6R99 | | CRYSTAL STRUCTURE OF HUMAN CLN PROTEIN 5 (CEROID LIPOFUSCINOSIS NEURONAL PROTEIN 5) | | Descriptor: | Ceroid-lipofuscinosis neuronal protein 5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Luebben, A.V., Sheldrick, G.M. | | Deposit date: | 2019-04-03 | | Release date: | 2020-04-22 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The CLN5 structure reveals a lysosomal protease with important role in neurodegeneration
To Be Published
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6Y2E | |
6Y2F | | CRYSTAL STRUCTURE (MONOCLINIC FORM) OF THE COMPLEX RESULTING FROM THE REACTION BETWEEN SARS-COV-2 (2019-NCOV) MAIN PROTEASE AND TERT-BUTYL (1-((S)-1-(((S)-4-(BENZYLAMINO)-3,4-DIOXO-1-((S)-2-OXOPYRROLIDIN-3-YL)BUTAN-2-YL)AMINO)-3-CYCLOPROPYL-1-OXOPROPAN-2-YL)-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)CARBAMATE (ALPHA-KETOAMIDE 13B) | | Descriptor: | Replicase polyprotein 1ab, DIMETHYL SULFOXIDE, ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate | | Authors: | Zhang, L., Lin, D., Sun, X., Hilgenfeld, R. | | Deposit date: | 2020-02-15 | | Release date: | 2020-03-04 | | Last modified: | 2020-05-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors.
Science, 368, 2020
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6Y2G | | CRYSTAL STRUCTURE (ORTHORHOMBIC FORM) OF THE COMPLEX RESULTING FROM THE REACTION BETWEEN SARS-COV-2 (2019-NCOV) MAIN PROTEASE AND TERT-BUTYL (1-((S)-1-(((S)-4-(BENZYLAMINO)-3,4-DIOXO-1-((S)-2-OXOPYRROLIDIN-3-YL)BUTAN-2-YL)AMINO)-3-CYCLOPROPYL-1-OXOPROPAN-2-YL)-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)CARBAMATE (ALPHA-KETOAMIDE 13B) | | Descriptor: | Replicase polyprotein 1ab, GLYCINE, ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate | | Authors: | Zhang, L., Lin, D., Sun, X., Hilgenfeld, R. | | Deposit date: | 2020-02-15 | | Release date: | 2020-03-04 | | Last modified: | 2020-05-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors.
Science, 368, 2020
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6I42 | |
6V5D | | EROS3 RDC AND NOE DERIVED UBIQUITIN ENSEMBLE | | Descriptor: | Ubiquitin | | Authors: | Lange, O.F., Lakomek, N.A., Smith, C.A., Griesinger, C., de Groot, B.L. | | Deposit date: | 2019-12-04 | | Release date: | 2020-01-01 | | Last modified: | 2020-02-26 | | Method: | SOLUTION NMR | | Cite: | Enhancing NMR derived ensembles with kinetics on multiple timescales.
J.Biomol.Nmr, 74, 2020
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6QCU | |
6QD7 | | EM STRUCTURE OF A EBOV-GP BOUND TO 3T0331 NEUTRALIZING ANTIBODY | | Descriptor: | Light chain, Heavy chain, Envelope glycoprotein,Virion spike glycoprotein,EBOV-GP1, ... | | Authors: | Diskin, R., Cohen-Dvashi, H. | | Deposit date: | 2019-01-01 | | Release date: | 2019-10-02 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV.
Nat. Med., 25, 2019
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6QD8 | | EM STRUCTURE OF A EBOV-GP BOUND TO 4M0368 NEUTRALIZING ANTIBODY | | Descriptor: | Light chain, Envelope glycoprotein,Virion spike glycoprotein,EBOV-GP1, Envelope glycoprotein, ... | | Authors: | Diskin, R., Cohen-Dvashi, H. | | Deposit date: | 2019-01-01 | | Release date: | 2019-10-02 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | rVSV-ZEBOV induces a polyclonal and convergent B cell response with potent Ebola virus-neutralizing antibodies
Nat.Med. (N.Y.), 2019
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6GEL | | THE STRUCTURE OF TWITCH-2B | | Descriptor: | Green fluorescent protein,Optimized Ratiometric Calcium Sensor,Green fluorescent protein,Green fluorescent protein, CALCIUM ION, GLYCEROL, ... | | Authors: | Trigo Mourino, P., Paulat, M., Thestrup, T., Griesbeck, O., Griesinger, C., Becker, S. | | Deposit date: | 2018-04-26 | | Release date: | 2019-08-21 | | Last modified: | 2019-09-11 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Dynamic tuning of FRET in a green fluorescent protein biosensor.
Sci Adv, 5, 2019
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6GEZ | | THE STRUCTURE OF TWITCH-2B N532F | | Descriptor: | Green fluorescent protein,Optimized Ratiometric Calcium Sensor,Green fluorescent protein,Green fluorescent protein, CALCIUM ION, FORMIC ACID | | Authors: | Trigo Mourino, P., Paulat, M., Thestrup, T., Griesbeck, O., Griesinger, C., Becker, S. | | Deposit date: | 2018-04-27 | | Release date: | 2019-08-21 | | Last modified: | 2019-09-11 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Dynamic tuning of FRET in a green fluorescent protein biosensor.
