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1JMS
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CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF MURINE TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE
Descriptor:TERMINAL DEOXYNUCLEOTIDYLTRANSFERASE, MAGNESIUM ION, SODIUM ION
Authors:Delarue, M., Boule, J.B., Lescar, J., Expert-Bezancon, N., Sukumar, N., Jourdan, N., Rougeon, F., Papanicolaou, C.
Deposit date:2001-07-19
Release date:2002-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase.
Embo J., 21, 2002
2J0E
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THREE DIMENSIONAL STRUCTURE AND CATALYTIC MECHANISM OF 6- PHOSPHOGLUCONOLACTONASE FROM TRYPANOSOMA BRUCEI
Descriptor:6-PHOSPHOGLUCONOLACTONASE, ZINC ION, MERCURY (II) ION, ...
Authors:Delarue, M., Duclert-Savatier, N., Miclet, E., Haouz, A., Giganti, D., Ouazzani, J., Lopez, P., Nilges, M., Stoven, V.
Deposit date:2006-08-02
Release date:2007-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Three Dimensional Structure and Implications for the Catalytic Mechanism of 6-Phosphogluconolactonase from Trypanosoma Brucei.
J.Mol.Biol., 366, 2007
1KDH
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BINARY COMPLEX OF MURINE TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE WITH A PRIMER SINGLE STRANDED DNA
Descriptor:5'-D(P*(BRU)P*(BRU)P*(BRU)P*(BRU))-3', Terminal deoxynucleotidyltransferase short isoform, MAGNESIUM ION, ...
Authors:Delarue, M., Boule, J.B., Lescar, J., Expert-Bezancon, N., Jourdan, N., Sukumar, N., Rougeon, F., Papanicolaou, C.
Deposit date:2001-11-13
Release date:2002-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase.
EMBO J., 21, 2002
1KEJ
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CRYSTAL STRUCTURE OF MURINE TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE COMPLEXED WITH DDATP
Descriptor:Terminal deoxynucleotidyltransferase short isoform, COBALT (II) ION, SODIUM ION, ...
Authors:Delarue, M., Boule, J.B., Lescar, J., Expert-Bezancon, N., Jourdan, N., Sukumar, N., Rougeon, F., Papanicolaou, C.
Deposit date:2001-11-16
Release date:2002-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase.
EMBO J., 21, 2002
1ATT
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CRYSTAL STRUCTURE OF CLEAVED BOVINE ANTITHROMBIN III AT 3.2 ANGSTROMS RESOLUTION
Descriptor:ANTITHROMBIN III
Authors:Mourey, L., Samama, J.P., Delarue, M., Moras, D.
Deposit date:1993-03-29
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of cleaved bovine antithrombin III at 3.2 A resolution.
J.Mol.Biol., 232, 1993
1N5I
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CRYSTAL STRUCTURE OF INACTIVE MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (TMP) AT PH 4.6 (RESOLUTION 1.85 A)
Descriptor:THYMIDYLATE KINASE, SULFATE ION, CITRATE ANION, ...
Authors:Fioravanti, E., Haouz, A., Ursby, T., Munier-Lehmann, H., Delarue, M., Bourgeois, D.
Deposit date:2002-11-06
Release date:2003-04-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 327, 2003
1N5J
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE DIPHOSPHATE (TDP) AND THYMIDINE TRIPHOSPHATE (TTP) AT PH 5.4 (1.85 A RESOLUTION)
Descriptor:THYMIDYLATE KINASE, SULFATE ION, MAGNESIUM ION, ...
Authors:Fioravanti, E., Haouz, A., Ursby, T., Munier-Lehmann, H., Delarue, M., Bourgeois, D.
Deposit date:2002-11-06
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 327, 2003
1N5K
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE CRYSTALLIZED IN SODIUM MALONATE (RESOLUTION 2.1 A)
Descriptor:THYMIDYLATE KINASE, ACETATE ION, THYMIDINE-5'-PHOSPHATE, ...
Authors:Fioravanti, E., Haouz, A., Ursby, T., Munier-Lehmann, H., Delarue, M., Bourgeois, D.
Deposit date:2002-11-06
Release date:2003-04-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 375, 2003
1N5L
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE CRYSTALLIZED IN SODIUM MALONATE, AFTER CATALYSIS IN THE CRYSTAL (2.3 A RESOLUTION)
Descriptor:THYMIDYLATE KINASE, ACETATE ION, THYMIDINE-5'-PHOSPHATE, ...
