*GP*AP*AP*C)-3', Transformer-2 protein homolog beta
Authors:Clery, A, Jayne, S, Benderska, N, Dominguez, C, Stamm, S, Allain, F.H.-T.
Deposit date:2010-05-10
Release date:2011-03-16
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-beta1
Nat.Struct.Mol.Biol., 18, 2011
4CBY
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BU of 4cby by Molmil
Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease
Descriptor: (1R,2R,3R)-2-[4-(1,3-oxazol-5-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide, HISTONE DEACETYLASE 4, SODIUM ION, ...
Authors:Burli, R.W, Luckhurst, C.A, Aziz, O, Matthews, K.L, Yates, D, Lyons, K.A, Beconi, M, McAllister, G, Breccia, P, Stott, A.J, Penrose, S.D, Wall, M, Lamers, M, Leonard, P, Mueller, I, Richardson, C.M, Jarvis, R, Stones, L, Hughes, S, Wishart, G, Haughan, A.F, O'Connell, C, Mead, T, McNeil, H, Vann, J, Mangette, J, Maillard, M, Beaumont, V, Munoz-Sanjuan, I, Dominguez, C.
Deposit date:2013-10-17
Release date:2013-12-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
J. Med. Chem., 56, 2013
4CBT
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BU of 4cbt by Molmil
Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease
Descriptor: (1R,2R,3R)-2-[4-(5-fluoranylpyrimidin-2-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide, HISTONE DEACETYLASE 4, ZINC ION
Authors:Burli, R.W, Luckhurst, C.A, Aziz, O, Matthews, K.L, Yates, D, Lyons, K.A, Beconi, M, McAllister, G, Breccia, P, Stott, A.J, Penrose, S.D, Wall, M, Lamers, M, Leonard, P, Mueller, I, Richardson, C.M, Jarvis, R, Stones, L, Hughes, S, Wishart, G, Haughan, A.F, O'Connell, C, Mead, T, McNeil, H, Vann, J, Mangette, J, Maillard, M, Beaumont, V, Munoz-Sanjuan, I, Dominguez, C.
Deposit date:2013-10-16
Release date:2013-12-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
J. Med. Chem., 56, 2013
8R3E
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BU of 8r3e by Molmil
Huntingtin, 1-17, MBP-N
Descriptor: Maltodextrin-binding protein, ZINC ION
Authors:Steinbacher, S, Toledo-Sherman, L, Dominguez, C.
Deposit date:2023-11-08
Release date:2024-09-18
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Post-translational modifications in the first 17 amino acids of huntingtin influence self-association and interaction with membranes
To Be Published
2LSV
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BU of 2lsv by Molmil
The NMR high resolution structure of yeast Tah1 in complex with the Hsp90 C-terminal tail
Descriptor: ATP-dependent molecular chaperone HSP82, TPR repeat-containing protein associated with Hsp90
Authors:Back, R, Dominguez, C, Rothe, B, Bobo, C, Beaufils, C, Morera, S, Meyer, P, Charpentier, B, Branlant, C, Allain, F, Manival, X.
Deposit date:2012-05-07
Release date:2013-05-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:High-Resolution Structural Analysis Shows How Tah1 Tethers Hsp90 to the R2TP Complex.
Structure, 21, 2013
6FYZ
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BU of 6fyz by Molmil
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor
Descriptor: (2~{S})-2-(2-fluorophenyl)-2-[4-(2-methylpyrimidin-5-yl)phenyl]-~{N}-oxidanyl-ethanamide, Histone deacetylase 4, SODIUM ION, ...
Authors:Luckhurst, C.A, Maillard, M.C, Dominguez, C.
Deposit date:2018-03-13
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.
Bioorg. Med. Chem. Lett., 29, 2019
6SP4
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BU of 6sp4 by Molmil
KEAP1 IN COMPLEX WITH COMPOUND 23
Descriptor: (1~{S},2~{R})-2-[[(1~{S})-1-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]-5-(2-hydroxyethyloxy)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]cyclobutane-1-carboxamide, Kelch-like ECH-associated protein 1
Authors:Ontoria, J.M, Biancofiore, I, Fezzardi, P, Torrente de Haro, E, Colarusso, S, Bianchi, E, Andreini, M, Patsilinakos, A, Summa, V, Pacifici, R, Munoz-Sanjuan, I, Park, L, Bresciani, A, Dominguez, C, Toledo-Sherman, L, Harper, S.
Deposit date:2019-08-30
Release date:2020-06-03
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction.
Acs Med.Chem.Lett., 11, 2020
6SP1
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BU of 6sp1 by Molmil
KEAP1 IN COMPLEX WITH COMPOUND 6
Descriptor: (1~{S},2~{R})-2-[[(1~{S})-1-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]-5-(2-hydroxyethyloxy)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]cyclohexane-1-carboxylic acid, ACETATE ION, Kelch-like ECH-associated protein 1
Authors:Ontoria, J.M, Biancofiore, I, Fezzardi, P, Torrente de Haro, E, Colarusso, S, Bianchi, E, Andreini, M, Patsilinakos, A, Summa, V, Pacifici, R, Munoz-Sanjuan, I, Park, L, Bresciani, A, Dominguez, C, Toledo-Sherman, L, Harper, S.
Deposit date:2019-08-30
Release date:2020-06-03
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction.
Acs Med.Chem.Lett., 11, 2020
2MTV
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BU of 2mtv by Molmil
Solution Structure of the YTH Domain of YT521-B in complex with N6-Methyladenosine containing RNA
Descriptor: RNA_(5'-R(*UP*GP*(6MZ)P*CP*AP*C)-3'), YTH domain-containing protein 1
Authors:Theler, D, Dominguez, C, Blatter, M, Boudet, J, Allain, F.H.-T.
Deposit date:2014-09-01
Release date:2014-11-26
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA.
Nucleic Acids Res., 42, 2014
1W4U
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BU of 1w4u by Molmil
NMR solution structure of the ubiquitin conjugating enzyme UbcH5B
Descriptor: UBIQUITIN-CONJUGATING ENZYME E2-17 KDA 2
Authors:Houben, K, Dominguez, C, Van Schaik, F.M.A, Timmers, H.T.M, Bonvin, A.M.J.J, Boelens, R.
Deposit date:2004-07-29
Release date:2004-11-10
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution Structure of the Ubiquitin-Conjugating Enzyme Ubch5B
J.Mol.Biol., 344, 2004

 

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