Sci Adv, 5, 2019
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6FCG | |
5NWX | | INSIGHT INTO THE MOLECULAR RECOGNITION MECHANISM OF THE COACTIVATOR NCOA1 BY STAT6 | | Descriptor: | Nuclear receptor coactivator 1, Signal transducer and activator of transcription 6 | | Authors: | Russo, L., Giller, K., Pfitzner, E., Griesinger, C., Becker, S. | | Deposit date: | 2017-05-08 | | Release date: | 2017-12-13 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6.
Sci Rep, 7, 2017
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5NWM | |
6EHL | | MODEL OF THE EBOLA VIRUS NUCLEOPROTEIN IN RECOMBINANT NUCLEOCAPSID-LIKE ASSEMBLIES | | Descriptor: | Nucleoprotein | | Authors: | Wan, W., Kolesnikova, L., Clarke, M., Koehler, A., Noda, T., Becker, S., Briggs, J.A.G. | | Deposit date: | 2017-09-13 | | Release date: | 2017-11-08 | | Last modified: | 2019-12-04 | | Method: | ELECTRON MICROSCOPY (6.6 Å) | | Cite: | Structure and assembly of the Ebola virus nucleocapsid.
Nature, 551, 2017
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6EHM | | MODEL OF THE EBOLA VIRUS NUCLEOCAPSID SUBUNIT FROM RECOMBINANT VIRUS-LIKE PARTICLES | | Descriptor: | Nucleoprotein, Membrane-associated protein VP24 | | Authors: | Wan, W., Kolesnikova, L., Clarke, M., Koehler, A., Noda, T., Becker, S., Briggs, J.A.G. | | Deposit date: | 2017-09-13 | | Release date: | 2017-11-08 | | Last modified: | 2019-12-04 | | Method: | ELECTRON MICROSCOPY (7.3 Å) | | Cite: | Structure and assembly of the Ebola virus nucleocapsid.
Nature, 551, 2017
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5FQ1 | |
5JDP | | E73V MUTANT OF THE HUMAN VOLTAGE-DEPENDENT ANION CHANNEL | | Descriptor: | Voltage-dependent anion-selective channel protein 1 | | Authors: | Jaremko, M., Jaremko, L., Villinger, S., Schmidt, C., Giller, K., Griesinger, C., Becker, S., Zweckstetter, M. | | Deposit date: | 2016-04-17 | | Release date: | 2016-08-10 | | Last modified: | 2019-05-08 | | Method: | SOLUTION NMR | | Cite: | High-Resolution NMR Determination of the Dynamic Structure of Membrane Proteins.
Angew.Chem.Int.Ed.Engl., 55, 2016
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2N64 | |
5ABS | | CRYSTAL STRUCTURE OF THE C-TERMINAL COILED-COIL DOMAIN OF CIN85 IN SPACE GROUP P321 | | Descriptor: | SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1, ZINC ION | | Authors: | Wong, L., Habeck, M., Griesinger, C., Becker, S. | | Deposit date: | 2015-08-07 | | Release date: | 2016-07-13 | | Last modified: | 2019-02-06 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | The Adaptor Protein Cin85 Assembles Intracellular Signaling Clusters for B Cell Activation.
Sci.Signal., 9, 2016
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5C58 | |
4ZG4 | | MYOSIN VC PRE-POWERSTROKE | | Descriptor: | myosin-Vc, MAGNESIUM ION, VANADATE ION, ... | | Authors: | Ropars, V., Pylypenko, O., Sweeney, L., Houdusse, A. | | Deposit date: | 2015-04-22 | | Release date: | 2016-03-23 | | Last modified: | 2017-09-06 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Force-producing ADP state of myosin bound to actin.
Proc.Natl.Acad.Sci.USA, 113, 2016
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2N3D | | ATOMIC STRUCTURE OF THE CYTOSKELETAL BACTOFILIN BACA REVEALED BY SOLID-STATE NMR | | Descriptor: | Bactofilin A | | Authors: | Shi, C., Fricke, P., Lin, L., Chevelkov, V., Wegstroth, M., Giller, K., Becker, S., Thanbichler, M., Lange, A. | | Deposit date: | 2015-05-29 | | Release date: | 2015-12-16 | | Last modified: | 2016-02-03 | | Method: | SOLID-STATE NMR | | Cite: | Atomic-resolution structure of cytoskeletal bactofilin by solid-state NMR.
Sci Adv, 1, 2015
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2N7H | | HYBRID STRUCTURE OF THE TYPE 1 PILUS OF UROPATHOGENIC E.COLI | | Descriptor: | FimA | | Authors: | Habenstein, B., Loquet, A., Giller, K., Vasa, S., Becker, S., Habeck, M., Lange, A. | | Deposit date: | 2015-09-11 | | Release date: | 2015-09-23 | | Last modified: | 2015-10-14 | | Method: | SOLID-STATE NMR | | Cite: | Hybrid Structure of the Type 1 Pilus of Uropathogenic Escherichia coli.
Angew.Chem.Int.Ed.Engl., 54, 2015
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2MY2 | |