Authors:Fioravanti, E., Haouz, A., Ursby, T., Munier-Lehmann, H., Delarue, M., Bourgeois, D.
Deposit date:2002-11-06
Release date:2003-04-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 375, 2003
1GSI
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (TMP)
Descriptor:THYMIDYLATE KINASE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
Authors:Ursby, T., Weik, M., Fioravanti, E., Delarue, M., Goeldner, M., Bourgeois, D.
Deposit date:2002-01-03
Release date:2002-03-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Cryophotolysis of Caged Compounds: A Technique for Trapping Intermediate States in Protein Crystals
Acta Crystallogr.,Sect.D, 58, 2002
1GTV
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE-5'-DIPHOSPHATE (TDP)
Descriptor:THYMIDYLATE KINASE, MAGNESIUM ION, THYMIDINE-5'-DIPHOSPHATE, ...
Authors:Ursby, T., Weik, M., Fioravanti, E., Delarue, M., Goeldner, M., Bourgeois, D.
Deposit date:2002-01-21
Release date:2002-03-28
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Cryophotolysis of Caged Compounds: A Technique for Trapping Intermediate States in Protein Crystals
Acta Crystallogr.,Sect.D, 58, 2002
5L47
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X-RAY STRUCTURE OF THE 2-22' LOCALLY-CLOSED MUTANT OF GLIC IN COMPLEX WITH CYANOSELENOBARBITAL (SELENIATED BARBITURATE)
Descriptor:Proton-gated ion channel, CHLORIDE ION, ACETATE ION, ...
Authors:Reinholds Ruza, R., Fourati, Z., Delarue, M.
Deposit date:2016-05-25
Release date:2016-12-21
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.
J. Biol. Chem., 292, 2017
5L4E
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X-RAY STRUCTURE OF THE 2-22' LOCALLY-CLOSED MUTANT OF GLIC IN COMPLEX WITH THIOPENTAL
Descriptor:Proton-gated ion channel, DODECANE, CHLORIDE ION, ...
Authors:Fourati, Z., Ruza, R.R., Delarue, M.
Deposit date:2016-05-25
Release date:2016-12-21
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.
J. Biol. Chem., 292, 2017
5L4H
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X-RAY STRUCTURE OF THE 2-22' LOCALLY-CLOSED MUTANT OF GLIC IN COMPLEX WITH 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (BROMINATED BARBITURATE)
Descriptor:Proton-gated ion channel, CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Fourati, Z., Ruza, R.R., Delarue, M.
Deposit date:2016-05-25
Release date:2016-12-21
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.
J. Biol. Chem., 292, 2017
1G3U
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (TMP)
Descriptor:THYMIDYLATE KINASE, SULFATE ION, MAGNESIUM ION, ...
Authors:Li de la Sierra, I., Munier-Lehmann, H., Gilles, A.M., Barzu, O., Delarue, M.
Deposit date:2000-10-25
Release date:2001-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution.
J.Mol.Biol., 311, 2001
1EQR
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CRYSTAL STRUCTURE OF FREE ASPARTYL-TRNA SYNTHETASE FROM ESCHERICHIA COLI
Descriptor:ASPARTYL-TRNA SYNTHETASE, MAGNESIUM ION
Authors:Rees, B., Webster, G., Delarue, M., Boeglin, M., Moras, D.
Deposit date:2000-04-06
Release date:2000-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Aspartyl tRNA-synthetase from Escherichia coli: flexibility and adaptability to the substrates.
J.Mol.Biol., 299, 2000
1MRN
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH BISUBSTRATE INHIBITOR (TP5A)
Descriptor:Thymidylate Kinase, SULFATE ION, MAGNESIUM ION, ...
Authors:Haouz, A., Vanheusden, V., Munier-Lehmann, H., Froeyen, M., Herdewijn, P., Van Calenbergh, S., Delarue, M.
Deposit date:2002-09-18
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J.Biol.Chem., 278, 2003
3EAM
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AN OPEN-PORE STRUCTURE OF A BACTERIAL PENTAMERIC LIGAND-GATED ION CHANNEL
Descriptor:Glr4197 protein, DODECYL-BETA-D-MALTOSIDE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Authors:Bocquet, N., Nury, H., Baaden, M., Le Poupon, C., Changeux, J.P., Delarue, M., Corringer, P.J.
