Author results

2NOX
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CRYSTAL STRUCTURE OF TRYPTOPHAN 2,3-DIOXYGENASE FROM RALSTONIA METALLIDURANS
Descriptor:Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Zhang, Y., Kang, S.A., Mukherjee, T., Bale, S., Crane, B.R., Begley, T.P., Ealick, S.E.
Deposit date:2006-10-26
Release date:2006-12-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis.
Biochemistry, 46, 2007
2QRY
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PERIPLASMIC THIAMIN BINDING PROTEIN
Descriptor:Thiamine-binding periplasmic protein, THIAMIN PHOSPHATE
Authors:Ealick, S.E., Soriano, E.V.
Deposit date:2007-07-30
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Similarities between Thiamin-Binding Protein and Thiaminase-I Suggest a Common Ancestor
Biochemistry, 47, 2008
3EP3
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HUMAN ADOMETDC D174N MUTANT WITH NO PUTRESCINE BOUND
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, PYRUVIC ACID, ...
Authors:Bale, S., Lopez, M.M., Makhatadze, G.I., Fang, Q., Pegg, A.E., Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-12-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47, 2008
3EP4
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HUMAN ADOMETDC E256Q MUTANT WITH NO PUTRESCINE BOUND
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, PYRUVIC ACID, ...
Authors:Bale, S., Lopez, M.M., Makhatadze, G.I., Fang, Q., Pegg, A.E., Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-12-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47, 2008
3EP5
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HUMAN ADOMETDC E178Q MUTANT WITH NO PUTRESCINE BOUND
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, PYRUVIC ACID, ...
Authors:Bale, S., Lopez, M.M., Makhatadze, G.I., Fang, Q., Pegg, A.E., Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-12-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47, 2008
3EP6
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HUMAN ADOMETDC D174N MUTANT COMPLEXED WITH S-ADENOSYLMETHIONINE METHYL ESTER AND NO PUTRESCINE BOUND
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, PYRUVIC ACID, ...
Authors:Bale, S., Lopez, M.M., Makhatadze, G.I., Fang, Q., Pegg, A.E., Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-12-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47, 2008
3EP7
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HUMAN ADOMETDC E256Q MUTANT COMPLEXED WITH S-ADENOSYLMETHIONINE METHYL ESTER AND NO PUTRESCINE BOUND
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, PYRUVIC ACID, ...
Authors:Bale, S., Lopez, M.M., Makhatadze, G.I., Fang, Q., Pegg, A.E., Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-12-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47, 2008
3EP8
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HUMAN ADOMETDC E178Q MUTANT COMPLEXED WITH S-ADENOSYLMETHIONINE METHYL ESTER AND NO PUTRESCINE BOUND
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, PYRUVIC ACID, ...
Authors:Bale, S., Lopez, M.M., Makhatadze, G.I., Fang, Q., Pegg, A.E., Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-12-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47, 2008
3EP9
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HUMAN ADOMETDC WITH NO PUTRESCINE BOUND
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, PYRUVIC ACID, ...
Authors:Bale, S., Lopez, M.M., Makhatadze, G.I., Fang, Q., Pegg, A.E., Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-12-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47, 2008
3EPA
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HUMAN ADOMETDC E178Q MUTANT COMPLEXED WITH PUTRESCINE
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Bale, S., Lopez, M.M., Makhatadze, G.I., Fang, Q., Pegg, A.E., Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-12-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47, 2008
3EPB
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HUMAN ADOMETDC E256Q MUTANT COMPLEXED WITH PUTRESCINE
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, 1,4-DIAMINOBUTANE, ...
Authors:Bale, S., Lopez, M.M., Makhatadze, G.I., Fang, Q., Pegg, A.E., Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-12-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47, 2008
3DZ2
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HUMAN ADOMETDC WITH 5'-[(3-AMINOPROPYL)METHYLAMINO]-5'DEOXY-8-METHYLADENOSINE
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, 1,4-DIAMINOBUTANE, ...
Authors:Bale, S., McCloskey, D.E., Pegg, A.E., Secrist III, J.A., Guida, W.C., Ealick, S.E.
Deposit date:2008-07-29
Release date:2009-03-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine
J.Med.Chem., 52, 2009
3DZ3
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HUMAN ADOMETDC F223A MUTANT WITH COVALENTLY BOUND S-ADENOSYLMETHIONINE METHYL ESTER
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, 1,4-DIAMINOBUTANE, ...
Authors:Bale, S., McCloskey, D.E., Pegg, A.E., Secrist III, J.A., Guida, W.C., Ealick, S.E.
Deposit date:2008-07-29
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine
J.Med.Chem., 52, 2009
3DZ4
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HUMAN ADOMETDC WITH 5'-[(2-CARBOXAMIDOETHYL)METHYLAMINO]-5'-DEOXY-8-METHYLADENOSINE
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, 1,4-DIAMINOBUTANE, ...
Authors:Bale, S., McCloskey, D.E., Pegg, A.E., Secrist III, J.A., Guida, W.C., Ealick, S.E.
