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5WZZ
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THE SIAH E3 UBIQUITIN LIGASES PROMOTE WNT/ BETA-CATENIN SIGNALING THROUGH MEDIATING WNT-INDUCED AXIN DEGRADATION
Descriptor:E3 ubiquitin-protein ligase SIAH1, Axin-1, ZINC ION
Authors:Ji, L., Jiang, B., Jiang, X., Charlat, O., Chen, A., Mickanin, C., Bauer, A., Xu, W., Yan, X.-X., Cong, F.
Deposit date:2017-01-19
Release date:2017-08-16
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation
Genes Dev., 31, 2017
3UDD
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TANKYRASE-1 IN COMPLEX WITH SMALL MOLECULE INHIBITOR
Descriptor:Tankyrase-1, ZINC ION, 3-(4-methoxyphenyl)-5-({[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)-1,2,4-oxadiazole, ...
Authors:Kirby, C.A., Stams, T.
Deposit date:2011-10-28
Release date:2012-02-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.
J.Med.Chem., 55, 2012
3UTM
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CRYSTAL STRUCTURE OF A MOUSE TANKYRASE-AXIN COMPLEX
Descriptor:Tankyrase-1, Axin-1
Authors:Cheng, Z., Morrone, S., Xu, W.
Deposit date:2011-11-26
Release date:2012-01-18
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment.
Proc.Natl.Acad.Sci.USA, 109, 2012
3V3L
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CRYSTAL STRUCTURE OF HUMAN RNF146 WWE DOMAIN IN COMPLEX WITH ISO-ADPRIBOSE
Descriptor:E3 ubiquitin-protein ligase RNF146, 2'-O-(5-O-phosphono-alpha-D-ribofuranosyl)adenosine 5'-(dihydrogen phosphate)
Authors:Wang, Z., Cheng, Z., Xu, W.
Deposit date:2011-12-13
Release date:2012-02-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination.
Genes Dev., 26, 2012
4QPL
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CRYSTAL STRUCTURE OF RNF146(RING-WWE)/UBCH5A/ISO-ADPR COMPLEX
Descriptor:E3 ubiquitin-protein ligase RNF146, Ubiquitin-conjugating enzyme E2 D1, 2'-O-(5-O-phosphono-alpha-D-ribofuranosyl)adenosine 5'-(dihydrogen phosphate), ...
Authors:Wang, Z., DaRosa, P.A., Klevit, R.E., Xu, W.
Deposit date:2014-06-23
Release date:2014-10-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
Nature, 517, 2015