Deposit date:2008-08-26
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation.
Nature, 457, 2009
3FHJ
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INDEPENDENT SATURATION OF THREE TRPRS SUBSITES GENERATES A PARTIALLY-ASSEMBLED STATE SIMILAR TO THOSE OBSERVED IN MOLECULAR SIMULATIONS
Descriptor:Tryptophanyl-tRNA synthetase, TRYPTOPHAN, PHOSPHATE ION, ...
Authors:Laowanapiban, P., Kapustina, M., Vonrhein, C., Delarue, M., Koehl, P., Carter Jr., C.W.
Deposit date:2008-12-09
Release date:2009-02-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Independent saturation of three TrpRS subsites generates a partially assembled state similar to those observed in molecular simulations.
Proc.Natl.Acad.Sci.Usa, 106, 2009
3FI0
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CRYSTAL STRUCTURE ANALYSIS OF B. STEAROTHERMOPHILUS TRYPTOPHANYL-TRNA SYNTHETASE COMPLEXED WITH TRYPTOPHAN, AMP, AND INORGANIC PHOSPHATE
Descriptor:Tryptophanyl-tRNA synthetase, TRYPTOPHAN, PHOSPHATE ION, ...
Authors:Laowanapiban, P., Kapustina, M., Vonrhein, C., Delarue, M., Koehl, P., Carter Jr., C.W.
Deposit date:2008-12-10
Release date:2009-02-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Independent saturation of three TrpRS subsites generates a partially assembled state similar to those observed in molecular simulations.
Proc.Natl.Acad.Sci.Usa, 106, 2009
3P4W
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STRUCTURE OF DESFLURANE BOUND TO A PENTAMERIC LIGAND-GATED ION CHANNEL, GLIC
Descriptor:Glr4197 protein, DODECYL-BETA-D-MALTOSIDE, (2S)-2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane, ...
Authors:Nury, H., Van Renterghem, C., Weng, Y., Tran, A., Baaden, M., Dufresne, V., Changeux, J.P., Sonner, J.M., Delarue, M., Corringer, P.J.
Deposit date:2010-10-07
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
Nature, 469, 2011
3P50
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STRUCTURE OF PROPOFOL BOUND TO A PENTAMERIC LIGAND-GATED ION CHANNEL, GLIC
Descriptor:Glr4197 protein, DODECYL-BETA-D-MALTOSIDE, 2,6-BIS(1-METHYLETHYL)PHENOL, ...
Authors:Nury, H., Van Renterghem, C., Weng, Y., Tran, A., Baaden, M., Dufresne, V., Changeux, J.P., Sonner, J.M., Delarue, M., Corringer, P.J.
Deposit date:2010-10-07
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
Nature, 469, 2011
1G51
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ASPARTYL TRNA SYNTHETASE FROM THERMUS THERMOPHILUS AT 2.4 A RESOLUTION
Descriptor:ASPARTYL-TRNA SYNTHETASE, SULFATE ION, ASPARTYL-ADENOSINE-5'-MONOPHOSPHATE, ...
Authors:Poterzsman, A., Delarue, M., Thierry, J.C., Moras, D.
Deposit date:2000-10-30
Release date:2000-12-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Synthesis and recognition of aspartyl-adenylate by Thermus thermophilus aspartyl-tRNA synthetase.
J.Mol.Biol., 244, 1994
1PYS
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PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS
Descriptor:PHENYLALANYL-TRNA SYNTHETASE, MAGNESIUM ION
Authors:Safro, M., Mosyak, L., Goldgur, Y., Reshetnikova, L., Delarue, M.
Deposit date:1996-11-14
Release date:1997-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus.
Nat.Struct.Biol., 2, 1995
3E7F
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CRYSTAL STRUCTURE OF 6-PHOSPHOGLUCONOLACTONASE FROM TRYPANOSOMA BRUCEI COMPLEXED WITH 6-PHOSPHOGLUCONIC ACID
Descriptor:6-phosphogluconolactonase, ZINC ION, 6-PHOSPHOGLUCONIC ACID
Authors:Poggi, L., Delarue, M., Duclert-Savatier, N., Stoven, V.
Deposit date:2008-08-18
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation.
J.Mol.Biol., 388, 2009