Author results

2J9F
  • Download 2j9f
  • View 2j9f
Molmil generated image of 2j9f
HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE-DECARBOXYLASE E1B
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, MANGANESE (II) ION, ...
Authors:Jun, L., Machius, M., Chuang, J.L., Wynn, R.M., Chuang, D.T.
Deposit date:2006-11-07
Release date:2007-02-27
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:The Two Active Sites in Human Branched-Chain Alpha- Keto Acid Dehydrogenase Operate Independently without an Obligatory Alternating-Site Mechanism.
J.Biol.Chem., 282, 2007
1V11
  • Download 1v11
  • View 1v11
Molmil generated image of 1v11
CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ...
Authors:Li, J., Wynn, R.M., Machius, M., Chuang, J.L., Karthikeyan, S., Tomchick, D.R., Chuang, D.T.
Deposit date:2004-04-05
Release date:2004-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain {Alpha}-Keto Acid Decarboxylase/Dehydrogenase
J.Biol.Chem., 279, 2004
1V16
  • Download 1v16
  • View 1v16
Molmil generated image of 1v16
CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ...
Authors:Li, J., Wynn, R.M., Machius, M., Chuang, J.L., Karthikeyan, S., Tomchick, D.R., Chuang, D.T.
Deposit date:2004-04-07
Release date:2004-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain {Alpha}-Keto Acid Decarboxylase/Dehydrogenase
J.Biol.Chem., 279, 2004
1V1M
  • Download 1v1m
  • View 1v1m
Molmil generated image of 1v1m
CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, THIAMIN DIPHOSPHATE, ...
Authors:Li, J., Wynn, R.M., Machius, M., Chuang, J.L., Karthikeyan, S., Tomchick, D.R., Chuang, D.T.
Deposit date:2004-04-20
Release date:2004-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain Alpha-Keto Acid Decarboxylase/Dehydrogenase.
J.Biol.Chem., 279, 2004
1V1R
  • Download 1v1r
  • View 1v1r
Molmil generated image of 1v1r
CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, CHLORIDE ION, ...
Authors:Li, J., Wynn, R.M., Machius, M., Chuang, J.L., Karthikeyan, S., Tomchick, D.R., Chuang, D.T.
Deposit date:2004-04-22
Release date:2004-06-03
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain {Alpha}-Keto Acid Decarboxylase/Dehydrogenase
J.Biol.Chem., 279, 2004
1WCI
  • Download 1wci
  • View 1wci
Molmil generated image of 1wci
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, CHLORIDE ION, ...
Authors:Machius, M., Wynn, R.M., Chuang, J.L., Tomchick, D.R., Brautigam, C.A., Chuang, D.T.
Deposit date:2004-11-16
Release date:2006-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
Structure, 14, 2006
2BEU
  • Download 2beu
  • View 2beu
Molmil generated image of 2beu
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, PEPTIDE ALA-TYR-ARG, ...
Authors:Machius, M., Wynn, R.M., Chuang, J.L., Tomchick, D.R., Brautigam, C.A., Chuang, D.T.
Deposit date:2004-11-30
Release date:2006-02-16
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
Structure, 14, 2006
2BEV
  • Download 2bev
  • View 2bev
Molmil generated image of 2bev
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, PEPTIDE ALA-TYR-ARG, ...
Authors:Machius, M., Wynn, R.M., Chuang, J.L., Tomchick, D.R., Brautigam, C.A., Chuang, D.T.
Deposit date:2004-11-30
Release date:2006-02-16
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
Structure, 14, 2006
2BEW
  • Download 2bew
  • View 2bew
Molmil generated image of 2bew
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, PEPTIDE ALA-TYR-ARG, ...
Authors:Machius, M., Wynn, R.M., Chuang, J.L., Tomchick, D.R., Brautigam, C.A., Chuang, D.T.
Deposit date:2004-11-30
Release date:2006-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
Structure, 14, 2006
2BFB
  • Download 2bfb
  • View 2bfb
Molmil generated image of 2bfb
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ...
Authors:Machius, M., Wynn, R.M., Chuang, J.L., Tomchick, D.R., Brautigam, C.A., Chuang, D.T.
Deposit date:2004-12-06
Release date:2006-02-16
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
Structure, 14, 2006
2BFC
  • Download 2bfc
  • View 2bfc
Molmil generated image of 2bfc
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ...
Authors:Machius, M., Wynn, R.M., Chuang, J.L., Tomchick, D.R., Brautigam, C.A., Chuang, D.T.
Deposit date:2004-12-06
Release date:2006-02-16
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
Structure, 14, 2006
2BFD
  • Download 2bfd
  • View 2bfd
Molmil generated image of 2bfd
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ...
Authors:Machius, M., Wynn, R.M., Chuang, J.L., Tomchick, D.R., Brautigam, C.A., Chuang, D.T.
Deposit date:2004-12-06
Release date:2006-02-16
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
Structure, 14, 2006
2BFE
  • Download 2bfe
  • View 2bfe
Molmil generated image of 2bfe
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ...
Authors:Machius, M., Wynn, R.M., Chuang, J.L., Tomchick, D.R., Brautigam, C.A., Chuang, D.T.
Deposit date:2004-12-06
Release date:2006-02-16
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
Structure, 14, 2006
2BFF
  • Download 2bff
  • View 2bff
Molmil generated image of 2bff
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Machius, M., Wynn, R.M., Chuang, J.L., Tomchick, D.R., Brautigam, C.A., Chuang, D.T.