Deposit date:2008-07-29
Release date:2009-03-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine
J.Med.Chem., 52, 2009
3DZ5
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HUMAN ADOMETDC WITH COVALENTLY BOUND 5'-[(2-AMINOOXYETHYL)METHYLAMINO]-5'-DEOXY-8-METHYLADENOSINE
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, 1,4-DIAMINOBUTANE, ...
Authors:Bale, S., McCloskey, D.E., Pegg, A.E., Secrist III, J.A., Guida, W.C., Ealick, S.E.
Deposit date:2008-07-29
Release date:2009-03-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine
J.Med.Chem., 52, 2009
3DZ6
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HUMAN ADOMETDC WITH 5'-[(4-AMINOOXYBUTYL)METHYLAMINO]-5'DEOXY-8-ETHYLADENOSINE
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, 1,4-DIAMINOBUTANE, ...
Authors:Bale, S., McCloskey, D.E., Pegg, A.E., Secrist III, J.A., Guida, W.C., Ealick, S.E.
Deposit date:2008-07-29
Release date:2009-03-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine
J.Med.Chem., 52, 2009
3DZ7
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HUMAN ADOMETDC WITH 5'-[(CARBOXAMIDOMETHYL)METHYLAMINO]-5'-DEOXY-8-METHYLADENOSINE
Descriptor:S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, 1,4-DIAMINOBUTANE, ...
Authors:Bale, S., McCloskey, D.E., Pegg, A.E., Secrist III, J.A., Guida, W.C., Ealick, S.E.
Deposit date:2008-07-29
Release date:2009-03-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine
J.Med.Chem., 52, 2009
3H0V
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HUMAN ADOMETDC WITH 5'-DEOXY-5'-(DIMETHYLSULFONIO) ADENOSINE
Descriptor:S-adenosylmethionine decarboxylase proenzyme, 1,4-DIAMINOBUTANE, 5'-deoxy-5'-(dimethyl-lambda~4~-sulfanyl)adenosine, ...
Authors:Bale, S., Brooks, W.H., Hanes, J.W., Mahesan, A.M., Guida, W.C., Ealick, S.E.
Deposit date:2009-04-10
Release date:2009-06-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.
Biochemistry, 48, 2009
3H0W
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HUMAN ADOMETDC WITH 5'-DEOXY-5'-[(N-DIMETHYL)AMINO]-8-METHYL-ADENOSINE
Descriptor:S-adenosylmethionine decarboxylase proenzyme, 1,4-DIAMINOBUTANE, 5'-deoxy-5'-(dimethylamino)-8-methyladenosine, ...
Authors:Bale, S., Brooks, W.H., Hanes, J.W., Mahesan, A.M., Guida, W.C., Ealick, S.E.
Deposit date:2009-04-10
Release date:2009-06-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.
Biochemistry, 48, 2009
3FPZ
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SACCHAROMYCES CEREVISIAE THI4P IS A SUICIDE THIAMIN THIAZOLE SYNTHASE
Descriptor:Thiazole biosynthetic enzyme, ADENOSINE DIPHOSPHATE 5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC ACID, SULFATE ION
Authors:Bale, S., Chatterjee, A., Dorrestein, P.C., Begley, T.P., Ealick, S.E.
Deposit date:2009-01-06
Release date:2010-01-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
Nature, 478, 2011
3IWB
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T. MARITIMA ADOMETDC IN PROCESSED FORM
Descriptor:S-adenosylmethionine decarboxylase
Authors:Bale, S., Kavita, B., Ealick, S.E.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity.
Acta Crystallogr.,Sect.D, 66, 2010
3IWC
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T. MARITIMA ADOMETDC COMPLEX WITH S-ADENOSYLMETHIONINE METHYL ESTER
Descriptor:S-adenosylmethionine decarboxylase, S-ADENOSYLMETHIONINE METHYL ESTER
Authors:Bale, S., Kavita, B., Ealick, S.E.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity.
Acta Crystallogr.,Sect.D, 66, 2010
3IWD
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T. MARITIMA ADOMETDC COMPLEX WITH 5'-DEOXY-5'-DIMETHYL THIOADENOSINE
Descriptor:S-adenosylmethionine decarboxylase, 5'-deoxy-5'-(dimethyl-lambda~4~-sulfanyl)adenosine
Authors:Bale, S., Kavita, B., Ealick, S.E.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity.
Acta Crystallogr.,Sect.D, 66, 2010
3JSK
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THIAZOLE SYNTHASE FROM NEUROSPORA CRASSA
Descriptor:CyPBP37 protein, ADENOSINE DIPHOSPHATE 5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC ACID, FE (II) ION
Authors:Kang, Y.N., Bale, S., Ealick, S.E.
Deposit date:2009-09-10
Release date:2010-09-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of thiazole synthase Thi4 from Neurospora crassa
to be published
3IX1
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PERIPLASMIC N-FORMYL-4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE BINDING PROTEIN FROM BACILLUS HALODURANS
Descriptor:N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine binding protein, N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamide
Authors:Bale, S., Rajashankar, K.R., Perry, K., Begley, T.P., Ealick, S.E.
Deposit date:2009-09-03
Release date:2010-10-13
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:HMP Binding Protein ThiY and HMP-P Synthase THI5 Are Structural Homologues.
Biochemistry, 49, 2010
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