Deposit date:2004-12-06
Release date:2006-02-16
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
Structure, 14, 2006
1OLS
  • Download 1ols
  • View 1ols
Molmil generated image of 1ols
ROLES OF HIS291-ALPHA AND HIS146-BETA' IN THE REDUCTIVE ACYLATION REACTION CATALYZED BY HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ...
Authors:Wynn, R.M., Machius, M., Chuang, J.L., Li, J., Tomchick, D.R., Chuang, D.T.
Deposit date:2003-08-12
Release date:2003-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site.
J.Biol.Chem., 278, 2003
1OLU
  • Download 1olu
  • View 1olu
Molmil generated image of 1olu
ROLES OF HIS291-ALPHA AND HIS146-BETA' IN THE REDUCTIVE ACYLATION REACTION CATALYZED BY HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ...
Authors:Wynn, R.M., Machius, M., Chuang, J.L., Li, J., Tomchick, D.R., Chuang, D.T.
Deposit date:2003-08-15
Release date:2003-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site.
J.Biol.Chem., 278, 2003
1OLX
  • Download 1olx
  • View 1olx
Molmil generated image of 1olx
ROLES OF HIS291-ALPHA AND HIS146-BETA' IN THE REDUCTIVE ACYLATION REACTION CATALYZED BY HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE
Descriptor:2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ...
Authors:Wynn, R.M., Machius, M., Chuang, J.L., Li, J., Tomchick, D.R., Chuang, D.T.
Deposit date:2003-08-18
Release date:2003-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site.
J.Biol.Chem., 278, 2003
1U5B
  • Download 1u5b
  • View 1u5b
Molmil generated image of 1u5b
CRYSTAL STRUCTURE OF THE HUMAN MITOCHONDRIAL BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE
Descriptor:2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, POTASSIUM ION, ...
Authors:Wynn, R.M., Kato, M., Machius, M., Chuang, J.L., Li, J., Tomchick, D.R., Chuang, D.T.
Deposit date:2004-07-27
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation
Structure, 12, 2004
1X7W
  • Download 1x7w
  • View 1x7w
Molmil generated image of 1x7w
CRYSTAL STRUCTURE OF THE HUMAN MITOCHONDRIAL BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE
Descriptor:2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, POTASSIUM ION, ...
Authors:Wynn, R.M., Kato, M., Machius, M., Chuang, J.L., Li, J., Tomchick, D.R., Chuang, D.T.
Deposit date:2004-08-16
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation
Structure, 12, 2004
1X7X
  • Download 1x7x
  • View 1x7x
Molmil generated image of 1x7x
CRYSTAL STRUCTURE OF THE HUMAN MITOCHONDRIAL BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE
Descriptor:2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, POTASSIUM ION, ...
Authors:Wynn, R.M., Kato, M., Machius, M., Chuang, J.L., Li, J., Tomchick, D.R., Chuang, D.T.
Deposit date:2004-08-16
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation
Structure, 12, 2004
1X7Y
  • Download 1x7y
  • View 1x7y
Molmil generated image of 1x7y
CRYSTAL STRUCTURE OF THE HUMAN MITOCHONDRIAL BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE
Descriptor:2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, POTASSIUM ION, ...
Authors:Wynn, R.M., Kato, M., Machius, M., Chuang, J.L., Li, J., Tomchick, D.R., Chuang, D.T.
Deposit date:2004-08-16
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation
Structure, 12, 2004
1X7Z
  • Download 1x7z
  • View 1x7z
Molmil generated image of 1x7z
CRYSTAL STRUCTURE OF THE HUMAN MITOCHONDRIAL BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE
Descriptor:2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, POTASSIUM ION, ...
Authors:Wynn, R.M., Kato, M., Machius, M., Chuang, J.L., Li, J., Tomchick, D.R., Chuang, D.T.
Deposit date:2004-08-16
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation
Structure, 12, 2004
1X80
  • Download 1x80
  • View 1x80
Molmil generated image of 1x80
CRYSTAL STRUCTURE OF THE HUMAN MITOCHONDRIAL BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE
Descriptor:2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, POTASSIUM ION, ...
Authors:Wynn, R.M., Kato, M., Machius, M., Chuang, J.L., Li, J., Tomchick, D.R., Chuang, D.T.
Deposit date:2004-08-16
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation
Structure, 12, 2004
5J6A
  • Download 5j6a
  • View 5j6a
Molmil generated image of 5j6a
CRYSTAL STRUCTURE OF PYRUVATE DEHYDROGENASE KINASE ISOFORM 2 IN COMPLEX WITH INHIBITOR PS46
Descriptor:[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, (3S)-3-amino-4-[4-({2-[(2,4-dihydroxyphenyl)sulfonyl]-2H-isoindol-5-yl}amino)piperidin-1-yl]-4-oxobutanamide
Authors:Gui, W.J., Tso, S.C., Chuang, J.L., Wu, C.Y., Qi, X., Wynn, R.M., Chuang, D.T.
Deposit date:2016-04-04
Release date:2017-01-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.045 Å)
Cite:Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.
J. Med. Chem., 60, 2017
1DTW
  • Download 1dtw
  • View 1dtw
Molmil generated image of 1dtw
HUMAN BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE
Descriptor:BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE ALPHA SUBUNIT, BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE BETA SUBUNIT, MAGNESIUM ION, ...
Authors:AEvarsson, A., Chuang, J.L., Wynn, R.M., Turley, S., Chuang, D.T., Hol, W.G.J.
Deposit date:2000-01-13
Release date:2000-03-27
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease.
Structure Fold.Des., 8, 2000
<123>